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Timing And Characterization Of The Change In The Redox State Of Uranium In Precambrian Surface Environments: A Proxy For The Oxidation State Of The Atmosphere, Gerald D. Pollack
Timing And Characterization Of The Change In The Redox State Of Uranium In Precambrian Surface Environments: A Proxy For The Oxidation State Of The Atmosphere, Gerald D. Pollack
Geosciences Dissertations
The redox-sensitive geochemical behavior of uranium permits the use of Th/U ratios as a geochemical proxy for the oxidation state of the atmosphere and oceans during sedimentary processes. Due to the effects of post-depositional uranium mobility on Th/U ratios during events involving oxygenated fluids, direct measurements of Th/U ratios are often misleading, but the whole rock Pb isotope composition may be used to determine a sample¡¦s apparent time-integrated Th/U ratio (ƒÛa) and the timing associated with the onset of the U-Th-Pb geochemistry. Rare earth element (REE) concentrations were determined by isotope dilution mass spectrometry to evaluate the influence of multiple …
Transformation Groups And Duality In The Analysis Of Musical Structure, Janine Du Plessis
Transformation Groups And Duality In The Analysis Of Musical Structure, Janine Du Plessis
Mathematics Theses
One goal of music theory is to describe the resources of a pitch system. Traditionally, the study of pitch intervals was done using frequency ratios of the powers of small integers. Modern mathematical music theory offers an independent way of understanding the pitch system by considering intervals as transformations. This thesis takes advantage of the historical emergence of algebraic structures in musicology and, in the spirit of transformational theory, treats operations that form mathematical groups. Aspects of Neo-Riemannian theory are explored and developed, in particular the T/I and PLR groups as dual. Pitch class spaces, such as 12, can also …
Factorization Of Quasiseparable Matrices, Paul D. Johnson
Factorization Of Quasiseparable Matrices, Paul D. Johnson
Mathematics Theses
This paper investigates some of the ideas and algorithms developed for exploiting the structure of quasiseparable matrices. The case of purely scalar generators is considered initially. The process by which a quasiseparable matrix is represented as the product of matrices comprised of its generators is explained. This is done clearly in the scalar case, but may be extended to block generators. The complete factoring approach is then considered. This consists of two stages: inner-outer factorization followed by inner-coprime factorization. Finally, the stability of the algorithm is investigated. The algorithm is used to factor various quasiseparable matrices R created first using …
Examination Of Initialization Techniques For Nonnegative Matrix Factorization, John Frederic
Examination Of Initialization Techniques For Nonnegative Matrix Factorization, John Frederic
Mathematics Theses
While much research has been done regarding different Nonnegative Matrix Factorization (NMF) algorithms, less time has been spent looking at initialization techniques. In this thesis, four different initializations are considered. After a brief discussion of NMF, the four initializations are described and each one is independently examined, followed by a comparison of the techniques. Next, each initialization's performance is investigated with respect to the changes in the size of the data set. Finally, a method by which smaller data sets may be used to determine how to treat larger data sets is examined.
