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Third Generation Gamma Camera Spect System, Narayan Bhusal

LSU Master's Theses

Single Photon Emission Computed Tomography (SPECT) is a non-invasive imaging modality, frequently used in myocardial perfusion imaging. The biggest challenges facing the majority of clinical SPECT systems are low sensitivity, poor resolution, and the relatively high radiation dose to the patient. New generation systems (GE Discovery, DSPECT) dedicated to cardiac imaging improve sensitivity by a factor of 5-8. The purpose of this work is to investigate a new gamma camera design with 21 hemi-ellipsoid detectors each with a pinhole collimator for Cardiac SPECT for further improvement in sensitivity, resolution, imaging time, and radiation dose.

To evaluate the resolution of our …

Structure And Thermodynamics Of Polyglutamine Peptides And Amyloid Fibrils Via Metadynamics And Molecular Dynamics Simulations, Riley Workman

Electronic Theses and Dissertations

Aggregation of polyglutamine (polyQ)-rich polypeptides in neurons is a marker for nine neurodegenerative diseases. The molecular process responsible for the formation of polyQ fibrils is not well understood and represents a growing area of study. To enable development of treatments that could interfere with aggregation of polyQ peptides, it is crucial to understand the molecular mechanisms by which polyQ peptides aggregate into fibrils. Many experimental techniques have been employed to probe polyQ aggregation, however, observations from these studies have not lead to a unified understanding of the properties of these systems, instead yielding competing, fragmented theories of polyQ aggregation. This …

Analytical Models Of Neutron Spectral Fluence, Kerma And Absorbed-Dose For Proton Therapy, Suman Shrestha

LSU Master's Theses

Abstract

Purpose: The accurate prediction of stray neutron dose has become increasingly important as it increases the risk of second cancer development after proton therapy. Previously reported analytical models predicted the quantity dose equivalent, which includes physical and biological considerations but does not explicitly take into account material dependence and variation in the radiation quality. The purpose of this study was to investigate the feasibility of an analytical model of absorbed dose to water from stray neutrons in proton therapy.

Methods: To calculate neutron absorbed dose and kerma in water, the authors developed analytical models of neutron spectral fluence and …

Automating Mobile Device File Format Analysis, Richard A. Dill

Theses and Dissertations

Forensic tools assist examiners in extracting evidence from application files from mobile devices. If the file format for the file of interest is known, this process is straightforward, otherwise it requires the examiner to manually reverse engineer the data structures resident in the file. This research presents the Automated Data Structure Slayer (ADSS), which automates the process to reverse engineer unknown file for- mats of Android applications. After statically parsing and preparing an application, ADSS dynamically runs it, injecting hooks at selected methods to uncover the data structures used to store and process data before writing to media. The resultant …

Three Dimensional Passive Localization For Single Path Arrival With Unknown Starting Conditions, Britt Aguda

University of New Orleans Theses and Dissertations

Introduced in this paper is the time difference of arrival (TDoA) conic approximation method (TCAM), a technique for passive localization in three dimensions with unknown starting conditions. The TDoA of a mutually detected signal across pairs of detectors is used to calculate the relative angle between the signal source and the center point of the separation between the detectors in the pair. The relative angle is calculated from the TDoA using a mathematical model called the TDoA approximation of the zenith angle (TAZA). The TAZA angle defines the opening angle of a conic region of probability that contains the signal …

Ultra-Low Temperature Properties Of Correlated Materials, Seyed Mohammad Ali Radmanesh

University of New Orleans Theses and Dissertations

Abstract

After the discovery of topological insulators (TIs), it has come to be widely recognized that topological states of matter can actually be widespread. In this sense, TIs have established a new paradigm about topological materials. Recent years have seen a surge of interest in topological semimetals, which embody two different ways of generalizing the effectively massless electrons to bulk materials. Dirac and, particularly, Weyl semimetals should support several transport and optical phenomena that are still being sought in experiments. A number of promising experimental results indicate superconductivity in members of half-Hesuler semimetals which realize the mixing singlet and triplet …

Verification And Evaluation Of A Passive Intensity Modulation Device For Bolus Conformal Therapy, Elizabeth Noel Hilliard

LSU Master's Theses

Purpose: Bolus electron conformal therapy (BECT) provides effective radiation treatment for superficial cancers and other diseases close to the skin surface, but can have as great as a 30% planning target volume (PTV) dose heterogeneity due to scattering from the irregular proximal bolus surface. Intensity modulated (IM) BECT can improve PTV dose homogeneity, but is not currently available. This study fabricated patient-specific passive intensity modulators and validated their delivering planned dose distributions calculated by a modified pencil beam redefinition algorithm (PBRA).

