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Articles 31 - 60 of 103
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Study Of Role Of Ribosomal Protein L13a In Resolving Inflammation, Darshana Poddar
Study Of Role Of Ribosomal Protein L13a In Resolving Inflammation, Darshana Poddar
ETD Archive
Inflammation is an obligatory attempt of the host immune system to protect the body against infection. However, unregulated synthesis of pro-inflammatory products can have detrimental effects. Though mechanisms which contribute to inflammation are well appreciated, those that resolve inflammation are poorly understood. Therefore, understanding the molecular basis of such pathways will provide an entirely novel approach to treat and prevent inflammatory diseases. Transcript-selective translational control can regulate the expression of a set of inflammatory genes. We have identified one such mechanism in a novel animal model which relies on the abrogation of ribosomal protein L13a-dependent translational silencing by creating macrophage-specific …
Treatment Outcomes Of Patients With Low Back Pain Treated In A Pain Rehabilitation Program, Sarah C. Rispinto
Treatment Outcomes Of Patients With Low Back Pain Treated In A Pain Rehabilitation Program, Sarah C. Rispinto
ETD Archive
The study utilized an individual change model to investigate the effectiveness of a chronic pain rehabilitation program at treating pain, mood (depression, anxiety, and stress), and function for chronic low back pain patients. This retrospective study consisted of a sample of 621 patients with a chronic low back pain diagnosis who completed an interdisciplinary rehabilitation program. The outcomes of pain, mood and function were assessed at four waves including admission, discharge, 6-month, and 12-month follow-ups using established instruments. The Depression, Anxiety, Stress Scale (DASS) by Lovibond and Lovibond (1995) was used to assess patients' self-reported levels of depression, anxiety and …
Role Of Mtorc1 And Autophagy In The Regulation Of Chemoresistance In Leukemic B-Cells, Arishya Sharma
Role Of Mtorc1 And Autophagy In The Regulation Of Chemoresistance In Leukemic B-Cells, Arishya Sharma
ETD Archive
Deregulated mTORC1 contributes to tumorigenesis and chemoresistance. However, mTORC1-specific inhibitors (rapalogs) show modest efficacy in the clinic, as they unleash the feedback inhibition on upstream, prosurvival pathways. An alternative approach is to target downstream functions of mTORC1. We investigated acquired resistance to fludarabine (Flu), a purine analog, active agent for chronic lymphocytic leukemia (CLL). Elevated phospho-p70S6k (T389), an mTORC1 activation marker, predicted Flu resistance in a panel of B-cell tumor lines, and primary CLL cells. However, the rapalogs induced moderate cell death in Flu-resistant (FluR) and primary CLL cells. Activation of oncogenic pathways, including mTORC1, induces profound metabolic reprogramming to …
Magnesium As A Regulator Of Hepatic Nadph In The Hepatocyte :;Prospective Roles Of Magnesium In Diabetes And Obesity Onset, Chesinta B. Voma
Magnesium As A Regulator Of Hepatic Nadph In The Hepatocyte :;Prospective Roles Of Magnesium In Diabetes And Obesity Onset, Chesinta B. Voma
ETD Archive
No abstract provided.
Combinatorial Activation Of Stat3 By Egf And Thrombin In Endothelial Cells, Matthew S. Waitkus
Combinatorial Activation Of Stat3 By Egf And Thrombin In Endothelial Cells, Matthew S. Waitkus
ETD Archive
Endothelial cells line the luminal surface of blood vessels and form a regulatory interface between the bloodstream and underlying tissues. The endothelium responds to diverse, and potentially conflicting, environmental signals to regulate vessel growth, leukocyte adhesion, thrombogenicity, and vascular tone. Signaling pathways may interact, or "crosstalk," in combinatorial signaling environments to enable cells to process disparate extracellular information at downstream signaling nodes and formulate appropriate biological responses based on combinations of extracellular stimuli. We have reported that simultaneous stimulation of endothelial cells with EGF and thrombin synergistically induces expression of immediate early genes (IEGs) associated with growth and angiogenesis. We …
Three Essays On Pricing And Volume Distributions Of Cross-Listed Stocks, Jing Wang
Three Essays On Pricing And Volume Distributions Of Cross-Listed Stocks, Jing Wang
ETD Archive
This dissertation provides empirical evidences in global cross-listed stocks trading volume and pricing. The first essay documents the global trading volume distribution of cross-listed stocks and examines factors that make a host market competitive in attracting order flows from the counterpart domestic market. The results show that host markets are more successful in attracting trading volume when they have a higher information factor, have lower bid-ask spreads, provide better investor protection and information disclosure, share the common language or legal origin with the counterpart home markets and locate closer to the home market. The second essay investigates the market competitiveness …
Between Bleakness And Hope In A Large Urban School District Culturally Responsive Pedagogy In Special Education, Kamilah Aisha Williams
