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Description Of Two New Genera And A Taxonomic Key To The World Genera Of Cybocephalidae (Coleoptera), Trevor Randall Smith
Description Of Two New Genera And A Taxonomic Key To The World Genera Of Cybocephalidae (Coleoptera), Trevor Randall Smith
Insecta Mundi
Abstract. The sixteen genera of Cybocephalidae (Coleoptera) occurring worldwide are listed and keyed. The genera included are Amedissia Kirejtshuk and Mantič, Apastillus Kirejtshuk and Mantič, Cybocephalus Erichson, Endrodiellus Endrödy-Younga, Eupastillus Lawrence, Hierronius Endrödy-Younga, Horadion Endrödy-Younga, Pacicephalus Kirejtshuk and Mantič, Pastillocenicus Kirejtshuk and Nel, Pastillodes Endrödy-Younga, Pastillus Endrödy-Younga, Pycnocephalus Sharp, Taxicephomerus Kirejtshuk, Theticephalus Kirejtshuk, a description of a new genus, Microthomas T. R. Smith, with one new species, M. brevicornis T. R. Smith, from Bolivia, and a new genus, Conglobatus T. R. Smith, with two …
A Review Of The Colaspis Suilla Species Group, With Description Of Three New Species From Florida (Coleoptera: Chrysomelidae: Eumolpinae), E.G. Riley
Insecta Mundi
The Colaspis suilla species group (Coleoptera: Chrysomelidae: Eumolpinae) is defined relative to other species of the genus Colaspis Fabricius occurring in the United States. The group is composed of five species, of which three from Florida are described as new species: C. ansa Riley from the Florida Panhandle, C. skelleyi Riley from Central Florida, and C. thomasi Riley from the southern Lake Wales Ridge. Colaspis suilla borealis Blake is reduced to a full synonym of C. suilla Fabricius, new synonymy. Comparative remarks, habitus images, images of male and female genitalia, range maps, specimen data, and a key to species …
Three New Species Of South American Checkered Beetles (Coleoptera: Cleridae: Clerinae), Weston Opitz
Three New Species Of South American Checkered Beetles (Coleoptera: Cleridae: Clerinae), Weston Opitz
Insecta Mundi
Three new species of Enoclerus Gahan (Coleoptera: Cleridae) are described and illustrated. They are: Enoclerus minas Opitz from Colombia and Brazil, E. salta Opitz from Argentina, and E. thomasi Opitz from Bolivia.
Corporaal (1950: 14) lists 185 species of Enoclerus Gahan (Coleoptera: Cleridae: Clerinae). I know of over 60 undescribed species. It is a daunting task to organize such a high number of species into some sort of taxonomic revision, which cannot be provided at this time. However, some of these new species can be described that will be added to a larger work at a later date. Such descriptive …
Acid-Triggered Self-Assembled Egg White Protein-Coated Gold Nanoclusters For Selective Fluorescent Detection Of Fe3+, No2-, And Cysteine, Wenyan Li, Xiangping Wen, Hemiao Zhao, Wenjun Yan, John F. Trant, Yingqi Li
Acid-Triggered Self-Assembled Egg White Protein-Coated Gold Nanoclusters For Selective Fluorescent Detection Of Fe3+, No2-, And Cysteine, Wenyan Li, Xiangping Wen, Hemiao Zhao, Wenjun Yan, John F. Trant, Yingqi Li
Chemistry and Biochemistry Publications
Herein, we present a simple and economical synthesis for the first multianalyte probe able to selectively quantify the concentrations of Fe3+, NO2-, and cysteine. It comprises H+-triggered self-assembled gold nanoclusters (AuNCs@EW/H+, AuEHs), showing enhanced red fluorescence at 640 nm. The AuEH is a good fluorescent nanosensor for Fe3+ and NO2- with detection limits of 1.40 and 2.82 nM, respectively. Iron detection, through fluorescence quenching, occurs because of nanocluster aggregation elicited by the complexation of Fe3+ with amino acids on the surface of AuEH; nitrite detection likely proceeds through fluorescence quenching via the disassembly of the nanoclusters following irreversible oxidation by …
“We’Re, Like, The Most Unhealthy People In The Country”: Employing An Equity Lens To Reduce Barriers To Healthy Food Access In Rural Appalachia, Kathryn Cardarelli, Emily M. Dewitt, Rachel Gillespie, Heather Norman-Burgdolf, Natalie Jones, Janet Tietyen Mullins
“We’Re, Like, The Most Unhealthy People In The Country”: Employing An Equity Lens To Reduce Barriers To Healthy Food Access In Rural Appalachia, Kathryn Cardarelli, Emily M. Dewitt, Rachel Gillespie, Heather Norman-Burgdolf, Natalie Jones, Janet Tietyen Mullins
Dietetics and Human Nutrition Faculty Publications
Introduction
Obesity disproportionately affects rural communities, and Appalachia has some of the highest obesity rates in the nation. Successful policy, systems, and environmental (PSE) interventions to reduce obesity must reflect the circumstances of the population. We used a health equity lens to identify barriers and facilitators for healthy food access in Martin County, Kentucky, to design interventions responsive to social, cultural, and historical contexts.
