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Investigating The Relationship Between Metabolic Reprogramming And Peripheral Cd4+ T-Cell Inflammation In Human Type 2 Diabetes Pathogenesis, Gabriella Kalantar
Investigating The Relationship Between Metabolic Reprogramming And Peripheral Cd4+ T-Cell Inflammation In Human Type 2 Diabetes Pathogenesis, Gabriella Kalantar
Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics
Chronic, low-grade systemic inflammation rises in obesity and promotes type 2 diabetes (T2D). Circulating immune cells are key indicators of obesity and T2D pathogenesis. T cells outnumber monocytes, in blood, suggesting that T cells might fuel peripheral inflammation in obesity/T2D. Our lab’s work supports this idea by identification of a Th17 cytokine profile in T2D from T-cell stimulated peripheral blood mononuclear cells. Work described herein further supported this work by demonstrating that T cells dominate peripheral inflammation over monocytes across the spectrum of obesity and glycemic control. Our lab has also recently shown that inflammation changes during prediabetes (preT2D), identified …
Effects Of Constant Load Exercise On Oxygen Consumption And Knee Joint Mechanics In Young Adults, Mariana Victoria Jacobs
Effects Of Constant Load Exercise On Oxygen Consumption And Knee Joint Mechanics In Young Adults, Mariana Victoria Jacobs
Theses and Dissertations--Kinesiology and Health Promotion
The rate of obesity and its adverse health consequences have continued to rise in the past several decades. Aerobic constant load exercise is recommended to reduce excess body mass, however the effects of constant load exercise on oxygen consumption (VO2) and knee joint mechanics are inconsistent when varying weight-status strategies are employed. The purpose of this study was to assess the influence of different weight classification strategies on VO2 and knee joint mechanics during constant load exercise. Participants walked on an instrumented treadmill at a self-selected speed for 30-minutes while gait mechanics and VO2 measures were determined. Between-group differences were …