Methods: Two test-patterns and four patient-specific intensity modulators were designed, fabricated, and tested. Dose plans were generated …

Room Temperature Operation Of Quantum Cascade Lasers Monolithically Integrated Onto A Lattice-Mismatched Substrate, Rowel Go

Electronic Theses and Dissertations

Quantum Cascade Lasers (QCLs) are semiconductor devices that, currently, have been observed to emit radiation from ~ 2.6 μm to 250 μm (1 to 100 terahertz range of frequencies.) They have established themselves as the laser of choice for spectroscopic gas sensing in the mid-wavelength infrared (3-8 μm) and long-wavelength infrared (8-15 μm) region. In the 4-12 μm wavelength region, the highest performing QCL devices, in terms of wall-plug efficiency and continuous wave operation, are indium phosphide (InP) based. The ultimate goal is to incorporate this InP-based QCL technology to silicon (Si) substrate since most opto-electronics are Si-based. The main …

Effect Of Chemistry On Electrodynamics In The Martian Dynamo Region, Morgan M. Matheny

Doctoral Dissertations and Master's Theses

Electromagnetic interactions between Mars remnant crustal magnetic fields and solar and planetary ions lead to time and space variations of the ionosphere. In this work, we continue the investigations started by Riousset et al. [2013] and address the effect of chemistry on ion populations in the dynamo region, where ion dynamics are driven by collisions while electrons are still mostly magnetized. We adopt a mesoscale model to simulate dynamics of electrons and ions in the upper atmosphere (100–400 km). Our approach focuses on numerical studies using the Martian Multifluid Magnetohy drodynamic (MF-MHD) Model (M4). The dynamo is a region which …

High Dynamic Range Optical Devices And Applications., Elijah Robert Jensen

Electronic Theses and Dissertations

Much of what we know about fundamental physical law and the universe derives from observations and measurements using optical methods. The passive use of the electromagnetic spectrum can be the best way of studying physical phenomenon in general with minimal disturbance of the system in the process. While for many applications ambient visible light is sufficient, light outside of the visible range may convey more information. The signals of interest are also often a small fraction of the background, and their changes occur on time scales so quickly that they are visually imperceptible. This thesis reports techniques and technologies developed …

Crystal Growth And Manipulation Of Intercalated Chalcogenides As Superconductors And Topological Insulators, Nathaniel Smith

Theses and Dissertations

Superconductors are unusual quantum materials which offer no resistance to electric current. The fascinating physics of this phenomenon is complemented by wide-ranging technical applications from power transmission to magnetic levitation. Commercially successful superconductors are found in powerful magnets in medical imaging, particle accelerators, and next-generation quantum computing. In my effort to uncover the mysteries and fundamental mechanisms of superconductivity, I use an array of techniques to synthesize and study single crystals of unconventional superconductors including the iron telluride and bismuth selenide family of superconductors. My study of atomic valence and crystal structure in iron telluride has uncovered previously unknown chemical …

Internal And External Harmonic Functions In Flat-Ring Coordinates, Lijuan Bi

Theses and Dissertations

The goal of this dissertation is to derive expansions for a fundamental solution of Laplace's equation in flat-ring coordinates in three-dimensional Euclidean space. These expansions are in terms of harmonic functions in the interior and the exterior of two different types of regions, "flat rings" and "peanuts" according to their shapes. We solve Laplace's equation in the interior and the exterior of these regions using the method of separation of variables. The internal and external "flat-ring" and "peanut" harmonic functions are expressed in terms of Lamé functions.