Methods
We conducted 5 focus groups in Martin County, Kentucky, in fall 2019 to obtain perspectives on the local food system and gauge acceptability of PSE interventions. We used grounded theory to identify perceived barriers and …
Two New Species Of Pharaxonotha Reitter Among The Early-Diverging Lineages, With A Key To The Species Of The Genus (Coleoptera: Erotylidae: Pharaxonothinae), Paul E. Skelley, William Tang
Two New Species Of Pharaxonotha Reitter Among The Early-Diverging Lineages, With A Key To The Species Of The Genus (Coleoptera: Erotylidae: Pharaxonothinae), Paul E. Skelley, William Tang
Insecta Mundi
Two species of the early-diverging lineages of Pharaxonotha Reitter (Coleoptera: Erotylidae: Pharaxonothinae) are described: Pharaxonotha taylori Skelley and Tang, new species, and Pharaxonotha thomasi Skelley and Tang, new species. A new key to described species of Pharaxonotha, based on previously unused characters, is presented.
In recent phylogenetic analyses of beetle diversity based on a large nuclear data set (McKenna et al. 2019) and on nuclear and mitochondrial legacy loci (Powell, pers. comm. 2020), the New World genus Pharaxonotha Reitter (Erotylidae: Pharaxonothinae) was shown to be sister to all remaining Erotylidae in a clade comprised of the Erotylidae+Phytophaga, …
December 23, 2020: Covid-19 Campus Update, Kettering University
December 23, 2020: Covid-19 Campus Update, Kettering University
Communication Updates
All residential and non-residential students, faculty and staff that will be on campus during Winter Term will be required to be tested on campus through Helix Diagnostics with a negative test result. The University will offer free, scheduled testing through Helix Diagnostics prior to the start of Winter Term at scheduled times during the first week of January.
The new Safe Campus 2021 Guidelines for Winter Term are now online on the University’s website. It includes: Testing & Health Services, Safety Measures, Academics & Co-op, Student Life, Facilities and Visiting Campus.
Effect Of Treadmill Exercise And Probiotic Ingestion On Motor Coordination And Brain Activity In Adolescent Mice, Junechul Kim, Bo-Eun Yoon
Effect Of Treadmill Exercise And Probiotic Ingestion On Motor Coordination And Brain Activity In Adolescent Mice, Junechul Kim, Bo-Eun Yoon
Kinesiology Faculty Publications
High-intensity exercise can lead to chronic fatigue, which reduces athletic performance. On the contrary, probiotic supplements have many health benefits, including improvement of gastrointestinal health and immunoregulation. However, the effects of probiotics combined with exercise interventions on motor functions and brain activity have not been fully explored. Therefore, this study aimed to identify the effects of probiotic supplements and aerobic exercise on motor function, immune response, and exercise intensity and probiotic ingestion. After four weeks of intervention, the motor functions were assessed by rotarod test, then the levels of cytokines, gamma-aminobutyric acid (GABA), and glutamate were detected. The improvement caused …
Modeling Action Potential Reversals In Tunicate Hearts, John W. Cain, Luran He, Lindsay D. Waldrop
Modeling Action Potential Reversals In Tunicate Hearts, John W. Cain, Luran He, Lindsay D. Waldrop
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
Tunicates are small invertebrates which possess a unique ability to reverse flow in their hearts. Scientists have debated various theories regarding how and why flow reversals occur. Here we explore the electrophysiological basis for reversals by simulating action potential propagation in an idealized model of the tubelike tunicate heart. Using asymptotic formulas for action potential duration and conduction velocity, we propose tunicate-specific parameters for a two-current ionic model of the action potential. Then, using a kinematic model, we derive analytical criteria for reversals to occur. These criteria inform subsequent numerical simulations of action potential propagation in a fiber paced at …
