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Articles 1 - 30 of 227
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The Redshift Search Receiver 3 Mm Wavelength Spectra Of 10 Galaxies, Ronald L. Snell, Gopal Naraynan, Min S. Yun, Mark Heyer, Aeree Chung, William M. Irvine, Neal R. Erickson, Guilin Liu
The Redshift Search Receiver 3 Mm Wavelength Spectra Of 10 Galaxies, Ronald L. Snell, Gopal Naraynan, Min S. Yun, Mark Heyer, Aeree Chung, William M. Irvine, Neal R. Erickson, Guilin Liu
Neal Erickson
The 3 mm wavelength spectra of 10 galaxies have been obtained at the Five College Radio Astronomy Observatory using a new, very broadband receiver and spectrometer, called the Redshift Search Receiver (RSR). The RSR has an instantaneous bandwidth of 37 GHz covering frequencies from 74 to 111 GHz, and has a spectral resolution of 31 MHz (~100 km/s). During tests of the RSR on the FCRAO 14 m telescope the complete 3 mm spectra of the central regions of NGC 253, Maffei 2, NGC1068, IC 342, M82, NGC 3079, NGC 3690, NGC 4258, Arp 220 and NGC 6240 were obtained. …
Application Of Cyclic Voltammetry To Investigate Enhanced Catalytic Current Generation By Biofilm-Modified Anodes Of Geobacter Sulfurreducens Strain Dl1 Vs. Variant Strain Kn400, Sarah M. Strycharz, Anthony P. Malanoski, Rachel M. Snider, Hana Yi, Derek Lovley, Leonard M. Tender
Application Of Cyclic Voltammetry To Investigate Enhanced Catalytic Current Generation By Biofilm-Modified Anodes Of Geobacter Sulfurreducens Strain Dl1 Vs. Variant Strain Kn400, Sarah M. Strycharz, Anthony P. Malanoski, Rachel M. Snider, Hana Yi, Derek Lovley, Leonard M. Tender
Derek Lovley
A biofilm of Geobacter sulfurreducens will grow on an anode surface and catalyze the generation of an electrical current by oxidizing acetate and utilizing the anode as its metabolic terminal electron acceptor. Here we report qualitative analysis of cyclic voltammetry of anodes modified with biofilms of G. sulfurreducens strains DL1 and KN400 to predict possible rate-limiting steps in current generation. Strain KN400 generates approximately 2 to 8-fold greater current than strain DL1 depending upon the electrode material, enabling comparative electrochemical analysis to study the mechanism of current generation. This analysis is based on our recently reported electrochemical model for biofilm-catalyzed …
Discrete Breathers At The Interface Between A Diatomic And A Monoatomic Granular Chain, C. Hoogeboom, G. Theocharis, Panos Kevrekidis
Discrete Breathers At The Interface Between A Diatomic And A Monoatomic Granular Chain, C. Hoogeboom, G. Theocharis, Panos Kevrekidis
Panos Kevrekidis
In the present work, we develop a systematic examination of the existence, stability, and dynamical properties of a discrete breather at the interface between a diatomic and a monoatomic granular chain. We remarkably find that such an “interface breather” is more robust than its bulk diatomic counterpart throughout the gap of the linear spectrum. The latter linear spectral gap needs to exist for the breather state to arise and the relevant spectral conditions are discussed. We illustrate the minimal excitation conditions under which such an interface breather can be “nucleated” and analyze its apparently weak interaction with regular highly nonlinear …
The Effect Of Intellidrive On The Efficiency Of Highway Transportation Systems, Mohammad Nekoui, Hossein Pishro-Nik, Daiheng Ni
The Effect Of Intellidrive On The Efficiency Of Highway Transportation Systems, Mohammad Nekoui, Hossein Pishro-Nik, Daiheng Ni
Daiheng Ni
