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University of the Pacific

Pentobarbital Physiological effect

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The Use Of Visually Evoked Cortical Potentials To Evaluate Changes In The Rate Of Recovery From Phenobarbital Anesthesia In The Rat, Steven Theodore Heggeness Jan 1981

The Use Of Visually Evoked Cortical Potentials To Evaluate Changes In The Rate Of Recovery From Phenobarbital Anesthesia In The Rat, Steven Theodore Heggeness

University of the Pacific Theses and Dissertations

Signal averaging of visually evoked cortical potentials was done on Wistar strain rats during recovery from nembutal (sodium pentobarbital) anesthesia. Several studies (Dafny, 1978; Gines et al., 1963; Roig et al., 1961) have shown significant differences between recordings from unanesthetized rats and from rats anesthetized with various agents. The purpose of this study was to evaluate changes in the cortical response throughout an eight hour nembutal recovery period in order to determine the feasibility of using a signal averaging technique for classification of anesthetic depth.

The results of this study show that the recovery from nembutal anesthesia is characterized by …