Digital Commons Network^™

Intra- And Inter-Rater Reliability Of Maximum Torque Applied During Passive Elbow Range Of Motion Testing Post-Casting Of Supracondylar And Lateral Condylar Fractures In Children, Joseph T. Armstrong

Theses and Dissertations--Kinesiology and Health Promotion

Elbow fractures account for a significant number of pediatric orthopedic injuries. The most common of these are the supracondylar and lateral condylar humeral fractures. When surgical repair is necessary casting and pinning of the elbow can affect the elbow’s range of motion (ROM), so recovery is monitored. Practices for measuring recovery are not standardized so measures may not be consistent. A possible novel measure to help account for different clinicians participating in the same study is maximum torque applied during elbow end ROM testing. This study uses several comparisons of maximum torque applied by three different clinicians during end ROM …

Responses To Exercise Anchored To Vigorous Intensity Heart Rates, Djadmann Gustave

Theses and Dissertations--Kinesiology and Health Promotion

Exercise prescription to improve cardiorespiratory endurance (CE) is often based on percentages of the reserve or maximum heart rate (HR_peak) or oxygen consumption rate (V̇O_2peak)that reflect vigorous intensities (77-95% HR_peak, 64-90% V̇O_2peak). These intensities elicit a rating of perceived exertion [RPE] response between 14-17 on the 6-20 Borg Scale. It is recommended that exercise within these ranges be sustained for 20-60min per session. The purposes of this study were to: 1) Determine the metabolic (V̇O₂) and perceptual (RPE) responses as well as the sustainability of exercise (time to exhaustion [T …

The Effect Of Physical Activity Courses On The Motivation For Physical Activity In College Students: A Scoping Review, Erica Fauste Waizenhofer Hill

Theses and Dissertations--Kinesiology and Health Promotion

The lack of physical activity and exercise participation has been an ongoing
problem for young adults aged 18-24. Universities and colleges worldwide offer a variety of required and elective physical activity courses for college credit to increase active participation in lifelong healthy lifestyles. This scoping review collected studies on college students’ motivation to participate in physical activity. The courses were taught using methods based on motivational theories. The authors of the studies collected information from the students before and after the classes to gather data on the theoretical framework’s effect on the students, if any. This review compiles this information, …

The Effects Of Saddle Angle/Inclination On Lumbopelvic Kinematics And Cardiometabolic Measures, Andrew Nathan Anderson

Theses and Dissertations--Kinesiology and Health Promotion

Lower back pain (LBP) is a condition which affects the lumbar portion of the spinal column that can lead to mild to extreme physical pain during seated tasks and has been shown to be prevalent in people who spend long durations sitting particularly in a slumped position or in a position with a large degree of lumbar flexion. LBP can cause regular interruptions in work and in a person’s ability to engage in exercise, and in most extreme cases warrants surgical interventions for clinical treatment. While LBP is prevalent in sedentary populations, it is also quite prevalent in cycling populations …

The Relationship Of Multidimensional Athlete Characteristics Versus Competition Performance And Participation In American Football Players, Alex Brownell

Theses and Dissertations--Kinesiology and Health Promotion

BACKGROUND: Athlete evaluation in American football is dominated by the evaluation characteristics that underly key performance indicators (KPI’s) in the physical domain of performance. Team sport athlete performance is comprised of a combination of attributes in the physical, technical, tactical, and mental domains of performance. Using only KPI’s in the physical domain of performance to predict competition performance of American football athletes is challenging due to the differences in performance outcomes of the varying positions in American football and absence of the other performance dimensions that are not accounted for. Advances in athlete assessment have revolutionized the process of evaluating …

Therapeutic Implications Of The Gut-Cns Axis In Promoting Recovery Following Cervical Spinal Cord Injury, Jessica Wilson

Theses and Dissertations--Neuroscience

Nearly 60% of all spinal cord injuries (SCI) occur at the cervical level. These high-level injuries can interrupt the descending respiratory pathways required for breathing. Indeed, therapies in animal studies have been successful at restoring breathing after SCI; however, these interventions appear to be more effective at chronic time points. One potential cause for this observation is the impact of the injury on the gut microbiome. Neurotrauma can induce gut dysbiosis, an imbalance of pathogenic and beneficial gut microbiota, which has previously been shown to negatively impact the central nervous system (CNS) and impair recovery. We aimed to build upon …

Development And Biological Evaluation Of Selective Small-Molecule Inhibitors Of The Human Cytochrome P450 1b1, Austin Hachey

