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Articles 31 - 32 of 32
Full-Text Articles in Entire DC Network
Five-Year Changes In Brain Volume And Episodic Memory In Cognitively Intact Elders With And Without An Apolipoprotein Ε4 Allele, Monica A. Matthews, Michael Seidenberg, John L. Woodard, Sally Durgerian, Kristy A. Nielson, J. Carson Smith, Melissa A. Lancaster, Alissa Butts, Nathan Hantke, Stephen M. Rao
Five-Year Changes In Brain Volume And Episodic Memory In Cognitively Intact Elders With And Without An Apolipoprotein Ε4 Allele, Monica A. Matthews, Michael Seidenberg, John L. Woodard, Sally Durgerian, Kristy A. Nielson, J. Carson Smith, Melissa A. Lancaster, Alissa Butts, Nathan Hantke, Stephen M. Rao
Psychology Faculty Research and Publications
The apolipoprotein ε4 allele is a risk factor for Alzheimer's disease. ε4 carriers diagnosed with AD or MCI exhibit an increased rate of atrophy on MRI relative to non-carriers. Few longitudinal studies have examined the rate of atrophy and cognitive change in older ε4 carriers who were cognitively intact at study entry. In this study, structural MRI and episodic memory testing were administered on two occasions separated by 5 years to 45 cognitively intact older adults, ages 65-90 years, divided into two groups: (1) carriers with one or both ε4 alleles (n=24) and (2) demographically-matched non-carriers (n=21). Longitudinal analysis of …
Longitudinal Associations Between Physical Activity, Cognitive Status, And Brain Function In Older Adults At Genetic Risk For Alzheimer’S Disease, J. Carson Smith, Sally Durgerian, John L. Woodard, Kristy A. Nielson, Alissa Butts, Nathan Hantke, Michael Seidenberg, Melissa A. Lancaster, Monica Matthews, Michael Sugarman, Stephen M. Rao
Longitudinal Associations Between Physical Activity, Cognitive Status, And Brain Function In Older Adults At Genetic Risk For Alzheimer’S Disease, J. Carson Smith, Sally Durgerian, John L. Woodard, Kristy A. Nielson, Alissa Butts, Nathan Hantke, Michael Seidenberg, Melissa A. Lancaster, Monica Matthews, Michael Sugarman, Stephen M. Rao
Psychology Faculty Research and Publications
The apolipoproteinE epsilon4 (APOE-?4) allele is associated with cognitive decline in old age and is a risk factor for Alzheimer's disease (AD). Physical activity (P A) is associated with a reduced risk of incident cognitive impairment, particularly among APOE-?4 carriers. We recently reported greater semantic memory related brain activation in cognitively intact physically active (High P A) APOE-?4 carriers compared to physically inactive (Low PA) ?4 carriers and non-carriers (Smith et al., 2011). Here, we compared longitudinal changes in semantic memory-related brain activation in High PA and Low PA APOE-?4 carriers. Thirty-two older ?4 carriers completed neuropsychological testing and a …