Proxy Module For System On Mobile Devices (Syd) Middleware, Joseph Gunawan
Proxy Module For System On Mobile Devices (Syd) Middleware, Joseph Gunawan
Computer Science Theses
Nowadays, users of mobile devices are growing. The users expect that they could communicate constantly using their mobile devices while they are also constantly moving. Therefore, there is a need to provide disconnection tolerance of transactions in the mobile devices’ platforms and its synchronization management. System on Mobile Devices (SyD) is taken as one of the examples of mobile devices’ platforms. The thesis studies the existing SyD architecture, from its framework into its kernel, and introduces the proxy module enhancement in SyD to handle disconnection tolerance, including its synchronization. SyD kernel has been extended for the purpose of enabling proxy …
802.11 Fingerprinting To Detect Wireless Stealth Attacks, Aravind Venkataraman
802.11 Fingerprinting To Detect Wireless Stealth Attacks, Aravind Venkataraman
Computer Science Theses
We propose a simple, passive and deployable approach for fingerprinting traffic on the wired side as a solution for three critical stealth attacks in wireless networks. We focus on extracting traces of the 802.11 medium access control (MAC) protocol from the temporal arrival patterns of incoming traffic streams as seen on the wired side, to identify attacker behavior. Attacks addressed include unauthorized access points, selfish behavior at the MAC layer and MAC layer covert timing channels. We employ the Bayesian binning technique as a means of classifying between delay distributions. The scheme requires no change to the 802.11 nodes or …
An Analysis Of Fourier Transform Infrared Spectroscopy Data To Predict Herpes Simplex Virus 1 Infection, Patrick D. Champion
An Analysis Of Fourier Transform Infrared Spectroscopy Data To Predict Herpes Simplex Virus 1 Infection, Patrick D. Champion
Mathematics Theses
The purpose of this analysis is to evaluate the usefulness of Fourier Transform Infrared (FTIR) spectroscopy in the detection of Herpes Simplex Virus 1 (hsv1) infection at an early stage. The raw absorption values were standardized to eliminate inter-sampling error. Wilcoxon-Mann-Whitney (WMW) statistic's Z score was calculated to select significant spectral regions. Partial least squares modeling was performed because of multicollinearity. Kolmogorov-Smirnov statistic showed models for healthy tissues from different time groups were not from same distribution. The additional 24 hour dataset was evaluated using the following methods. Variables were selected by WMW Z score. Difference of Composites statistic, DC, …
Semi-Parametric Inference For The Partial Area Under The Roc Curve, Fangfang Sun
Semi-Parametric Inference For The Partial Area Under The Roc Curve, Fangfang Sun
Mathematics Theses
Diagnostic tests are central in the field of modern medicine. One of the main factors for interpreting a diagnostic test is the discriminatory accuracy. For a continuous-scale diagnostic test, the area under the receiver operating characteristic (ROC) curve, AUC, is a useful one-number summary index for the diagnostic accuracy of the test. When only a particular region of the ROC curve would be of interest, the partial AUC (pAUC) is a more appropriate index for the diagnostic accuracy. In this thesis, we develop seven confidence intervals for the pAUC under the semi-parametric models for the diseased and non-diseased populations by …
Do R_{Aa} And R_{Cp} Quantify Nuclear Medium Effects?, Robert Adrian Zaballa
Do R_{Aa} And R_{Cp} Quantify Nuclear Medium Effects?, Robert Adrian Zaballa
Physics and Astronomy Dissertations
With the use of an incoherent binary nucleon-nucleon collision model of heavy ion collisions for simulating particle production, it is demonstrated that the nuclear modification factors, R_{AA} and R_{CP}, are less than unity for hard scattering in the absence of any nuclear modification effects. The nuclear modification factor R_{dAu} is also shown to approach or exceed unity only if p_T broadening is taken into account. With a simple phenomenological parameter, the mean nucleon energy loss fraction, this model yields particle distributions that are comparable to those of experiment. The nuclear geometry is described by the Glauber model, and particle production …
Time Series Forecasting Model For Chinese Future Marketing Price Of Copper And Aluminum, Zhejin Hu
Time Series Forecasting Model For Chinese Future Marketing Price Of Copper And Aluminum, Zhejin Hu
Mathematics Theses
This thesis presents a comparison for modeling and forecasting Chinese futures market of copper and aluminum with single time series and multivariate time series under linear restrictions. For single time series, data transformation for stationary purpose has been tested and performed before ARIMA model was built. For multivariate time series, co-integration rank test has been performed and included before VECM model was built. Based on selected models, the forecasting shows multivariate time series analysis has a better result than single time series, which indicates utilizing the relationships among the series can improve the accuracy of time series forecasting.