Between Bleakness And Hope In A Large Urban School District Culturally Responsive Pedagogy In Special Education, Kamilah Aisha Williams
ETD Archive
This qualitative case study explored the experience of teachers in special education settings within an urban district in the Midwest. The particular emphasis of the study was to attend to efforts used by teachers to address the issue of equality of opportunity in special education settings serving low-income students of color. Using a case study approach, the research explored what barriers teachers see as getting in the way of equal educational opportunity and how teachers reduce barriers of inequality for their students. In particular, the study looked at the ways in which educators facilitate equality by creating opportunities for students …
Metal Containing Nucleosides That Function As Therapeutic Diagnostic Agents Against Brain Cancer, Jennifer Nicole Williams
Metal Containing Nucleosides That Function As Therapeutic Diagnostic Agents Against Brain Cancer, Jennifer Nicole Williams
ETD Archive
Nucleoside transporters are essential components for the hyperproliferative capabilities of brain cancer cells. These transporters play important roles to increase nucleoside metabolism which is necessary for higher levels of DNA and RNA synthesis. The goal here is to use a series of metal containing nucleoside (MCN) analogues as novel chemical agents to study how nucleosides are imported into cells. In addition, we expect that these MCNs will ultimately function as therapeutic and/or diagnostic agents for brain cancer. Concentrative nucleoside transporters (CNTs) and equilibrative nucleoside transporters (ENTs) represent the two classes of transporters that allow MCNs to travel in (and out) …
Dispersal Capabilities Of Two Plecopteran Species And Macroinvertebrate Community From Four Watersheds In Northeast Ohio, Alison L. Yasick
Dispersal Capabilities Of Two Plecopteran Species And Macroinvertebrate Community From Four Watersheds In Northeast Ohio, Alison L. Yasick
ETD Archive
This dissertation focused on the insect order Plecoptera, and hypothesized that Allocapnia recta populations would have lower genetic diversity than Leuctra tenuis between adjacent Chagrin and Grand Rivers due to wing structure and season of terrestrial adult emergence. Genetic variations within the 16s rRNA region of mtDNA in A. recta, a winter emerging adult with rudimentary wing structure, and L. tenuis, a summer emerging adult with fully developed wings, were compared and revealed significant genetic variability between A. recta samples from the two rivers (FST = 0.20) but not between L. tenuis samples (FST = 0.07). Further genetic variation investigation …
A Probabilistic Based Failure Model For Components Fabricated From Anisotropic Graphite, Chengfeng Xiao
A Probabilistic Based Failure Model For Components Fabricated From Anisotropic Graphite, Chengfeng Xiao
ETD Archive
The nuclear moderator for high temperature nuclear reactors are fabricated from graphite. During reactor operations graphite components are subjected to complex stress states arising from structural loads, thermal gradients, neutron irradiation damage, and seismic events. Graphite is a quasi-brittle material. Two aspects of nuclear gradegraphite, i.e., material anisotropy and different behavior in tension and compression, are explicitly accounted for in this effort. Fracture mechanic methods are useful for metal alloys, but they are problematic for anisotropic materials with a microstructure that makes it difficult to identify a "critical" flaw. In fact cracking in a graphite core component does not necessarily …
Byzantine Fault Tolerance For Distributed Systems, Honglei Zhang
Byzantine Fault Tolerance For Distributed Systems, Honglei Zhang
ETD Archive
The growing reliance on online services imposes a high dependability requirement on the computer systems that provide these services. Byzantine fault tolerance (BFT) is a promising technology to solidify such systems for the much needed high dependability. BFT employs redundant copies of the servers and ensures that a replicated system continues providing correct services despite the attacks on a small portion of the system. In this dissertation research, I developed novel algorithms and mechanisms to control various types of application nondeterminism and to ensure the long-term reliability of BFT systems via a migration-based proactive recovery scheme. I also investigated a …
The Role Of Rnase L In Thymic Homeostasis And Humoral Responses, Lin Zhang
The Role Of Rnase L In Thymic Homeostasis And Humoral Responses, Lin Zhang
ETD Archive
RNase L is highly expressed in the spleen, thymus, and multiple immune cells, suggesting that it may play an important role in the immune system against microbes. Previous studies in the lab have shown that deficiency of RNase L results in enlarged thymuses in mice at young age. However, relatively little is known about its influence on the thymic development and adaptive immunogenicity. The present Ph.D. study focuses on investigating the role of RNase L in the thymic homeostasis and humoral immune responses, thereby gaining new insights into the molecular aspects in thymocyte development, maturation and adaptive immunity.By using RNase …
