Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Sensitivity (10)
- Specificity (10)
- Bioinformatics (7)
- AUC (6)
- Astronomy (5)
-
- Calcium (5)
- Confidence interval (5)
- Wireless sensor networks (5)
- Active galaxies (4)
- Calmodulin (4)
- DNA (4)
- Diagnostic test (4)
- Empirical Likelihood (4)
- Fluorescence (4)
- Genotype (4)
- Haplotype (4)
- Heterojunction (4)
- Infrared (4)
- Machine learning (4)
- NMR (4)
- ROC curve (4)
- Simulation (4)
- Active galactic nuclei (3)
- Algorithm (3)
- Associated primes (3)
- Blazars (3)
- Bootstrap (3)
- Boronic acid (3)
- Bursting (3)
- CHARA (3)
Articles 61 - 90 of 331
Full-Text Articles in Entire DC Network
Looking In The Crystal Ball: Determinants Of Excess Return, Kokou S. Akolly
Looking In The Crystal Ball: Determinants Of Excess Return, Kokou S. Akolly
Mathematics Theses
This paper investigates the determinants of excess returns using dividend yields as a proxy in a cross-sectional setting. First, we find that types of industry and the current business cycle are determining factors of returns. Second, our results suggest that dividend yield serves a signaling mechanism indicating “healthiness” of a firm among prospective investors. Third we see that there is a positive relationship between dividend yield and risk, especially in the utility and financial sectors. And finally, using actual excess returns, instead of dividend yield in our model shows that all predictors of dividend yield were also significant predictors of …
Rational Drug Design For Neglected Diseases: Implementation Of Computational Methods To Construct Predictive Devices And Examine Mechanisms, Catharine Jane Collar
Rational Drug Design For Neglected Diseases: Implementation Of Computational Methods To Construct Predictive Devices And Examine Mechanisms, Catharine Jane Collar
Chemistry Dissertations
Over a billion individuals worldwide suffer from neglected diseases. This equates to approximately one-sixth of the human population. These infections are often endemic in remote tropical regions of impoverished populations where vectors can flourish and infected individuals cannot be effectively treated due to a lack of hospitals, medical equipment, drugs, and trained personnel. The few drugs that have been approved for the treatments of such illnesses are not widely used because they are riddled with inadequate implications of cost, safety, drug availability, administration, and resistance. Hence, there exists an eminent need for the design and development of improved new therapeutics. …
Design And Synthesis Of Novel Serotonin Receptor Ligands, Jeffrey D. Klenc
Design And Synthesis Of Novel Serotonin Receptor Ligands, Jeffrey D. Klenc
Chemistry Dissertations
Novel and potent ligands to the serotonin7 (5-HT7) receptor have been synthesized. The synthesized compounds include a set of substituted pyrimidines which show high affinity to the 5-HT7 receptor, synthesized by previously described methods [1,2] in high yield. Comparing the affinities of substituted pyrimidines to previously calculated models [3,4] yielded new hypotheses about the nature of interaction between the pyrimidine ligands and the 5-HT7 binding site. Several new series of compounds were synthesized by various methods to validate these hypotheses, including a conjugate addition to vinylpyrimidines [5]. These compounds include benzofurans, oximes, hydrazones, as well as a group of substituted …
K-Ar Age Values Of Bulk Soil Samples And Clay Fractions: Effects Of Acid Extraction And Implications For The Origin Of Micaceous Clay In Savannah River Site Soils, South Carolina, Usa, Thomas E. Naumann
Geosciences Theses
Understanding how natural Cs, Rb, and K have been redistributed in Savannah River Site (SRS) soils during pedogenesis is important to understanding how radiocesium released to the soils will behave over the long term. In this effort, it is important to distinguish K that has participated in mineral-water reactions from that still residing in primary silicate structures, particularly in the clay fraction. The impact of different degrees of acid extraction on K and radiogenic Ar in bulk soil and in clay from five SRS soil samples has been determined. Strong treatment (50% HNO3, three hours, 100°C) releases K from primary …
Enhanced Web Search Engines With Query-Concept Bipartite Graphs, Yan Chen
Enhanced Web Search Engines With Query-Concept Bipartite Graphs, Yan Chen
Computer Science Dissertations
With rapid growth of information on the Web, Web search engines have gained great momentum for exploiting valuable Web resources. Although keywords-based Web search engines provide relevant search results in response to users’ queries, future enhancement is still needed. Three important issues include (1) search results can be diverse because ambiguous keywords in queries can be interpreted to different meanings; (2) indentifying keywords in long queries is difficult for search engines; and (3) generating query-specific Web page summaries is desirable for Web search results’ previews. Based on clickthrough data, this thesis proposes a query-concept bipartite graph for representing queries’ relations, …
