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Buprenorphine And Its Formulations: A Comprehensive Review., Salomon Poliwoda, Nazir Noor, Jack S. Jenkins, Cain W. Stark, Mattie Steib, Jamal Hasoon, Giustino Varrassi, Ivan Urits, Omar Viswanath, Adam M. Kaye, Alan David Kaye Jan 2022

Buprenorphine And Its Formulations: A Comprehensive Review., Salomon Poliwoda, Nazir Noor, Jack S. Jenkins, Cain W. Stark, Mattie Steib, Jamal Hasoon, Giustino Varrassi, Ivan Urits, Omar Viswanath, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Buprenorphine, a novel long-acting analgesic, was developed with the intention of two purposes: analgesia and opioid use disorder. Regarding its pharmacodynamics, it is a partial agonist at mu receptors, an inverse agonist at kappa receptors, and an antagonist at delta receptors. For the purpose of analgesia, three formulations of buprenorphine were developed: IV/IM injectable formulation (Buprenex®), transdermal patch formulation (Butrans®), and buccal film formulation (Belbuca®). Related to opioid dependence, the formulations developed were subcutaneous extended release (Sublocade®), subdermal implant (Probuphine®), and sublingual tablets (Subutex®). Lastly, in order to avoid misuse of buprenorphine for opioid dependence, two combination formulations paired with …


Nipped In The Bud: Covid-19 Reveals The Malleability Of Stem Student Self-Efficacy, Eileen K. Camfield, Natasha R. Schiller, Kirkwood M. Land Jun 2021

Nipped In The Bud: Covid-19 Reveals The Malleability Of Stem Student Self-Efficacy, Eileen K. Camfield, Natasha R. Schiller, Kirkwood M. Land

College of the Pacific Faculty Articles

When a global pandemic hits during a longitudinal study of biology student success, researchers can unearth rich information about student resilience. By sharing case studies from two demographically different midsized 4-year institutions, this article illustrates the aspects of student self-efficacy beliefs that were undercut by the shift to emergency remote instruction (ERI) in introductory biology courses in Spring 2020: agency and belonging. By assessing student predictions of exam performance and analyzing themes from 276 student narrative surveys, we highlight the power of a careful balance between cognitive and social interventions to help students recover. Students in this study showed a …


Mechanisms Underlying Neuroprotection By The Nsaid Mefenamic Acid In An Experimental Model Of Stroke, Parto S. Khansari, Robert F. Halliwell Jan 2019

Mechanisms Underlying Neuroprotection By The Nsaid Mefenamic Acid In An Experimental Model Of Stroke, Parto S. Khansari, Robert F. Halliwell

School of Pharmacy Faculty Articles

Stroke is a devastating neurological event with limited treatment opportunities. Recent advances in understanding the underlying pathogenesis of cerebral ischemia support the involvement of multiple biochemical pathways in the development of the ischemic damage. Fenamates are classical non-steroidal anti-inflammatory drugs but they are also highly subunit-selective modulators of GABAA receptors, activators of IKS potassium channels and antagonists of non-selective cation channels and the NLRP3 inflammosome. In the present study we investigated the effect of mefenamic acid (MFA) in a rodent model of ischemic stroke and then addressed the underlying pharmacological mechanisms in vitro for its actions in vivo. The efficacy …


Expression, Purification, And Characterization Of Recombinant Basic Fibroblast Growth Factor In Pichia Pastoris, Henry Hieu Minh Le Jan 2019

Expression, Purification, And Characterization Of Recombinant Basic Fibroblast Growth Factor In Pichia Pastoris, Henry Hieu Minh Le

University of the Pacific Theses and Dissertations

Wounds in the mouth, occurring after oral surgery, take time to heal. No ointment can be added to help with the healing process because mouth saliva will constantly wash it away. In order to combat this problem, we propose engineering a normal flora microbe to grow at the site of injury and secrete a recombinant growth factor to promote healing of the damaged tissue. Our goal is to have the yeast Pichia pastoris produce human basic fibroblast growth factor (bFGF), which aids in cellular proliferation. P. pastoris is a good choice for this application because not only is it considered …


Managing Patient Expectations With Implant Treatment, Daniel B. Kamran, Mark Booth Dds, Eduardo Gonzalez Dds, Ed Shaw Dds May 2018

Managing Patient Expectations With Implant Treatment, Daniel B. Kamran, Mark Booth Dds, Eduardo Gonzalez Dds, Ed Shaw Dds

Excellence Day

This patient came to University of the Pacific, Arthur A. Dugoni School of Dentistry to get implants and implant crowns to improve his smile, replacing his upper partial denture. Different approaches were made by the faculty to arrive at best outcomes, which took four years for the patient to receive the treatment he wanted. This abstract will further detail how the treatment was conducted and the results afterwards.


