Digital Commons Network^™

Thalamic Shape Abnormalities Differentially Relate To Cognitive Performance In Early-Onset And Adult-Onset Schizophrenia, Derin J. Cobia, Chaz Rich, Matthew J. Smith, Pedro Engel Gonzalez, Will Cronenwett, John G. Csernansky, Lei Wang

Faculty Publications

Early-onset schizophrenia (EOS) shares many biological and clinical features with adult-onset schizophrenia (AOS), but may represent a unique subgroup with greater susceptibility for disease onset and worsened symptomatology and progression, which could potentially derive from exaggerated neurodevelopmental abnormalities. Neurobiological explanations of schizophrenia have emphasized the involvement of deep-brain structures, particularly alterations of the thalamus, which have been linked to core features of the disorder. The aim of this study was to compare thalamic shape abnormalities between EOS and AOS subjects and determine whether unique behavioral profiles related to these differences. It was hypothesized abnormal thalamic shape would be observed in …

Maternal Depression Moderated By Family Resources When Children Have Developmental Disabilities., Timothy B. Smith, Terisa P. Gabrielsen

Faculty Publications

Children with developmental disabilities require extensive parental involvement in intervention, but parents with depression may be less able to intervene effectively. We examined prevalence of depression symptoms and predictors among 131 mothers of children with disabilities enrolled in early childhood special education. Participants completed several self-report measures of depression and child and family functioning. Children were directly evaluated using the Battelle Developmental Inventory. One year later, 68 mothers repeated self-report measures. Participants (30%) reported elevated depression symptoms across time. Depression scores were correlated with parental stress and family resources. An interaction between higher maternal depression and higher child functioning with …

The Eschatological Hope Scale: Construct Development And Measurement Of Theistic Eschatological Hope, Charlotte Vanoyen-Witvliet, M. Elizabeth Lewis Hall, Julie J. Exline, David C. Wang, Lindsey M. Root Luna, Daryl R. Van Tongeren, David G. Myers, Alexis D. Abernethy, John D. Witvliet

Faculty Publications

This study aimed to expand psychological research on hope by contributing a construct and scale to measure central dimensions of theistic eschatological hope derived from Christian scriptures. Eschatological hope was conceptualized as the anticipation that God will make all things new, raising people to everlasting life with God in joyful celebration, including people from every culture and nation, ending all personal pain and suffering, eliminating all societal evil and harm, and bringing reconciliation and healing to all of creation. We developed the Eschatological Hope Scale with three studies (N = 1,466). Exploratory and confirmatory factor analyses supported the single-factor structure …

A Resilience-Based Intervention To Mitigate The Effect Of Hiv-Related Stigma: Protocol For A Stepped Wedge Cluster Randomized Trial, Xiaoming Li, Shan Qiao, Xueying Yang, Sayward Harrison, Cheuk Chi Tam, Zhiyong Shen, Yuejiao Zhou

Faculty Publications

Background: Despite decades of global efforts to tackle HIV-related stigma, previous interventions designed to reduce stigma have had limited effects that were typically in the small- to-moderate range. The knowledge gaps and challenges for combating HIV-related stigma are rooted both in the complexity of the stigma and in the limitations of current conceptualizations of stigma reduction efforts. Recent research has shown the promise of resilience-based approaches that focus on the development of strengths, competencies, resources, and capacities of people living with HIV (PLWH) and their key supporting systems (e.g., family members and healthcare providers) to prevent, reduce, and mitigate the …

Accountability As A Key Virtue In Mental Health And Human Flourishing, John R. Peteet, Charlotte Vanoyen-Witvliet, C. Stephen Evans

Faculty Publications

We propose that accountability plays an implicit, important, and relatively unexamined role in psychiatry. People generally think of accountability as a relation in which one party is held accountable by another. In this paper, we examine accountability as a virtue, drawing on philosophy, psychiatry, and psychology to examine what it means to welcome being accountable in an excellent way that promotes flourishing. When people manifest accountability as a virtue, they are both responsive to others they owe a response, and they are responsible for their attitudes and actions in light of these relationships. Psychiatric treatment often aims to correct disordered …

Accountability And Autonomy, Motivation, And Psychiatric Treatment, John R. Peteet, Charlotte Vanoyen-Witvliet, C. Stephen Evans

Faculty Publications

No abstract provided.

