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Thiamine Deficiency And Alcohol Exposure Both Lead To An Impulsive Phenotype, Robin J. Zimmer
Thiamine Deficiency And Alcohol Exposure Both Lead To An Impulsive Phenotype, Robin J. Zimmer
Graduate Dissertations and Theses
The detrimental effects of alcohol consumption, including impulsivity, cognitive inflexibility, and neuropathology, are due to a confluence of factors that often occur in addition to alcoholism. We examined the effects of chronic alcohol exposure and thiamine deficiency (or supplementation) in isolation, as well as in concert, to further our understanding of the independent effects of each treatment and how they interact. Our results demonstrated that both chronic alcohol exposure and moderate thiamine deficiency induce an impulsive phenotype. Importantly, the increased impulsivity induced by thiamine deficiency was protracted as compared to that exhibited after chronic alcohol alone. Additionally, differential pathology was …
Cognitive Modeling Analysis Of Decision-Making Processes In Young Adults At-Risk And Not At-Risk For Alcohol Dependence, Lori Anne Wagner
Cognitive Modeling Analysis Of Decision-Making Processes In Young Adults At-Risk And Not At-Risk For Alcohol Dependence, Lori Anne Wagner
Graduate Dissertations and Theses
This study used the Valence-Expectancy Learning model, a mathematical cognitive model, to dissect young adult performance on the Iowa Gambling Task (IGT). Drinking behavior and monetary incentive were examined as predictors of performance on the IGT. No differences were found among groups when data were analyzed using traditional behavioral analyses. However, when the Expectancy-Valence Learning model was applied to the data, differences between groups were found related to attention and choice consistency. Importantly, the cognitive model was not a good fit for fifty-seven percent of the data, meaning that it did not succeed in explaining how the participants' choices were …