Substance Abuse and Addiction Commons^™

Adolescent And Adult Nicotine Exposure On The Acquisition Of Methamphetamine Self-Administration And The Reinstatement Of Extinguished Methamphetamine-Seeking In Male Rats, Joseph Allan Pipkin

Theses Digitization Project

This study sought to determine the individual and combined contribution of adolescent and adult nicotine exposure on METH self-administration and METH-seeking behavior in male rats. Nicotine is a commonly abused substance among adolescents and is believed to be a "gateway" to other drugs of abuse. In support of the gateway hypothesis, cigarette smoking during adolescence is related to increased methamphetamine (METH) use in adulthood.

Preweanling Exposure To Selective Catecholamine Transporter Inhibitors Differentially Effects Morphine-Induced Antinociception In Adulthood, Joseph Marco Valentine

Theses Digitization Project

The purpose of this project is to determine how early methylphenidate exposure alters opioid receptor functioning in adulthood. To this end, we will administer selective monoamine transporter inhibitors for dopamine and norepinephrine (GBR-12904 and atomoxetine) during preweanling period and assess opioid function in adult rats by testing morphine-induced antinociception using the hot-plate and tail-flick tasks. In order to assess the effects of methylphenidate use on brain functions during development, investigations have been conducted in rats using ages roughly analogous to early and late childhood.

Prevalence Of Hiv, Hepatitis B And C, And Co-Infection In A Cohort Of Male Injection Drug Users In Delhi, Lopamudra Saraswati, Mary Philip Sebastian, Avina Sarna, Vartika Sharma, Ira Madan, Dean Lewis, Ibou Thior, Waimar Tun

HIV and AIDS

India has a large injection drug user (IDU) population estimated at 177,000 nationally with an HIV prevalence of 7.2 percent. Historically, the presence of IDU populations and associated HIV infection was concentrated in the northeastern states of the country. Recent evidence documents IDU populations in other parts of the country. Delhi has an estimated 17,000 IDUs and the second highest HIV prevalence in India at 18.3 percent. The probability of becoming infected with HIV after using an infected syringe ranges from 0.34 percent to 1.4 percent. By comparison, the risk for hepatitis C (HCV) ranges from 1.5 percent to 5 …

2013 Annual Report, Center For Applied Research On Substance Use And Health Disparities

Center for Applied Research on Substance Use and Health Disparities Annual Reports

No abstract provided.

Social Workers' Perceptions Of Psychotropic Medication Use On Children And Adolescents In Foster Care, Tina Latrice Johnson Hollman, Dominic Marcus Ruffin

Theses Digitization Project

The purpose of this study was to evaluate the attitudes of social workers' regarding psychotropic medication use on children in foster care. This study also addressed any prospective concerns that social workers may have had as they relate to psychotropic medications being administered to children in foster care.

The Health And Well-Being Of Indigenous Drug And Alcohol Workers: Results From A National Australian Survey, Ann M. Roche, Vinita Duraisingam, Allan Trifonoff, Amanda Tovell

Aboriginal Policy Research Consortium International (APRCi)

The increasing demand for alcohol and other drug (AOD) treatment services among the Australian Indigenous population, complex organisational challenges and limitations, and high unemployment rates are likely to negatively impact Indigenous AOD workers' health and well-being. Building the capacity of Indigenous AOD workers is vital, as they play a crucial role in the delivery of treatment services and offer essential support to their communities. A national online survey was conducted to examine organisational, workplace and individual factors that might contribute to levels of stress and well-being among workers who provide services to Indigenous clients. A total of 294 eligible surveys …

High Hiv Incidence Among Male Injection Drug Users In Delhi, India, Waimar Tun, Lopamudra Saraswati, Mary Philip Sebastian, Vartika Sharma, Amita Yadav, Ira Madan, Ibou Thior, Avina Sarna

HIV and AIDS

India has a large injection drug user (IDU) population estimated at 177,000. The overall national HIV prevalence is around 7.2 percent in this group, the highest among all key populations in the country. There is limited HIV incidence data among IDUs in India. In collaboration with Arise—Enhancing HIV Prevention Programs for At-Risk Populations, the Population Council initiated a prospective cohort study at five centers in Delhi to examine HIV incidence and behavior change both pre-introduction and post-introduction of HIV prevention services among IDUs. HIV transmission risk remains high among IDUs in Delhi despite targeted prevention interventions. Despite the widespread availability …

Random Assignment Of Schools To Groups In The Drug Resistance Strategies Rural Project: Some New Methodological Twists, John W. Graham, Jonathan Pettigrew, Michelle Miller-Day, Janice L. Krieger, Jiangxiu Zhou, Michael L. Hecht