Theses and Dissertations--Chemistry

The human cytochrome P450 1B1 (CYP1B1) is an emerging target for small- molecule therapeutics. Several solid tumors overexpress CYP1B1 to the degree that it has been referred to as a universal tumor antigen. Conversely, its expression is low in healthy tissues. CYP1B1 may drive tumorigenesis through promoting the formation of reactive toxins from environmental pollutants or from endogenous hormone substrates. Additionally, the expression of CYP1B1 in tumors is associated with resistance to several common chemotherapies and with poor prognoses in cancer patients. However, inhibiting CYP1B1 with small molecules has been demonstrated in cellular and murine model systems to reverse this …

Effect Of Menstrual Cycle Phase On The Rewarding Properties Of Alcohol In Women, Annie K. Griffith

Theses and Dissertations--Psychology

Compared with men, women are disproportionately affected by alcohol, including greater risks of behavioral impairment and relapse. One likely mechanism underlying this disparity is fluctuations of ovarian hormones, particularly estradiol (E2), across phases of the menstrual cycle. Pre-clinical and clinical studies have shown that higher E2 levels correlate with heavier patterns of alcohol consumption, suggesting E2 may modulate drinking. This relationship is thought to be mediated by the rewarding properties of alcohol. The present thesis tested the hypothesis that elevated E2 during the late follicular phase would increase the rewarding properties of alcohol. Fifty young-adult women participated in a within-subjects …

The Effects Of Extended Fructose Access On Relative Value And Demand For Fructose, Saccharin, And Ventral Tegmental Stimulation, Megan Halloran

Theses and Dissertations--Psychology

Globally, food addiction (FA) is a growing area of research and is largely attributed to the availability of foods that are both energy dense and high in fats and sugars. Further, it has been suggested, that sugar and fat, when consumed frequently, have properties similar to drugs of abuse. While the validity of FA is questioned, researchers have drawn parallels between substance use disorder (SUD) and FA. For example, sugar binge models emphasize craving, withdrawal and binging as primary components of FA, which are also hallmarks of SUD. Additionally, both natural rewards, like sugars, and drug rewards act on the …

Community Supported Agriculture Values: A Comparison Across Groups, Thomas B. Pierce

Theses and Dissertations--Agricultural Economics

Community Supported Agriculture (CSA) programs offer consumers the chance to share the risk with farming operations while gaining access to fresh, local foods. While research on CSA shareholder values such as share affordability or the local impact of participation has been conducted in the past decade and beyond, less attention has been paid to direct value-mapping of the shareholders themselves. This research seeks to determine consumer values around the CSA purchasing decision using the Best-Worst Scaling Approach. Based on a focus group discussion with CSA shareholders in a university wellness voucher program, we used affinity diagramming to develop a list …

Surveillance For Ticks And Tick-Borne Pathogens In Kentucky, Anna Rosalee Pasternak

Theses and Dissertations--Entomology

Tick-borne diseases are an emerging threat to human and animal health. In Kentucky, tick-borne disease surveillance has identified rising incidences of spotted fever rickettsiosis, ehrlichiosis, and Lyme disease. Since these diseases occur through the bites of infected ticks, effective prevention efforts are reliant upon knowing where the risk of exposure to tick bites exists. Historical data on tick distribution in Kentucky is variable, with very little reported on a statewide scale, leaving vector control workers, public health personnel, physicians, veterinarians, and others to rely on outdated, intermittent, or out-of-state information. In my dissertation, I surveyed ticks and select tick-borne pathogens …

Managing Death In Termites, Jizhe Shi

Theses and Dissertations--Entomology

Death of individuals from the same species represents potential risks from disease, predation or competition for animals. Diverse responses associated with death have evolved ranging from simply avoiding or being attracted to the corpses in solitary animals to complicated undertaking behavioral repertoire in eusocial insects. A systematic review in chapter 1 suggested cannibalism is an ancestral and widespread death-related behavior in all non-human animals. Termites are suggested to switch their undertaking behavioral responses from cannibalism to burial based on interactions between chemicals associated with death to balance risks and benefits associated with decomposition. In eusocial animals like termites with caste …

Landscape Influences And Preventive Management For Drosophila Suzukii In Small Fruit Crops, Ryan William Kuesel

Theses and Dissertations--Entomology

Small fruit production has been greatly challenged by the repeated invasion of non-native arthropod pests, impacting economic feasibility, and increasing the need for insecticides. Spotted wing drosophila (Drosophila suzukii (Matsumura)) is the most recent invasive pest of small fruits. It causes damage by ovipositing beneath the skin of ripening fruits. Its wide-spread distribution and development of resistance to insecticides has resulted in the need for improved alternative management strategies for small fruit growers.