Recently, the IntelliDrive initiative has been proposed by the US Department of Transportation (USDOT) to enhance on-road safety and efficiency. In this study, we provide a mathematical framework which predicts the effect of such technologies on the efficiency of multilane highway systems prior to their real-life deployment. Our study shall encompass mixed traffic conditions in which a variety of assisted, automated and unequipped vehicles coexist. We show that intervehicular communications improves the flow of vehicles by reducing the perception-reaction (P-R) times of drivers and, in some cases, allowing for more efficient lane-changing operations. As we shall see, unlike the latter, …
Discovering Issue-Based Voting Groups Within The Us Senate, Rachel Shorey, Andrew Mccallum, Hanna Wallach
Discovering Issue-Based Voting Groups Within The Us Senate, Rachel Shorey, Andrew Mccallum, Hanna Wallach
Andrew McCallum
Members of the US Senate cast votes on a wide array of issues. Understanding a senator's position on an issue is important to constituents, sources of campaign funding, and groups seeking to persuade senators or build consensus. Classifying senators' positions often falls into the hands of interest groups. Many lobbyists and issue-based organizations give senators scores based on the number of times senators vote in accordance with the organization's ideals. Organization staff must choose which bills to consider and then investigate their content manually. To produce more objective and replicable rankings, political scientists have developed statistical models to group and …
The Effect Of Intellidrive On The Efficiency Of Highway Transportation Systems, Mohammad Nekoui, Hossein Pishro-Nik, Daiheng Ni
The Effect Of Intellidrive On The Efficiency Of Highway Transportation Systems, Mohammad Nekoui, Hossein Pishro-Nik, Daiheng Ni
Hossein Pishro-Nik
Recently, the IntelliDrive initiative has been proposed by the US Department of Transportation (USDOT) to enhance on-road safety and efficiency. In this study, we provide a mathematical framework which predicts the effect of such technologies on the efficiency of multilane highway systems prior to their real-life deployment. Our study shall encompass mixed traffic conditions in which a variety of assisted, automated and unequipped vehicles coexist. We show that intervehicular communications improves the flow of vehicles by reducing the perception-reaction (P-R) times of drivers and, in some cases, allowing for more efficient lane-changing operations. As we shall see, unlike the latter, …
Ecological Boundary Detection Using Bayesian Areal Wombling, Joseph Elkinton, M. C. Fitzpatrick, E. L. Preisser, A. H. Porter, L. A. Wallwe, B. P. Carlin, A. M. Ellison
Ecological Boundary Detection Using Bayesian Areal Wombling, Joseph Elkinton, M. C. Fitzpatrick, E. L. Preisser, A. H. Porter, L. A. Wallwe, B. P. Carlin, A. M. Ellison
Joseph Elkinton
The study of ecological boundaries and their dynamics is of fundamental importance to much of ecology, biogeography, and evolution. Over the past two decades, boundary analysis (of which wombling is a subfield) has received considerable research attention, resulting in multiple approaches for the quantification of ecological boundaries. Nonetheless, few methods have been developed that can simultaneously (1) analyze spatially homogenized data sets (i.e., areal data in the form of polygons rather than point-reference data); (2) account for spatial structure in these data and uncertainty associated with them; and (3) objectively assign probabilities to boundaries once detected. Here we describe the …
Symbiogenesis. A New Principle Of Evolution Rediscovery Of Boris Mikhaylovich Kozo-Polyansky (1890–1957), Lynn Margulis
Symbiogenesis. A New Principle Of Evolution Rediscovery Of Boris Mikhaylovich Kozo-Polyansky (1890–1957), Lynn Margulis
Lynn Margulis (1938 - 2011)
