Digital Commons Network^™

Incidence And Mortality Of Uveal Melanoma In Australia (1982–2014), Aaron B. Beasley, David B. Preen, Samuel Mclenachan, Elin S. Gray, Fred K. Chen

Research outputs 2014 to 2021

Aims:

We aimed to estimate the incidence and mortality of uveal melanoma (UM) in Australia from 1982 to 2014.

Methods:

Deidentified unit data for all cases of ocular melanoma were extracted from the Australian Cancer Database from 1 January 1982 to 31 December 2014. UM cases were extracted and trends in incidence and disease-specific mortality were calculated. Incidence rates were age-standardised against the 2001 Australian Standard Population. Mortality was assessed using Cox regression.

Results:

From 1982 to 2014, there were 5087 cases of ocular melanoma in Australia, of which 4617 were classified as UM. The average age-standardised incidence rate of …

Burden And Preference-Based Quality Of Life Associated With Bullying In Children, Long K. D. Le, Mary L. Chatterton, Ronald M. Rapee, Sally Fitzpatrick, Kay Bussey, Jennie Hudson, Caroline Hunt, Donna Cross, Anne Magnus, Cathrine Mihalopoulos

Research outputs 2014 to 2021

The objectives of this study are to assess the association between childhood bullying and preference-based health-related quality of life (QoL) in Australian school children and their parents and estimate quality-adjusted life years (QALYs) associated with bullying chronicity. Children aged 8–10 years completed the child health utilities (CHU-9D), while parents completed the Australian quality of life (AQoL-8D). Children were grouped into four categories of bullying involvement (no bullying, victim, perpetrator, or both perpetrator and victim) based on the Revised Olweus Bully/Victim Questionnaire. Parental data were compared across two bullying involvement groups (bullying vs. no bullying). QALYs were calculated for children over …

Abdominal Aortic Calcification, Cardiac Troponin I And Atherosclerotic Vascular Disease Mortality In Older Women, Ryan Teh, Richard L. Prince, Marc Sim, John T. Schousboe, Warren Raymond, Pawel Szulc, Wai Lim, Jonathan M. Hodgson, Kun Zhu, Douglas P. Kiel, Carl Schultz, Peter L. Thompson, Joshua Lewis

Research outputs 2014 to 2021

Objective:

Examine if two inexpensive measures of atherosclerotic vascular diseases (ASVD), abdominal aortic calcification (AAC) and high-sensitivity cardiac troponin I (hs-cTnI) provide complementary information for 10-year ASVD mortality and all-cause mortality risk in older women.

Methods:

908 community-dwelling women without prevalent ASVD ( ≥ 75 years) were followed-up between 2003 and 2013. AAC and plasma hs-cTnI measures were obtained in 2003. AAC was assessed on lateral spine images using a semiquantitative method (AAC24). Linked health records were used for mortality outcomes.

Results:

Mean±SD age was 79.9±2.6 years. 276 (30.4%) women died during follow-up, including 138 (15.2%) ASVD-related deaths. AAC24 and …

Factors Affecting Hospital Readmission Rates Following An Acute Coronary Syndrome: A Systematic Review, Amineh Rashidi, Lisa Whitehead, Courtney Glass

Research outputs 2014 to 2021

Aim

To synthesise quantitative evidence on factors that impact hospital readmission rates following ACS with comorbidities.

Design

Systematic review and narrative synthesis.

Data Sources

A search of eight electronic databases, including Embase, Medline, PsycINFO, Web of Science, CINAHL, Cochrane Library, Scopus and the Joanna Briggs Institute (JBI).

Review Methods

The search strategy included keywords and MeSH terms to identify English language studies published between 2001 and 2020. The quality of included studies was assessed by two independent reviewers, using Joanna Briggs Institute (JBI) critical appraisal tools.

