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Role Of Inflammatory And Growth Factors In Diabetes Mellitus, Sayed Mohammed Firdous, Sourav Pal
Role Of Inflammatory And Growth Factors In Diabetes Mellitus, Sayed Mohammed Firdous, Sourav Pal
Palestinian Medical and Pharmaceutical Journal
In diabetes mellitus, both inflammatory and growth factors play significant roles in the development and progression of the disease and its associated complications. Diabetics frequently show signs of chronic, low-grade inflammation. Insulin resistance and beta-cell dysfunction are exacerbated by the high levels of pro-inflammatory cytokines prevalent in diabetes, such as TNF-α and IL-6. High levels of the inflammatory marker C-reactive protein are linked to insulin resistance and an increased risk of cardiovascular disease. An upsurge in in diabetes is caused by NF-κB activation. Complications and pathological processes in diabetes may be exacerbated by a dysregulation of growth factors. The angiogenesis-related …