African Land Mammal Ages, John Van Couvering, Eric Delson
African Land Mammal Ages, John Van Couvering, Eric Delson
Publications and Research
We define 17 African land mammal ages, or AFLMAs, covering the Cenozoic record of the Afro-arabian continent, the planet’s second largest land mass. While fossiliferous deposits are absent on the eroded plateau of the continent’s interior, almost 800 fossil genera from over 350 locations have now been identified in coastal deposits, karst caves, and in the Neogene rift valleys. Given a well-developed geochronologic framework, together with continuing revision to the fossil record—both stimulated by the story of human evolution in Africa—and also to compensate for the variation in fossil ecosystems across such great distances, the AFLMAs are biochronological units defined …
Arp2/3-Independent Wave/Scar Pathway And Class Xi Myosin Control Sperm Nuclear Migration In Flowering Plants, Mohammad F. Ali, Umma Fatema, Xiongbo Peng, Samuel W. Hacker, Daisuke Maruyama, Meng-Xiang Sun, Tomokazu Kawashima
Arp2/3-Independent Wave/Scar Pathway And Class Xi Myosin Control Sperm Nuclear Migration In Flowering Plants, Mohammad F. Ali, Umma Fatema, Xiongbo Peng, Samuel W. Hacker, Daisuke Maruyama, Meng-Xiang Sun, Tomokazu Kawashima
Plant and Soil Sciences Faculty Publications
After eukaryotic fertilization, gamete nuclei migrate to fuse parental genomes in order to initiate development of the next generation. In most animals, microtubules control female and male pronuclear migration in the zygote. Flowering plants, on the other hand, have evolved actin filament (F-actin)-based sperm nuclear migration systems for karyogamy. Flowering plants have also evolved a unique double-fertilization process: two female gametophytic cells, the egg and central cells, are each fertilized by a sperm cell. The molecular and cellular mechanisms of how flowering plants utilize and control F-actin for double-fertilization events are largely unknown. Using confocal microscopy live-cell imaging with a …
Melanogenesis, Its Regulatory Process, And Insights On Biomedical, Biotechnological, And Pharmacological Potentials Of Melanin As Antiviral Biochemical, Toluwase Hezekiah Fatoki, Omodele Ibraheem, Catherine Joke Adeseko, Boluwatife Lawrence Afolabi, Daniel Uwaremhevho Momodu, David Morakinyo Sanni, Jesupemi Mercy Enibukun, Ibukun Oladejo Ogunyemi, Akinwunmi Oluwaseun Adeoye, Harriet U. Ugboko, Amoge Chidinma Ogu, Abiodun Samuel Oyedele, Adejoju Omodolapo Adedara, Abiodun Joseph Jimoh, Oluwakemi Ruth Ogundana, Oritsetimeyin Eworitse Ebosa
Melanogenesis, Its Regulatory Process, And Insights On Biomedical, Biotechnological, And Pharmacological Potentials Of Melanin As Antiviral Biochemical, Toluwase Hezekiah Fatoki, Omodele Ibraheem, Catherine Joke Adeseko, Boluwatife Lawrence Afolabi, Daniel Uwaremhevho Momodu, David Morakinyo Sanni, Jesupemi Mercy Enibukun, Ibukun Oladejo Ogunyemi, Akinwunmi Oluwaseun Adeoye, Harriet U. Ugboko, Amoge Chidinma Ogu, Abiodun Samuel Oyedele, Adejoju Omodolapo Adedara, Abiodun Joseph Jimoh, Oluwakemi Ruth Ogundana, Oritsetimeyin Eworitse Ebosa
Chemistry Student Research
Melanin is s most widely distributed pigment and is found in bacteria, fungi, plants, and animals. Melanogenesis is under complex regulatory control by multiple agents interacting through pathways activated by hormonal and receptor-dependent and -independent mechanisms. There are about 20 genes that are involved in the biochemical pathway of melanogenesis and its regulation, which include: tyrosinase, microphthalmia-associated transcription factor, melanocortin1 receptor, adenylate cyclase, protein kinase A. Human melanogenesis regulatory proteins such as MAPK1, CREB3, and CREBP, have binary interaction with the protein of herpesvirus, hepatitis C virus, Human immunodeficiency virus type 1, Simian virus 40, and Human adenovirus A and …
