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Cleveland State University

2018

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Roles Of H3v In Trypanosoma Brucei, Sandra Haswani Jan 2018

Roles Of H3v In Trypanosoma Brucei, Sandra Haswani

Undergraduate Research Posters 2018

African trypanosomiasis, or sleeping sickness, is caused by the parasite Trypanosoma brucei, a protozoan that affects the central nervous system. This unicellular eukaryote can be transmitted to mammals by the bite of a tsetse fly. T. brucei evades the host’s adaptive immune response by carrying out antigenic variation of its protective coat of Variant Surface Glycoprotein which allows the infection to persist and be further transmitted. T. brucei lacks the sequence-specific transcription factors found in other eukaryotes, thus chromatin structures at PTU (polycistronic transcription units) boundaries are thought to play important roles in control of gene expression. This paper focuses …

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Multi-Phase Waste Gasification – Reaction Engineering For Sustainable Living Environments, Kristen M. Reyes, Mason J. Lang Jan 2018

Multi-Phase Waste Gasification – Reaction Engineering For Sustainable Living Environments, Kristen M. Reyes, Mason J. Lang

Undergraduate Research Posters 2018

Gasification converts carbon-based (organic) materials into gaseous products typically referred to as synthetic gas. This technology is an alternative for reducing carbon footprint of energy generation as well as for waste management. This research examines Catalytic Gasification as a route to Sustainability while converting spaceflight and municipal waste into high-value products. As polyethylene (PE) makes up one of the largest portions of both municipal and space waste, this project centered its attention on the gasification of mid-density PE. We used a slurry containing middensity PE, water, and solid catalysts (ruthenium on alumina, Ru/Al2O3) in a 1:1 PE/Ru ratio. The gasification …

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Treatment Of Non-Epithelial Vaginal Cells From Lysyl Oxidase Like One Knockout Mice (Loxl 1) With Nanoparticles (Nps), Priya Patel Jan 2018

Treatment Of Non-Epithelial Vaginal Cells From Lysyl Oxidase Like One Knockout Mice (Loxl 1) With Nanoparticles (Nps), Priya Patel

Undergraduate Research Posters 2018

Female pelvic floor dysfunction includes pelvic organ prolapse (POP) due to multiple vaginal births causing elastin strength to be reduced. Several normal functions are compromised including bladder control, fecal continence, and painful urination and many other symptoms. Currently no effective treatment is known and women seek surgical mesh implants to correct these issues which are not entirely safe nor effective. The condition of POP affects women across the world and effective treatment is sought. Varying proteins including lysyl oxidase (LOX), tissue inhibitors of metalloproteinases, and matrix metalloproteinases are involved in elastin homeostasis. In this experiment, non-epithelial vaginal cells (NEVCs) retrieved …

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Toward The Crystallization Of An Archaeal Dihydrorotase, Haley Newman, Ryan Godin Jan 2018

Toward The Crystallization Of An Archaeal Dihydrorotase, Haley Newman, Ryan Godin

Undergraduate Research Posters 2018

Dihydroorotase catalyzes the conversion of N-carbamoyl-L-aspartate to Ldihydroorotate in the de novo biosynthesis of pyrimidines. M. jannaschii is an archaeon that thrives in extreme environments such as the hypothermal vents at the bottom of the oceans in which both temperature and pressure are extremely high. It can serve as a model organism for research purposes. This experiment is a first step toward elucidating the structure of this enzyme in M. jannaschii. Our summer research started using a partially purified enzyme preparation from previous experiments. We further purified the enzyme primarily using hydrophobic interaction and hydroxyapatite chromatographies. Twenty-four closely related conditions …

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Reading Between The Bigrams, Gina M. Cascone, Deion L. Colbert Jan 2018

Reading Between The Bigrams, Gina M. Cascone, Deion L. Colbert

Undergraduate Research Posters 2018

In lexical decision experiments in which target strings were flanked by pairs of bigrams, Grainger, Mathot, and Vitu (2014) and Palinski (2016) found, for words, better performance when flanking bigrams contained target-string letters (e.g., FR FROG OG; OG FROG FR; RF FROG GO; GO FROG RF) than when they did not (e.g., EX FROG IT); better performance when flanking bigrams contained letters ordered as in the target (e.g., FR FROG OG; OG FROG FR) than switched (e.g., RF FROG GO; GO FROG RF); and no effect on performance of proximity of flanking letters to their locations in the targets. We …