The Separated Fringe Packet Survey: Updating Multiplicity Of Solar-Type Stars Within 22 Parsecs, Christopher Donald Farrington
The Separated Fringe Packet Survey: Updating Multiplicity Of Solar-Type Stars Within 22 Parsecs, Christopher Donald Farrington
Physics and Astronomy Dissertations
Over the past half century, multiplicity studies have provided a foundation for the theories of stellar formation and evolution through understanding how likely it is that stars form alone or with companions. If spectroscopic orbits are combined with techniques that can determine visual orbits, we can access the most fundamental parameter of stellar evolution, stellar mass. This dissertation is composed of two main sections. The first involves the investigation of the seminal multiplicity study of Duquennoy & Mayor (1991b) which has been the ``gold standard" for solar-type stars for nearly 20 years. Improvements in technology in the intervening years have …
Theory Of Electronic And Optical Properties Of Nanostructures, Prabath Hewageegana
Theory Of Electronic And Optical Properties Of Nanostructures, Prabath Hewageegana
Physics and Astronomy Dissertations
"There is plenty of room at the bottom." This bold and prophetic statement from Nobel laureate Richard Feynman back in 1950s at Cal Tech launched the Nano Age and predicted, quite accurately, the explosion in nanoscience and nanotechnology. Now this is a fast developing area in both science and technology. Many think this would bring the greatest technological revolution in the history of mankind. To understand electronic and optical properties of nanostructures, the following problems have been studied. In particular, intensity of mid-infrared light transmitted through a metallic diffraction grating has been theoretically studied. It has been shown that for …
Short-Wave Infrared Diffuse Reflectance Of Textile Materials, Terence Haran
Short-Wave Infrared Diffuse Reflectance Of Textile Materials, Terence Haran
Physics and Astronomy Theses
This thesis analyzes the reflectance behavior of textiles in the short-wave infrared (SWIR) band (1 – 2 microns) in order to identify/design potential diagnostic tools that allow the remote detection of human presence in a scene. Analyzing the spectral response of fabrics in the SWIR band has gained significant interest in the remote sensing community since it provides a potential path to discriminate camouflaged clothing from backgrounds that appear similar to the object of interest in the visible band. Existing research, originating primarily from the textiles community, has thoroughly documented the behavior of clothing fabrics in the visible band. Other …
Infrared Spectroscopy In Combination With Advanced Statistical Methods For Distinguishing Viral Infected Biological Cells, Tian Tang
Mathematics Theses
Fourier Transform Infrared (FTIR) microscopy is a sensitive method for detecting difference in the morphology of biological cells. In this study FTIR spectra were obtained for uninfected cells, and cells infected with two different viruses. The spectra obtained are difficult to discriminate visually. Here we apply advanced statistical methods to the analysis of the spectra, to test if such spectra are useful for diagnosing viral infections in cells. Logistic Regression (LR) and Partial Least Squares Regression (PLSR) were used to build models which allow us to diagnose if spectral differences are related to infection state of the cells. A three-fold, …
Design Genetic Fluorescent Probes To Detect Protease Activity And Calcium-Dependent Protein-Protein Interactions In Living Cells, Ning Chen
Chemistry Dissertations
Proteases are essential for regulating a wide range of physiological and pathological processes. The imbalance of protease activation and inhibition will result in a number of major diseases including cancers, atherosclerosis, and neurodegenerative diseases. Although fluorescence resonance energy transfer (FRET)-based protease probes, a small molecular dye and other methods are powerful, they still have drawbacks or limitations for providing significant information about the dynamics and pattern of endogenous protease activation and inhibition in a single living cell or in vivo. Currently protease sensors capable of quantitatively measuring specific protease activity in real time and monitoring activation and inhibition of enzymatic …
The Design And Evaluation Of Boronic Acid Derivatives For The Recognition Of Cell Surface Carbohydrates For Medicinal Applications, Sandra Navonne Craig