Providing Clean Energy Solutions To India’S Bottom Of The Pyramid Population, Jill Howard, Fiona Wilson, E. Hachemi Aliouche
Providing Clean Energy Solutions To India’S Bottom Of The Pyramid Population, Jill Howard, Fiona Wilson, E. Hachemi Aliouche
Carsey School of Public Policy
Despite a scheme launched by the Indian government in 2017 that has declared achieving close to 100 percent electrification in the country, studies have shown that only 65 percent of rural enterprises in India report having electricity grid connection. While millions of households have been positively impacted by access to electricity, small businesses and smallholder farmers (those with holdings of less than 2 acres) in rural India have been left out of the equation or receive very unreliable power supply. Byproducts of the energy poverty experienced by India’s Bottom of the Pyramid population include an enormous carbon footprint produced by …
High-Resolution Sampling Of A Broad Marine Life Size Spectrum Reveals Differing Size- And Composition-Based Associations With Physical Oceanographic Structure, Adam T. Greer, John C. Lehrter, Benjamin M. Binder, Aditya R. Nayak, Ranjoy Barua, Ana E. Rice, Jonathan H. Cohen, Malcolm N. Mcfarland, Alexis Hagemeyer, Nicole D. Stockley, Kevin M. Boswell, Igor Shulman, Sergio Derada, Bradley Penta
High-Resolution Sampling Of A Broad Marine Life Size Spectrum Reveals Differing Size- And Composition-Based Associations With Physical Oceanographic Structure, Adam T. Greer, John C. Lehrter, Benjamin M. Binder, Aditya R. Nayak, Ranjoy Barua, Ana E. Rice, Jonathan H. Cohen, Malcolm N. Mcfarland, Alexis Hagemeyer, Nicole D. Stockley, Kevin M. Boswell, Igor Shulman, Sergio Derada, Bradley Penta
Faculty Publications
Observing multiple size classes of organisms, along with oceanographic properties and water mass origins, can improve our understanding of the drivers of aggregations, yet acquiring these measurements remains a fundamental challenge in biological oceanography. By deploying multiple biological sampling systems, from conventional bottle and net sampling to in situ imaging and acoustics, we describe the spatial patterns of different size classes of marine organisms (several microns to ∼10 cm) in relation to local and regional (m to km) physical oceanographic conditions on the Delaware continental shelf. The imaging and acoustic systems deployed included (in ascending order of target organism size) …
Ogre-Faced, Net-Casting Spiders Use Auditory Cues To Detect Airborne Prey, Jay A. Stafstrom, Gil Menda, Eya I. Nitzany, Eileen A. Hebets, Ronald R. Hoy
Ogre-Faced, Net-Casting Spiders Use Auditory Cues To Detect Airborne Prey, Jay A. Stafstrom, Gil Menda, Eya I. Nitzany, Eileen A. Hebets, Ronald R. Hoy
Eileen Hebets Publications
Prey-capture behavior among spiders varies greatly from passive entrapment in webs to running down prey items on foot. Somewhere in the middle are the ogre-faced, net-casting spiders (Deinopidae: Deinopis) that actively capture prey while being suspended within a frame web. Using a net held between their front four legs, these spiders lunge downward to ensnare prey from off the ground beneath them. This “forward strike” is sensorially mediated by a massive pair of hypersensitive, night-vision eyes. Deinopids can also intercept flying insects with a “backward strike,” a ballistically rapid, overhead back-twist, that seems not to rely on visual cues. Past …
The State Of Outdoor Recreation In Utah 2020, Jordan Smith, Anna B. Miller
The State Of Outdoor Recreation In Utah 2020, Jordan Smith, Anna B. Miller
All Current Publications