The Impact Of Substance Abuse Training And Support On Psychologists' Functioning As Alcohol And Drug Counselors, Yvona Layla Pabian
The Impact Of Substance Abuse Training And Support On Psychologists' Functioning As Alcohol And Drug Counselors, Yvona Layla Pabian
ETD Archive
Alcohol and other drug (AoD) problems occur at epidemic levels in society, yet many individuals do not receive adequate treatment. Research suggests that psychologists are disinterested in AoD counseling, and have AoD training, attitude, and skill deficits. The current study examined the role of AoD training and professional support on psychologists' functioning as AoD counselors. The ultimate purpose of the study was to determine what interventions may be useful for improving psychologists' ability to provide AoD counseling. One hundred and seventy-eight members of four divisions of the American Psychological Association were surveyed using a measure developed by the author based …
Mineral Uptake Rates And Yield Coefficients Of The Green Microalgae Scenedesmus Dimorphus, Grace N. Mahfouz
Mineral Uptake Rates And Yield Coefficients Of The Green Microalgae Scenedesmus Dimorphus, Grace N. Mahfouz
ETD Archive
The need for renewable sources of energy has become critical as fossil fuel resources, which include oil, coal, and natural gas, are known to contribute to climate change and will eventually be depleted. Biofuels that originate from the fat of plants, animals, microalgae, and bacteria are an attractive alternative. Microalgae, in particular, are strong candidates for biofuel production since they have a high growth rate and lipid content (up to 50 in some species). The goal of this research was to optimize 3N-BBM+V recipe (Bold Basal Medium with 3-fold Nitrogen and Vitamins) in an effort of reducing the amount of …
Looking And Liking: Applying Information Processing To Facebook Ads, Jennie A. Ford
Looking And Liking: Applying Information Processing To Facebook Ads, Jennie A. Ford
ETD Archive
This study applied the Limited Capacity Model (Lang, 2000) to understand how individuals' process their Facebook pages. It is an eye tracking study that collected data from students at a Midwestern university to analyze how individuals process, encode, store and retrieve posts from their Facebook pages, specifically suggested/sponsored posts that are integrated into their newsfeed and targeted to them based on known information. The individuals explored their Facebook pages and were asked to recall the brands or advertisements they were first exposed to on their page. The results from eye tracking were used to analyze how they oriented to and …
Acoustic And Respiratory Measures As A Function Of Age In The Male Voice, Mark Selent
Acoustic And Respiratory Measures As A Function Of Age In The Male Voice, Mark Selent
ETD Archive
The purpose of this study was to extend understanding of the effects of aging on the male voice by obtaining and analyzing both acoustic and respiratory measures across the aging continuum. Aerodynamic measurements such as vital capacity (VC), maximum phonation time (MPT) and the acoustic measurement Speaking Fundamental Frequency (SFF) are used commonly in Speech-language Pathology to aid in the assessment and treatment outcomes of vocal dysfunction. However, current research lacks analysis of the interaction across these parameters within males and younger ages. This information may be important in understanding the normal changes in the speech mechanism with age and …
Installation And Field Testing Of High Performance Repair Materials For Pavements And Bridge Decks, Andrew Lesak
Installation And Field Testing Of High Performance Repair Materials For Pavements And Bridge Decks, Andrew Lesak
ETD Archive
Pavement patching is a common maintenance activity in the state of Ohio, due to numerous freeze-thaw cycles. The Ohio Transportation (ODOT) has a need for durable, more permanent high performing pavement and bridge deck materials that allow for a faster repair and for user safety. New or proprietary products were chosen, installed, and monitored in order to specify for use in future ODOT construction, based on the field performance of the products. The objective of this study was to document the investigation, installation, and field testing of the previously chosen high performance patching materials. The investigation determined the proper field …
Implementation And Field Testing Of Improved Bridge Parapet Designs, Amy E. Kalabon
Implementation And Field Testing Of Improved Bridge Parapet Designs, Amy E. Kalabon
ETD Archive
Premature cracking of concrete bridge parapets is a potentially complex problem, with a number of possible causes. Identifying the cause of premature cracking, and avoiding this problem in the future has several benefits, including: a potential cost savings for the district, improving the safety of these structures in future construction, and increasing the overall understanding of parapets. The objective of this study was to analyze the reasons for uncontrolled cracking in order to establish an improved parapet design, and provide recommendations to the Ohio Transportation (ODOT) to prevent such cracking in the future. Previous research carried out a forensic investigation …