Results

Twenty-four articles were included in the review. All cause 30-day readmission rate was …

Evaluation Of An Australian Neurological Nurse-Led Model Of Postdischarge Care, Judith Dianne Pugh, Kathleen Mccoy, Merrilee Needham, Leanne Jiang, Margaret Giles, Elizabeth Mckinnon, Kym Heine

Research outputs 2014 to 2021

Neurological disorders are a leading cause of disease burden worldwide, placing a heavy demand on health systems. This study evaluated the impacts and cost savings of a community-based nursing service providing supported discharge for neurological patients deemed high-risk for unplanned emergency department presentations and/or hospital readmissions. It focused on adult patients with stroke, epilepsy, migraine/headache or functional neurological disorders discharged from a Western Australian tertiary hospital. An observational design was used comprising prospective enrolment of patients receiving nurse-led supported discharge and follow-up (Neurocare), 21 August 2018 to 6 December 2019 (N = 81), and hospital administrative data, 1 February …

Work-Based Concerns Of Australian Frontline Healthcare Workers During The First Wave Of The Covid-19 Pandemic, Michella Hill, Erin Smith, Brennen W. Mills

Research outputs 2014 to 2021

Objective: This research sought to gauge the extent to which doctors, nurses and paramedics in Australia were concerned about contracting SARS-CoV-2 during the country's first wave of the virus in April 2020.

Methods: Australian registered doctors, nurses and paramedics (n=580) completed an online questionnaire during April 16–30, 2020 (period immediately following the highest four-week period (first wave) of SARS-CoV-2 confirmed cases in Australia).

Results: During April 2020, two-thirds of participants felt it was likely they would contract SARS-CoV-2 at work. Half the participants suggested Personal Protective Equipment (PPE) supplies were inadequate for them to safely perform their job, with two-thirds …

Protocol For The Development Of The International Population Registry For Aphasia After Stroke (I-Praise), M. Ali, A. L. Ben Basat, M. Berthier, M. B. Johansson, C. Breitenstein, D. A. Cadilhac, F. Constantinidou, M. Cruice, G. Davila, M. Gandolfi, M. Gil, R. Grima, Erin Godecke, L. Jesus, L. M. Jiminez, M. Kambanaros, T. Kukkonen, A. Laska, I. Mavis, R. Mc Menamin, C. Mendez-Orellana, H. Obrig, P. Ostberg, H. Robson, K. Sage, M. Van De Sandt-Koenderman, K. Sprecht, E. Visch-Brink, E. Wehling, S. Wielaert, S. J. Wallace, L. J. Williams, M. C. Brady

Research outputs 2014 to 2021

Background: We require high-quality information on the current burden, the types of therapy and resources available, methods of delivery, care pathways and long-term outcomes for people with aphasia. Aim: To document and inform international delivery of post-stroke aphasia treatment, to optimise recovery and reintegration of people with aphasia. Methods & Procedures: Multi-centre, prospective, non-randomised, open study, employing blinded outcome assessment, where appropriate, including people with post-stroke aphasia, able to attend for 30 minutes during the initial language assessment, at first contact with a speech and language therapist for assessment of aphasia at participating sites. There is no study-mandated intervention. Assessments …

Detection Of Clinical Progression Through Plasma Ctdna In Metastatic Melanoma Patients: A Comparison To Radiological Progression, Gabriela Marsavela, Ashleigh C. Mcevoy, Michelle R. Pereira, Anna L. Reid, Zeyad Al-Ogaili, Lydia Warburton, Muhammad K. Khattak, Afaf Abed, Tarek M. Meniawy, Michael Millward, Melanie R. Ziman Dr, Leslie Calapre, Elin S. Gray

Research outputs 2014 to 2021

Background

The validity of circulating tumour DNA (ctDNA) as an indicator of disease progression compared to medical imaging in patients with metastatic melanoma requires detailed evaluation.

Methods

Here, we carried out a retrospective ctDNA analysis of 108 plasma samples collected at the time of disease progression. We also analysed a validation cohort of 66 metastatic melanoma patients monitored prospectively after response to systemic therapy.