The purpose of this report is to provide a high-level review of the trends that define outdoor recreation within Utah. We do this by distilling data from a variety of sources, focusing on ‘key metrics’ that can be tracked over time, serving as a finger on the pulse on the health of outdoor recreation within Utah. Data on outdoor recreation participation and its benefits and impacts varies considerably across the state depending upon the managing agency collecting the data. This report focuses on statewide data available for outdoor recreation opportunities provided on lands managed by the Bureau of Land Management, …
Juvenile Leaves Or Adult Leaves: Determinants For Vegetative Phase Change In Flowering Plants, Darren Manuela, Mingli Xu
Juvenile Leaves Or Adult Leaves: Determinants For Vegetative Phase Change In Flowering Plants, Darren Manuela, Mingli Xu
Faculty Publications
Vegetative leaves in Arabidopsis are classified as either juvenile leaves or adult leaves based on their specific traits, such as leaf shape and the presence of abaxial trichomes. The timing of the juvenile-to-adult phase transition during vegetative development, called the vegetative phase change, is a critical decision for plants, as this transition is associated with crop yield, stress responses, and immune responses. Juvenile leaves are characterized by high levels of miR156/157, and adult leaves are characterized by high levels of miR156/157 targets, SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) transcription factors. The discovery of this miR156/157-SPL module provided a critical tool for …
The Supercam Instrument Suite On The Nasa Mars 2020 Rover: Body Unit And Combined System Tests, Roger C. Wiens, Sylvestre Maurice, Scott H. Robinson, Anthony E. Nelson, Philippe Cais, Pernelle Bernardi, Raymond T. Newell, Sam Clegg, Shiv K. Sharma, Steven Storms, Jonathan Deming, Darrel Beckman, Ann M. Ollila, Olivier Gasnault, Ryan B. Anderson, Yves André, Stanley M. Angel, Gorka Arana, Elizabeth Auden, Pierre Beck, Et. Al.
The Supercam Instrument Suite On The Nasa Mars 2020 Rover: Body Unit And Combined System Tests, Roger C. Wiens, Sylvestre Maurice, Scott H. Robinson, Anthony E. Nelson, Philippe Cais, Pernelle Bernardi, Raymond T. Newell, Sam Clegg, Shiv K. Sharma, Steven Storms, Jonathan Deming, Darrel Beckman, Ann M. Ollila, Olivier Gasnault, Ryan B. Anderson, Yves André, Stanley M. Angel, Gorka Arana, Elizabeth Auden, Pierre Beck, Et. Al.
Faculty Publications
The SuperCam instrument suite provides the Mars 2020 rover, Perseverance, with a number of versatile remote-sensing techniques that can be used at long distance as well as within the robotic-arm workspace. These include laser-induced breakdown spectroscopy (LIBS), remote time-resolved Raman and luminescence spectroscopies, and visible and infrared (VISIR; separately referred to as VIS and IR) reflectance spectroscopy. A remote micro-imager (RMI) provides high-resolution color context imaging, and a microphone can be used as a stand-alone tool for environmental studies or to determine physical properties of rocks and soils from shock waves of laser-produced plasmas. SuperCam is built in three parts: …
Control Of Blood Volume Following Hypovolemic Challenge In Vertebrates: Transcapillary Versus Lymphatic Mechanisms., Stanley S. Hillman, Robert C. Drewes, Michael S. Hedrick
Control Of Blood Volume Following Hypovolemic Challenge In Vertebrates: Transcapillary Versus Lymphatic Mechanisms., Stanley S. Hillman, Robert C. Drewes, Michael S. Hedrick
Biology Faculty Publications and Presentations
Anurans have an exceptional capacity for maintaining vascular volume compared with other groups of vertebrates. They can mobilize interstitial fluids via lymphatic return at rates that are ten-fold higher than mammals. This extraordinary capacity is the result of coordination of specialized skeletal muscles and pulmonary ventilation that vary volume and pressure of subcutaneous lymph sacs, thus moving lymph to dorsally located lymph hearts that return lymph to the vascular space. Variation in the capacity to mobilize lymph within anurans varies with the degree of terrestriality, development of skeletal muscles, lung volume and lung compliance, and lymph heart pressure development. This …