The Design And Evaluation Of Boronic Acid Derivatives For The Recognition Of Cell Surface Carbohydrates For Medicinal Applications, Sandra Navonne Craig
Chemistry Dissertations
ABSTRACT Carbohydrates in various forms play vital roles in numerous critical biological processes including cell-cell adhesion and communication, embryo development, immune response, etc. Fluorescent sensors for such carbohydrates have a wide range of potential applications including glucose concentration determination, cell labeling and targeting based on carbohydrate biomarkers, as in vitro diagnostic tools, and biomarker-directed cellular imaging. Our group has been interested in the design and synthesis of multi-boronic acid compounds with well-defined three-dimensional scaffolding for the specific recognition of selected carbohydrate biomarkers. Aberrant expression of carbohydrate antigens such as sialyl Lewis X (sLex), sialyl Lewis A (sLea), Lewis X (Lex), …
Using Protein Design To Understand The Role Of Electrostatic Interactions On Calcium Binding Affinity And Molecular Recognition, Lisa Michelle Jones
Using Protein Design To Understand The Role Of Electrostatic Interactions On Calcium Binding Affinity And Molecular Recognition, Lisa Michelle Jones
Chemistry Dissertations
Calcium regulates many biological processes through interaction with proteins with different conformational, dynamic, and metal binding properties. Previous studies have shown that the electrostatic environment plays a key role in calcium binding affinity. In this research, we aim to dissect the contribution of the electrostatic environment to calcium binding affinity using protein design. Many natural calcium binding proteins undergo large conformational changes upon calcium binding which hampers the study of these proteins. In addition, cooperativity between multiple calcium binding sites makes it difficult to study site-specific binding affinity. The design of a single calcium binding site into a host system …
Determining The Site Specific Metal Binding And Structural Properties Of Ef-Hand Protein Using Grafting Approach, Hsiau-Wei Lee
Determining The Site Specific Metal Binding And Structural Properties Of Ef-Hand Protein Using Grafting Approach, Hsiau-Wei Lee
Chemistry Dissertations
Calmodulin is an essential EF-hand protein with a helix-loop-helix calcium binding motif. Understanding Ca(II) dependent activation of calmodulin and other EF-hand proteins is limited by Ca(II)-induced conformational change, multiple and cooperative binding of Ca(II) ions, and interactions between the paired EF-hand motifs. The goal of this research project is to probe key determinants for calcium binding properties and pairing interactions at the site specific level using a grafting approach and high resolution NMR. An individual Ca(II) binding site of the EF-hand motifs of calmodulin was grafted into a non-calcium dependent protein, CD2, to bypass limitations associated with natural EF-hand proteins …
Rational Design Of Calcium Biosensors, April L. Ellis
Rational Design Of Calcium Biosensors, April L. Ellis
Chemistry Dissertations
Understanding the temporal and spatial changes in calcium concentration has been a difficult endeavor for many years due to the relatively small changes in calcium concentration during messenging events, the rapid changes upon physiological messenging, and the unavailability of fast, efficient, and sensitive sensors to detect calcium changes. In addition, the key factors in calcium binding have yet to be determined due to the metal-metal interactions, cooperativity, and conformational change involved in calcium binding to natural calcium-binding proteins. To overcome these obstacles and to engineer calcium sensors for in vivo studies of calcium signaling events, calcium binding sites have been …
Some Conclusions Of Statistical Analysis Of The Spectropscopic Evaluation Of Cervical Cancer, Hailun Wang
Some Conclusions Of Statistical Analysis Of The Spectropscopic Evaluation Of Cervical Cancer, Hailun Wang
Mathematics Theses
To significantly improve the early detection of cervical precancers and cancers, LightTouch™ is under development by SpectRx Inc.. LightTouch™ identifies cancers and precancers quickly by using a spectrometer to analyze light reflected from the cervix. Data from the spectrometer is then used to create an image of the cervix that highlights the location and severity of disease. Our research is conducted to find the appropriate models that can be used to generate map-like image showing disease tissue from normal and further diagnose the cervical cancerous conditions. Through large work of explanatory variable search and reduction, logistic regression and Partial Least …