Results

ctDNA was detected in 62% of patients at the time of disease progression. For 67 patients that responded to treatment, the mean ctDNA level at progressive disease was significantly higher than at the time of …

Universal Child Health And Early Education Service Use From Birth Through Kindergarten And Developmental Vulnerability In The Preparatory Year (Age 5 Years) In Tasmania, Australia, Catherine L. Taylor, Daniel Christensen, Kim Jose, Stephen R. Zubrick

Research outputs 2014 to 2021

This study investigated patterns of universal health and education service use from birth through Kindergarten (age 4 years) and estimated associations between cumulative risk and service use patterns, and between service use patterns and children's developmental vulnerability in the Preparatory Year (age 5 years). The study used population-wide linkage of health and education administrative data records for 5168 children who had a 2018 AEDC instrument collected in Tasmania and were born in Tasmania (2011–2013). Latent class analysis (LCA) identified three service use patterns: Regular (72.2 per cent of children; reference group), Low (15.6 per cent of children) and High service …

Patients’ Experiences Of A Communication Enhanced Environment Model On An Acute/Slow Stream Rehabilitation And A Rehabilitation Ward Following Stroke: A Qualitative Description Approach, Sarah D'Souza, Deborah J. Hersh, Erin Godecke, Natalie Ciccone, Heidi Janssen, Elizabeth Armstrong

Research outputs 2014 to 2021

Background

Patients in hospital following stroke express a desire to continue therapy tasks outside of treatment activities. However, they commonly describe experiences of boredom and inactivity. An enriched environment aims to provide opportunities for physical, cognitive and social activity and informed the development of a Communication Enhanced Environment (CEE) model to promote patient engagement in language activities.

Purpose

Explore patient perceptions of a CEE model, and barriers and facilitators to engagement in the model.

Methods

A qualitative description study from a larger project that implemented a CEE model into acute and rehabilitation private hospital wards in Western Australia. Semi-structured interviews …

Urinary Metabotype Of Severe Asthma Evidences Decreased Carnitine Metabolism Independent Of Oral Corticosteroid Treatment In The U-Biopred Study, Stacey N. Reinke, Shama Naz, Romanas Chaleckis, Hector Gallart-Ayala, Johan Kolmert, Nazanin Z. Kermani, Angelica Tiotiu, David I. Broadhurst, Anders Lundqvist, Henric Olsson, Marika Strom, Asa M. Wheelock, Cristina Gómez, Magnus Ericsson, Ana R. Sousa, John H. Riley, Stewart Bates, James Scholfield, Matthew Loza, Frederic Baribaud, Per S. Bakke, Massimo Caruso, Pascal Chanez, Stephen J. Fowler, Thomas Geiser, Peter Howarth, Ildiko Horvath, Norbert Krug, Paolo Montuschi, Annelie Behndig, Florian Singer, Jacek Musial, Dominick E. Shaw, Barbro Dahlén, Sile Hu, Jessica Lasky-Su, Peter J. Sterk, Kian Fan Chung, Ratko Djukanovic, Sven Erik Dahlé, Ian M. Adcock, Craig E. Wheelock

Research outputs 2014 to 2021

Introduction: Asthma is a heterogeneous disease with poorly defined phenotypes. Severe asthmatics often receive multiple treatments including oral corticosteroids (OCS). Treatment may modify the observed metabotype, rendering it challenging to investigate underlying disease mechanisms. Here, we aimed to identify dysregulated metabolic processes in relation to asthma severity and medication. Methods: Baseline urine was collected prospectively from healthy participants (n=100), mild-to-moderate asthmatics (n=87) and severe asthmatics (n=418) in the cross-sectional U-BIOPRED cohort; 12–18-month longitudinal samples were collected from severe asthmatics (n=305). Metabolomics data were acquired using high-resolution mass spectrometry and analysed using univariate and multivariate methods. Results: Ninety metabolites were identified, …

Competing Worlds: The Private Lives Of Women Nurse Students And Gender Equity In Higher Education, Lesley Andrew, Ken Robinson, Leesa Costello, Julie Dare

Research outputs 2014 to 2021

© 2020 Society for Research into Higher Education. A longitudinal qualitative study of undergraduate women nursing students demonstrated the profound and pervasive influence of the heterosexual intimate relationship on their university engagement and achievement. Hitherto, the importance of women’s private lives have been underappreciated in the arenas of student equity and retention. The study showed that traditional ideas of gender held within the intimate relationship were highly detrimental to student autonomy and capacity to engage, and that the university’s organisation and delivery of the curriculum exacerbated the situation. Participants made personal sacrifices, which, while enabling continuation of their studies, were …