Organic Production Of Livestock And Livestock Products In Nebraska, Elliott James Dennis
Organic Production Of Livestock And Livestock Products In Nebraska, Elliott James Dennis
Extension Farm and Ranch Management News
First paragraph:
USDA “Certified Organic” is a form of production that has received considerable public attention in the last 10 years, particularly among small, beginning and/or minority farmers. Spiking retail prices for red meat and poultry have seemingly accelerated consumer’s interest in organic locally produced products. Consumers demonstrate their desire for these products by paying premiums when purchasing meat products. Producers receive premiums by either directly marketing live animals to consumers that are custom harvested or marketing animals to meat wholesalers. The primary difference is the way premiums are captured. Producers doing custom harvesting capture the full premium whereas producers …
Quantifying Anticancer Drug Doxorubicin Binding To Dna Using Optical Tweezers, Zachary Ells
Quantifying Anticancer Drug Doxorubicin Binding To Dna Using Optical Tweezers, Zachary Ells
Honors Program Theses and Projects
Doxorubicin is a successful anticancer drug approved for use in the 1970s and is considered to be one of the most effective cancer treatment methods today. Although Doxorubicin has positive survival statistics it has very negative side effects in many cases. Bleeding from the soles of the palms and feet, along with excruciating pain is often exhibited through the administration of this drug. Based on the preliminary findings utilizing optical tweezers we anticipate that this study will provide critical information about the drug binding mechanism. Single molecule biophysics techniques have provided useful insight into the DNA-binding mechanisms of small molecules. …
Effects Of Consuming Sugar-Sweetened Beverages For 2 Weeks On 24-H Circulating Leptin Profiles, Ad Libitum Food Intake And Body Weight In Young Adults, Desiree M. Sigala, Adrianne M. Widaman, Bettina Hieronimus, Marinelle V. Nunez, Vivien Lee, Yanet Benyam, Andrew A. Bremer, Valentina Medici, Peter J. Havel, Kimber L. Stanhope, Nancy L. Keim
Effects Of Consuming Sugar-Sweetened Beverages For 2 Weeks On 24-H Circulating Leptin Profiles, Ad Libitum Food Intake And Body Weight In Young Adults, Desiree M. Sigala, Adrianne M. Widaman, Bettina Hieronimus, Marinelle V. Nunez, Vivien Lee, Yanet Benyam, Andrew A. Bremer, Valentina Medici, Peter J. Havel, Kimber L. Stanhope, Nancy L. Keim
Faculty Research, Scholarly, and Creative Activity
Sugar-sweetened beverage (sugar-SB) consumption is associated with body weight gain. We investigated whether the changes of (Δ) circulating leptin contribute to weight gain and ad libitum food intake in young adults consuming sugar-SB for two weeks. In a parallel, double-blinded, intervention study, participants (n = 131; BMI 18–35 kg/m2; 18–40 years) consumed three beverages/day containing aspartame or 25% energy requirement as glucose, fructose, high fructose corn syrup (HFCS) or sucrose (n = 23–28/group). Body weight, ad libitum food intake and 24-h leptin area under the curve (AUC) were assessed at Week 0 and at the end of Week …
Loss-Of-Function Genomic Variants Highlight Potential Therapeutic Targets For Cardiovascular Disease, Jonas B. Nielsen, Oren Rom, Ida Surakka, Sarah E. Graham, Wei Zhou, Tanmoy Roychowdhury, Lars G. Fritsche, Sarah A. Gagliano Taliun, Carlo Sidore, Yuhao Liu, Maiken E. Gabrielsen, Anne Heidi Skogholt, Brooke Wolford, William Overton, Ying Zhao, Jin Chen, He Zhang, Whitney E. Hornsby, Akua Acheampong, Austen Grooms, Amanda Schaefer, Gregory J. M. Zajac, Luis Villacorta, Jifeng Zhang, Ben Brumpton, Mari Løset, Vivek Rai, Pia R. Lundegaard, Morten S. Olesen, Kent D. Taylor, Donna K. Arnett