The following is a heavily edited transcript of my illustrated lecture, that included our 14 minute video (with a 2 minute animation model) that shows each step in live organisms hypothesized in the origin of nucleated cells from bacteria (“eukaryosis”). New observations presented with modern examples of live phenomena make us virtually certain that B.M. Kozo-Polyansky’s “new principle” (1924) of the importance of symbiogenesis in the evolutionary process of at least 2000 million years of life on Earth is correct. The widely touted but undocumented explanation of the origin of evolutionary novelty by “gradual accumulation of random mutations” will be …
Bioinformatic Analysis Of Gene Regulation In The Metal-Reducing Bacteria Family, Derek Lovley, Julia Krushkal, Ronald M. Adkins, Yanhua Qu, Jeanette Peeples, Sreedhar Sontineni, Ching Leang, Peter Brown, Nelson D. Young, Toshiyuki Ueki, Katy Juarez
Bioinformatic Analysis Of Gene Regulation In The Metal-Reducing Bacteria Family, Derek Lovley, Julia Krushkal, Ronald M. Adkins, Yanhua Qu, Jeanette Peeples, Sreedhar Sontineni, Ching Leang, Peter Brown, Nelson D. Young, Toshiyuki Ueki, Katy Juarez
Derek Lovley
Knowledge of how structural genome differences among microorganisms lead to variation in gene regulation is fundamentally important for our understanding of the functioning of gene regulatory pathways and their individual components. This knowledge is also necessary for our better understanding of the genomic changes leading to adaptation to diverse and changing environments. Our research focuses on Geobacteraceae, a metal-reducing family of delta-Proteobacteria, which are capable of harvesting electricity from organic matter and environmental bioremediation of organic and metal pollutants. We are investigating molecular mechanisms which allow these species to adapt and regulate their responses to environmental stimuli, which result in …
A Spectrum Of Traffic Flow Modeling At Multiple Scales, Daiheng Ni
A Spectrum Of Traffic Flow Modeling At Multiple Scales, Daiheng Ni
Daiheng Ni
his paper presents a broad perspective on traffic flow modeling at a spectrum of four scales. Modeling objectives and model properties at each scale are discussed and existing efforts are reviewed. In order to ensure modeling consistency and provide a microscopic basis for macroscopic models, it is critical to address the coupling among models at different scales, i.e. how less detailed models are derived from more detailed models and, conversely, how more detailed models are aggregated to less detailed models. With this understanding, a consistent modeling approach is proposed based on field theory and modeling strategies at each of the …
Validation, Resistance, And Exclusion: Neo-Nationalist Cultural Heritage In A Globalized World, Neil A. Silberman
Validation, Resistance, And Exclusion: Neo-Nationalist Cultural Heritage In A Globalized World, Neil A. Silberman
Neil A. Silberman
No abstract provided.
Open Education Resources At Umass Amherst, Marilyn S. Billings
Open Education Resources At Umass Amherst, Marilyn S. Billings
Marilyn S. Billings
This presentation was the third part of a panel discussion entitled Open Textbook Models: View from the Library.
Comment On “Direct Mapping Of The Finite Tem- Perature Phase Diagram Of Strongly Correlated Quantum Models”, L Pollet, N Prokof’Ev, B Svistunov
Comment On “Direct Mapping Of The Finite Tem- Perature Phase Diagram Of Strongly Correlated Quantum Models”, L Pollet, N Prokof’Ev, B Svistunov
Nikolai Prokof'ev
In their Letter, Zhou, Kato, Kawashima, and Trivedi claim that finite-temperature critical points of strongly correlated quantum models emulated by optical lattice experiments can generically be deduced from kinks in the derivative of the density profile of atoms in the trap with respect to the external potential, $\kappa = -dn(r)/dV(r)$. In this comment we demonstrate that the authors failed to achieve their goal: to show that under realistic experimental conditions critical densities $n_c(T,U)$ can be extracted from density profiles with controllable accuracy.