Why Do Parents Refuse Childhood Vaccination? Reasons Reported In Finland, Johanna Nurmi, Bronwyn Harman

Research outputs 2014 to 2021

Aims: This article examines the reasons for partial and complete refusal of childhood vaccination as reported by parents in Finland. It analyzes perceptions and experiences central in vaccination decisions. Methods: The analysis is based on 38 in-depth interviews with Finnish parents who have refused all or several vaccines for their children. The interviews were analyzed using qualitative content analysis. Results: Three categories of reasons were identified in the analysis: 1) risks and effects of vaccination – concern about and/or experiences of possible side-effects was the most important reason for avoiding vaccines; 2) distrust – participants did not trust vaccination recommendations …

Experiences Of Western Australian Rural Nursing Graduates: A Mixed Method Analysis, Amanda C. Graf, Barbara Nattabi, Elisabeth Jacob, Diane Twigg

Research outputs 2014 to 2021

Aims and objectives:

To determine whether the current rural graduate programmes in Western Australia adequately support new graduate nurses transitioning into practice.

Background:

Graduate nurse's transition to employment is a time of significant change and challenge, often resulting in periods of transition shock. These challenges are magnified in rural areas where graduates have to relocate to commence their career with limited rural nursing experience. Graduate programmes were developed to smooth the transition for university trained bachelor's degree registered nurses into the workforce. Supportive graduate nursing programmes are essential for enabling transition to practice and reduce attrition rates.

Design:

Longitudinal convergent …

It Cannot Happen, Never: A Qualitative Study Exploring Youth Views On Disclosure Of Hiv Diagnosis To Their Sexual Partners In Southern Malawi, Maggie Zgambo, Diana Arabiat, Deborah M. Ireson Dr

Research outputs 2014 to 2021

With the availability of antiretroviral therapy, more children living with HIV live longer than before and grow into young adulthood. This study examined the concerns of youth about disclosure of an HIV diagnosis to their sexual partners and attempted to gain an understanding of their HIV status disclosure experiences, views, and plans. A focused ethnography was undertaken. Using semi-structured interviews, data were collected from 20 youth between the ages of 15 and 24 years who were attending an HIV clinic. The findings highlight that youth generally struggled to disclose their HIV status to their sexual partners. The most frequent reasons …

Lipocalin-2 Variants And Their Relationship With Cardio-Renal Risk Factors, Dahui Li, Haoyun Li, Carlie Bauer, Yue Hu, Joshua R. Lewis, Aimin Xu, Itamar Levinger, Yu Wang

Research outputs 2014 to 2021

Objectives:

To investigate the serum, plasma and urine levels of lipocalin-2 (LCN2) variants in healthy humans and their associations with risk factors for cardiometabolic (CMD) and chronic kidney (CKD) diseases.

Methods:

Fifty-nine males and 41 females participated in the study. Blood and urine were collected following an overnight fasting. LCN2 variants were analyzed using validated in-house ELISA kits. Heart rate, blood pressure, lipids profile, glucose, adiponectin, high-sensitivity C-reactive protein (hsCRP), creatinine, cystatin C, and biomarkers for kidney function were assessed.

Results:

The levels of hLcn2, C87A and R81E in serum and urine, but not plasma, were significantly higher in men …

How Community Participation In Water And Sanitation Interventions Impacts Human Health, Wash Infrastructure And Service Longevity In Low-Income And Middle-Income Countries: A Realist Review, Sarah Nelson, Dorothy Drabarek, Aaron Jenkins, Joel Negin, Seye Abimbola

Research outputs 2014 to 2021

Objective:

To understand how, and under what circumstances community participation in water and sanitation interventions impacts the availability of safe water and sanitation, a change in health status or behaviour and the longevity of water, sanitation and hygiene (WASH) resources and services.

Design:

Realist review.

Data sources:

PubMed, Web of Science and Scopus databases were used to identify papers from low-income and middle-income countries from 2010 to 2020.