Cox Model Analysis With The Dependently Left Truncated Data, Ji Li
Cox Model Analysis With The Dependently Left Truncated Data, Ji Li
Mathematics Theses
A truncated sample consists of realizations of a pair of random variables (L, T) subject to the constraint that L ≤T. The major study interest with a truncated sample is to find the marginal distributions of L and T. Many studies have been done with the assumption that L and T are independent. We introduce a new way to specify a Cox model for a truncated sample, assuming that the truncation time is a predictor of T, and this causes the dependence between L and T. We develop an algorithm to obtain the adjusted risk sets and use the Kaplan-Meier …
Assessing The Effectiveness Of Studio Physics At Georgia State University, Brianna M. Upton
Assessing The Effectiveness Of Studio Physics At Georgia State University, Brianna M. Upton
Physics and Astronomy Theses
Previous studies have shown that many students have misconceptions about basic concepts in physics which persist after instruction. It has been concluded that one of the challenges lies in the teaching methodology. To address this, Georgia State University (GSU) has begun teaching studio algebra-based physics. Although many institutions have implemented studio physics, most have done so in calculus-based sequences. Additionally, the unique environment of GSU’s population as a diverse, urban research institution is considered. The effectiveness of the studio approach for this demographic in an algebra-based introductory physics course was assessed. This five-semester pilot study presents demographic survey results and …
Energy-Efficient Data Management In Wireless Sensor Networks, Chunyu Ai
Energy-Efficient Data Management In Wireless Sensor Networks, Chunyu Ai
Computer Science Dissertations
Wireless Sensor Networks (WSNs) are deployed widely for various applications. A variety of useful data are generated by these deployments. Since WSNs have limited resources and unreliable communication links, traditional data management techniques are not suitable. Therefore, designing effective data management techniques for WSNs becomes important. In this dissertation, we address three key issues of data management in WSNs. For data collection, a scheme of making some nodes sleep and estimating their values according to the other active nodes’ readings has been proved energy-efficient. For the purpose of improving the precision of estimation, we propose two powerful estimation models, Data …
Bead Modeling Of Transport Properties Of Macromolecules In Free Solution And In A Gel, Hongxia Pei
Bead Modeling Of Transport Properties Of Macromolecules In Free Solution And In A Gel, Hongxia Pei
Chemistry Dissertations
On the bead modeling methodology, or BMM, a macromolecule is modeled as a rigid, non-overlapping bead array with arbitrary radii. The BMM approach was pioneered by Kirkwood and coworkers (Kirkwood, J.G., Macromolecules, E.P. Auer (Ed.), Gordon and Breach, New York, 1967; Kirkwood, J.G., Riseman, J., J. Chem. Phys., 1948, 16, 565) and applied to such transport properties as diffusion, sedimentation, and viscosity. With the availability of computers, a number of investigators extended the work to account for the detailed shape of biomolecules in the 1970s. A principle objective of my research has been to apply the BMM approach to more …
Mineralogical And Geochemical Indicators Of Subaerial Weathering In The Pozzolane Rosse Ignimbrite (Alban Hills Volcanic District, Italy), Jennifer M. Dickie
Mineralogical And Geochemical Indicators Of Subaerial Weathering In The Pozzolane Rosse Ignimbrite (Alban Hills Volcanic District, Italy), Jennifer M. Dickie
Geosciences Theses
The Pozzolane Rosse ignimbrite [PR] (457±4 ka) in the Alban Hills Volcanic District, Rome, Italy was exposed ~ 40 ka prior to a subsequent volcanic event which coverd it entirely. XRF, XRD, and clay separation results from PR samples from INGV and CA1 boreholes and Castel di Leva quarry show evidence of paleopedogenesis. All locations display loss of base cations, loss of K is consistent with XRD datat showing dissolution or alteration of leucite to analcime. Accumulation of Al and high L.O.I. support XRD evidence of 1:1 clay species at upper depth. Data suggest alteration extent can be determined by …
Censoring Maps In Google China? Visual Analysis Through Foucault't Power/Knowledge, Zhanar Karimbayeva
Censoring Maps In Google China? Visual Analysis Through Foucault't Power/Knowledge, Zhanar Karimbayeva
Geosciences Theses
This thesis explores aspects of map censorship in Google China through a theoretical framework based on Foucault’s power/knowledge. Comparing results of content analysis of maps in Google Ditu in Google China and Google Maps in Google Dot Com, the thesis analyzes the degree of censorship of maps in the Google geoweb. My findings are a higher density of labeling in Google Ditu in comparison with Google Maps, the absence of VGI in Google Ditu, the limitation of zoom level at Google Ditu, and the absence of Street View in China. This thesis suggests possible explanations to differences in map information …