My surveys of D. suzukii at thirteen blackberry (Rubus fruticosus L.) and raspberry (Rubus idaeus L.) fields found that while D. suzukii was present …

Rnai-Mediated Gene Silencing In The Exotic Redbay Ambrosia Beetle, Xyleborus Glabratus, And Insect-Fungal Interactions Within The Laurel Wilt Complex, Morgan Christine Knutsen

Theses and Dissertations--Entomology

Laurel wilt disease (LWD) is a lethal vascular disease impacting lauraceous hosts caused by Harringtonia lauricola, the fungal symbiont of the redbay ambrosia beetle (Xyleborus glabratus Eichoff) (RAB) (Coleoptera: Curculionidae). LWD has caused tree mortality throughout the southeastern United States and is continuing to spread into new regions. Current management methods have not been successful in preventing spread, warranting investigation into innovative techniques including RNA interference (RNAi).

Elongation factor-1 alpha (ef1a) and actin (act) were established as stably expressed reference genes after exposing beetles to different photoperiod, temperature, and dsRNA exposure. After RAB oral …

Costs And Benefits Of Integrating Poultry Into Cover Crop - Vegetable Rotations, Viktor Halmos

Theses and Dissertations--Entomology

Integrated livestock systems were once common leading up to the 20th century where livestock generated manure that was then used to fertilizer crop production in a closed- or semi-closed system. However, with the industrialization of agriculture in the mid to late 20th century, specialization drove simplified systems that segregated livestock from cropping systems. This segregation led to nutrient surpluses occurring in livestock operations, and nutrient demands in cropping systems creating a plethora of environmental issues. With the increased awareness of environmental issues, a renewed interest in integration has driven producers and researchers to experiment with integration again. For research, the …

Linking Previous Experiences To Behavior And Health In The Honey Bee (Apis Mellifera), Rebecca R. Westwick

Theses and Dissertations--Entomology

An organism’s ability to respond to changing conditions can be vital to its success. Indeed, plasticity is a common feature of living organisms. Much of the research in this area, though, has focused on effects caused by environmental conditions. What has received relatively less attention is how social experiences and broader features of an organism’s social environment can lead to long-lasting changes in health and behavior. This knowledge gap exists despite the well-documented existence of health and behavioral effects after social interactions in certain taxa such as humans.

Social insects such as honey bees provide an excellent opportunity to better …

Understanding The Effects Of Age, Environmental Conditions, And Placement On Cockroach Gel Bait Performance, Isabelle Lucero

Theses and Dissertations--Entomology

Cockroach baits are one of the most effective tools used for German cockroach (Blattella germanica L.) control. This is due in part to the number of cockroach baits on the market with various matrix compositions and active ingredients, aiding in the control of resistant (physiologically and behaviorally) cockroach populations through bait rotation. However, it remains unclear how cockroach gel baits perform over time and under different environmental conditions. Therefore, we aged six cockroach gel baits for varying times (24 hours, one month, three months, six months) and at three relative humidities (15%, 40%, and 80%), and tested their performance …

Understanding The Role Of Peroxiredoxin Iv In Colorectal Cancer Development, Pratik Thapa

Theses and Dissertations--Toxicology and Cancer Biology

Reactive oxygen species (ROS) are oxygen-containing free radicals and/or molecules that are more reactive than O₂. ROS such as hydroxyl radical (•OH) and hydrogen peroxide (H₂O₂) are produced naturally in the body as a result of reactions such as aerobic respiration and oxidative protein folding. ROS undergo reduction-oxidation (redox) reactions and mediate cell signaling. Accumulation of excessive ROS can damage DNA, RNA, protein and lipids. Antioxidants are enzymes and small molecules that react with ROS to modulate redox signaling and to prevent and repair oxidative damage. Examples of antioxidants include glutathione, thioredoxin, superoxide dismutase, …

Targeting Ezh2 To Improve Outcomes Of Lung Squamous Cell Carcinoma, Tanner Ducote

Theses and Dissertations--Toxicology and Cancer Biology

Only 20% of patients diagnosed with lung squamous cell carcinoma (LSCC) respond to immunotherapy. Anti-PD1 immunotherapy is most commonly prescribed to these patients; however, most will become refractory. It is important to understand the mechanisms underlying this problem to increase durability and survival. Building upon the work of other groups, our lab has demonstrated that the inhibition of the histone methyltransferase, EZH2, is crucial to maintaining an immunologically responsive microenvironment. Based on our data, we hypothesize that combining EZH2 inhibitors with anti-PD1 therapy will increase response and durability. To study non-small cell lung cancers (NSLC) our lab uses a variety …