Hiv/Aids Relative Survival And Mean Residual Life Analysis, Xinjian Zhang
Hiv/Aids Relative Survival And Mean Residual Life Analysis, Xinjian Zhang
Mathematics Theses
HIV/Aids Relative Survival and Mean Residual Life Analysis BY XINJIAN ZHANG Under the Direction of Gengsheng (Jeff) Qin and Ruiguang (Rick) Song ABSTRACT Generalized linear models with Poisson error were applied to investigate HIV/AIDS relative survival. Relative excess risk for death within 3 years after HIV/AIDS diagnosis was significantly higher for non-Hispanic blacks, American Indians and Hispanics compared with Whites. Excess hazard for death was also higher in men injection drug users compared with men who have sex with men (MSM). The relative excess hazard of old HIV/AIDS patients is significantly higher compared with younger patients. When CD4 increased, the …
Noetherian Filtrations And Finite Intersection Algebras, Sara Malec
Noetherian Filtrations And Finite Intersection Algebras, Sara Malec
Mathematics Theses
This paper presents the theory of Noetherian filtrations, an important concept in commutative algebra. The paper describes many aspects of the theory of these objects, presenting basic results, examples and applications. In the study of Noetherian filtrations, a few other important concepts are introduced such as Rees algebras, essential powers filtrations, and filtrations on modules. Basic results on these are presented as well. This thesis discusses at length how Noetherian filtrations relate to important constructions in commutative algebra, such as graded rings and modules, dimension theory and associated primes. In addition, the paper presents an original proof of the finiteness …
New Non-Parametric Confidence Interval For The Youden, Haochuan Zhou
New Non-Parametric Confidence Interval For The Youden, Haochuan Zhou
Mathematics Theses
Youden index, a main summary index for the Receiver Operating Characteristic (ROC) curve, is a comprehensive measurement for the effectiveness of a diagnostic test. For a continuous-scale diagnostic test, the optimal cut-point for the positive of disease is the cut-point leading to the maximization of the sum of sensitivity and specificity. Finding the Youden index of the test is equivalent to maximize the sum of sensitivity and specificity for all the possible values of the cut-point. In this thesis, we propose a new non-parametric confidence interval for the Youden index. Extensive simulation studies are conducted to compare the relative performance …
Senmincom: Pervasive Distributed Dynamic Sensor Data Mining For Effective Commerce, Naveen Hiremath
Senmincom: Pervasive Distributed Dynamic Sensor Data Mining For Effective Commerce, Naveen Hiremath
Computer Science Theses
In last few years, the use of wireless sensor networks and cell phones has become ubiquitous; fusing these technologies in the field of business will open up new possibilities. To fill this lacuna, I propose a novel idea where the combination of these will facilitate companies to receive feedback on their products and services. System's unobtrusive sensors will not only collect shopping, mobile usage data from consumers but will also make effective use of this information to increase revenue, cut costs, etc.; the use of mobile agent based data mining allows analyzing the data from different dimensions, categorizing it on …
Bootstrap And Empirical Likelihood-Based Semi-Parametric Inference For The Difference Between Two Partial Aucs, Xin Huang
Mathematics Theses
With new tests being developed and marketed, the comparison of the diagnostic accuracy of two continuous-scale diagnostic tests are of great importance. Comparing the partial areas under the receiver operating characteristic curves (pAUC) is an effective method to evaluate the accuracy of two diagnostic tests. In this thesis, we study the semi-parametric inference for the difference between two pAUCs. A normal approximation for the distribution of the difference between two pAUCs has been derived. The empirical likelihood ratio for the difference between two pAUCs is defined and its asymptotic distribution is shown to be a scaled chi-quare distribution. Bootstrap and …
Investigation Of Fundamental Black Hole Properties Of Agn Through Optical Variability, Wesley Thomas Ryle
Investigation Of Fundamental Black Hole Properties Of Agn Through Optical Variability, Wesley Thomas Ryle
Physics and Astronomy Dissertations