Measuring The Effective Wavelength Of Chara Classic, Emily Collins Bowsher
Measuring The Effective Wavelength Of Chara Classic, Emily Collins Bowsher
Physics and Astronomy Theses
This thesis presents an engineering project measuring the effective wavelength of the CHARA Classic beam combiner on the CHARA Array. Knowing the actual effective wavelength of light observed is very important because that value is necessary for determining astrophysical parameters of stars. Currently, the value used for CHARA Classic data comes from a model of the system and is based on numbers published by the manufacturer of the filter; it is not derived from measurements done on the system directly. We use two data collection methods to observe standard stars of different spectral types and calculate the wavelength of light …
Ontology And Knowledge Base Of Brittle Deformation Microstructures For The San Andreas Fault Observatory At Depth (Safod) Core Samples, Cynthia Marie Broda
Ontology And Knowledge Base Of Brittle Deformation Microstructures For The San Andreas Fault Observatory At Depth (Safod) Core Samples, Cynthia Marie Broda
Geosciences Theses
The quest to answer fundamental questions and solve complex problems is a principal tenet of Earth science. The pursuit of scientific knowledge has generated profuse research, resulting in a plethora of information-rich resources. This phenomenon offers great potential for scientific discovery. However, a deficiency in information connectivity and processing standards has become evident. This deficiency has resulted in a demand for tools to facilitate and process this upsurge in information. This ontology project is an answer to the demand for information processing tools. The primary purpose of this domain-specific ontology and knowledge base is to organize, connect, and correlate research …
Weak Primary Decomposition Of Modules Over A Commutative Ring, Harrison Stalvey
Weak Primary Decomposition Of Modules Over A Commutative Ring, Harrison Stalvey
Mathematics Theses
This paper presents the theory of weak primary decomposition of modules over a commutative ring. A generalization of the classic well-known theory of primary decomposition, weak primary decomposition is a consequence of the notions of weakly associated prime ideals and nearly nilpotent elements, which were introduced by N. Bourbaki. We begin by discussing basic facts about classic primary decomposition. Then we prove the results on weak primary decomposition, which are parallel to the classic case. Lastly, we define and generalize the Compatibility property of primary decomposition.
The Optical And Radio Properties Of A Low-Redshift Sample Of Broad-Lined Active Galactic Nuclei, Stephen E. Rafter
The Optical And Radio Properties Of A Low-Redshift Sample Of Broad-Lined Active Galactic Nuclei, Stephen E. Rafter
Physics and Astronomy Dissertations
The question as to whether the distribution of radio loudness in active galactic nuclei (AGN) is actually bimodal has been discussed extensively in the literature. Furthermore, there have been claims that radio loudness depends on black hole mass and Eddington ratio. We investigate these claims using the low redshift broad line AGN sample of Greene & Ho 2007, which consists of 8434 objects at z < 0.35 from the Sloan Digital Sky Survey (SDSS) Fourth Data Release. We obtained radio fluxes from the Very Large Array Faint Images of the Radio Sky at Twenty-Centimeters (FIRST) survey for the SDSS AGN. Out of the 8434 SDSS AGN, 846 have radio emission within 4" of the optical counterpart and are considered to be core emission. We also perform a systematic search for extended emission in FIRST that can be positively associated with the optical counterparts and find 51 out of the 846 previously detected core sources have extended emission that must be taken into account when calculating the total radio luminosity. Further, we find an additional 12 objects that have extended radio emission but no detectable radio core and have classic FR II type morphologies. Using these data, the question of radio bimodality and the dependence of radio-loudness on physical parameters are investigated for different subsets of the total sample. We find modest trends in the radio-loud fraction as a function of black hole mass and Eddington ratio, where the fraction of RL AGN increases for the largest black hole mass group and decreases with increasing Eddington ratio. With extended emission taken into account, we find strong evidence for a bimodal distribution in radio-loudness, where the lower radio luminosity core-only sources appear as a population separate from the extended sources with a dividing line at log(R) = 1.75. This dividing line is interesting in that it requires the radio luminosity to be 50 times the optical luminosity, ensuring that these are indeed the most RL AGN, which may have different or extreme physical conditions in their central engines when compared to the more numerous radio quiet AGN in this sample.