Loss-Of-Function Genomic Variants Highlight Potential Therapeutic Targets For Cardiovascular Disease, Jonas B. Nielsen, Oren Rom, Ida Surakka, Sarah E. Graham, Wei Zhou, Tanmoy Roychowdhury, Lars G. Fritsche, Sarah A. Gagliano Taliun, Carlo Sidore, Yuhao Liu, Maiken E. Gabrielsen, Anne Heidi Skogholt, Brooke Wolford, William Overton, Ying Zhao, Jin Chen, He Zhang, Whitney E. Hornsby, Akua Acheampong, Austen Grooms, Amanda Schaefer, Gregory J. M. Zajac, Luis Villacorta, Jifeng Zhang, Ben Brumpton, Mari Løset, Vivek Rai, Pia R. Lundegaard, Morten S. Olesen, Kent D. Taylor, Donna K. Arnett
Epidemiology and Environmental Health Faculty Publications
Pharmaceutical drugs targeting dyslipidemia and cardiovascular disease (CVD) may increase the risk of fatty liver disease and other metabolic disorders. To identify potential novel CVD drug targets without these adverse effects, we perform genome-wide analyses of participants in the HUNT Study in Norway (n = 69,479) to search for protein-altering variants with beneficial impact on quantitative blood traits related to cardiovascular disease, but without detrimental impact on liver function. We identify 76 (11 previously unreported) presumed causal protein-altering variants associated with one or more CVD- or liver-related blood traits. Nine of the variants are predicted to result in loss-of-function of …
Epigenetic Regulation Of Wnt Signaling By Carboxamide-Substituted Benzhydryl Amines That Function As Histone Demethylase Inhibitors, Wen Zhang, Vitaliy M. Sviripa, Yanqi Xie, Tianxin Yu, Meghan G. Haney, Jessica S. Blackburn, Charles A. Adeniran, Chang-Guo Zhan, David S. Watt, Chunming Liu
Epigenetic Regulation Of Wnt Signaling By Carboxamide-Substituted Benzhydryl Amines That Function As Histone Demethylase Inhibitors, Wen Zhang, Vitaliy M. Sviripa, Yanqi Xie, Tianxin Yu, Meghan G. Haney, Jessica S. Blackburn, Charles A. Adeniran, Chang-Guo Zhan, David S. Watt, Chunming Liu
Molecular and Cellular Biochemistry Faculty Publications
Aberrant activation of Wnt signaling triggered by mutations in either Adenomatous Polyposis Coli (APC) or CTNNB1 (β-catenin) is a hallmark of colorectal cancers (CRC). As part of a program to develop epigenetic regulators for cancer therapy, we developed carboxamide-substituted benzhydryl amines (CBAs) bearing either aryl or heteroaryl groups that selectively targeted histone lysine demethylases (KDMs) and functioned as inhibitors of the Wnt pathway. A biotinylated variant of N-((5-chloro-8-hydroxyquinolin-7-yl) (4-(diethylamino)phenyl)-methyl)butyramide (CBA-1) identified KDM3A as a binding partner. KDM3A is a Jumonji (JmjC) domain-containing demethylase that is significantly upregulated in CRC. KDM3A regulates the demethylation of histone H3's lysine …
Efficacy Of Pulmonary Ultrasound Compared To N-Terminal Prohormone Brain Natriuretic Peptide As A Diagnostic Tool For Congestive Heart Failure In Patients Presenting With Acute Dyspnea In The Emergency Setting, Leah Krohn, Michael Burns
Efficacy Of Pulmonary Ultrasound Compared To N-Terminal Prohormone Brain Natriuretic Peptide As A Diagnostic Tool For Congestive Heart Failure In Patients Presenting With Acute Dyspnea In The Emergency Setting, Leah Krohn, Michael Burns
Physician Assistant Capstones, 2020-current
Objective: To determine the efficacy of using pulmonary ultrasound as a diagnostic tool in acute dyspnea of undetermined cause compared to the use of serum N-Terminal prohormone Brain Natriuretic Peptide (NT-proBNP) in the diagnosis of heart failure.
Design: Systematic literature review
Methods: Searches were conducted in PubMed and Scopus using the terms pulmonary ultrasound and congestive heart failure and studies within the last 10 years. Studies that used pulmonary ultrasound compared to BNP as a marker for the diagnosis of heart failure were included.
