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Evaluating Heterogeneous Conservation Effects Of Forest Protection In Indonesia, Payal Shah, Kathy Baylis Dec 2014

Evaluating Heterogeneous Conservation Effects Of Forest Protection In Indonesia, Payal Shah, Kathy Baylis

Kathy Baylis

Establishing legal protection for forest areas is the most common policy used to limit forest loss. This article evaluates the effectiveness of Indonesian forest protected areas introduced between 2000 and 2012. Specifically, we explore how the effectiveness of these parks varies over space. Protected areas have mixed success in preserving forest, and it is important for conservationists to understand where they work and where they do not. Observed differences in the estimated treatment effect of protection may be driven by several factors. Indonesia is particularly diverse, with the landscape, forest and forest threats varying greatly from region to region, and …


Epidemiology Of Latency And Relapse In Plasmodium Vivax Malaria, Andrew A. Lover Dec 2014

Epidemiology Of Latency And Relapse In Plasmodium Vivax Malaria, Andrew A. Lover

Andrew Lover

Malaria is a major contributor to health burdens throughout the regions where it is endemic. Historically, it was believed that there was limited morbidity and essentially no mortality associated with Plasmodium vivax; however, evidence from diverse settings now suggests that infections with P. vivax can be both severe and fatal. This awareness has highlighted a critical gap: the vast majority of research has been directed towards P. falciparum, leading to a decades-long neglect of epidemiological and clinical studies of P. vivax. There exists a large body of historical data on human experimental infections with P. vivax; these studies in controlled …


Considerations For Comprehensive Analyses Of Sporozoite-Based Controlled Human Malaria Infection Studies, Andrew A. Lover Dec 2014

Considerations For Comprehensive Analyses Of Sporozoite-Based Controlled Human Malaria Infection Studies, Andrew A. Lover

Andrew Lover

There has been renewed interest in the use of sporozoite-based approaches for controlled human malaria infections (CHMIs), and several sets of human challenge studies have recently completed. A study undertaken in Tanzania and published in 2014 found dose dependence between 10,000 and 25,000 sporozoite doses, as well as divergent times-to-parasitemia relative to earlier studies in European volunteers, with important implications for planning future studies. Analysis of time-to-event data has had extensive development in recent years, but these methods have had limited exposure outside biostatistics. Expansion of the published analyses to include recent methodological approaches optimized for the types of data …


Short Report: Study Variability In Recent Human Challenge Experiments With Plasmodium Falciparum Sporozoites (Pfspz Challenge), Andrew A. Lover Dec 2014

Short Report: Study Variability In Recent Human Challenge Experiments With Plasmodium Falciparum Sporozoites (Pfspz Challenge), Andrew A. Lover

Andrew Lover

There has been renewed interest in the use of sporozoite-based approaches for malaria vaccination and controlled human infections, and several sets of human challenge studies have recently completed. A study undertaken in Tanzania and published in 2014 found dose-dependence between 10,000 and 25,000 sporozoite doses, as well as divergent times-to-parasitemia relative to earlier studies in European volunteers. However, this analysis shows that these conclusions are based upon suboptimal analytical methods; with more optimal analysis, there is no evidence for dose-dependence within this dose range; and more importantly, no evidence for differences in event times between Dutch and Tanzanian study sites. …


Laypeople's Risky Decisions In The Climate Change Context: Climate Engineering As A Risk-Defusing Strategy?, Dorothee Amelung, Joachim Funke Dec 2014

Laypeople's Risky Decisions In The Climate Change Context: Climate Engineering As A Risk-Defusing Strategy?, Dorothee Amelung, Joachim Funke

Joachim Funke

This study explores the development of laypeople’s preferences for newly emerg- ing climate engineering technology (CE). It examines whether laypeople perceive CE to be an acceptable back-up strategy (plan B) if current efforts to mitigate CO2 emissions were to fail. This idea is a common justification for CE research in the scientific debate andmay significantly influence future public debates. Ninety-eight German participants chose their preferred climate policy strategy in a quasi-realistic scenario. Participants could chose between mitigation and three CE techniques as alternative options.We employed a think-aloud interview technique, which allowed us to trace participants’ informational needs and thought processes. …