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Nutritional Hormesis And Aging, Daniel P Hayes
Nutritional Hormesis And Aging, Daniel P Hayes
Dose-Response: An International Journal
Nutritional hormesis has the potential to serve as a pro-healthy aging intervention by reducing the susceptibility of the elderly to various chronic degenerative diseases and thereby extending human healthspan. Supportive evidence for nutritional hormesis arising from essential nutrients (vitamins and minerals), dietary pesticides (natural and synthetic), dioxin and other herbicides, and acrylamide will be reviewed and discussed.
Clinical Application Of Ischemic Preconditioning In The Elderly, Pasquale Abete, Francesco Cacciatore, Gianluca Testa, David Della-Morte, Gianluigi Galizia, Nicola Ferrara, Franco Rengo
Clinical Application Of Ischemic Preconditioning In The Elderly, Pasquale Abete, Francesco Cacciatore, Gianluca Testa, David Della-Morte, Gianluigi Galizia, Nicola Ferrara, Franco Rengo
Dose-Response: An International Journal
A mild stress such as brief ischemic episodes may protect the heart from a successive and more prolonged myocardial ischemia (ischemic preconditioning). This phenomenon is considered a typical “hormetic mechanism” by which the heart is immunized from pathological insults such as myocardial ischemia. This mechanism is reduced with aging and it may be restored and/or preserved by drugs such as adenosine or nicorandil, a mitochondrial KATP channels, and lifestyle interventions such as physical activity and/or hypocaloric diet. Moreover, since the mechanisms involved in cardiac ischemic preconditioning have been established basic and clinical investigators are encouraged to test several drug …
Hormesis Is Applicable As A Pro-Healthy Aging Intervention In Mammals And Human Beings, Marie-Christine Pardon
Hormesis Is Applicable As A Pro-Healthy Aging Intervention In Mammals And Human Beings, Marie-Christine Pardon
Dose-Response: An International Journal
The aging of the population brings new heath challenges, and in particular, the need to implement suitable pro-healthy aging interventions. This paper discusses the potential of mild stressors inducing hormesis as a lifespan and healthspan extension strategy and how it can be applied to the human. There is some evidence that the anti-aging benefits of lifestyle factors, such as diet, exercise or engaging in activities may be achieved via hormetic regulation. This supports the validity of the concept in human. There are, however, gaps in knowledge and ethical barriers that need to be addressed to establish the suitability of the …
Hormesis Against Aging And Diseases: Using Properties Of Biological Adaptation For Health And Survival Improvement, A I Yashin
Dose-Response: An International Journal
The idea of using hormesis for postponing aging and improving human health has been recently discussed in scientific literature. This paper shows that redundancy in renewal capacity, some portion of which become activated and manifested in hormesis effects, may originate as a result of interaction between living organisms and their environment. It is shown that such redundancy may normally exist for organisms in the wild, and not only in domesticated and laboratory animals. Further development of the hormesis idea requires: (i) investigating regularities of response to multiple stimuli; (ii) studying slow-time responses (e.g., physiological adaptation) to repeated stimuli; (iii) studying …
Stress To The Rescue: Is Hormesis A ‘Cure’ For Aging?, Arnold Kahn, Anders Olsen
Stress To The Rescue: Is Hormesis A ‘Cure’ For Aging?, Arnold Kahn, Anders Olsen
Dose-Response: An International Journal
Despite the fact that the phenomenon of hormesis has been known for many years it is still very much an area of controversy just how useful hormetic treatments are in preventing age-related human diseases and increasing life expectancy. Since there are no data in humans demonstrating hormesis as an effective anti-ageing strategy we turn to a simple model organism for insight. In this review we explore what can be predicted about the usefulness of hormetic treatments in humans based upon studies conducted in the soil nematode Caenorhabditis elegans.
Exercise-Induced Hormesis May Help Healthy Aging, Li Li Ji, Jonathan R Dickman, Chounghun Kang, Ryan Koenig
Exercise-Induced Hormesis May Help Healthy Aging, Li Li Ji, Jonathan R Dickman, Chounghun Kang, Ryan Koenig
Dose-Response: An International Journal
Hormesis plays a critical role in producing some major benefits derived from physical exercise. However whether these known cellular mechanisms are applicable to ameliorate age-related deterioration of muscle function is not entirely clear. The present communication proposes that antioxidant adaptation, the peroxisome proliferator-activated receptor gamma coactivator (PGC)-1α activated mitochondrial biogenesis, and eccentric contraction- induced, cytokine-propelled muscle inflammation could be important redox-sensitive pathways by which exercise-induced disturbance in oxidant-antioxidant hemeostasis may serve as a heretic stimulus to promote adaptations that help healthy aging and improve the quality of life.
It Is Time To Thoroughly Study The Effects Of Mild Stress In Rodents, But Also In Human Beings, Éric Le Bourg
It Is Time To Thoroughly Study The Effects Of Mild Stress In Rodents, But Also In Human Beings, Éric Le Bourg
Dose-Response: An International Journal
Many experiments on the effect of mild stress on aging have been done in invertebrates, but not in mammals. Using mild stress to improve healthspan seems to be possible, because the few studies on humans which have been published appear to be promising. Particularly, one may wonder whether heat shocks could be of some use in therapy or as an integrated part of daily life of elderly people. However, the top priority is probably to study more thoroughly the effects of mild stress in rodents, and not only in invertebrates.
Mimetics Of Hormetic Agents: Stress-Resistance Triggers, Joan Smith Sonneborn
Mimetics Of Hormetic Agents: Stress-Resistance Triggers, Joan Smith Sonneborn
Dose-Response: An International Journal
Mimetics of hormetic agents offer a novel approach to adjust dose to minimize the risk of toxic response, and maximize the benefit of induction of at least partial physiological conditioning. Nature selected and preserved those organisms and triggers that promote tolerance to stress. The induced tolerance can serve to resist that challenge and can repair previous age, disease, and trauma damage as well to provide a more youthful response to other stresses. The associated physiological conditioning may include youthful restoration of DNA repair, resistance to oxidizing pollutants, protein structure and function repair, improved immunity, tissue remodeling, adjustments in central and …
A Stitch In Time: The Needlework Of Aging Women In Antebellum America, Aimee E. Newell
A Stitch In Time: The Needlework Of Aging Women In Antebellum America, Aimee E. Newell
Open Access Dissertations
In October 1852, Amy Fiske (1785-1859) of Sturbridge, Massachusetts, stitched a sampler. But she was not a schoolgirl making a sampler to learn her letters. Instead, as she explained: “The above is what I have taken from my sampler that I wrought when I was nine years old. It was w[rough]t on fine cloth it tattered to pieces. My age at this time is 66 years.” Drawing from 167 examples of decorative needlework – primarily samplers and quilts from 114 collections across the United States – made by individual women aged forty years and over between 1820 and 1860, this …