Eligibility criteria for selecting studies:

Criteria were developed for papers to be included. The contribution of each paper was assessed based on its relevance and rigour (eg, can it contribute to context, …

Host Defence Peptides In Diabetes Mellitus Type 2 Patients With Periodontal Disease. A Systematic Review, Muhammad Saad Shaikh, Muhammad Sohail Zafar, Farhan Saleem, Ahmad Alnazzawi, Mohid Abrar Lone, Syed Jawad Ali Bukhari, Zohaib Khurshid

Research outputs 2014 to 2021

The aim of the study was to critically assess and review the latest evidence relating the associations between host defence peptides (HDPs), periodontal diseases (PD) and diabetes mellitus type 2 (DM2). To explore studies on HDPs, periodontal disease, and DM2, researchers utilised specific key phrases to search the electronic databases PubMed (National Library of Medicine), Embase (Ovid), Medline (EBSCO), and Dentistry and Oral Sciences (EBSCO). Quality assessment was conducted by means of the Newcastle Ottawa scale and the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool. Following a thorough screening process, a total of 12 papers (4 case‐control, 6 …

Influence Of Physical And Technical Aspects On Change Of Direction Performance Of Rugby Players: An Exploratory Study, Tomás T. Freitas, Pedro E. Alcaraz, Julio Calleja-González, Ademir F. S. Arruda, Aristide Guerriero, Valter P. Mercer, Lucas A. Pereira, Felipe P. Carpes, Michael R. Mcguigan, Irineu Loturco

Research outputs 2014 to 2021

We examined the relationships between change of direction (COD) speed and deficit, and a series of speed-and power-related measurements in national team rugby union players and analyzed the influence of movement patterns on COD ability. Eleven male athletes completed the following physical assessments on different days: day 1—anthropometric measurements, and lower-body kinematic parameters (assessed with eight inertial sensors) and completion time in COD tests (proagility, 45◦ cutting maneuver (CUT), and “L” (L-Drill)); day 2—bilateral and unilateral squat and countermovement jumps, 40 m linear sprint, and bar-power output in the jump squat and half-squat exercises. Pearson’s product–moment correlations were performed to …

Insights Into The Complexity Of Presentation And Management Of Patients: The Sport And Exercise Physician’S Perspective, Prasanna J. Gamage, Saran Seker, Jessica Orchard, David Humphries, Kylie Fitzgerald, Jane Fitzpatrick

Research outputs 2014 to 2021

Objectives:

Sport and Exercise Physicians represent a relatively new specialty focusing on exercise in complex diseases including musculoskeletal diseases. Our objective was to describe the characteristics, type and complexity of patient presentations, their management strategies and referral information in Australian practice.

Methods:

A cross-sectional study including a cohort of 11 senior Sport and Exercise Physicians in Australia studied all new patient consultations within an 8-week period. Data were analysed relating to presentation, referral source, follow-up referrals, and patient management strategies.

Results:

Data from 419 patients were recorded. The majority, 97% (n=406), had musculoskeletal conditions, 53% (n=222) had one or more …

Higher Coffee Consumption Is Associated With Slower Cognitive Decline And Less Cerebral Aβ-Amyloid Accumulation Over 126 Months: Data From The Australian Imaging, Biomarkers, And Lifestyle Study, Samantha L. Gardener, Stephanie R. Rainey-Smith, Victor L. Villemagne, Jurgen Fripp, Vincent Doré, Pierrick Bourgeat, Kevin Taddei, Christopher Fowler, Colin L. Masters, Paul Maruff, Christopher C. Rowe, David Ames, Ralph N. Martins, Aibl Investigators

Research outputs 2014 to 2021

Background:

Worldwide, coffee is one of the most popular beverages consumed. Several studies have suggested a protective role of coffee, including reduced risk of Alzheimer’s disease (AD). However, there is limited longitudinal data from cohorts of older adults reporting associations of coffee intake with cognitive decline, in distinct domains, and investigating the neuropathological mechanisms underpinning any such associations.