Exploring The Use Of Numerical Relativity Waveforms In Burst Analysis Of Precessing Black Hole Mergers, Sebastian Fischetti, James Healy, Laura Cadonati, Lionel London, Satyanarayan R.P. Mohapatra, Deirdre Shoemaker
Exploring The Use Of Numerical Relativity Waveforms In Burst Analysis Of Precessing Black Hole Mergers, Sebastian Fischetti, James Healy, Laura Cadonati, Lionel London, Satyanarayan R.P. Mohapatra, Deirdre Shoemaker
Laura Cadonati
Recent years have witnessed tremendous progress in numerical relativity and an ever improving performance of ground-based interferometric gravitational wave detectors. In preparation for Advanced LIGO and a new era in gravitational wave astronomy, the numerical relativity and gravitational wave data analysis communities are collaborating to ascertain the most useful role for numerical relativity waveforms in the detection and characterization of binary black hole coalescences. In this paper, we explore the detectability of equal mass, merging black hole binaries with precessing spins and total mass M_T in [80,350]Msol, using numerical relativity waveforms and template-less search algorithms designed for gravitational wave bursts. …
Financing Peace: International And National Resources For Postconflict Countries And Fragile States, James K. Boyce, Shepard Forman
Financing Peace: International And National Resources For Postconflict Countries And Fragile States, James K. Boyce, Shepard Forman
James K. Boyce
This background paper for the World Bank’s World Development Report 2011 discusses current financing arrangements for postconflict countries and fragile states, with a focus on official development assistance. In recent years a consensus has emerged that in these “difficult environments” the core objective is to build effective and legitimate governance structures that secure public confidence through provision of personal security, equal justice and the rule of law, economic well-being, and essential social services including education and health. Yet tensions persist between business-as-usual development policies on the one hand and policies responsive to the demands of peacebuilding on the other. The …
Why Should We Care About Buckling?, Alfred Crosby
Feronia Receptor-Like Kinase Regulates Rho Gtpase Signaling Of Root Hair Development, Q. Duan, D. Kita, C. Li, Alice Cheung, H. M. Wu
Feronia Receptor-Like Kinase Regulates Rho Gtpase Signaling Of Root Hair Development, Q. Duan, D. Kita, C. Li, Alice Cheung, H. M. Wu
Alice Cheung
Plant RHO GTPases (RAC/ROPs) mediate multiple extracellular signals ranging from hormone to stress and regulate diverse cellular processes important for polarized cell growth, differentiation, development, reproduction, and responses to the environment. They shuttle between the GDP-bound inactive state and the GTP-bound activated state and their activation is predominantly mediated by a family of guanine nucleotide exchange factors (GEFs) referred to as ROPGEFs. Using the Arabidopsis ROPGEF1 as bait, we identified members of a receptor-like kinase (RLK) family as potential upstream regulators for RAC/ROP signaling. NADPH oxidase-derived reactive oxygen species (ROS) are emerging as important regulators for growth and development and …
Operating Parameters And Selectivity In Batch Reactive Distillation, W. Qi, M. F. Malone
Operating Parameters And Selectivity In Batch Reactive Distillation, W. Qi, M. F. Malone