Functional Differentiation In The Language Network Revealed By Lesion-Symptom Mapping, William Matchin, Alexandra Basilaskos, Dirk-Bart Den-Ouden, Brielle C. Stark, Gregory Hickok, Julius Fridiksson

Faculty Publications

Theories of language organization in the brain commonly posit that different regions underlie distinct linguistic mechanisms. However, such theories have been criticized on the grounds that many neuroimaging studies of language processing find similar effects across regions. Moreover, condition by region interaction effects, which provide the strongest evidence of functional differentiation between regions, have rarely been offered in support of these theories. Here we address this by using lesion-symptom mapping in three large, partially-overlapping groups of aphasia patients with left hemisphere brain damage due to stroke ( N = 121, N = 92, N = 218). We identified multiple measure …

Moral Disengagement Mechanisms Predict Cyber Aggression Among Emerging Adults, Taylor R. Nocera, Eric R. Dahlen, Alison Poor, Jacqueline Strowd, Amanda Dortch, Erica C. Van Overloop

Faculty Publications

The Internet has given rise to many new communication tools (e.g., social media, text messaging), which, while beneficial in many respects, have become a means for aggressing against others. As evidence of the adverse correlates of cyber aggression mounts, improved understanding of the mechanisms that facilitate electronic aggression is needed. Moral disengagement (i.e., cognitive processes through which individuals disengage from their moral values) has been shown to predict cyber aggression when assessed as a unitary construct. The present study investigated the eight moral disengagement mechanisms measured by the Moral Disengagement Measure (Detert et al., 2008) and their relationships to four …

The Effects Of Team Surface-Level Diversity On Creativity & Innovation, Roman Mitchell

Faculty Publications

During the last 20 years, the global marketplace has become more competitive due to increased globalization, aggressive market competition, and changing customer demands. This has forced organizations to assemble teams with diverse knowledge, skills, and abilities to remain competitive. However, previous meta-analytic investigations examining the relationship between team surface-level diversity (i.e., race or gender identity), creativity, and innovation have indicated a small negative relationship. Despite the said positive effects of team diversity, theory and empirical evidence suggests that increased surface-level team diversity leads to decreased team collaboration, team cohesion, and diminished creativity and innovation (Bell, 2007).

This study explores the …

Family History Of Fxtas Is Associated With Age-Related Cognitive-Linguistic Decline Among Mothers With The Fmr1 Premutation, Jessica Klusek, Amanda Fairchild, Carly Moser, Marsha R. Mailick, Angela John Thurman, Leonard Abbeduto

Faculty Publications

BACKGROUND: Women who carry a premutation allele of the FMR1 gene are at increased vulnerability to an array of age-related symptoms and disorders, including age-related decline in select cognitive skills. However, the risk factors for age-related decline are poorly understood, including the potential role of family history and genetic factors. In other forms of pathological aging, early decline in syntactic complexity is observed and predicts the later onset of neurodegenerative disease. To shed light on the earliest signs of degeneration, the present study characterized longitudinal changes in the syntactic complexity of women with the FMR1 premutation across midlife, and associations …

Disruptions Of The Human Connectome Associated With Hemispatial Neglect, Sadhvi Saxena, Zafer Keser, Chris Rorden, Leonardo Bonilha, Julius Fridriksson Ph.D., Alexandra Walker, Argye Elizabeth Hillis

Faculty Publications

Background and Objectives

Hemispatial neglect is a heterogeneous and complex disorder that can be classified by frame of reference for “left” vs “right,” including viewer-centered neglect (VCN, affecting the contralesional side of the view), stimulus-centered neglect (SCN, affecting the contralesional side of the stimulus, irrespective of its location with respect to the viewer), or both. We investigated the effect of acute stroke lesions on the connectivity of neural networks that underlie VCN or SCN.