Implementation And Optimization Of Time Reversal For Use In Nondestructive Evaluation Of Stress Corrosion Cracking, Sarah Marie Young

Theses and Dissertations

The time reversal (TR) process manipulates a system's impulse response in order to focus a peak of acoustic energy at a specific location in space and time. This technique has been implemented in both fluid and solid media for purposes ranging from communications to source localization. This thesis will examine both the implementation and processing of TR for nondestructive evaluation in steel, specializing in nonlinear detection methods. A series of steel samples are inspected for stress corrosion cracking (SCC) using TR focusing to excite nonlinearities inherent in cracks. It is determined that SCC exists in the expected regions of the …

A Study Into Data Analysis Of Varying Types Of Langmuir Probes, William Merritt

Doctoral Dissertations and Master's Theses

Langmuir probes are ubiquitously used for in-situ measurements of plasma parameters. These probes have been placed on many different platforms, including experimental sounding rockets for measurements in mesosphere-lower-thermosphere, and also onboard satellites to obtain data sets over an extended period of time in the ionosphere. To accommodate such different situations, many different variations of the Langmuir probe design have been made. This thesis covers two such implementations, as well as the data analysis and issues that can arise with such instruments. The first of these implementations is a set of sweeping Langmuir probes on the Floating Potential Measurement Unit (FPMU) …

Development And Commissioning Of An Independent Peer Review System For A Small Animal Irradiator, Mary Peters

Dissertations & Theses (Open Access)

Dosimetry for small animal irradiators lacks the standardization of clinical radiotherapy practice, yet plays a central translational role in human trial design. The purpose of this work was to improve the dosimetric accuracy and consistency of animal studies by developing an independent peer review system to verify dose delivery from animal irradiators. This study focused on the development of a mouse phantom and characterization of the thermoluminescent dosimetry system for a commonly used small animal irradiator.

First, a mouse model and irradiation stand were designed with the purpose of being used in a mailable audit. Two mouse phantoms were machined …

A System For Conducting Laser-Induced Fluorescence Measurements On Gas Mixtures Exposed To Alpha Radiation, Patrick Ables

Master's Theses

This paper documents modifications to an existing vacuum system to allow laser-induced fluorescence spectroscopy measurements within simulated atmospheres under a variety of conditions. This added capability will expand the laboratory’s ability to experimentally validate a computational model that calculates the effects of radiation within the atmosphere. The computational model could reveal radiation-induced chemical products that can be used to develop an alternative detection method that can be implemented from a safe distance. The selection of molecules for experimental validation has been limited to those which can be detected utilizing cavity ringdown spectroscopy. The current model indicates nitric oxide and ozone …

Identification Of Intracranial Lesions With Dual-Energy Computed Tomography And Magnetic Resonance Phase Imaging, Megan C. Jacobsen

Dissertations & Theses (Open Access)

On conventional Single-energy Computed Tomography (SECT), lesions with an attenuation greater than 100 Hounsfield Units (HU) can be definitively diagnosed as calcification. However, low-density calcifications and hemorrhage may have overlapping attenuation ranges between 40 and 100 HU and, therefore, cannot be differentiated with SECT alone. On T2*-weighted Gradient Recalled Echo (GRE) MRI, these lesions appear as “foci of susceptibility” in which their signal is hypointense due to the magnetic susceptibility of the lesions differing from that of the background tissue.

Dual-energy Computed Tomography (DECT) and Phase-Sensitive Magnetic Resonance Imaging (PS-MRI) represent two new imaging paradigms which both have the potential …

Improved Target Coverage Of Spinal Metastases Through The Use Of Flattening Filter Free Beams, Laura Bennett

Dissertations & Theses (Open Access)

Of the patients that are diagnosed with metastatic disease, up to 40% will develop vertebral osseous metastases. These metastases tend to be located in close proximity to the spinal cord itself, making it difficult to achieve the recommended minimum dose of 14 Gy for single fraction SBRT or 21 Gy¹ for three fraction SBRT while maintaining acceptable doses to the cord and cauda equina. This proximity of the target to critical structures has the potential to compromise the efficacy of the radiation treatment plan in favor of reducing normal tissue dose, resulting in poor local control and tumor recurrence …

Developing A Femtosecond Stimulated Raman Spectroscopy Experiment For Solid State Materials, Daniel Hammerland

Electronic Theses and Dissertations

Femtosecond Stimulated Raman Spectroscopy (FSRS) is a ultrafast spectroscopy technique first implemented by chemists to understand isomerization and other ultrafast molecular morphology changes by resolving vibrational dynamics[1, 2, 3]. FSRS has an unparalleled temporal and spectral resolution [4, 1, 5, 6] that arises as a result of a clever combination of picosecond and femtosecond pulses. However, despite this capability, FSRS has yet to be applied to modern materials in condensed matter physics. This thesis explores the design and implementation of FSRS to study two-dimensional materials in order to measure their quantum confined vibrational dynamics on utlrafast time scales.