Michael F. Malone
This Article provides new predictions for selectivity in batch reactive distillation, identifying the reflux or reboil ratio and a Damkhler number (Da) as the key operating parameters. The dimensionless Da incorporates the influence of liquid holdup, vapor rate, and rate of reaction. Example results for a system of serial isomerization reactions and for the synthesis of ethylene glycol are provided. The results show that selectivity improvements in BRD are limited for high values of Da or for high values of the reflux or reboil ratio and that selectivity is enhanced as Da or reflux or reboil ratio is decreased. However, …
Herschel/Hifi Measurements Of The Ortho/Para Ratio In Water Towards Sagittarius B2(M) And W31c*, D. C. Lis, T. G. Phillips, P. F. Goldsmith, D. A. Neufeld, E. Herbst, C. Comito, P. Schilke, H. S. P. Müller, E. A. Bergin, M. Gerin, T. A. Bell, M. Emprechtinger, J. H. Black, G. A. Blake, F. Boulanger, E. Caux, C. Ceccarelli, J. Cernicharo, F. Daniel, N. R. Crockett, A. Coutens, E. Dartois, M. De Luca, M.-L. Dubernet, P. Encrenaz, E. Falgarone, T. R. Geballe, B. Godard, T. F. Giesen, J. R. Goicoechea, C. Gry, H. Gupta, P. Hennebelle, P. Hily-Blant, R. Kołos, J. Krełowski, C. Joblin, D. Johnstone, M. Kaźmierczak, S. D. Lord, S. Maret, P. G. Martin, J. Martín-Pintado, G. J. Melnick, K. M. Menten, R. Monje, B. Mookerjea, P. Morris, J. A. Murphy, V. Ossenkopf, J. C. Pearson, M. Pérault, C. Persson, R. Plume, S.-L. Qin, M. Salez, S. Schlemmer, M. Schmidt, P. Sonnentrucker, J. Stutzki, D. Teyssier, N. Trappe, F. F. S. Van Der Tak, C. Vastel, S. Wang, H. W. Yorke, S. Yu, J. Zmuidzinas, A. Boogert, Neal R. Erickson, A. Karpov, J. Kooi, F. W. Maiwald, R. Schieder
Herschel/Hifi Measurements Of The Ortho/Para Ratio In Water Towards Sagittarius B2(M) And W31c*, D. C. Lis, T. G. Phillips, P. F. Goldsmith, D. A. Neufeld, E. Herbst, C. Comito, P. Schilke, H. S. P. Müller, E. A. Bergin, M. Gerin, T. A. Bell, M. Emprechtinger, J. H. Black, G. A. Blake, F. Boulanger, E. Caux, C. Ceccarelli, J. Cernicharo, F. Daniel, N. R. Crockett, A. Coutens, E. Dartois, M. De Luca, M.-L. Dubernet, P. Encrenaz, E. Falgarone, T. R. Geballe, B. Godard, T. F. Giesen, J. R. Goicoechea, C. Gry, H. Gupta, P. Hennebelle, P. Hily-Blant, R. Kołos, J. Krełowski, C. Joblin, D. Johnstone, M. Kaźmierczak, S. D. Lord, S. Maret, P. G. Martin, J. Martín-Pintado, G. J. Melnick, K. M. Menten, R. Monje, B. Mookerjea, P. Morris, J. A. Murphy, V. Ossenkopf, J. C. Pearson, M. Pérault, C. Persson, R. Plume, S.-L. Qin, M. Salez, S. Schlemmer, M. Schmidt, P. Sonnentrucker, J. Stutzki, D. Teyssier, N. Trappe, F. F. S. Van Der Tak, C. Vastel, S. Wang, H. W. Yorke, S. Yu, J. Zmuidzinas, A. Boogert, Neal R. Erickson, A. Karpov, J. Kooi, F. W. Maiwald, R. Schieder
Neal Erickson
We present Herschel/HIFI observations of the fundamental rotational transitions of ortho- and para-H$_2^{16}$O and H$_2^{18}$O in absorption towards Sagittarius~B2(M) and W31C. The ortho/para ratio in water in the foreground clouds on the line of sight towards these bright continuum sources is generally consistent with the statistical high-temperature ratio of 3, within the observational uncertainties. However, somewhat unexpectedly, we derive a low ortho/para ratio of $2.35 \pm 0.35$, corresponding to a spin temperature of $\sim$27~K, towards Sagittarius~B2(M) at velocities of the expanding molecular ring. Water molecules in this region appear to have formed with, or relaxed to, an ortho/para ratio close …