Methods

A total of 174 patients within 48 hours of acute right hemispheric infarct underwent a detailed hemispatial neglect assessment that included oral reading, scene copy, …

Postseptic Cognitive Impairment And Expression Of Apoe In Peripheral Blood: The Cognition After Sepsis (Cass) Observational Pilot Study, Samuel M. Brown, Sarah J. Beesley, Chris Stubben, Emily L. Wilson, Angela P. Presson, Colin Grissom, Colin Maguire, Matthew T. Rondina, Ramona O. Hopkins

Faculty Publications

Background: Cognitive impairment after sepsis is an important clinical problem. Determinants of postseptic cognitive impairment are not well understood. We thus undertook a systems biology approach to exploring a possible role for apolipoprotein E (APOE) in postseptic cognitive impairment.

Design: Prospective, observational cohort. Setting: Intermountain Medical Center, a tertiary referral center in Utah.

Patients/Participants: Patients with sepsis admitted to study intensive care units. Interventions: None.

Methods: We obtained peripheral blood for deep sequencing of RNA and followed up survivors at 6 months with a battery of cognitive instruments. We defined cognitive impairment based on the 6-month Hayling test of executive …

The Contributions Of Immediate Retrieval And Spaced Retrieval To Word Learning In Preschoolers With Developmental Language Disorder, Laurence B. Leonard, Justin B. Kueser, Patricia Deevy, Eileen Haebig, Jeffrey D. Karpicke, Christine Weber

Faculty Publications

Background and Aims: Children with developmental language disorder (DLD) benefit from word learning procedures that include a mix of immediate retrieval and spaced retrieval trials. In this study, we examine the relative contribution of these two types of retrieval.

Methods: We examine data from Haebig et al. (2019) in their study that compared an immediate retrieval condition and a condition of spaced retrieval that also included immediate retrieval trials. Participants were 4- and 5-year old children with DLD and same-age peers with typical language development. Each child learned novel (made-up) words referring to unusual plants and animals in both conditions. …

Understanding Spiritual Well-Being Among Critical Incident Stress Management-Trained First Responders, Harvey Burnett

Faculty Publications

No abstract provided.

Occupational Characteristics Of Psychology Baccalaureate Graduates, Adam Butler, Michael Gasser

Faculty Publications

Although the field of psychology is classically associated with a career path in mental health services, career options for graduates with a baccalaureate degree in psychology are far broader. Yet, we do not have a good understanding of the occupational spectrum for psychology graduates or of the skills necessary to excel in those positions. The goal of the present study was to identify the characteristics of occupations held by alumni with a baccalaureate degree in psychology. Understanding these occupational characteristics is useful for career advising and for developing job-relevant skills in the psychology major.

Protocol For Escitalopram And Language Intervention For Subacute Aphasia (Elisa): A Randomized, Double Blind, Placebo-Controlled Trial, Melissa D. Stockbridge, Julius Fridriksson, Souvik Sen, Leonardo Bonilha

Faculty Publications

In this forthcoming multicenter, prospective, randomized, double-blind placebo-controlled trial, we will investigate the augmentative effects of a selective serotonin reuptake inhibitor, escitalopram, on language therapy in individuals with post-stroke aphasia. We hypothesize that, when combined with language therapy, daily escitalopram will result in greater improvement than placebo in an untrained picture naming task (Philadelphia Naming Test short form) administered one week after the end of language therapy. We also will examine whether escitalopram's effect on language is independent of its effect on depression, varies with lesion location, or is associated with increased functional connectivity within the left hemisphere. Finally, we …

Isolating The White Matter Circuitry Of The Dorsal Language Stream: Connectome-Symptom Mapping In Stroke Induced Aphasia, Vatche Baboyan, Alexandra Basilaskos, Grigori Yourganov, Chris Rorden, Leonardo Bonilha, Julius Fridiksson, Gregory Hickok

