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Colistin And Antimicrobial Resistance Among Gram-Negative Bacteria Isolated From Poultry In West Bank, Palestine, Mohammad Qadi, Rasha Khayyat, Safaa Alhato, Abdelraouf A. Elmanama, Ashraf R. Zayed, Muna M. Abbas, Maysa Daqqa, Faizeh Hussein, Ahmed Mousa Jun 2024

Colistin And Antimicrobial Resistance Among Gram-Negative Bacteria Isolated From Poultry In West Bank, Palestine, Mohammad Qadi, Rasha Khayyat, Safaa Alhato, Abdelraouf A. Elmanama, Ashraf R. Zayed, Muna M. Abbas, Maysa Daqqa, Faizeh Hussein, Ahmed Mousa

Palestinian Medical and Pharmaceutical Journal

Background: The escalating incidence of antimicrobial resistance in Gram-negative bacteria has elicited worldwide apprehension owing to its profound ramifications, such as the emergence of infections that cannot be effectively treated and may result in mortality. The poultry industry is of significant concern due to its substantial utilization of antimicrobials, including those regarded as last-resort therapies for complex multi-drug resistant Gram-negative infections. Methods: A comprehensive collection of ninety cloacal swabs was undertaken from a diverse range of thirty poultry farms located within the Nablus governorate during the period spanning from March to June in the year 2019. The swabs, specifically collected …


Dereplication Study And Pharmacological Potentials Of Phytochemical Constituents Of Nigerian Propolis From Umudike, Sylvester N. Ugariogu, Stephanie A. Ezirim, Ijeoma A. Duru, Samya S. Alenezi, Anyam John V., Igoli John O. Jun 2024

Dereplication Study And Pharmacological Potentials Of Phytochemical Constituents Of Nigerian Propolis From Umudike, Sylvester N. Ugariogu, Stephanie A. Ezirim, Ijeoma A. Duru, Samya S. Alenezi, Anyam John V., Igoli John O.

Palestinian Medical and Pharmaceutical Journal

Liquid chromatography-mass spectroscopy (LC-MS) was used to detect the phytochemicals present in the extracts of propolis from Umudike. The dereplication study of the hexane and ethyl acetate extracts of green, brown and red propolis samples from a hive in Umudike Umuahia Nigeria were studied using MestReNova software. About 31 compounds previously reported from Africa propolis were detected. The results revealed the presence of 23compounds were found in the ethyl acetate extract of the brown propolis, while 20 were detected in both the ethyl acetate extract of the green and red propolis. The hexane extract of the brown propolis showed 20 …


Antioxidative And Antidiabetic Investigations Of The Aqueous Extract Of Pelargonium Graveolens Grown In Palestine, Belal Rahhal, Maysa`A Radwan, Yasmeen Edili Jun 2024

Antioxidative And Antidiabetic Investigations Of The Aqueous Extract Of Pelargonium Graveolens Grown In Palestine, Belal Rahhal, Maysa`A Radwan, Yasmeen Edili

Palestinian Medical and Pharmaceutical Journal

Plants have been used for many healing aims since outdated times, and to this day, many essential pharmaceutical dosage forms originated from herbal products. The utilization of herbal products recognized by therapeutic agents in modern healthcare systems has increased over the past two decades. The present biological screening study employed reference methods to estimate Pelargonium graveolens four extracts from the Nablus governorate in Palestine. The outcomes affirmed that the four extracts of the P. graveolens plant have potent antioxidant activity compared with Trolox. The aqueous extract has very potent activity, followed by acetone extract in comparison with Trolox (((s)-(-)-6 …


A Bibliometric Analysis Of Cannabis-Related Research From 2010 To 2022, Chaimae Haboubi, Yahya El Hammoudani, Nidal Jaradat, Shehde Jodeh, Khadija Haboubi, Fouad Dimane Jun 2024

A Bibliometric Analysis Of Cannabis-Related Research From 2010 To 2022, Chaimae Haboubi, Yahya El Hammoudani, Nidal Jaradat, Shehde Jodeh, Khadija Haboubi, Fouad Dimane