Detection Of Oh+ And H2o+ Towards Orion Kl, H. Gupta, P. Rimmer, J. C. Pearson, S. Yu, E. Herbst, N. Harada, E. A. Bergin, D. A. Neufeld, G. J. Melnick, R. Bachiller, W. Baechtold, T. A. Bell, G. A. Blake, E. Caux, C. Ceccarelli, J. Cernicharo, G. Chattopadhyay, C. Comito, S. Cabrit, N. R. Crockett, F. Daniel, E. Falgarone, M. C. Diez-Gonzalez, M.-L. Dubernet, Neal R. Erickson, M. Emprechtinger, P. Encrenaz, M. Gerin, J. J. Gill, T. F. Giesen, J. R. Goicoechea, P. F. Goldsmith, C. Joblin, D. Johnstone, W. D. Langer, B. Larsson, W. B. Latter, R. H. Lin, D. C. Lis, R. Liseau, S. D. Lord, F. W. Maiwald, S. Maret, P. G. Martin, J. Martin-Pintado, K. M. Menten, P. Morris, H. S. P. Müller, J. A. Murphy, L. H. Nordh, M. Olberg, V. Ossenkopf, L. Pagani, M. Pérault, T. G. Phillips, R. Plume, S.-L. Qin, M. Salez, L. A. Samoska, P. Schilke, E. Schlecht, S. Schlemmer, R. Szczerba, J. Stutzki, N. Trappe, F. F. S. Van Der Tak, C. Vastel, S. Wang, H. W. Yorke, J. Zmuidzinas, A. Boogert, R. Güsten, P. Hartogh, N. Honingh, A. Karpov, J. Kooi, J.-M. Krieg, R. Schieder, P. Zaal
Detection Of Oh+ And H2o+ Towards Orion Kl, H. Gupta, P. Rimmer, J. C. Pearson, S. Yu, E. Herbst, N. Harada, E. A. Bergin, D. A. Neufeld, G. J. Melnick, R. Bachiller, W. Baechtold, T. A. Bell, G. A. Blake, E. Caux, C. Ceccarelli, J. Cernicharo, G. Chattopadhyay, C. Comito, S. Cabrit, N. R. Crockett, F. Daniel, E. Falgarone, M. C. Diez-Gonzalez, M.-L. Dubernet, Neal R. Erickson, M. Emprechtinger, P. Encrenaz, M. Gerin, J. J. Gill, T. F. Giesen, J. R. Goicoechea, P. F. Goldsmith, C. Joblin, D. Johnstone, W. D. Langer, B. Larsson, W. B. Latter, R. H. Lin, D. C. Lis, R. Liseau, S. D. Lord, F. W. Maiwald, S. Maret, P. G. Martin, J. Martin-Pintado, K. M. Menten, P. Morris, H. S. P. Müller, J. A. Murphy, L. H. Nordh, M. Olberg, V. Ossenkopf, L. Pagani, M. Pérault, T. G. Phillips, R. Plume, S.-L. Qin, M. Salez, L. A. Samoska, P. Schilke, E. Schlecht, S. Schlemmer, R. Szczerba, J. Stutzki, N. Trappe, F. F. S. Van Der Tak, C. Vastel, S. Wang, H. W. Yorke, J. Zmuidzinas, A. Boogert, R. Güsten, P. Hartogh, N. Honingh, A. Karpov, J. Kooi, J.-M. Krieg, R. Schieder, P. Zaal
Neal Erickson
We report observations of the reactive molecular ions OH+, H2O+, and H3O+ towards Orion KL with Herschel/HIFI. All three N = 1-0 fine-structure transitions of OH+ at 909, 971, and 1033 GHz and both fine-structure components of the doublet ortho-H2O+ 111–000 transition at 1115 and 1139 GHz were detected; an upper limit was obtained for H3O+. OH+ and H2O+ are observed purely in absorption, showing a narrow component at the source velocity of 9 km s-1, and a broad blueshifted absorption similar to that reported recently for HF and para-H218O, and attributed to the low velocity outflow of Orion KL. …
Herschel Observations Of Ortho- And Para-Oxidaniumyl (H2o+) In Spiral Arm Clouds Toward Sagittarius B2(M), Neal A. Erickson
Herschel Observations Of Ortho- And Para-Oxidaniumyl (H2o+) In Spiral Arm Clouds Toward Sagittarius B2(M), Neal A. Erickson
Neal Erickson
H2O+ has been observed in its ortho- and para- states toward the massive star forming core Sgr B2(M), located close to the Galactic center. The observations show absorption in all spiral arm clouds between the Sun and Sgr B2. The average o/p ratio of H2O+ in most velocity intervals is 4.8, which corresponds to a nuclear spin temperature of 21 K. The relationship of this spin temperature to the formation temperature and current physical temperature of the gas hosting H2O+ is discussed, but no firm conclusion is reached. In the velocity interval 0 to 60 km/s, an ortho/para ratio of …