Communication Faculty Articles and Research

Random assignment to groups is the foundation for scientifically rigorous clinical trials. But assignment is challenging in group randomized trials when only a few units (schools) are assigned to each condition. In the DRSR project, we assigned 39 rural Pennsylvania and Ohio schools to three conditions (rural, classic, control). But even with 13 schools per condition, achieving pretest equivalence on important variables is not guaranteed. We collected data on six important school-level variables: rurality, number of grades in the school, enrollment per grade, percent white, percent receiving free/assisted lunch, and test scores. Key to our procedure was the inclusion of …

The Conceptualization And Communication Of Risk Among Rural Appalachian Adolescents, Jennifer J. Moreland, Janice L. Krieger, Michael L. Hecht, Michelle Miller-Day

Communication Faculty Articles and Research

This study employs a meta-theoretical perspective for examining risk perceptions and behavior in the rural, Appalachian cultural context, an area that remains largely unexplored. In-depth interviews were conducted with 113 rural adolescents to describe how youth conceptualize risk and how risk is communicated in the rural environment. Analyses revealed adolescents viewed behavior as risky when they had personal or vicarious experiences resulting in a loss of control or physical harm. Elements of the rural Appalachian culture including activities, familism, and community ties can both prevent and promote adolescent risk-taking in various forms. This study demonstrates the conceptualization of risk and …

Adapting School-Based Substance Use Prevention Curriculum Through Cultural Grounding: A Review And Exemplar Of Adaptation Processes For Rural Schools, Margaret Colby, Michael L. Hecht, Michelle Miller-Day, Janice L. Krieger, Amy K. Syvertsen, John W. Graham, Jonathan Pettigrew

Communication Faculty Articles and Research

A central challenge facing twenty-first century community-based researchers and prevention scientists is curriculum adaptation processes. While early prevention efforts sought to develop effective programs, taking programs to scale implies that they will be adapted, especially as programs are implemented with populations other than those with whom they were developed or tested. The principle of cultural grounding, which argues that health message adaptation should be informed by knowledge of the target population and by cultural insiders, provides a theoretical rational for cultural regrounding and presents an illustrative case of methods used to reground the keepin’ it REAL substance use prevention curriculum …

Personality And Substance Abuse, Juliana Gonzalez

Masters Theses

The Big Five have shown to be distinct personality traits that do not overlap and have universal applicability, so this study examined whether there are specific personality trait differences in users of Marijuana, Pain Medication, Sedative/Hypnotics, and Stimulants.

Study was placed in the 50 most visited Craigslist pages in the United States. Anonymous web users (N = 547) were recruited through Craigslist. High Neuroticism was associated with Marijuana and Stimulant use. Low Conscientiousness was associated with Marijuana and Stimulant use. High Extraversion was associated with Pain Medication use only. Implications, limitations, and suggestions for future research were discussed.

Predictors Of Smoking Behavior And Readiness To Quit In Addiction Treatment, Arturo Soto-Nevarez, Joseph Guydish

McNair Poster Presentations

Background: Prevalence of tobacco use is 3 times higher for those seeking substance abuse treatment than those in the general population. Clinical practice guidelines recommend addressing smoking cessation. This population has more difficulty quitting than the general population. Methods: This paper analyzes predictors of smoking behavior and readiness to quit in patients enrolled in addiction treatment programs. Data from six substance abuse treatment centers was collected. A total of 235 clients were surveyed on their smoking attitudes and behaviors. Results: Survey data from 139 current smokers was analyzed. In logistic regression analyses predicting readiness to quit smoking, and controlling for …

Effects Of Restraint Stress And Allopregnanolone Inhibition On Amphetamine Locomotor Sensitivity, Kelly Abuali, Laurel M. Pritchard

McNair Poster Presentations

The chronic, recurring nature of addiction remains a worldwide problem. Even after apparently successful clinical treatment and long term abstinence, individuals may still relapse many months or years later. Although many individual differences exist among substance abusers, relapse tends to occur during periods of high stress (Sinha et al., 2006). Behavioral training and therapy can help cope during these high stress times, but pharmacological interventions have not been shown to be effective (Ross & Peselow, 2009). Although some therapeutic options decrease relapse rates, more effective treatments for relapse need further consideration.

The effect of stress on use of and relapse …

Does The Use Of Varenicline For Smoking-Cessation Therapy Create Or Increase Depression In Patients Without Existing Depressive Illness?, Brett R. Brown

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not the use of varenicline for smoking-cessation therapy creates or increases depression in patients without existing depressive illness.

STUDY DESIGN: Review of two randomized controlled trials published in 2011 and one observational cohort study published in 2009, all English language.
DATA SOURCES: Two randomized, double-blind, controlled clinical trials comparing varenicline to placebo in smoking cessation, and one observational cohort study comparing varenicline use within subjects. All articles were found using PubMed and EBSCO.