Faculty Publications

The application of 𝓁 1 -regularized machine learning models to high-dimensional connectomes offers a promising methodology to assess clinical-anatomical correlations in humans. Here, we integrate the connectome-based lesion-symptom mapping framework with sparse partial least squares regression (sPLS-R) to isolate elements of the connectome associated with speech repetition deficits. By mapping over 2,500 connections of the structural connectome in a cohort of 71 stroke-induced cases of aphasia presenting with varying left-hemisphere lesions and repetition impairment, sPLS-R was trained on 50 subjects to algorithmically identify connectomic features on the basis of their predictive value. The highest ranking features were subsequently used to …

Upper And Lower Limb Motor Function Correlates With Ipsilesional Corticospinal Tract And Red Nucleus Structural Integrity In Chronic Stroke: A Cross-Sectional, Roi-Based Mri Study, Denise M. Peters, Julius Fridriksson, Jessica D. Richardson, Jill C. Stewart, Chris Rorden, Leonardo Bonilha, Addie Middleton, Stacy L. Fritz

Faculty Publications

Background. Structural integrity of the ipsilesional corticospinal tract (CST) is important for upper limb motor recovery after stroke. However, additional neuromechanisms associated with motor function poststroke are less well understood, especially regarding the lower limb. Objective. To investigate the neural basis of upper/lower limb motor deficits poststroke by correlating measures of motor function with diffusion tensor imaging-derived indices of white matter integrity (fractional anisotropy (FA), mean diffusivity (MD)) in primary and secondary motor tracts/structures. Methods. Forty-three individuals with chronic stroke (time poststroke, 64.4 ± 58.8 months) underwent a comprehensive motor assessment and MRI scanning. Correlation and multiple regression analyses were …

Neurodevelopmental Processes In The Prefrontal Cortex Derailed By Chronic Hiv-1 Viral Protein Exposure, Kristen A. Mclaurin, Hailong Li, Rosemarie M. Booze, Charles F. Mactutus

Faculty Publications

Due to the widespread access to, and implementation of, combination antiretroviral therapy, individuals perinatally infected with human immunodeficiency virus type 1 (HIV-1) are living into adolescence and adulthood. Perinatally infected adolescents living with HIV-1 (pALHIV) are plagued by progressive, chronic neurocognitive impairments; the pathophysiological mechanisms underlying these deficits, however, remain understudied. A longitudinal experimental design from postnatal day (PD) 30 to PD 180 was utilized to establish the development of pyramidal neurons, and associated dendritic spines, from layers II-III of the medial prefrontal cortex (mPFC) in HIV-1 transgenic (Tg) and control animals. Three putative neuroinflammatory markers (i.e., IL-1β, IL-6, and …

Sexual Dimorphism In Titi Monkeys’ Digit (2d:4d) Ratio Is Associated With Maternal Urinary Sex Hormones During Pregnancy, Alexander Baxter, Elizabeth K. Wood, Lynea R. Witczak, Karen L. Bales, James Dee Higley

Faculty Publications

The second-to-fourth digit (2D:4D) ratio is a sexually-dimorphic biomarker for prenatal sex hormone exposure. We investigated whether titi monkeys (Plecturocebus cupreus) exhibit sexually-dimorphic 2D:4D ratio, and whether variation in 2D:4D ratio correlates with maternal testosterone and estrogen levels during early pregnancy. Subjects were 61 adult titi monkeys (32 males, 29 females). For 26 subjects, maternal urine samples were collected approximately 15–20 weeks before birth and assayed for testosterone and estrone conjugate (E1C). Titi monkeys exhibited a human-like pattern of sexual dimorphism in right-hand 2D:4D ratio, with females exhibiting higher 2D:4D ratio than males (β = −0.29, p = .023). For …

A Scoping Review Investigating Relationships Between Depression, Anxiety, And The Prep Care Continuum In The United States, Sarah J. Miller, Sayward Harrison, Kamla Devi Sanasi-Bhola