Methods: The aim of the current study was to investigate the relationship between self-reported habitual coffee intake, and cognitive decline assessed using a comprehensive neuropsychological battery in 227 cognitively normal older adults from the Australian Imaging, Biomarkers, and Lifestyle (AIBL) study, over …

Genetic Studies Of Metabolic Syndrome In Arab Populations: A Systematic Review And Meta-Analysis, Zahrah Al-Homedi, Nariman Afify, Mashal Memon, Habiba Alsafar, Guan Tay, Herbert F. Jelinek, Mira Mousa, Nadia Abu-Samra, Wael Osman

Research outputs 2014 to 2021

Background:

The metabolic syndrome (MetS) is prevalent in Arabian populations. Several small-scale studies have been performed to investigate the genetic basis of MetS. This systematic review and meta-analysis aimed to examine whether candidate gene polymorphisms are associated with MetS susceptibility among ethnic groups of the Arabian world and to suggest possible directions for future research regarding genetic markers and MetS.

Methods:

A search was conducted for peer-reviewed articles that examined the genetic association of MetS in Arabian populations in the following databases: Medline, Embase, Scopus, Direct Science, Web of Science, ProQuest, and Google Scholar until March 31, 2021. Articles were …

Muscle Damage Indicated By Maximal Voluntary Contraction Strength Changes From Immediately To 1 Day After Eccentric Exercise Of The Knee Extensors, Mikio Shoji, Ryoichi Ema, Kazunori Nosaka, Akihiro Kanda, Kosuke Hirata, Ryota Akagi

Research outputs 2014 to 2021

The present study examined if the magnitude of changes in indirect muscle damage markers could be predicted by maximal voluntary isometric contraction (MVIC) torque changes from immediately to 1 day after eccentric exercise. Twenty-eight young men performed 100 maximal isokinetic (60°/s) eccentric contractions of the knee extensors. MVIC torque, potentiated doublet torque, voluntary activation (VA) during MVIC, shear modulus of rectus femoris (RF), vastus medialis and lateralis, and muscle soreness of these muscles were measured before, immediately after, and 1–3 days post-exercise. Based on the recovery rate of the MVIC torque from immediately to 1-day post-exercise, the participants were placed …

Healthy Eating And Physical Activity Among New Graduate Nurses: A Qualitative Study Of Barriers And Enablers During Their First Year Of Clinical Practice, Elizabeth Brogan, Chris Rossiter, Christine Duffield, Elizabeth Denney-Wilson

Research outputs 2014 to 2021

Background: New graduate nurses entering the workforce experience numerous barriers to maintaining a healthy lifestyle including shift work, the high cost of healthy foods at the workplace and high levels of exhaustion which reduce motivation to participate in regular physical activity. Research has documented unhealthy lifestyles among nurses across the profession. However, few studies focus on graduates' experiences during their transition into their careers. Aim: To investigate the barriers and enablers to healthy eating and participation in physical activity for new graduate nurses during their first year of clinical practice, and to explore attitudes to participation in workplace health promotion …

Uptake Of Health Services By Youth Living With Hiv: A Focused Ethnography, Maggie Zgambo, Diana Arabiat, Deb Ireson

Research outputs 2014 to 2021

Background:

Although several programs have been initiated to increase the uptake of health services amongst youth living with human immunodeficiency virus in the world, disparities in access to these care services still exist.

Aim:

This study aimed to explore the experiences of young people as they attend the human immunodeficiency virus clinic and to identify factors affecting their uptake of health services in southern Malawi.

Methods:

A focused ethnography was conducted to collect data from 20 youths living with human immunodeficiency virus and aged between 15 and 24 years through one-on-one in-depth interviews and casual observations. The interviews data were …

Dental Professionals’ Perspectives Working With Aboriginal Children In Western Australia: A Qualitative Study, A. Durey, Lydia Hearn, S. Lund, M. O’Grady, L. Slack-Smith

Research outputs 2014 to 2021

Background:

The disproportionate burden of oral disease in Aboriginal children and the issues in accessing mainstream dental services are well documented. Yet little is known about dental professionals’ perspectives in providing oral care for Aboriginal children. This paper presents findings from a study exploring such perspectives.