Palestinian Medical and Pharmaceutical Journal

Cannabis plant cultivation was prohibited for a period, but in recent times, there has been a shift in its perception. It is now being researched extensively to identify the best methods for its utilization. This article provides a bibliometric review of studies related to cannabis. Bibliometric analysis is a widely used technique for analyzing large volumes of scientific data. For this study, 3,761 documents were collected from the popular Scopus database, published between 2010 and 2022. The collected data was analyzed using the "Bibliometrics" package in the R programming language. "Biblioshiny" and "Vosviewer" were employed to visualize the results. The …


Menopausal Symptoms And Quality Of Life Among Palestinian Women: A Cross-Sectional Study, Souad Belkebir, Lubna Saudi, Balqees Nassar, Noor Nabresi, Mohammad Abuawad Jun 2024

Menopausal Symptoms And Quality Of Life Among Palestinian Women: A Cross-Sectional Study, Souad Belkebir, Lubna Saudi, Balqees Nassar, Noor Nabresi, Mohammad Abuawad

Palestinian Medical and Pharmaceutical Journal

Background: Natural menopause is associated with somatic, vasomotor, psychological, and sexual complaints that may affect women's quality of life (QOL). Aims: To determine the prevalence and severity of menopausal symptoms and their impact on QoL among Palestinian women visiting primary care centers. Methods: A cross-sectional study was conducted from November 2018 through March 2019. Convenience sampling was used to interview 380 women aged 45–60 years attending primary care centers in the West Bank city of Nablus. The Menopause Rating Scale (MRS) assessed the prevalence and severity of menopausal symptoms and QoL. Mean scores of menopausal categories were compared for different …


Synthesis, Characterization, Molecular Docking, And Preliminary Antimicrobial Evaluation Of Thiazolidinone Derivatives, Sarmad S. Hussein, Karima F. Ali, Fouad A. Al-Saady Jun 2024

Synthesis, Characterization, Molecular Docking, And Preliminary Antimicrobial Evaluation Of Thiazolidinone Derivatives, Sarmad S. Hussein, Karima F. Ali, Fouad A. Al-Saady

Palestinian Medical and Pharmaceutical Journal

Several derivatives carrying thiazolidine-4-one pharmacophore were prepared to evaluate their antimicrobial activities. The set of compounds were shown to possess potential activities as determined by molecular docking studies for both candidal (14-alpha demethylase) and bacterial enzymes (Penicillin binding protein of E. coli). In vitro antimicrobial activities were also performed to confirm the molecular docking results. Molecular characterization by spectral techniques (FT-IR, 13C NMR and 1H NMR) was carried out to confirm the identity of the synthesized compounds. The synthesized compounds were evaluated for antibacterial and anticandidal activity by comparing them with the reference drugs (positive controls) ceftriaxone …


Perception And Factors Associated With Patient Safety Culture In An Academic University Hospital In Palestine, Loai M. Zabin Jun 2024

Perception And Factors Associated With Patient Safety Culture In An Academic University Hospital In Palestine, Loai M. Zabin

Palestinian Medical and Pharmaceutical Journal

Background: Patient safety culture plays a pivotal role in enhancing care quality, preventing errors, promoting clinical outcomes, and reducing healthcare costs. It also helps minimize adverse events, increasing patient safety, and elevating the quality of medical care provided. This study aims to evaluate the perception of patient safety culture within a university hospital. It aims to examine the correlation between the demographic and workplace characteristics of the staff and their perceptions of patient safety culture. Methods: A quantitative cross-sectional study design was employed for this study. The Arabic version of the Hospital Survey of Patient Safety Culture (HSOPSC) v2.0 was …


Molecular And Physicochemical Studies Of Mrsa Resistant To Antibiotics: A Known Beyond, Himanshu Bhogekar, Ritesh P. Bhole, Pramod B. Khedekar, Rupesh V. Chikhale Jun 2024

Molecular And Physicochemical Studies Of Mrsa Resistant To Antibiotics: A Known Beyond, Himanshu Bhogekar, Ritesh P. Bhole, Pramod B. Khedekar, Rupesh V. Chikhale

