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Electronic And Geometric Structure Of Alnom And Alnom +, Albert R. Armstrong

Theses and Dissertations

Generally, the electronic stability of aluminum clusters is associated with either closed electronic shells of delocalized electrons, or aluminum in the +3 state. To explore alternative routes for electronic stability in aluminum oxide clusters, theoretical methods were used to examine the geometric and electronic structure of Al_nO_m (2≤n≤7; 1≤m≤10) clusters. Two types of electronically stable clusters with large HOMO-LUMO gaps were identified the first being Al_2nO_3m clusters with a +3 oxidation state on the aluminum, and the second being planar clusters such as Al₄O₄, Al₅O₃, Al …

Manufactured By Nature: Growing Generatively Designed Products, Mohammad Jawad

Theses and Dissertations

Mass production and assembly lines are yesterday’s manufacturing methods. They have exhausted Earth’s resources and limited the possibilities of design in terms of both form and material, prompting designers to search for new processes. A new generation of making includes biomimicry-inspired technologies such as 3D printing and parametric simulation, which have transformed the production paradigm. Utilizing nature as industry, this thesis explores the possibility of “growing” designed objects by employing nature’s own processes and resources. It integrates bio materials, generative design and additive manufacturing to produce objects for a post-industrial world. The project outcomes employ natural minerals, crystallization and 3D …

The Development Of Intrinsically Cell-Permeable Peptide Libraries Using Mrna Display, Nicolas A. Abrigo

Theses and Dissertations

Peptides are emerging as promising therapeutics due to their inhibitory affinity towards protein-protein interactions (PPI). However, peptides have been limited mainly by their poor bio-stability and lack of cell permeability. Efforts to generate drug-like peptides have led to the development of macrocyclic peptides, which exhibit improved stability. Yet, most macrocyclic peptides still require the assistance of a cell penetrating peptide (CPP) for cellular entry.

High throughput technologies have been exceptional tools for the discovery of peptides to interrupt PPIs. This work details the recent advancements we have made to improve our high throughput technique, mRNA display, to yield more therapeutically …

Characterization Of The Histone Binding Properties Of The Epigenetic Reader Protein Uhrf2 To H3 In Phd Domain, Marisa Gilliam

Senior Honors Theses and Projects

Every cell contains the same genetic code, to have cell differentiation this genetic code needs to be regulated on what is expressed. The regulation of gene expression without altering the genetic code itself is known as epigenetics. An example of epigenetic regulation can be seen between the binding of UHRF2 and H3 histones. The purpose of this project is to determine ifD363 in UHRF2 is important for histone H3 binding. To do so, D363 was mutated to alanine, lysine or asparagine. The mutant protein was expressed, purified, and its ability to binding to H3 was tested by fluorescence polarization. Compared …

Quantifying The Magnitude And Spatial Variability Of Bedrock Erosion Beneath The Sisters Glacier, Washington, Using Cosmogenic 3he Concentrations, Sarah W. Francis

WWU Graduate School Collection

Cosmogenic ³He analyses provide a tool to infer spatial variation of cirque-glacial bedrock erosion. ³He accumulates in bedrock exposed at the surface as a result of cosmic ray bombardment; the concentration of cosmogenic ³He increases with exposure time as well as proximity to the surface. The Twin Sisters range, North Cascades, WA is an ideal location to use cosmogenic ³He to infer cirque-glacial erosion depths and rates, due to the dunite bedrock and the detailed record of Holocene glaciation from the nearby Mount Baker. We used field mapping, lidar data and aerial imagery to identify bedrock …

Seismic Structure Of Tanaga Island, Alaska, Kevin F. (Kevin Francis) Lally

WWU Graduate School Collection

Tanaga Island is located in the Central Aleutian Islands and includes four stratovolcanoes: Sajaka, Tanaga, and East Tanaga in the northwest, and Takawangha in the central part of the island. Of these volcanoes, only Tanaga has a record of historical eruptive activity (in 1914). Over 3,000 earthquakes have been recorded beneath the island and the surrounding offshore region since the six-station seismic network was emplaced in 2003. The origin of these earthquakes is not completely understood, and to arrive at this understanding, more accurate hypocenter locations and power spectra need to be determined. A better analyses including improved locations of …

Pre-Service Teachers’ Emerging Views On Educational Equity, Melody Wilson

Master's Theses and Doctoral Dissertations

An equity-based Statistics course for pre-service mathematics teachers could play a role in the development of pre-service teachers’ equity literacy, encouraging conversations about equity in education and illuminating structural factors that contribute to the educational opportunity gap in the U.S. In the Winter 2019 semester, a faculty team at the author’s university piloted such a course. The course included data explorations dealing with structural inequities by race – one of the most difficult topics to address productively in a teacher preparation course. For the present study, a survey of pre-service teachers’ views on educational equity was administered in a required …

Designing A Modified Zeeman Slower For The Paschen-Back Magnetic Regime, Leo Michael Nofs

Master's Theses and Doctoral Dissertations

Controlled study of high-density plasmas, such as those found in fusion reactions and stars, is difficult due to their highly-magnetized environments. A specialized high magnetic field (High-B) trap was developed at the University of Michigan in Georg Raithel's research group to study such highly magnetized, high density plasmas using rubidium atoms. By replacing the atom source with a Zeeman slower, a well-studied device to slow and cool atoms, the atom flux could be increased by a factor more than 1000, leading to higher High-B plasma densities. The goal of this project is to design a Zeeman slower that differs from …

I3: Isomerization Of Isomer Ions, Krisztián Gabor Torma

University of the Pacific Theses and Dissertations

Photoelectron Photoion Coincidence (PEPICO) spectroscopy is a robust tool for elucidating complex unimolecular dissociation mechanisms and for determining thermochemical and kinetic data of gas-phase ion dissociations with high accuracy. In this work, the dissociative photoionization of two sets of isomeric systems were analyzed with PEPICO: 1) C7H7+ ions of toluene (Tol) and 1,3,5-cycloheptatriene (CHT), and 2) two butyl alcohol isomers, 1-butanol and isobutanol. Threshold dissociative photoionization data on these four molecules of interest were collected on the imaging PEPICO apparatus at the VUV beamline of the Swiss Light Source. Data analysis was aided by ab initio calculations and Rice-Ramsperger-Kassel-Marcus (RRKM) …

Synthesis And Conformational Studies Of Various Amides, Marcos Beltran-Sanchez

University of the Pacific Theses and Dissertations

In the past, aminocyclohexanol rings have been successfully utilized as pH-triggered molecular switches in various trans-2-aminocyclohexanol derivatives. By changing the groups on the amine nitrogen, these models provided a wide pH range in which a switch can occur. The pH-induced switch of conformation was monitored by 1H-NMR spectroscopy. The models were also incorporated into the bilayer membrane of liposome structures and tested for their ability to disrupt their membrane upon their conformational flip induced by a decrease in pH.

In this work, the amide bond has been studied as a molecular switch and various amide derivatives have been tested for …