Plasma Based Synthesis And Surface Modification Of Graphene., Rong Zhao

Electronic Theses and Dissertations

Graphene, an atom thick layer of carbon, has attracted intense scientific interest due to its exceptional electrical, mechanical and chemical properties. Especially, it provides a perfect platform to explore the unique electronic properties in absolute two-dimension. Pristine graphene possesses zero band gap and weakens its competitiveness in the field of semiconductors. In order to induce a band gap and control its semiconducting properties, functionalization and doping are two of the most feasible methods. In the context of functionalization, large area monolayer graphene synthesized by chemical vapor deposition was subjected to controlled and sequential fluorination using radio frequency plasma while monitoring …

Development And Implementation Of A Homogeneous And A Heterogeneous Anthropomorphic End To End Quality Assurance Audit System Phantom For Magnetic Resonance Guided Radiotherapy Modalities Ranging From 0.35 T To 1.50 T, Angela Steinmann

Dissertations & Theses (Open Access)

Introduction: Magnetic resonance (MR) guided radiation therapy (MRgRT) is an emerging field that integrates an MR imager with either a linear accelerator or three radioactive cobalt-60 sources. Before institutions participate in multi-institutional NCI-sponsored clinical trials, they are required to perform a credentialing test provided by IROC-Houston. During the credentialing test, end-to-end phantoms are used to evaluate the institution’s ability to perform consistent and accurate radiation treatments. IROC-Houston’s conventional anthropomorphic phantoms are not visible in MR, thus they are insufficient for MRgRT systems. The purpose of this work was to create an anthropomorphic thorax and a head and neck (H&N) phantom …

Nonlinear Acoustic Waves Generated By Surface Disturbances And Their Effect On Lower Thermospheric Composition, Benedict Piñeyro

Doctoral Dissertations and Master's Theses

Recent nonlinear atmospheric models have provided important insight into acoustic waves generated by seismic events, which may steepen into shocks or saw-tooth trains while also dissipating strongly in the thermosphere. Although they have yielded results that agree with observations of ionospheric perturbations, dynamical models for the diffusive and stratified lower thermosphere often use single gas approximations with height-dependent physical properties (e.g. mean molecular weight, specific heats) that do not vary with time (fixed composition). This approximation is simpler and less computationally expensive than a true multi-fluid model, yet captures the important physical transition between molecular and atomic gases in the …

Scanning Tunneling Microscopy Studies Of Superconducting Single Layer Iron Selenide On Strontium Titanate, Zhuozhi Ge

Theses and Dissertations

The search for high temperature superconductivity has been a prominent topic in the field of condensed matter physics ever since the discovery of this novel phenomenon more than 100 years ago. In addition to the search for new materials, interfacial superconductivity has shown great potential as demonstrated recently in monolayer FeSe grown on SrTiO3 (STO) (001) substrate, where superconducting transition temperature (Tc) has been enhanced by more than an order of magnitude compared to the bulk value. The uniqueness of this approach is the direct placement of the superconducting layer on a secondary substrate, which facilitates the independent control of …

Neutron Star Tidal Deformability And Gravitational Self-Force, Eric Van Oeveren

Theses and Dissertations

The recent direct observations of gravitational waves by the LIGO-Virgo collaboration [1-6] have been important pieces of evidence in agreement with Einstein's theory of gravity, the General Theory of Relativity. In addition, they open an era of gravitational wave astronomy that promises to give us much more information on the systems that produce gravitational radiation. Perhaps most prominent among these are binary systems composed of either two black holes, two neutron stars, or one black hole and one neutron star. This dissertation details theoretical predictions regarding such systems.