Palestinian Medical and Pharmaceutical Journal

As we see in the community, environment, and daily life, bacterial, microbial, and viral infection creates the severe problem. The medical field is continuously worried about the treatment of infections caused by the microorganism. Day by day, the microorganism in nature becomes stronger and gains more susceptibility to major infections. The researcher continuously works on the development of new antibiotic to break infectivity of the microorganism. But bacteria have the characteristic to adapt in a new environment by generating resistance. Many antibiotics since the discovery of penicillin work on the effects of bacteria for a short duration of time, and …


Head-To-Head Comparison Between Magnetic Resonance Imaging And Arthroscopy Findings For Ligamentous And Meniscal Knee Injuries: A Cross-Sectional Observational Study In Palestine, Zada Hamad, Ali Hewari, Aminah Birawi, Ahmed Awadghanem, Mazen Abdalla, Mohammad M. Jaber, Mosab Maree Mar 2024

Head-To-Head Comparison Between Magnetic Resonance Imaging And Arthroscopy Findings For Ligamentous And Meniscal Knee Injuries: A Cross-Sectional Observational Study In Palestine, Zada Hamad, Ali Hewari, Aminah Birawi, Ahmed Awadghanem, Mazen Abdalla, Mohammad M. Jaber, Mosab Maree

Palestinian Medical and Pharmaceutical Journal

Background: Traumatic knee injuries are widespread, especially among young adults; when a clinical exam suspects the diagnosis, it is evaluated by magnetic resonance imaging (MRI) and confirmed by arthroscopy. MRI is non-invasive and saves patients from potential general anesthesia and surgical site infection complications. We aim to assess the precision of ligamentous and meniscal injuries by MRI compared to the gold standard knee arthroscopy. Methods: We performed a cross-sectional observational study at An-Najah University Hospital (NNUH). Patients who underwent knee arthroscopic surgery and had preoperative MRIs were included in this study. The magnetic resonance and intraoperative findings during …


Percutaneous Coronary Intervention In Unprotected Left Main Coronary Artery Stenosis Patients. A Retrospective Study From Palestine, Yunis Daralammouri, Hamza Hamayel, Raya Yassin, Ameer Kittaneh, Aya Asaly, Zaher Nazzal, Yahya Ismail Mar 2024

Percutaneous Coronary Intervention In Unprotected Left Main Coronary Artery Stenosis Patients. A Retrospective Study From Palestine, Yunis Daralammouri, Hamza Hamayel, Raya Yassin, Ameer Kittaneh, Aya Asaly, Zaher Nazzal, Yahya Ismail

Palestinian Medical and Pharmaceutical Journal

Objective: The study aimed to assess the results of stenting in unprotected left main coronary artery disease (uLMCAD) at a tertiary hospital center. Methods: We assessed all patients who received stenting for uLMCAD, including stable patients who underwent elective, urgent, or emergent procedures. Data were gathered by reviewing hospital records and coronary angiograms and calculating SYNTAX scores. Patient follow-up was conducted via clinic visits and phone calls. Results: Percutaneous coronary intervention (PCI) was performed on seventy patients with uLMCAD, all of whom had successful revascularization. During their hospital stay, only one patient (1.4%) died from a noncardiac cause and no …


Prevalence And Associated Factors Of Smartphone Addiction Among Medical And Health Sciences University Students: A Cross-Sectional Study, Adnan Sarhan Mar 2024

Prevalence And Associated Factors Of Smartphone Addiction Among Medical And Health Sciences University Students: A Cross-Sectional Study, Adnan Sarhan

Palestinian Medical and Pharmaceutical Journal

In recent years, dependence on smartphones is seen to be the rise. Despite its numerous communicative affordances, past research suggests potential adverse effects when smartphones are over-used. The primary objective of this study was to estimate the prevalence of Smart Phone Addiction (SPA) as it connects to smartphone usage and associated factors among An-Najah medical and health sciences students in Palestine. A cross-sectional design and convenient sampling technique were used to select eligible students from different programs in the faculty of Medicine and Health Sciences at the An-Najah National University. Three hundred sixty-seven students were recruited. The Smartphone …


Illness Perceptions In Patients With Coronary Artery Disease In A Private Hospital In Malaysia, Ahmed Nouri, Jufine Majalu, Maha Aldraimly, Nahid A. Lamfon, Nourah Al Enazi, Manahel Alshaer, Reem Fahad Alanazi, Nouf Alanazi Mar 2024