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Synthesis Of Sialic Acid Derivative For Modifying Cell Surface Sialylation, Isaac Turan, Joseph Keil Jan 2018

Synthesis Of Sialic Acid Derivative For Modifying Cell Surface Sialylation, Isaac Turan, Joseph Keil

Undergraduate Research Posters 2018

The exterior of cell surfaces express a dense layer of glycans which are often terminated by sialic acid (SA). SA is an acidic monosaccharide whose presence is found on the terminal ends of glycans of either glycoproteins or glycolipids. Due to its hydrophilic and electronegative nature, SA is often involved in both physiological and pathological processes, such as in regulating cellular interactions with ligands, microbes and neighboring cells. In addition to these functions, SA is also implicated in controlling cellular activation, differentiation, transformation and migration. Cell surface glycometabolic engineering provides a useful tool to remodel cell surface SA. In this …

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A 3d Cancer Cell Migration Assay On A 384-Pillar Plate With Sidewalls, Nicholas Lesh, Alexander Roth, Stephen Hong, Oju Jeon, Eben Alsberg Jan 2018

A 3d Cancer Cell Migration Assay On A 384-Pillar Plate With Sidewalls, Nicholas Lesh, Alexander Roth, Stephen Hong, Oju Jeon, Eben Alsberg

Undergraduate Research Posters 2018

Hepatocellular carcinoma (HCC) is an aggressive liver cancer where prognosis is heavily tied to metastasis progression. Researchers look to determine the triggers for metastasis to control its spread. The goal of this project is to determine these triggers by quantifying Hep3B cell migration on a high-throughput platform. We infected Hep3B cells with lentiviruses containing mCherry to produce stable fluorescent cells. Next, we determined the stability of growth factors in oxidized, methacrylated alginate (OMA) hydrogel by binding growth factors with methacrylated heparin sulfate (MHS) before encapsulating in OMA, printing onto the 384-pillar plate with sidewalls, and quantifying growth factor release via …

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Spark Plasma Sintering Of Soft Magnetic Materials, Harnavdeep Kaur, Taban Larimian, Javier Esquivel Jan 2018

Spark Plasma Sintering Of Soft Magnetic Materials, Harnavdeep Kaur, Taban Larimian, Javier Esquivel

Undergraduate Research Posters 2018

Over the past 3 decades, iron-based soft magnetic alloys such as Finemet (Fe73.5Si13.5B9Nb3Cu1 (at%)) have attracted great interest due to their exceptional magnetic properties like high magnetization, low coercivity, and high curie temperature. However, the production of amorphous precursor requires very high cooling rates, and thus only wires, powders, and thin ribbons are achievable, yet these are not suitable in industrial applications where large volume of bulk magnetic components is required. Mechanical alloying (MA) has gained special attention as a powerful non-equilibrium process for fabricating amorphous and nanocrystalline materials, whereas spark plasma sintering (SPS) is a unique technique for processing …

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Intercultural Bilingual Education In The Urban Andes, Brenda Castaneda Yupanqui Jan 2018

Intercultural Bilingual Education In The Urban Andes, Brenda Castaneda Yupanqui

Undergraduate Research Posters 2018

In Peru, there are 3 million people whose primary language is the indigenous Quechua. Further, in the provinces where it is most prominent, the language enjoys co-official status with Spanish and is a symbol of cultural and ethnic identity that has deep roots. Despite the vitality of indigenous languages on the decline worldwide, especially in urban settings, Quechua has remained strong in Peru. Intercultural Bilingual Education (IBE) is a language-planning model that has been criticized for attempting to normalize Quechua from a purely Spanish-speaking context in its application, stripping the language of its agency and cultural power. The current study …

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Influence Of Stimulus Amplitude On African Clawed Frogs' Choices Between Two Stimuli, Geetha Somarouthu, Austin Shaffer, Joseph Taraba Jan 2018