A Modified “Wound Healing” And Hypoxia Model In Vitro, Schuyler G. Tang, Isabel Kwon, Marie M. Tolarova, Mirek Tolar May 2018

A Modified “Wound Healing” And Hypoxia Model In Vitro, Schuyler G. Tang, Isabel Kwon, Marie M. Tolarova, Mirek Tolar

Excellence Day

Closing a wound may resemble some aspects of fusion of embryonic processes during development of face. In addition, both are sensitive to oxygen supply.


Geometric Morphometric Shape Assessment Of Juvenile Mandibles, Tiffany Tran, Vicki Lo, Hee Soo Oh, Gary D. Richards May 2018

Geometric Morphometric Shape Assessment Of Juvenile Mandibles, Tiffany Tran, Vicki Lo, Hee Soo Oh, Gary D. Richards

Excellence Day

OBJECTIVES: We explore three-dimensional data to delineate idiosyncratic and progressive growth variation in 6.0-8.0 year old mandibles (n=45).


Variation In And Assessment Of Inferior Alveolar Nerve Block Landmarks In Children And Adolescents, Soi Park, Younjin Lee, Younyoung Lee, Tiffany Tran, Gary D. Richards May 2018

Variation In And Assessment Of Inferior Alveolar Nerve Block Landmarks In Children And Adolescents, Soi Park, Younjin Lee, Younyoung Lee, Tiffany Tran, Gary D. Richards

Excellence Day

OBJECTIVES: In earlier work (Lambert et al., 2017) we demonstrated the efficacy of new landmarks for inferior alveolar nerve (IAN) block injections. While the latter study focused on adult morphology, the landmarks were shown to be effective in cases where the M3/3 were present but unerupted. Based on these result a question arose as to their applicability of the landmarks to children and adolescents, given the known changes in mandibular foramen position during growth. Here we quantify the position of the mandibular foramen relative to standard landmarks during growth and assess the new landmarks applicability for IAN …


Root Analogue Implant Creation: Establishing Procedures For The General Dentist, Alicia Hazdovac, Sarah Osborne, Gary D. Richards May 2018

Root Analogue Implant Creation: Establishing Procedures For The General Dentist, Alicia Hazdovac, Sarah Osborne, Gary D. Richards

Excellence Day

The possibility of replacing damaged teeth with custom-made root analogue implants was initially suggested around 1969 and reintroduced by Lungren et al. in 1992. The latter authors created custom implants in titanium and reported good osteointegration and aesthetic results. Following this effort there has been an increasing focus on custom root analogue implants as a replacement for ‘screw-type’ implants. Given the availability of software to manipulate 3D image data and the rapid rise of 3D printing technology, the question arises as to whether a general dentist can produce their own implants. Here we test the feasibility of practitioners producing custom …


Case Report: Use Of Non-Ridgid Connector, Veniamin Dronov May 2018

Case Report: Use Of Non-Ridgid Connector, Veniamin Dronov

Excellence Day

Long span bridges have a tendency to experience harmful stress due to the increased surface area and of the restoration. These stresses can cause several problems including failure of the restoration or cause significant discomfort to the patient.


Treatment Planning: Facially Generated, Digitally Guided, Manually Fabricated Smile Design, Neal Atul Patel May 2018

Treatment Planning: Facially Generated, Digitally Guided, Manually Fabricated Smile Design, Neal Atul Patel

Excellence Day

A clinical case presentation of a smile design that consists of 10 units of minimally invasive indirect restorations.


Changes In Airway Volume In Adult Patients Following Orthodontic Treatment With Premolar Extractions Versus Non-Extraction, Sunny Jisun Lee, Allison Kawata, Hayoung Michael Shin, David Chambers, Joorok Park, Heesoo Oh May 2018

Changes In Airway Volume In Adult Patients Following Orthodontic Treatment With Premolar Extractions Versus Non-Extraction, Sunny Jisun Lee, Allison Kawata, Hayoung Michael Shin, David Chambers, Joorok Park, Heesoo Oh