Design, Synthesis And Mechanistic Studies Of Small Molecule Inhibitors Of The Hypoxia Inducible Factor Pathway, Suazette Reid Mooring
Design, Synthesis And Mechanistic Studies Of Small Molecule Inhibitors Of The Hypoxia Inducible Factor Pathway, Suazette Reid Mooring
Chemistry Dissertations
Cancer accounts for nearly one-quarter of deaths in the United States, exceeded only by heart diseases. In 2006, there were 559,888 cancer deaths in the US. Finding effective treatments for cancer is a major challenge among researchers. In solid tumor, hypoxia increases the progression of malignancy and metastasis by promoting angiogenesis. The transcription factor HIF-1 is responsible for the regulation of cellular processes, including glycolysis and angiogenesis. Clinical evidence has determined that expression of HIF-1 is strongly associated with poor patient prognosis. Also, activation of HIF-1 contributes to malignant behavior and therapeutic resistance. In view of these observations, there is …
Synthesis Of Fused Heterocyclic Diamidines For The Treatment Of Human African Trypanosomiasis And Fluorescence Studies Of Selected Diamidines, Jennifer Crystal Brown Barber
Synthesis Of Fused Heterocyclic Diamidines For The Treatment Of Human African Trypanosomiasis And Fluorescence Studies Of Selected Diamidines, Jennifer Crystal Brown Barber
Chemistry Dissertations
A class of linear diamidines was synthesized for the evaluation as a treatment of Human African Trypanosomiasis. These fused heterocyclic compounds are thiazole[5,4-d]thiazoles and are of interest because the parent compound, 2,5-Bis(4-amidinophenyl)-thiazolo[5,4-d]thiazole HCl salt, which is also called DB 1929, has exhibited a low nanomolar IC50 value against Trypanosoma brucei rhodesiense and has shown selectivity for binding to the human telomere G-quadruplex over that of DNA duplex. A fluoro and a methoxy derivative have been synthesized and are currently undergoing testing for activity and binding affinity. In addition, fluorescence studies of selected diamidines were done to study the effect of …
On The Catalytic Roles Of His351, Asn510, And His466 In Choline Oxidase And The Kinetic Mechanism Of Pyranose 2-Oxidase, Kunchala Rungsrisuriyachai
On The Catalytic Roles Of His351, Asn510, And His466 In Choline Oxidase And The Kinetic Mechanism Of Pyranose 2-Oxidase, Kunchala Rungsrisuriyachai
Chemistry Dissertations
Choline oxidase (E.C. 1.1.3.17) from Arthrobacter globiformis catalyzes the four-electron oxidation of choline to glycine betaine (N,N,N-trimethylglycine) via two sequential, FAD-dependent reactions in which betaine aldehyde is formed as an enzyme-bound intermediate. In each oxidative half-reaction, molecular oxygen acts as electron acceptor and is converted into hydrogen peroxide. Biochemical, structural, and mechanistic studies on the wild-type and a number of mutant variants of choline oxidase have recently been carried out, allowing for the depiction of the mechanism of alcohol oxidation catalyzed by the enzyme. Catalysis by choline oxidase is initiated by the removal of the hydroxyl proton of alcohol substrate …
Analysis Of Precipitates And Waters Associated With An Alkaline Leachate, Gulf State Steel Property, Gadsden, Alabama: A Reconnaissance Study, Craig Vantrees
Analysis Of Precipitates And Waters Associated With An Alkaline Leachate, Gulf State Steel Property, Gadsden, Alabama: A Reconnaissance Study, Craig Vantrees
Geosciences Theses
Calcite stalactites ranging in length from several inches to a foot long are found forming on the southeastern slag pile at the former Gadsden Steel Mill of the Gulf States Steel Corporation. Analyses of samples collected per EISOPQAM guidelines include the following: petrographic, conductivity, pH, XRD, XRF, TDS, and major cations and anions. Preliminary field pH and conductivity measurements indicate that waters near the slag pile have a pH ranging from 11-12 and a conductivity ranging from 1115-6300 μS/ cm. Titration data indicate that the maximum pH value is 12.5. These calcite stalactites and stream coatings result from the dissolution …
Roles Of Serine 101, Histidine 310 And Valine 464 In The Reaction Catalyzed By Choline Oxidase From Arthrobacter Globiformis, Steffan Finnegan
Roles Of Serine 101, Histidine 310 And Valine 464 In The Reaction Catalyzed By Choline Oxidase From Arthrobacter Globiformis, Steffan Finnegan
Chemistry Dissertations