Illness Perceptions In Patients With Coronary Artery Disease In A Private Hospital In Malaysia, Ahmed Nouri, Jufine Majalu, Maha Aldraimly, Nahid A. Lamfon, Nourah Al Enazi, Manahel Alshaer, Reem Fahad Alanazi, Nouf Alanazi

Palestinian Medical and Pharmaceutical Journal

Background: The prevalence of Coronary Artery Disease (CAD) makes it a significant public health concern. Studies on illness perceptions have established a clear correlation between patients' beliefs and the outcomes of their recovery from various illnesses and risk factors. As a result, gaining a deeper understanding of patients' illness perceptions of CAD is imperative for nurses, as it enables them to provide more tailored education and interventions. This, in turn, can improve patient outcomes and reduce the overall burden of CAD. Aim: The study aims to determine the illness perceptions in patients with coronary artery disease in an …


Knowledge, Attitude, And Practice Regarding Deep Dentinal Caries Removal Before Root Canal Treatment And Restoration Among Practicing Dental Surgeons, Sangram Panda, Anamika Sinha, Shakti Rath, Kajal Kiran Sahoo Mar 2024

Knowledge, Attitude, And Practice Regarding Deep Dentinal Caries Removal Before Root Canal Treatment And Restoration Among Practicing Dental Surgeons, Sangram Panda, Anamika Sinha, Shakti Rath, Kajal Kiran Sahoo

Palestinian Medical and Pharmaceutical Journal

This article aims to determine the knowledge, attitude, and practice regarding Deep Dentinal Caries Removal before Root Canal Treatment (RCT) and Restoration among practicing dental surgeons. A descriptive cross-sectional study was executed amongst dental surgeons practicing with undergraduate and post-graduate degrees. A Google questionnaire form was developed and distributed, and 111 authentic entries were short-listed. Data obtained from the study were recorded in Microsoft Excel 2007 version, and SPSS version 18.0 was used for statistical analysis. Most dental surgeons who participated in the study practiced for over 15-20 years. Among them, 60% believe in removing dentinal caries before RCT; 83.8% …


Prevalence Of Vitamin D Deficiency Among Acute Coronary Syndrome Patients In Palestine, Iyad Ali, Ahmad Khalil, Alaa Daibes, Khaled Qushair, Ahmed Al-Sabi, Muhammad Yasser Alsedfy, Hassan Kanj, Mahmoud Abuissa, Kamel Jebreen Mar 2024

Prevalence Of Vitamin D Deficiency Among Acute Coronary Syndrome Patients In Palestine, Iyad Ali, Ahmad Khalil, Alaa Daibes, Khaled Qushair, Ahmed Al-Sabi, Muhammad Yasser Alsedfy, Hassan Kanj, Mahmoud Abuissa, Kamel Jebreen

Palestinian Medical and Pharmaceutical Journal

Introduction: Research has suggested that having low Vitamin D levels is associated with a higher likelihood of developing cardiovascular disease. Specifically, several observational studies have found that Vitamin D is linked to a decreased risk of coronary artery disease. Our study aimed to determine how prevalent Vitamin D deficiency is in Palestinian patients with acute coronary syndrome, a type of cardiovascular disease. Methods: This study used a cross-sectional design, which involved collecting 84 blood samples from patients diagnosed with acute coronary syndrome at two hospitals in Palestine. The blood samples were collected over approximately two months, from late January to …


Stability Indicating Validated Novel Rp-Hplc Method For Dexlansoprazole And Lc-Ms/Ms Study Of Degradation Product, Ritesh P. Bhole, Chandrakant G. Bonde, Ghansham Girase, Shaliendra Gurav Mar 2024

Stability Indicating Validated Novel Rp-Hplc Method For Dexlansoprazole And Lc-Ms/Ms Study Of Degradation Product, Ritesh P. Bhole, Chandrakant G. Bonde, Ghansham Girase, Shaliendra Gurav