Methods:

Semi-structured interviews were carried out in Western Australia following purposive sampling of non-Aboriginal dentists, dental clinic assistants (dental nurses) and oral health therapists/dental hygienists. Interviews were recorded, transcribed and analysed guided by grounded theory for key themes related to the topic.

Results:

Findings included a service delivery model sometimes unresponsive to Aboriginal families’ …

Language Abilities In Children Born To Mothers Diagnosed With Diabetes: A Systematic Review And Meta-Analysis, Diana Arabiat, Mohammad Al Jabery, Mark Jenkins, Vivien Kemp, Lisa Whitehead, Gary Adams

Research outputs 2014 to 2021

Background:

This meta-analysis reviewed and synthesized the available evidence on the association between intrauterine exposure to maternal diabetes and language abilities in children.

MEDLINE/PubMed, EMBASE, PsycINFO, Proquest Dissertations and Theses Global, and Google Scholar databases were searched through December 2020. Studies were systematically searched, and effect sizes were calculated using random effects models.

Results:

Twelve studies were identified for inclusion in this review, however, only 10 were included in the meta-analysis. Sample size ranged from 9 to 115 participants in the diabetes group and 28 to 8192 in the control and aged around 3 years. The pooled results of the …

Variation Of Igg N-Linked Glycosylation Profile In Diabetic Retinopathy, Zhiyuan Wu, Huiying Pan, Di Liu, Di Zhou, Lixin Tao, Jie Zhang, Xiaonan Wang, Xia Li, Youxin Wang, Wei Wang, Xiuhua Guo

Research outputs 2014 to 2021

Background:

The relationship of immunoglobulin G (IgG) glycosylation with diabetes and diabetic nephropathy has been reported, but its role in diabetic retinopathy (DR) remains unclear. We aimed to investigate and validate the association of IgG glycosylation with DR.

Methods:

We analyzed the IgG N-linked glycosylation profile and primarily selected candidate glycans by lasso (least absolute shrinkage and selection operator) regression analysis in the discovery population. The findings were validated in the replication population using a binary logistics model. The association between the significant glycosylation panel and clinical features was illustrated with Spearman's coefficient. The results were confirmed by sensitivity analyses. …

Construct Validity And Invariance Assessment Of The Social Impacts Of Occupational Heat Stress Scale (Siohss) Among Ghanaian Mining Workers, Victor F. Nunfam, Ebenezer Afrifa-Yamoah, Kwadwo Adusei-Asante, Eddie J. Van Etten, Kwasi Frimpong, Isaac Adjei-Mensah, Jacques Oosthuizen

Research outputs 2014 to 2021

Heat exposure studies over the last decade have shown little attention in assessing and reporting the psychometric properties of the various scales used to measure impacts of occupational heat stress on workers. A descriptive cross-sectional survey including 320 small- and large-scale mining workers was employed to assess the construct validity of the social impacts of occupational heat stress scale (SIOHSS) in the Western Region of Ghana in 2017. A confirmatory factor analysis (CFA) and invariance analysis were carried out using AMOS version 25 and statistical product and service solutions (SPSS) version 26 to examine the model fit and establish consistency …

Do People With Unilateral Mid-Portion Achilles Tendinopathy Who Participate In Running-Related Physical Activity Exhibit A Meaningful Conditioned Pain Modulation (Cpm) Effect: A Pilot Study, Myles C. Murphy, Ebonie K. Rio, Paola Chivers, James Debenham, Sean I. Docking, Mervyn Travers, William Gibson

Research outputs 2014 to 2021

Objectives: Our primary objective was to report the presence of a conditioned pain modulation (CPM) effect in people with localised mid-portion Achilles tendinopathy and whether changes occur over a 12-week period. Our secondary objectives were to quantify the proportion of participants who present for tendinopathy research with previous interventions or co-morbidities, which may impact the CPM-effect and investigate modulating factors. Design: Prospective, observational cohort pilot study. Method: 215 participants presented for this Achilles tendinopathy research and were screened for inclusion with nine being included. Included participants had the CPM-effect (cold-pressor test) assessed using pressure pain thresholds at the Achilles tendon …