The enzymatic oxidation of choline to glycine betaine is of interest because organisms accumulate glycine betaine intracellularly in response to stress conditions, as such it is of potential interest for the genetic engineering of crops that do not naturally possess efficient pathways for the synthesis of glycine betaine, and for the potential development of drugs that target the glycine betaine biosynthetic pathway in human pathogens. To date, one of the best characterized enzymes belonging to this pathway is the flavin-dependent choline oxidase from Arthrobacter globiformis. In this enzyme, choline oxidation proceeds through two reductive half-reactions and two oxidative half-reactions. In …
Design And Synthesis Of Boronic Acid-Modified Nucleotides For Fluorescent Sensing And Cell Imaging, Xiaochuan Yang
Design And Synthesis Of Boronic Acid-Modified Nucleotides For Fluorescent Sensing And Cell Imaging, Xiaochuan Yang
Chemistry Dissertations
With the rapidly increasing interest in the field of glycomics, which is the comprehensive study of the roles carbohydrates play in a living system, urgent need for developing quick and highly selective carbohydrate sensors is growing. The boronic acid group, with its electron-deficient structure (6 valence electrons with an open shell), acts as a Lewis acid with high intrinsic affinity towards Lewis bases such as fluoride, cyanide and hydroxyl groups. Specifically, formation of a 5- or 6- membered ring between the boronic acid moiety and a1,2- or 1,3-diol in aqueous solution has been fully explored as a strategy of carbohydrate …
Nanoscopic Investigation Of Surface Morphology Of Neural Growth Cones And Indium Containing Group-Iii Nitrides, Göksel Durkaya
Nanoscopic Investigation Of Surface Morphology Of Neural Growth Cones And Indium Containing Group-Iii Nitrides, Göksel Durkaya
Physics and Astronomy Dissertations
This research focuses on the nanoscopic investigation of the three-dimensional surface morphology of the neural growth cones from the snail Helisoma trivolvis, and InN and InGaN semiconductor material systems using Atomic Force Microscopy (AFM). In the analysis of the growth cones, the results obtained from AFM experiments have been used to construct a 3D architecture model for filopodia. The filopodia from B5 and B19 neurons have exhibited different tapering mechanisms. The volumetric analysis has been used to estimate free Ca2+ concentration in the filopodium. The Phase Contrast Microscopy (PCM) images of the growth cones have been corrected to thickness provided …
Integrating Information Theory Measures And A Novel Rule-Set-Reduction Tech-Nique To Improve Fuzzy Decision Tree Induction Algorithms, Nael Mohammed Abu-Halaweh
Integrating Information Theory Measures And A Novel Rule-Set-Reduction Tech-Nique To Improve Fuzzy Decision Tree Induction Algorithms, Nael Mohammed Abu-Halaweh
Computer Science Dissertations
Machine learning approaches have been successfully applied to many classification and prediction problems. One of the most popular machine learning approaches is decision trees. A main advantage of decision trees is the clarity of the decision model they produce. The ID3 algorithm proposed by Quinlan forms the basis for many of the decision trees’ application. Trees produced by ID3 are sensitive to small perturbations in training data. To overcome this problem and to handle data uncertainties and spurious precision in data, fuzzy ID3 integrated fuzzy set theory and ideas from fuzzy logic with ID3. Several fuzzy decision trees algorithms and …
Analysis Of Gan/Alxga1?Xn Heterojunction Dual-Band Photodetectors Using Capacitance Profiling Techniques, Laura E. Byrum
Analysis Of Gan/Alxga1?Xn Heterojunction Dual-Band Photodetectors Using Capacitance Profiling Techniques, Laura E. Byrum
Physics and Astronomy Theses
Capacitance-voltage-frequency measurements on n+-GaN/AlxGa1−xN UV/IR dual-band detectors are reported. The presence of shallow Si-donor, deep Si-donor, and C-donor/N-vacancy defect states were found to significantly alter the electrical characteristics of the detectors. The barrier Al fraction was found to change the position of the interface defect states relative to the Fermi level. The sample with Al fraction of 0.1 shows a distinct capacitance-step and hysteresis, which is attributed to C-donor/N-vacancy electron trap states located above the Fermi level (200 meV) at the heterointerface; whereas, the sample with Al fraction of 0.026 shows negative capacitance and dispersion, indicating C-donor/N-vacancy and deep Si-donor …
Some Contributions In Statistical Discrimination Of Different Pathogens Using Observations Through Ftir, Dongmei Wang
Some Contributions In Statistical Discrimination Of Different Pathogens Using Observations Through Ftir, Dongmei Wang
Mathematics Theses