Influence Of Stimulus Amplitude On African Clawed Frogs' Choices Between Two Stimuli, Geetha Somarouthu, Austin Shaffer, Joseph Taraba

Undergraduate Research Posters 2018

African clawed frogs locate prey using their lateral line systems to sense water movements the prey make. We’ve previously studied how the frogs choose between two stimuli; their choice is influenced by several factors including most importantly which stimulus is more rostral (i.e. more in front of them) and which is closer, which also means it arrives first with a larger amplitude. Here, we test whether stimulus amplitude affects choice. We generated surface waves by dipping two rods of different sizes into the water. Rods make waves both entering and leaving the water; both the material and diameter affect wave …

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Screen For Interacting Factors For Trypanosoma Brucei Telomere Protein Rap1, Annelise Radzin, Elizabeth Beran Jan 2018

Screen For Interacting Factors For Trypanosoma Brucei Telomere Protein Rap1, Annelise Radzin, Elizabeth Beran

Undergraduate Research Posters 2018

Trypanosoma brucei is a protozoan parasite that causes human African Trypanosomiasis (sleeping sickness) in people and nagana in cattle, both of which are fatal without treatment. This parasite is injected into the host through the bite of the tsetse fly and is able to evade the host’s immune response due to changes in its major surface antigen, variant surface glycoproteins (VSGs). This constant switching prevents the host from making a single antibody that can recognize the antigen and eliminate the parasite. VSG expression sites have been found to be near the telomeres of Trypanosoma brucei, and studies from our lab …

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Characterizing Complexes Of Dna And Elastin-Like Polypeptides, Bryce Noe Jan 2018

Characterizing Complexes Of Dna And Elastin-Like Polypeptides, Bryce Noe

Undergraduate Research Posters 2018

Elastin-like polypeptides (ELPs) are a class of environmental responsive materials. When prepared with a protein motif that selectively binds to nucleic acids, a nucleic acid-ELP complex can be formed, conferring the responsive properties of ELP onto the nucleic acid. One possible use for such a complex is in DNA origami, where nanoscaled assemblies of DNA can be transformed into nanomachines by using the ELP as an actuator. Other possible uses include the isolation and extraction of a selected strands of genetic material, or the delivery of genetic material to a cell. Using a bacterial expression system, our lab has prepared …

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Surface Functionalization Of Pure-Chirality Carbon Nanotubes By Covalent And Noncovalent Chemistry, Fjorela Xhyliu, Niyousha Mohammad Shafie Jan 2018

Surface Functionalization Of Pure-Chirality Carbon Nanotubes By Covalent And Noncovalent Chemistry, Fjorela Xhyliu, Niyousha Mohammad Shafie

Undergraduate Research Posters 2018

Single-wall carbon nanotubes (SWCNTs) are one-dimensional cylindrical nanostructures with distinct electronic and optical properties. With all its atoms on the surface, SWCNTs have been widely explored for chemical modification through noncovalent and covalent chemistry, which can provide promising applications in bioimaging and sensing. Here we investigated surface functionalization of purechirality SWCNTs with various glycopolymers, surfactants, and RPMI cell culture media with and without fetal bovine serum (FBS). Raman, vis-NIR absorption, and vis-NIR fluorescence spectra of SWCNTs in various solvent environments were monitored over time. While nanotube aggregation was not observed for incubation in FBS containing RPMI for 8 hours, interactions …

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Peer Quizzing: Are Two Heads Really Better Than One?, Leah Bunnell Jan 2018

Peer Quizzing: Are Two Heads Really Better Than One?, Leah Bunnell

Undergraduate Research Posters 2018

Instructors are often plagued with a difficult opened ended question; what measures can be implemented during class that will maximize students’ academic benefit? During this research project, the impact of frequent peer quizzing in introductory college level physics courses on subsequent learning assessments, such as midterms and percent gain, are examined. A peer quiz is initially administered to a student individually and graded but not returned to the students until they are given the opportunity to revisit the same quiz question with a partner. Two physics instructors’ student data is included in the data set, which is comprised of Introductory …

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