A High Resolution Line Survey Of Irc+10216 With Herschel/Hifi⋆ First Results: Detection Of Warm Silicon Dicarbide (Sic2), Neal A. Erickson, J. Cernicharo, L. B. F. M. Waters, L. Decin, P. Enrenaz, A. G. G. M. Tielens, M. Agúndez, E. De Beck, H. S. P. Müller, J. R. Goicoechea, M. J. Barlow, A. Benz, N. Crimier, F. Daniel, A. M. Di Giorgio, M. Fich, T. Gaier, P. García-Lario, A. De Koter, T. Khouri, R. Liseau, R. Lombaert, N. Erickson, J. R. Pardo, J. C. Pearson, R. Shipman, C. Sánchez Contreras, D. Teyssier
A High Resolution Line Survey Of Irc+10216 With Herschel/Hifi⋆ First Results: Detection Of Warm Silicon Dicarbide (Sic2), Neal A. Erickson, J. Cernicharo, L. B. F. M. Waters, L. Decin, P. Enrenaz, A. G. G. M. Tielens, M. Agúndez, E. De Beck, H. S. P. Müller, J. R. Goicoechea, M. J. Barlow, A. Benz, N. Crimier, F. Daniel, A. M. Di Giorgio, M. Fich, T. Gaier, P. García-Lario, A. De Koter, T. Khouri, R. Liseau, R. Lombaert, N. Erickson, J. R. Pardo, J. C. Pearson, R. Shipman, C. Sánchez Contreras, D. Teyssier
Neal Erickson
We present the first results of a high-spectral-resolution survey of the carbon-rich evolved star IRC+10216 that was carried out with the HIFI spectrometer onboard Herschel. This survey covers all HIFI bands, with a spectral range from 488 to 1901GHz. In this letter we focus on the band-1b spectrum, in a spectral range 554.5-636.5GHz, where we identified 130 spectral features with intensities above 0.03 K and a signal-to-noise ratio >5. Detected lines arise from HCN, SiO, SiS, CS, CO, metal-bearing species and, surprisingly, silicon dicarbide (SiC2). We identified 55 SiC2 transitions involving energy levels between 300 and 900 K. By analysing …
Essential Genes For Astroglial Development And Axon Pathfinding During Zebrafish Embryogenesis, Michael J.F. Barresi, Sean Burton, Kristina Dipietrantonio, Adam Amsterdam, Nancy Hopkins, Rolf O. Karlstrom
Essential Genes For Astroglial Development And Axon Pathfinding During Zebrafish Embryogenesis, Michael J.F. Barresi, Sean Burton, Kristina Dipietrantonio, Adam Amsterdam, Nancy Hopkins, Rolf O. Karlstrom
Rolf O Karlstrom
The formation of the central nervous system depends on the coordinated development of neural and glial cell types that arise from a common precursor. Using an existing group of zebrafish mutants generated by viral insertion, we performed a “shelf-screen” to identify genes necessary for astroglial development and axon scaffold formation. We screened 274 of 315 viral insertion lines using antibodies that label axons (anti-Acetylated Tubulin) and astroglia (anti-Gfap) and identified 25 mutants with defects in gliogenesis, glial patterning, neurogenesis, and axon guidance. We also identified a novel class of mutants affecting radial glial cell numbers. Defects in astroglial patterning were …
The Land Institute, Madeleine K. Charney
The Land Institute, Madeleine K. Charney
Madeleine K. Charney
An overview of the mission and current projects of The Land Institute in Salinas, Kansas. This organization strives to develop an agricultural system with the ecological stability of the prairie and a grain yield comparable to that from annual crops.
