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Opioids Disrupt Sleep And Wakefulness In C57bl/6j Mice, Clarence E. Locklear
Opioids Disrupt Sleep And Wakefulness In C57bl/6j Mice, Clarence E. Locklear
Masters Theses
Opioid use disorder (OUD) is a major public health burden. According to the National Institutes of Health (NIH), studies helping to understand the mechanisms of OUD will help improve prevention and treatment. Opioids long have been shown to disrupt sleep and sleep disruption enhances the likelihood of addiction relapse in humans. The NIH refers to the mouse as one of the most powerful animal systems to study because of the genetic homologies between human and mouse. Prior to the present research, no studies have quantified the effect of opioids on states of sleep and wakefulness in mice. The current study …