Palestinian Medical and Pharmaceutical Journal

This work effectively developed and validated a stability-indicating RP-HPLC technique for precisely measuring dexlansoprazole in bulk samples. An Acetonitrile and 0.5 mmol Ammonium Acetate (pH 4.5) gradient mobile phase, a 1 ml/min flow rate, and detection at 283 nm were all part of the method's unique chromatographic conditions. A Kromasil C18 column was also used. Dexlansoprazole had a 5.14-minute retention period, and the technique showed a linear range of 5–30 mg/ml with a strong correlation value of 0.997. The technique showed high sensitivity with a limit of detection (LOD) of 1.2 mg/ml and a limit of quantification (LOQ) of 3.64 …


Investigation Of Antidiabetic Of Antidiabetic Activity And Pharmacokinetics In Herbo-Mineral Ayurvedic Formulation ‘Arogyavardhini Gutika In Streptozotocin Induced Wistar Rat, Ruchi Bhattacharya, Bina Gidwani Prof., Shiv Shankar Shukla Prof., Ravindra Kumar Pandey Prof. Mar 2024

Investigation Of Antidiabetic Of Antidiabetic Activity And Pharmacokinetics In Herbo-Mineral Ayurvedic Formulation ‘Arogyavardhini Gutika In Streptozotocin Induced Wistar Rat, Ruchi Bhattacharya, Bina Gidwani Prof., Shiv Shankar Shukla Prof., Ravindra Kumar Pandey Prof.

Palestinian Medical and Pharmaceutical Journal

Aim: Herbs, spices, and minerals are important therapeutic attributes of ayurvedic formulations. The formulation Arogyavardhini Gutika is mentioned in the essential drug list of the Ayurvedic Formulary of India. It has a claimed safety profile and is used for the treatment of jaundice, leprosy, fever, oedema, obesity, skin disorders, and other hepatic issues. Methods: An in- vitro study was performed by alpha-amylase inhibition using starch, iodine, and dinitrosalicyclic acid. An in-vivo study was performed using a streptozotocin-induced diabetic rat model. Graded doses of Arogyavardhini gutika (200 and 500 mg/kg) were administered orally for 14 days to normal and streptozotocin-induced …


Role Of Inflammatory And Growth Factors In Diabetes Mellitus, Sayed Mohammed Firdous, Sourav Pal Jan 2024

Role Of Inflammatory And Growth Factors In Diabetes Mellitus, Sayed Mohammed Firdous, Sourav Pal

Palestinian Medical and Pharmaceutical Journal

In diabetes mellitus, both inflammatory and growth factors play significant roles in the development and progression of the disease and its associated complications. Diabetics frequently show signs of chronic, low-grade inflammation. Insulin resistance and beta-cell dysfunction are exacerbated by the high levels of pro-inflammatory cytokines prevalent in diabetes, such as TNF-α and IL-6. High levels of the inflammatory marker C-reactive protein are linked to insulin resistance and an increased risk of cardiovascular disease. An upsurge in in diabetes is caused by NF-κB activation. Complications and pathological processes in diabetes may be exacerbated by a dysregulation of growth factors. The angiogenesis-related …


In Vitro Anticoagulant Effect Analysis Of Leaves Different Extract Types Of Calotropis Procera (Asclepiadaceae) In West Bank/ Palestine, Ghadeer Omar, Kholoud Thiab, Ghaleb Adwan, Ali Barakat Aug 2023

In Vitro Anticoagulant Effect Analysis Of Leaves Different Extract Types Of Calotropis Procera (Asclepiadaceae) In West Bank/ Palestine, Ghadeer Omar, Kholoud Thiab, Ghaleb Adwan, Ali Barakat

Palestinian Medical and Pharmaceutical Journal

As several plants have anticoagulant activity, Calotropis procera has been investigated "in vitro" in this study. Hot and cold water, ethanol, and methanol extracts of these plant leaves were prepared to final concentrations of 100, 50, and 25 mg/ml. In vitro, PT and aPTT assays were conducted on normal platelet poor plasma blood samples of 20 healthy volunteers by a digital coagulation analyzer. Results showed that all evaluated extracts prolonged both PT and aPTT at 100 and 50 mg/ml concentrations. The highest effect on PT was observed for ethanol and methanol extracts by recording 128.52±24.45 sec and 105.99±17.76 sec at …