Results: All three studies found that the use of pulmonary ultrasound was a more specific …
Sobre El Estatus Taxonómico De Ectinogonia Darwini Waterhouse, 1913 Y Ectinogonia Angulicollis (Fairmaire Y Germain, 1858) (Coleoptera: Buprestidae): Fijación Del Holotipo Por Monotipia, Designación De Lectotipo Y Descripción De Dos Nuevas De Ectinogonia (Ectinogonia) Spinola Del Norte De Chile, Cristian Pineda, José Mondaca
Insecta Mundi
Los ejemplares tipos de Ectinogonia darwini Waterhouse, 1913 y Psiloptera angulicollis Fairmaire y Germain, 1858 (Coleoptera: Buprestidae), fueron localizados, estudiados y establecidos como holotipo por monotipia y lectotipo, respectivamente. Como las descripciones originales son ambiguas e incompletas, ambas especies son redescritas e ilustradas. Basados en estas nominaciones, y en el examen de ejemplares de Ectinogonia Spinola recolectados en el litoral de las provincias de Chañaral (Región de Atacama) y Antofagasta (Región de Antofagasta), y en la zona andina de la Provincia del Tamarugal (Región de Tarapacá), se describen dos nuevas especies del norte de Chile: E. superba Pineda y Mondaca, …
A Remarkable New Species Of Nothochodaeus Nikolajev From Sumatra (Coleoptera: Scarabaeoidea: Ochodaeidae), M. J. Paulsen
A Remarkable New Species Of Nothochodaeus Nikolajev From Sumatra (Coleoptera: Scarabaeoidea: Ochodaeidae), M. J. Paulsen
Insecta Mundi
Nothochodaeus marsupialis Paulsen, new species (Coleoptera: Ochodaeidae), is described from Aceh Province, Indonesia, on the island of Sumatra. The species possesses deep abdominal cavities behind a shield-like central process, as well as rows of conical tubercles laterally on the second and third ventrites. These structures have not been found in any other members of the genus or family.
Primer Registro Del Pequeño Escarabajo De La Colmena Aethina Tumida Murray (Coleoptera: Nitidulidae) En Colmenas De Abejas Africanizadas En Guatemala, José Francisco García Ochaeta
Primer Registro Del Pequeño Escarabajo De La Colmena Aethina Tumida Murray (Coleoptera: Nitidulidae) En Colmenas De Abejas Africanizadas En Guatemala, José Francisco García Ochaeta
Insecta Mundi
Se registra por primera vez la presencia del pequeño escarabajo de la colmena (PEC), Aethina tumida Murray (Coleoptera: Nitidulidae), en colmenas de abejas africanizadas en el departamento de Petén, Guatemala, alimentándose de miel y polen. Se presenta información básica sobre la especie, su distribución conocida actual e ilustraciones para ayudar en su identificación.
The presence of the small hive beetle (SHB), Aethina tumida Murray (Coleoptera: Nitidulidae), is recorded for the first time in Africanized beehives from Petén department, Guatemala, feeding on honey and pollen. Basic information about the species, including its currently known distribution, and illustrations, are presented to aid …
Two New Species Of Phyllophaga Of The Schizorhina Species Group From Cloud Forests Of Chiapas, México And Guatemala (Coleoptera: Scarabaeidae: Melolonthinae), Enio B. Cano
Insecta Mundi
Phyllophaga (Phyllophaga) badbunnyi Cano new species, and Phyllophaga (Phyllophaga) sechi Cano new species, of the Schizorhina species group (Coleoptera: Scarabaeidae: Melolonthinae), are described and illustrated from specimens collected at cloud forests between 1300-1750 m elevation of southeastern Chiapas, México and western Guatemala. A key to the Guatemalan and Chiapanecan species of Phyllophaga Harris, group Schizorhina, with dorsal finger-like projections of genital capsule, is provided.
Con base en especímenes colectados en bosques nubosos entre 1300 y 1750 m de altitud del sureste de Chiapas, México y del oeste de Guatemala, se describe y se ilustra a Phyllophaga (Phyllophaga) badbunnyi Cano …
Beyond Low-Earth Orbit: Characterizing Immune And Microrna Differentials Following Simulated Deep Spaceflight Conditions In Mice, Amber M. Paul, Margareth Cheng-Campbell, Elizabeth A. Blaber, Sulekha Anand, Sharmila Bhattacharya
Beyond Low-Earth Orbit: Characterizing Immune And Microrna Differentials Following Simulated Deep Spaceflight Conditions In Mice, Amber M. Paul, Margareth Cheng-Campbell, Elizabeth A. Blaber, Sulekha Anand, Sharmila Bhattacharya
Publications
Spaceflight missions can cause immune system dysfunction in astronauts with little understanding of immune outcomes in deep space. This study assessed immune responses in mice following ground-based, simulated deep spaceflight conditions, compared with data from astronauts on International Space Station missions. For ground studies, we simulated microgravity using the hindlimb unloaded mouse model alone or in combination with acute simulated galactic cosmic rays or solar particle events irradiation. Immune profiling results revealed unique immune diversity following each experimental condition, suggesting each stressor results in distinct circulating immune responses, with clear consequences for deep spaceflight. Circulating plasma microRNA sequence analysis revealed …