OUTCOMES MEASURED: Changes in depression was evaluated using the MontgomeryÅsberg Depression Rating Scale …

Evidence-Based Treatment For Anxiety Disorders And Marijuana Use Across The Lifespan, Tanya Borchert

All Graduate Theses, Dissertations, and Other Capstone Projects

The purpose of this capstone project was to identify evidence-based practices relating to anxiety disorders and cannabis use throughout the lifespan. Identification of the practices will more effectively meet the needs of the clients served at the Dual Recovery Program and allow the agency to best serve clients with co-occurring anxiety disorders and cannabis use in a parallel manner. The literature indicates that there is a correlation between anxiety disorders and cannabis abuse (Buckner & Schmidt, 2011; Buckner, Zvolensky, & Schmidt, 2012; Bricker, et al., 2006; Bonn-Miller, Vujanovic, Boden, & Gross, 2011). If the anxiety disorder can be properly diagnosed …

Methylphenidate And Atomoxetine Treatment During Adolescence In The Spontaneously Hypertensive Rat: Mechanisms Underlying High Cocaine Abuse Liability In Attention Deficit/Hyperactivity Disorder, Sucharita S. Somkuwar

Theses and Dissertations--Pharmacy

Effects of pharmacotherapies for Attention Deficit/Hyperactivity Disorder (ADHD) on cocaine abuse liability in ADHD are not understood. Spontaneously Hypertensive Rats (SHR), an ADHD model, exhibited greater cocaine self-administration than control Wistar-Kyoto and Wistar rats. Methylphenidate, but not atomoxetine during adolescence enhanced cocaine self-administration in adult SHRs compared to controls. The mesocortical dopaminergic system, including medial prefrontal (mPFC) and orbitofrontal (OFC) cortices, is important for ADHD and cocaine addiction. Dopamine and norepinephrine transporter (DAT and NET) are molecular targets for methylphenidate, atomoxetine and cocaine action.

In the current studies, SHR, Wistar-Kyoto and Wistar were administered methylphenidate (1.5 mg/kg/day, p.o.), atomoxetine (0.3 …

Student-Athletes And Drug Abuse Policies: A Study Of Drug Abuse Policies Of Athletics Departments In A Major Intercollegiate Athletics Conference, Jennifer Hale

MPA/MPP/MPFM Capstone Projects

No executive summary.

Papanicoloau Smear Uptake Among Substance-Using Mothers In Western Australia, Sadie Geraghty, Sara J. Bayes, Renate Mclaurin, Angela O'Connor

Research outputs 2013

Background: Papanicoloau (Pap) smear screening has helped to reduce cervical cancer rates significantly through the detection of premalignant cells (Bray et al, 2005). Uptake among women who use alcohol and other drugs (AOD) is known to be low (Chau et al, 2002) so they are at increased risk of being under-represented in the adequately screened population. AOD-using women experience disproportionately increased morbidity and mortality from cervical dysplasia and cancer (Nogara et al, 2013). Pregnancy may provide the midwife an opportunity to offer this vital screening test.

Objective: The audit investigated Pap smear uptake and results among AOD-using pregnant women.

Setting: …

Internet-Based Photoaging Within Australian Pharmacies To Promote Smoking Cessation: Randomized Controlled Trial, Oksana Burford, Moyez Jiwa, Owen B. Carter, Richard Parsons, Delia Hendrie

Research outputs 2013

Background: Tobacco smoking leads to death or disability and a drain on national resources. The literature suggests that cigarette smoking continues to be a major modifiable risk factor for a variety of diseases and that smokers aged 18-30 years are relatively resistant to antismoking messages due to their widely held belief that they will not be lifelong smokers. Objective: To conduct a randomized controlled trial (RCT) of a computer-generated photoaging intervention to promote smoking cessation among young adult smokers within a community pharmacy setting. Methods: A trial was designed with 80% power based on the effect size observed in a …

Does Nicotine Replacement Therapy Reduce The Withdrawal Symptom Of Craving, Or Urge To Smoke, In Dependent Adult Smokers During Smoking Cessation?, Theresa Dijoseph

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not nicotine replacement therapy reduces the withdrawal symptom of craving, or urge to smoke, in dependent adult smokers during smoking cessation.

STUDY DESIGN: Systematic review of three English language and peer-reviewed randomized-controlled trials published in 2009, 2010, and 2011.

DATA SOURCES: One single-blinded randomized-controlled crossover trial, one double-blinded, placebo controlled, randomized-controlled crossover trial, and one single-blinded, placebo controlled, randomized-controlled crossover trial

OUTCOMES MEASURED: Withdrawal symptoms of craving, irritability, difficulty concentrating, and restlessness were measured on a 100mm visual analog scale (VAS). Adverse effects (AEs) of mouth and …