Selection Of High Performance Repair Materials For Pavements And Bridge Decks, Alice E. Sommerville
Selection Of High Performance Repair Materials For Pavements And Bridge Decks, Alice E. Sommerville
ETD Archive
The Ohio Transportation has identified the need to specify durable, more permanent high performing pavement and bridge deck patching materials. These materials need to allow for expedited pavement and bridge deck wearing surface repair for worker and user safety. Currently, either temporary or generally specified in-kind or like materials are being used to perform pavement patching. Usually, the Department provides generically specified cementitious or cold mix asphalt materials for patching wearing surfaces with varied performance characteristics. Current products used for these repairs are generally those that have been used for many decades for which competition exists. However, new or proprietary …
How Coping, Ptsd And Treatment Preferences Interact?, Martha Mae Golubski
How Coping, Ptsd And Treatment Preferences Interact?, Martha Mae Golubski
ETD Archive
Posttraumatic Stress Disorder (PTSD) is a mental disorder characterized by symptoms of intrusive recollection, avoidance or numbing, and hyper arousal following being exposed to a traumatic event involving threatened or actual death or serious injury (4th ed., text rev, DSM-IV-TR American Psychiatric Association, 2000). Those with PTSD, employ a variety of coping strategies to deal with the symptoms following their trauma exposure. Across studies, it has been found that coping styles which are active have a positive effect on both physical and psychological health (Gil & Caspi, 2005 Lazarus & Moskowits, 2004 Olff, Langeland, & Gersons, 2005). However, avoidance coping …
Determining The Relationship Between Language And Attention In Elders With Nonfluent Aphasia, Amanda Wadams
Determining The Relationship Between Language And Attention In Elders With Nonfluent Aphasia, Amanda Wadams
ETD Archive
Researchers have questioned whether the occurrence of aphasia creates executive function deficiencies that result in cognitive-linguistic deficits. Aphasia is a breakdown in language comprehension and production caused by a focal lesion in the left hemisphere of the brain (Papathanasiou, Coppens, & Potagas, 2013). Executive function refers to a set of "higher order component functions required to control and coordinate performance on complex problem solving tasks" (Dick & Overton, 2010). Researchers have speculated that attention, an important part of executive function, may be compromised in addition to language deficits in persons with aphasia. The purpose of this exploratory multiple case comparison …
Relationships Between Diet, Exercise And Learning In The Regular Science Classroom Setting, Joseph R. Sieracki
Relationships Between Diet, Exercise And Learning In The Regular Science Classroom Setting, Joseph R. Sieracki
ETD Archive
The purpose of this study is to examine how diet and exercise relate to student achievement and learning in the regular classroom setting. Research questions include whether or not there is a positive correlation between the amount/type of exercise a student receives per week and learning, as well as relationships between their diet and learning in the classroom. Forty high school honors biology students were surveyed as to their dietary and exercise habits. This data was compared to their individual average test grades as a measure of learning
Design Of Recombinant Tenebrio Molitor Antifreeze Protein For Purification Using Elastin-Like Polypeptide Tag, Joongseok Oh
Design Of Recombinant Tenebrio Molitor Antifreeze Protein For Purification Using Elastin-Like Polypeptide Tag, Joongseok Oh
ETD Archive
Fusion protein technologies can aid to improve solubility of recombinant protein from microorganisms and help recombinant protein purification. Elastin-like polypeptides (ELP) as a fusion tag can be utilized to facilitate the purification of recombinant proteins because ELP can provide its thermally responsive behavior to ELP tagged proteins. An ELP tag can be used as the purification carrier through inverse transition cycling (ITC), which is a simple and non chromatographic separation process. The purification through ITC can reduce cost and can be quickly performed compared to other purification methods. However, we further considered ELP tag removal because it may possibly hinder …
Color Removal From Dye And Sugar Wastewater Using Coagulation And Microfiltration Processes, Saketh Thanneeru
Color Removal From Dye And Sugar Wastewater Using Coagulation And Microfiltration Processes, Saketh Thanneeru
ETD Archive
The water is widely used in process industries, but its use is not always made in a rational way. Due to the growing demand for water by the people and industries, it is necessary to consider the new problem of water supply. Water contamination by organic and inorganic compounds is of great public concern. The textile and sugar industry are the major producers of the wastewater with a varying parameters. Even though there are new technologies for color removal till this date coagulation is seen as the most economical alternative to all technologies present now. In this thesis we study …