Excellence Day

Recent concerns about the prevalence of obstructive sleep apnea (OSA) and its negative sequelae have led to investigations of how manipulation of the dentofacial complex may affect airway problems. CBCT can be used to measure airway dimensions of patients. Extraction of premolars is indicated as part of orthodontic treatment for patients who have severe crowding or protrusion of incisors. Some have suggested that the reduction in arch circumference after premolar extraction would lead to decreased airway volume, which may predispose a patient for sleep disordered breathing (SDB). The purpose of this study was to determine whether there is a significant …


Changes In Cephalometric Measurements In Adult Patients Following Orthodontic Treatment With Premolar Extractions Versus Non-Extraction, Byron Chou, David Dang, Adrienne Joy, David Chambers, Joorok Park, Heesoo Oh May 2018

Changes In Cephalometric Measurements In Adult Patients Following Orthodontic Treatment With Premolar Extractions Versus Non-Extraction, Byron Chou, David Dang, Adrienne Joy, David Chambers, Joorok Park, Heesoo Oh

Excellence Day

Extraction of premolars is indicated as part of orthodontic treatment for patients who have severe crowding or protrusion of incisors. CBCT can be used to locate cephalometric landmarks in 3D. The purpose of this study was to determine whether there are differences in sagittal, transverse, and vertical skeletal and dental dimensions for adult patients who were treated with premolar extractions in conjunction with orthodontic treatment compared to those who received orthodontic treatment without extractions.


Condylar Degeneration In Patients With Dental Open Bite Versus Skeletal Open Bite Utilizing Cbct, Alex Rauchle, Alston Trinh, Linda Phi, Brad Albertson, Joorok Park, Heesoo Oh May 2018

Condylar Degeneration In Patients With Dental Open Bite Versus Skeletal Open Bite Utilizing Cbct, Alex Rauchle, Alston Trinh, Linda Phi, Brad Albertson, Joorok Park, Heesoo Oh

Excellence Day

Idiopathic condylar resorption (ICR) is a condition in which either one or both condyles undergo degeneration. Bilateral TMJ involvement presents as a clockwise rotation of the mandible in the posterior-inferior direction, resulting in an anterior open bite. The purpose of the study was to assess TMJ condylar degeneration in dental open bites compared to skeletal open bites.


Shear Bond Strength Of Nine Dual Cured Build-Up Materials And A Light-Curing Adhesive System On Dentin, Deepali Malla, Karen Schulze, Patrick Roetzer May 2018

Shear Bond Strength Of Nine Dual Cured Build-Up Materials And A Light-Curing Adhesive System On Dentin, Deepali Malla, Karen Schulze, Patrick Roetzer

Excellence Day

The purpose of this study was to measure the shear bond strength of nine different commercially available dual cured core build-up materials on human dentin in conjunction with a light curing adhesive system. The null hypothesis was that there is no statistical significant difference among the core build-up systems.


An Unconventional Collaboration At The College Level To Improve Stem Student Success, Amy N. Scott, Eileen Kogl Camfield, Alex Miller, Kirkwood M. Land Jan 2018

An Unconventional Collaboration At The College Level To Improve Stem Student Success, Amy N. Scott, Eileen Kogl Camfield, Alex Miller, Kirkwood M. Land

College of the Pacific Faculty Articles

The purpose of this article is to illustrate the work that has resulted from a collaboration between a biology professor, a school psychology professor, a researcher in higher education access, and the writing programs director. The essential school psychologist role, as classroom observer and data analyzer, is discussed through an example of work done as part of a larger project focusing on student success and retention for at-risk populations in introductory college biology courses. Best practices for consulting at the college level are discussed and include: collaborate to cultivate the willing, collect and analyze data to sustain instructor involvement, and …


19th Annual Pacific Research Day Abstracts, University Of The Pacific May 2017

19th Annual Pacific Research Day Abstracts, University Of The Pacific

Excellence Day

No abstract provided.


Mri Applications In Tissue Engineering, Shadi Othman May 2017

Mri Applications In Tissue Engineering, Shadi Othman

Science Seminar Series

Shadi Othman of the School of Engineering and Computer Science Bioengineering Program, will speak on his research on MRI applications in tissue engineering.