Faculty Publications

Men who have sex with men and transgender women in the United States are at increased risk for HIV and may benefit from pre-exposure prophylaxis (PrEP), a once-a-day pill to prevent HIV. Due to stigma and discrimination, sexual and gender minority (SGM) populations are also at risk for depression and anxiety. This scoping review sought to identify literature addressing relationships between the PrEP care continuum, depression, and anxiety among SGM individuals and others at high risk for HIV. We conducted a systematic review of four databases (i.e., PubMed, PsycInfo, Web of Science, Google Scholar) and identified 692 unique articles that …

Trajectories Of Heart Activity Across Infancy To Early Childhood Differentially Predict Autism And Anxiety Symptoms In Fragile X Syndrome, Abigail Hogan, Erin Hunt, Kayla Smith, Conner Black, Katherine Bangert, Jessica Klusek, Jane Roberts

Faculty Publications

Fragile X syndrome (FXS) is a monogenic disorder characterized by high rates of autism spectrum disorder (ASD) and anxiety. A longstanding "hyperarousal hypothesis" in FXS has argued that ANS dysfunction underpins many symptoms of FXS. However, the developmental onset and trajectory of ANS dysfunction, as well as the consequences of ANS dysfunction on later psychiatric symptoms, remain poorly understood in FXS. Insight into the emergence, trajectory, and consequences of ANS dysfunction across early development in FXS has critical implications for prevention, intervention, and optimal outcomes in both typical and atypical development. This longitudinal study investigated whether and when males with …

Agency: What Does It Mean To Be A Human Being?, Richard N. Williams, Edwin E. Gantt, Lane Fischer

Faculty Publications

This paper will look at the results of what has been termed “the crisis of modernism” and the related rise of postmodern perspectives in the 19th and 20th centuries. It concentrates on what is arguably the chief casualty of this crisis – human agency – and the social science that has developed out of the crisis. We argue that modern and postmodern social science ultimately obviate human agency in the understanding of what it means to be a human being. Attention is given to the contemporary intellectual world and the way in which it has been deeply informed by neo-Hegelian …

Trigger Warnings In Psychology Classrooms?: Comparing Sexes From A Diverse Religious Institution, Jasmine Collard, Herbert W. Helm Jr

Faculty Publications

Sensitive, oftentimes unsettling topics are inherent, especially in psychology education (Boysen et al., 2018). Prior notification - also known as trigger warnings - to help students prepare for, or avoid, possibly disturbing, upcoming education topics (Boysen, 2017, p. 164) are being pushed for by college students on potentially disturbing content. We previously replication Guy A. Boysen’s “Trigger Warnings in psychology Classes: What Do Students Think?” and found that students from a diverse, religious institution had few significant differences, but, in general, the results from the two data sets were quite similar (Kim et al, 2020). To expand on this knowledge, …

Pre-Exposure Prophylaxis (Prep) Uptake Among Black Men Who Have Sex With Men (Bmsm) In The Southern U.S., Oluwafemi Atanda Adeagbo, Sayward Harrison, Shan Qiao, Xiaoming Li

Faculty Publications

Black men who have sex with men (BMSM) living in the United States (U.S.) South are disproportionately affected by HIV and experience significant disparities in HIV incidence, access to HIV care, and prevention across ages and socio-economic statuses. The aim of this commentary is to critically review current literature on the state of PrEP use among BMSM in the U.S. South, including identifying barriers and facilitators to PrEP use in order to inform intervention development. Extant literature shows that despite the documented benefits of PrEP as an effective HIV-prevention method, its uptake among BMSM is limited across the U.S. South. …

Concurrent Associations Between Expressive Language Ability And Independence In Adolescents And Adults With Fragile X Syndrome, Leonard Abbeduto, Jessica Klusek, Julie Lounds Taylor, Nadia Abdelnur, Nicole Sparapani, Angela John Thurman