Fourier Transform Infrared (FTIR) has been use to discriminate different pathogens by signals from cells infected with these versus normal cells as references. To do the statistical analysis, Partial Least Square Regression (PLSR) was utilized to distinguish any two kinds of virus‐infected cells and normal cells. Validation using Bootstrap method and Cross‐validations were employed to calculate the shrinkages of Area Under the ROC Curve (AUC) and specificities corresponding to 80%, 90%, and 95% sensitivities. The result shows that our procedure can significantly discriminate these pathogens when we compare infected cells with the normal cells. On the height of this success, …
Theoretical And Numerical Study Of Tikhonov's Regularization And Morozov's Discrepancy Principle, Marygeorge L. Whitney
Theoretical And Numerical Study Of Tikhonov's Regularization And Morozov's Discrepancy Principle, Marygeorge L. Whitney
Mathematics Theses
A concept of a well-posed problem was initially introduced by J. Hadamard in 1923, who expressed the idea that every mathematical model should have a unique solution, stable with respect to noise in the input data. If at least one of those properties is violated, the problem is ill-posed (and unstable). There are numerous examples of ill- posed problems in computational mathematics and applications. Classical numerical algorithms, when used for an ill-posed model, turn out to be divergent. Hence one has to develop special regularization techniques, which take advantage of an a priori information (normally available), in order to solve …
Analyzing Gene Expression Data In Terms Of Gene Sets: Gene Set Enrichment Analysis, Wei Li
Analyzing Gene Expression Data In Terms Of Gene Sets: Gene Set Enrichment Analysis, Wei Li
Mathematics Theses
The DNA microarray biotechnology simultaneously monitors the expression of thousands of genes and aims to identify genes that are differently expressed under different conditions. From the statistical point of view, it can be restated as identify genes strongly associated with the response or covariant of interest. The Gene Set Enrichment Analysis (GSEA) method is one method which focuses the analysis at the functional related gene sets level instead of single genes. It helps biologists to interpret the DNA microarray data by their previous biological knowledge of the genes in a gene set. GSEA has been shown to efficiently identify gene …
Analysis Of The Total Food Folate Intake Data From The National Health And Nutrition Exa-Amination Survey (Nhanes) Using Generalized Linear Model, Kyung Ah Lee
Mathematics Theses
The National health and nutrition examination survey (NHANES) is a respected nation-wide program in charge of assessing the health and nutritional status of adults and children in United States. Recent cal research found that folic acid play an important role in preventing baby birth defects. In this paper, we use the generalized estimating equation (GEE) method to study the generalized linear model (GLM) with compound symmetric correlation matrix for the NHANES data and investigate significant factors to ence the intake of food folic acid.
Comparative Studies Between Robotic Laparoscopic Myomectomy And Abdominal Myomectomy With Factors Affecting Short-Term Surgical Outcomes, Amy N. Fomo
Mathematics Theses
The purpose of this study is to compare short-term surgical outcomes of robotic and abdominal myomectomy and to analyze the factors affecting the total operative time, estimated blood loss and length of hospital stay from a retrospective study of a consecutive case series of 122 pa-tients with symptomatic leiomyomata. Wilcoxon, t tests, multiple linear and logistic regressions analyses were performed. Patients in abdominal group had larger number of leiomyomata, larger tumor size and BMI. The operative time was longer in robotic group and was affected by the size and number of tumors, parity and interaction between parity and BMI. Estimated …
Metabolic Network Alignments And Their Applications, Qiong Cheng
Metabolic Network Alignments And Their Applications, Qiong Cheng
Computer Science Dissertations
The accumulation of high-throughput genomic and proteomic data allows for the reconstruction of the increasingly large and complex metabolic networks. In order to analyze the accumulated data and reconstructed networks, it is critical to identify network patterns and evolutionary relations between metabolic networks. But even finding similar networks becomes computationally challenging. The dissertation addresses these challenges with discrete optimization and the corresponding algorithmic techniques. Based on the property of the gene duplication and function sharing in biological network,we have formulated the network alignment problem which asks the optimal vertex-to-vertex mapping allowing path contraction, vertex deletion, and vertex insertions. We have …