It is hoped that gravitational radiation emanating from binary systems that include …

A Detailed Chandra X-Ray Study Of The Galactic Core-Collapse Supernova Remnant G292.0+1.8, Jayant Bhalerao

Physics Dissertations

In this thesis, we describe our detailed analysis of the core-collapse supernova remnant (CCSNR) G292.0+1.8 (G292 hereafter) using data collected by NASA's Chandra X-ray Observatory (Chandra). In the first part of this thesis, we use data collected by Chandra's grating spectrometer to study the motion of the SNR's ejecta. We study this motion by measuring Doppler shifts of atomic spectral emission lines. We measure the radial velocities (vr) of 33 emission features in the remnant. We find that the ejecta have high vr (-2300 ≲ vr ≲ 1400 km s-1). We also find that most of the ejecta are moving …

Scatter Correction And 4d Reconstruction Of Cone Beam Computed Tomography (Cbct) With A Moving Blocker, Cong Zhao

Physics Dissertations

Come-beam computed tomography (CBCT) is being widely used as an image guidance tool in radiation therapy nowadays. The quality of CBCT image is important to localize and delineate the tumor and to define relevant volumes when the patient is in the treatment position. However, there are several factors that can deteriorate the image quality of CBCT. The large amount of scatter signal due to the use of the flat panel detector (FPD) is a major factor and greatly degrades the quality of reconstruction images. Another major factor is the respiratory motion of the patient, which can cause severe motion blurring …

Evaluation And Development Of Beta Particle Imagers, Thomas Burwell Bates

Physics Theses

Compact beta imagers have the great potential for tumor localization for radio-guided treatment interventions thanks, in part, to their natural collimation of beta particles. Their rapid survey capabilities of small areas, on the scale of tens of square centimeters, are important for clinical adoption. In this work we investigate the experimental methods and evaluate the performance of the uniformity, sensitivity, spatial resolution and field of view (FOV) of a hand-held beta camera. Results from this work have demonstrated a high degree of sensitivity and uniformity and a millimeter scale spatial resolution within a FOV close to 1 square centimeter. In …

Scattering Of Few Photon Fields By Two Level Systems In A One Dimensional Geometry, William Konyk

Graduate Theses and Dissertations

Recent experimental progress has realized strong, efficient coupling of effective two level systems to waveguides. We study the scattering of multimode photons from such emitters coupled losslessly to the confined geometry of a one dimensional waveguide. We develop novel techniques for describing the scattered state of both single and multi-photon wavepackets and explore how such wavepackets interact with arrays of emitters coupled to a one dimensional waveguide. Finally, we apply these techniques and analyze the capability of two particular systems to act as a quantum conditional logic gate.

Impacts Of Anisotropy, Wave Heating, And Neutral Winds On High-Latitude Ionospheric Dynamics, Meghan R. Burleigh

Doctoral Dissertations and Master's Theses

Significant amounts of ionospheric plasma can be transported to high altitudes (ion upflow) in response to a variety of plasma heating and uplifting processes such as DC electric fields and precipitation. Once ions have been lifted to high altitudes, transverse ion acceleration by broadband ELF waves can give the upflowing ions sufficient energy for the mirror force to propel these ions to escape into the magnetosphere (ion outflow). In order to accurately examine the connection between upflow and outflow processes, a new two dimensional, anisotropic fluid model is developed.

The new model, named GEMINI-TIA, is based on a Bi-Maxwellian distribution …

Conformal Mapping Improvement Of The Boundary Element Method Solution For Underground Water Flow In A Domain With A Very Singular Boundary, Megan Romero

UNLV Theses, Dissertations, Professional Papers, and Capstones

Numerical solutions using a Boundary Element Method (BEM) for a confined flow in a very singular finite domain are developed. Typically, in scientific journal publications, authors avoid domains with many and more malignant singularities due to the extremely big and difficult to estimate errors in the numerical calculations. Using exact Conformal Mapping solutions for simplified domains with the same singularity as in the original domain, this problem can be solved numerically with improvements introduced by Conformal Mapping solutions. Firstly, to experiment with improving the BEM solution by Conformal Mapping, a domain inside a rectangle is considered. The exact solution inside …