Active galactic nuclei (AGN) are known to vary in brightness in all regions of the electromagnetic spectrum and over a wide range of timescales. Many methods have been utilized to transform this observed variability into meaningful information about the central engines of AGN. One such technique, adapted from time series analysis of galactic x-ray binary systems, has been used to detect a characteristic break timescale in the power density spectra of x-ray variability in Seyfert galaxies. This timescale, thought to be related to instabilities in the accretion disk, appears to scale with black hole mass over many orders of magnitude. …
Improving Summer Drought Prediction In The Apalachicola-Chattahoochee- Flint River Basin With Empirical Downscaling, John Robert Dean
Improving Summer Drought Prediction In The Apalachicola-Chattahoochee- Flint River Basin With Empirical Downscaling, John Robert Dean
Geosciences Theses
The Georgia General Assembly, like many states, has enacted pre-defined, comprehensive, drought-mitigation apparatus, but they need rainfall outlooks. Global circulation models (GCMs) provide rainfall outlooks, but they are too spatially course for jurisdictional impact assessment. To wed these efforts, spatially averaged, time-smoothed, daily precipitation observations from the National Weather Service cooperative network are fitted to eight points of 700 mbar atmospheric data from the NCEP/NCAR Reanalysis Project for climate downscaling and drought prediction in the Apalachicola-Chattahoochee-Flint (ACF) river basin. The domain is regionalized with a factor analysis to create specialized models. All models complied well with mathematical assumptions, though the …
Structure And Energetics Of Rna - Protein Interactions For Hiv Rreiib Targeting Zinc Finger Proteins., Subrata H. Mishra
Structure And Energetics Of Rna - Protein Interactions For Hiv Rreiib Targeting Zinc Finger Proteins., Subrata H. Mishra
Chemistry Dissertations
RNA - protein interactions constitute a vital part of numerous biochemical processes. In the HIV life cycle, the interaction of the viral protein Rev and the Rev Responsive Element (RRE), a part of unspliced HIV RNA, is crucial for the propagation of infectious virions. Intervention of this interaction disrupts the viral life cycle. Rev - RRE interaction initially occurs at a high affinity binding site localized to a relatively small stem loop structure called RREIIB. This binding event has been well characterized by a variety of biochemical, enzymatic and structural studies. Our collaborators have previously demonstrated the efficacy of zinc …
Design Of A Structure Search Engine For Chemical Compound Database, Hao Wang
Design Of A Structure Search Engine For Chemical Compound Database, Hao Wang
Computer Science Dissertations
The search for structural fragments (substructures) of compounds is very important in medicinal chemistry, QSAR, spectroscopy, and many other fields. In the last decade, with the development of hardware and evolution of database technologies, more and more chemical compound database applications have been developed along with interfaces of searching for targets based on user input. Due to the algorithmic complexity of structure comparison, essentially a graph isomorphism problem, the current applications mainly work by the approximation of the comparison problem based on certain chemical perceptions and their search interfaces are often e-mail based. The procedure of approximation usually invokes subjective …
Application Of Computer-Aided Drug Discovery Methodologies Towards The Rational Design Of Drugs Against Infectious Diseases, Prashanth Athri
Application Of Computer-Aided Drug Discovery Methodologies Towards The Rational Design Of Drugs Against Infectious Diseases, Prashanth Athri
Chemistry Dissertations
Computer-aided drug discovery involves the application of computer science and programming to solve chemical and biological problems. Specifically, the QSAR (Quantitative Structure Activity Relationships) methodology is used in drug development to provide a rational basis of drug synthesis, rather than a trial and error approach. Molecular dynamics (MD) studies focus on investigating the details of drug-target interactions to elucidate various biophysical characteristics of interest. Infectious diseases like Trypanosoma brucei rhodesiense (TBR) and P. falciparum (malaria) are responsible for millions of deaths annually around the globe. This necessitates an immediate need to design and develop new drugs that efficiently battle these …