Nucleoside-Diphosphate-Kinase Of P. Gingivalis Is Secreted From Epithelial Cells In The Absence Of A Leader Sequence Through A Pannexin-1 Interactome, Kalina Atanasova, Jungnam Lee, Joann Roberts, Kyulim Lee, David M. Ojcius, Özlem Yilmaz Nov 2016

Nucleoside-Diphosphate-Kinase Of P. Gingivalis Is Secreted From Epithelial Cells In The Absence Of A Leader Sequence Through A Pannexin-1 Interactome, Kalina Atanasova, Jungnam Lee, Joann Roberts, Kyulim Lee, David M. Ojcius, Özlem Yilmaz

All Dugoni School of Dentistry Faculty Articles

Nucleoside-diphosphate-kinases (NDKs) are leaderless, multifunctional enzymes. The mode(s) of NDK secretion is currently undefined, while extracellular translocation of bacterial NDKs is critical for avoidance of host pathogen clearance by opportunistic pathogens such as Porphyromonas gingivalis. P. gingivalis-NDK during infection inhibits extracellular-ATP (eATP)/P2X7-receptor mediated cell death in gingival epithelial cells (GECs) via eATP hydrolysis. Furthermore, depletion of pannexin-1-hemichannel (PNX1) coupled with P2X7-receptor blocks the infection-induced eATP release in GECs, and P. gingivalis-NDK impacts this pathway. Ultrastructural and confocal microscopy of P. gingivalis-co-cultured GECs or green-fluorescent-protein (GFP)-P. gingivalis-NDK transfected GECs revealed a perinuclear/cytoplasmic localization of NDK. eATP stimulation induced NDK recruitment to …


17th Annual Pacific Research Day Abstracts, University Of The Pacific May 2015

17th Annual Pacific Research Day Abstracts, University Of The Pacific

Excellence Day

No abstract provided.


Aggregatibacter Actinomycetemcomitans Cytolethal Distending Toxin Activates The Nlrp3 Inflammasome In Human Macrophages Leading To The Release Of Pro-Inflammatory Cytokines, Bruce J. Shenker, David M. Ojcius, Lisa P. Walker, Ali Zekavat, Monika Damek Scuron, Kathleen Boesze-Battaglia Apr 2015

Aggregatibacter Actinomycetemcomitans Cytolethal Distending Toxin Activates The Nlrp3 Inflammasome In Human Macrophages Leading To The Release Of Pro-Inflammatory Cytokines, Bruce J. Shenker, David M. Ojcius, Lisa P. Walker, Ali Zekavat, Monika Damek Scuron, Kathleen Boesze-Battaglia

All Dugoni School of Dentistry Faculty Articles

The cytolethal distending toxin (Cdt) is produced from a number of bacteria capable of causing infection and inflammatory disease. Our previous studies with Actinobacillus actinomycetemcomitans Cdt demonstrate not only that the active toxin subunit functions as a phosphatidylinositol-3,4,5-triphosphate (PIP3) phosphatase but also that macrophages exposed to the toxin were stimulated to produce proinflammatory cytokines. We now demonstrate that the Cdt-induced proinflammatory response involves the activation of the NLRP3 inflammasome. Specific inhibitors and short hairpin RNA (shRNA) were employed to demonstrate requirements for NLRP3 and ASC as well as caspase-1. Furthermore, Cdt-mediated inflammasome activation is dependent upon upstream signals, including reactive …


16th Annual Pacific Research Day Abstracts, University Of The Pacific May 2014

16th Annual Pacific Research Day Abstracts, University Of The Pacific

Excellence Day

No abstract provided.


15th Annual Pacific Research Day Abstracts, University Of The Pacific May 2013

15th Annual Pacific Research Day Abstracts, University Of The Pacific

Excellence Day

No abstract provided.


14th Annual Pacific Research Day Abstracts, University Of The Pacific May 2012

14th Annual Pacific Research Day Abstracts, University Of The Pacific

Excellence Day

No abstract provided.


13th Annual Pacific Research Day Abstracts, University Of The Pacific May 2011

13th Annual Pacific Research Day Abstracts, University Of The Pacific

Excellence Day

No abstract provided.


12th Annual Pacific Research Day Abstracts, University Of The Pacific May 2010

12th Annual Pacific Research Day Abstracts, University Of The Pacific

Excellence Day

No abstract provided.


11th Annual Pacific Research Day Abstracts, University Of The Pacific May 2009

11th Annual Pacific Research Day Abstracts, University Of The Pacific

Excellence Day

No abstract provided.


10th Annual Pacific Research Day Abstracts, University Of The Pacific May 2008

10th Annual Pacific Research Day Abstracts, University Of The Pacific

Excellence Day

No abstract provided.


9th Annual Pacific Research Day Abstracts, University Of The Pacific May 2007

9th Annual Pacific Research Day Abstracts, University Of The Pacific

Excellence Day

No abstract provided.


7th Annual Pacific Research Day Abstracts, University Of The Pacific May 2005

7th Annual Pacific Research Day Abstracts, University Of The Pacific

Excellence Day

No abstract provided.