Faculty Publications

BACKGROUND: Few individuals with fragile X syndrome (FXS) successfully meet adult normative expectations in education, employment, peer relations, and habitation, although there is within-syndrome variability in this regard. The primary goal of this study was to determine whether expressive language skills contribute to the capacity for independent functioning in adulthood even after controlling for nonverbal cognitive ability. METHODS: Participants were 18- to 23-year-olds with FXS. Expressive language was assessed using the psychometrically validated Expressive Language Sampling (ELS) conversation and narration procedures. The language produced was transcribed and analyzed to yield measures of expressive vocabulary, syntax, and intelligibility. Parents concurrently completed …

Multilevel Modeling Of Interval-Contingent Data In Neuropsychology Research Using The Imertest Package In R, Richard S. Pond Jr., Matison W. Mccool, Brian A. Bulla

Faculty Publications

Intensive longitudinal research designs are becoming more common in the field of neuropsychology. They are a powerful approach to studying development and change in naturally occurring phenomena. However, to fully capitalize on the wealth of data yielded by these designs, researchers have to understand the nature of multilevel data structures. The purpose of the present article is to describe some of the basic concepts and techniques involved in modeling multilevel data structures. In addition, this article serves as a step-by-step tutorial to demonstrate how neuropsychologists can implement basic multilevel modeling techniques with real data and the R package, lmerTest. R …

Examining Associations Between Knowledge And Vaccine Uptake Using The Human Papillomavirus Knowledge Questionnaire (Hpv-Kq), Sayward Harrison, Valerie Yelverton, Yunfei Wang, Jan Ostermann, Laura J. Fish, Charnetta L. Williams, Lavanya Vasudevan, Emmanuel B. Walter

Faculty Publications

Objectives: Understanding the relationship between human papillomavirus (HPV) knowledge and vaccination behavior is important to inform public health interventions, yet few validated HPV knowledge scales exist. This study describes development of the Human Papillomavirus Knowledge Questionnaire (HPV-KQ) and its validation with parents residing in the southern United States (US). Methods: Drawing on previously published measures, we developed the 13-item HPV-KQ and administered the scale via Web-based survey to parents (N=1105) of adolescents ages 9 to 17 years. Dimensionality, internal consistency, model fit, and predictive validity were assessed. Results: The scale was bidimensional. One factor captured general HPV knowledge, and the …

Eye Movement Desensitization And Reprocessing (Emdr) Practitioners’ Beliefs About Memory, Sanne T.L. Houben, Henry Otgaar, Jeffrey Roelofs, Ineke Wessel, Lawrence Patihis, Harald Merckelbach

Faculty Publications

Eye movement desensitization and reprocessing (EMDR) is a widely used treatment for posttraumatic stress disorder. The idea behind EMDR is that lateral eye movements may mitigate the emotional impact of traumatic memories. Given the focus on changing patients’ memories, it is important that EMDR practitioners have detailed knowledge about human memory. We explored beliefs and ideas about memory in samples of EMDR practitioners (Study 1: n = 12; Study 2: n = 41), students (Study 1: n =35; Study 2: n = 24), and researchers (Study 2: n = 30). All groups seemed to be aware of the fallibility of …

Cortical Microstructural Changes Associated With Treated Aphasia Recovery, Allen J. Chang, Janina Wilmonskoetter, Julius Fridriksson, Emilie R. Mckinnon, Lorelei P. Johnson, Alexandra Basilakos, Jens H. Jensen, Chris Rorden, Leonardo Bonilha

Faculty Publications

Objectives

To investigate the hypothesis that language recovery in post-stroke aphasia is associated with structural brain changes.

Methods

We evaluated whether treatment-induced improvement in naming is associated with reorganization of tissue microstructure within residual cortical regions. To this end, we performed a retrospective longitudinal treatment study using comprehensive language-linguistic assessments and diffusion MRI sequences optimized for the assessment of complex microstructure (diffusional kurtosis imaging) to evaluate the relationship between language treatment response and cortical changes in 26 individuals with chronic stroke-induced aphasia. We employed elastic net statistical models controlling for baseline factors including age, sex, and time since the stroke, …