Numerical Investigation Of Boiling In A Sealed Tank In Microgravity, Sonya Lynn Hylton
Numerical Investigation Of Boiling In A Sealed Tank In Microgravity, Sonya Lynn Hylton
ETD Archive
NASA's missions in space depend on the storage of cryogenic fluids for fuel and for life support. During long-term storage, heat can leak into the cryogenic fluid tanks. Heat leaks can cause evaporation of the liquid, which pressurizes the tank. However, when the tanks are in a microgravity environment, with reduced natural convection, heat leaks can also create superheated regions in the liquid. This may lead to boiling, resulting in much greater pressure rises than evaporation at the interface between the liquid and vapor phases. Models for predicting the pressure rise are needed to aid in developing methods to control …
Land Use And Transportation Modeling, Gerayeli Alireza
Land Use And Transportation Modeling, Gerayeli Alireza
ETD Archive
Across the United States, the need and value of coordinated land use and transportation planning have become a highly debated topic. There are those who believe that the coordination of land use and transportation is best served in the development of compact communities with alternate modes of travel. This approach is thought to preserve natural resources and result in a reduction in the number and length of vehicle trips. Others believe that such compact developments will lead to highly congested transportation systems. The Federal Highway Administration (FHWA) has acknowledged the need and value of coordinating land use and transportation planning, …
Sports Sponsorship: Fan Loyalty And Perception Of The Lake County Captains Minor League Baseball Team, Mark Daniel Weissman
Sports Sponsorship: Fan Loyalty And Perception Of The Lake County Captains Minor League Baseball Team, Mark Daniel Weissman
ETD Archive
Sports sponsorship is a multi-billion dollar industry that takes place at all levels of sport. Each sponsorship comes with a different level of exposure for the sponsoring company. In most cases, the cost of the sponsorship has a significant relationship to the level of exposure received. Numerous studies have been conducted to assess fans' perception of sponsorship in sport. However, the majority of these studies were conducted at the professional or intercollegiate level. More than 41 million people attended Minor League Baseball games in 2012, and this number was higher than both the National Basketball Association and National Football League …
Computation Of Fifteen Thermodynamic Properties Along Arbitrary Paths From Fundamental Equations Of State Correlations, Prashanth Krishnamoorthy
Computation Of Fifteen Thermodynamic Properties Along Arbitrary Paths From Fundamental Equations Of State Correlations, Prashanth Krishnamoorthy
ETD Archive
In this work, a set of fifteen thermodynamic properties for thirty pure compounds has been estimated using fundamental equations of state (FEOS). A computer program was written which allows to input any two of four fundamental thermodynamic properties entropy, pressure, temperature and density to fix a state point and then use the FEOS to generate any other property at that given state. The program further applies the FEOS to trace thermodynamic processes like isochoric, isobaric, isenthalpic, isothermal and isentropic state changes to find the final state of the compound. The program subsequently displays the initial, final and intermediate state points …
The Effect Of The Muscular Ideal Prime In A Lexical Decision Task, Stephanie A. Henley
The Effect Of The Muscular Ideal Prime In A Lexical Decision Task, Stephanie A. Henley
ETD Archive
Research has shown that body dissatisfaction (BD) is prevalent among males and is associated with unhealthy outcomes (Karazsia & Crowther 2009). Muscular ideal internalization and social comparison are predictors of BD in males. However, the majority of body image research has focused on females, with limited research having been conducted with males. In particular, little research has been aimed at understanding the internal mechanisms associated with male BD. In the current study, I examined the effect of priming an extreme muscular body and a moderate muscular body on the subsequent perception of positive and negative feeling words and positive and …
Effects Of Shear Stress On The Distribution Of Kindlins In Endothelial Cells, Sidney V. Jones
Effects Of Shear Stress On The Distribution Of Kindlins In Endothelial Cells, Sidney V. Jones
ETD Archive
Endothelial cells (ECs) are exposed to changes in shear stress under a variety of physiological and pathological circumstances and respond by changing their shape, gene expression and cytoskeletal arrangement. Integrins are central mediators of these mechanotransduction responses of ECs and integrin function is in turn controlled by interaction of their short cytoplasmic tails with cytoplasmic binding partners. Recent studies have demonstrated the importance of the kindlin family members, known cytoplasmic tail binding proteins, as regulators of integrin function. Our lab has previously shown that kindlin-2 (K2) and kindlin-3 (K3) are both expressed and functionally significant for integrin mediated cellular events …