An Interdomain Sector Mediating Allostery In Hsp70 Molecular Chaperones, Robert G. Smock, Olivier Rivoire, William P. Russ, Joanna F. Swain, Stanislas Leibler, Rama Ranganathan, Lila Gierasch
An Interdomain Sector Mediating Allostery In Hsp70 Molecular Chaperones, Robert G. Smock, Olivier Rivoire, William P. Russ, Joanna F. Swain, Stanislas Leibler, Rama Ranganathan, Lila Gierasch
Lila Gierasch
Allosteric coupling between protein domains is fundamental to many cellular processes. For example, Hsp70 molecular chaperones use ATP binding by their actin-like N-terminal ATPase domain to control substrate interactions in their C-terminal substrate-binding domain, a reaction that is critical for protein folding in cells. Here, we generalize the statistical coupling analysis to simultaneously evaluate co-evolution between protein residues and functional divergence between sequences in protein sub-families. Applying this method in the Hsp70/110 protein family, we identify a sparse but structurally contiguous group of co-evolving residues called a ‘sector’, which is an attribute of the allosteric Hsp70 sub-family that links the …
Between Home And History, Neil A. Silberman
Smoking During Pregnancy And Risk Of Abnormal Glucose Tolerance: A Prospective Cohort Study, Amy E. Haskins, Elizabeth R. Bertone-Johnson, Penelope Pekow, Elena T. Carbone, Renée T. Fortner, Lisa Chasan-Taber
Smoking During Pregnancy And Risk Of Abnormal Glucose Tolerance: A Prospective Cohort Study, Amy E. Haskins, Elizabeth R. Bertone-Johnson, Penelope Pekow, Elena T. Carbone, Renée T. Fortner, Lisa Chasan-Taber
Elena T Carbone
Background: Disturbances in glucose metabolism during pregnancy are associated with negative sequalae for both mother and infant. The association between smoking and abnormal glucose tolerance (AGT) remains controversial. Therefore, the aim of this study was to examine the relationship between smoking prior to and during pregnancy and risk of AGT. Methods: We utilized data from a prospective cohort of 1,006 Hispanic (predominantly Puerto Rican) prenatal care patients in Western Massachusetts. Women reported pre- and early pregnancy smoking at recruitment (mean = 15 weeks) and mid pregnancy smoking at a second interview (mean = 28 weeks). AGT was defined as > 135 …
Role Of Hsp70 Atpase Domain Intrinsic Dynamics And Sequence Evolution In Enabling Its Functional Interactions With Nefs, Ying Liu, Lila Gierasch, Ivet Bahar
Role Of Hsp70 Atpase Domain Intrinsic Dynamics And Sequence Evolution In Enabling Its Functional Interactions With Nefs, Ying Liu, Lila Gierasch, Ivet Bahar
Lila Gierasch
12 Hide Figures Abstract Author Summary Introduction Materials and Methods Results Discussion Supporting Information Acknowledgments Author Contributions References Reader Comments (0) Figures Abstract Catalysis of ADP-ATP exchange by nucleotide exchange factors (NEFs) is central to the activity of Hsp70 molecular chaperones. Yet, the mechanism of interaction of this family of chaperones with NEFs is not well understood in the context of the sequence evolution and structural dynamics of Hsp70 ATPase domains. We studied the interactions of Hsp70 ATPase domains with four different NEFs on the basis of the evolutionary trace and co-evolution of the ATPase domain sequence, combined with elastic …
Compactons In Nonlinear Schrödinger Lattices With Strong Nonlinearity Management, F. Kh. Abdullaev, Panos Kevrekidis, M. Salerno
Compactons In Nonlinear Schrödinger Lattices With Strong Nonlinearity Management, F. Kh. Abdullaev, Panos Kevrekidis, M. Salerno
Panos Kevrekidis
The existence of compactons in the discrete nonlinear Schr\"odinger equation in the presence of fast periodic time modulations of the nonlinearity is demonstrated. In the averaged DNLS equation the resulting effective inter-well tunneling depends on modulation parameters {\it and} on the field amplitude. This introduces nonlinear dispersion in the system and can lead to a prototypical realization of single- or multi-site stable discrete compactons in nonlinear optical waveguide and BEC arrays. These structures can dynamically arise out of Gaussian or compactly supported initial data.
Association Between Hiv Replication And Serum Leptin Levels: An Observational Study Of A Cohort Of Hiv-1-Infected South African Women, Livio Azzoni, Nigel J. Crowther, Cynthia Firnhaber, Andrea S. Foulkes
Association Between Hiv Replication And Serum Leptin Levels: An Observational Study Of A Cohort Of Hiv-1-Infected South African Women, Livio Azzoni, Nigel J. Crowther, Cynthia Firnhaber, Andrea S. Foulkes
Andrea S Foulkes
Background - Advanced HIV infection can result in lipoatrophy and wasting, even in the absence of ongoing opportunistic infections, suggesting that HIV may directly affect adipose tissue amount and distribution. Methods - We assessed the relationship of fat (measured using anthropometry, DEXA, MRI scans) or markers related to glucose and lipid metabolism with viral load in a cross-sectional sample of 83 antiretroviral-naïve HIV-1-infected South African women. A multivariable linear model was fitted to log10VL to assess the combined effect of these variables. Results - In addition to higher T cell activation, women with viral load greater than the population median …