Substance Abuse and Addiction Commons^™

Effects Of Kappa Opioid Receptor Manipulation On Methamphetamine-Induced Behavioral Sensitization In Adolescent Male And Female Rats, Hiroyoshi Matsui Mr, Sarah Seeley, Manoranjan S. D'Souza

ONU Student Research Colloquium

Methamphetamine abuse amongst adolescents has been on the rise in the United States. In this study, we assessed the effects of manipulation of KORs on methamphetamine-induced behavioral sensitization in adolescent male and female rats. Methamphetamine-induced behavioral sensitization is an animal model to study methamphetamine addiction. Behavioral sensitization usually occurs in animals who have been treated with methamphetamine followed by a period of withdrawal. It is hypothesized that brain circuits are altered during the period of withdrawal after methamphetamine exposure resulting in sensitized (increased) responses to methamphetamine at the end of the withdrawal period. The experiment was conducted over 28 days. …

A Case Of “Neptune’S Fix Elixir” - The Dangerous Consequences Of Unregulated Use Of Tianeptine In Over-The-Counter Products, Priscilla Lozano, Maya Qutob Do, Eduardo Espiridion

Tower Health Research Day

No abstract provided.

Health Care Professionals’ Stigma Toward People With An Opioid Use Disorder: Preliminary Findings On The Effect Of Amount Of Contact Has On Stigma, Gabriela Murza, Cris Meier, Lily Ward, Sydney O'Shay, Rachel Myrer

Transforming Communities

Opioid-related deaths are the leading cause of injury deaths in Utah. Individuals who seek treatment for opioid misuse report stigma from healthcare professionals as the leading barrier to accessing treatment. Health professionals provide a variety of treatment options in efforts of combating high rates of opioid misuse. However, these professionals may not be properly trained in stigma reduction strategies, thus leading to poor client care and outcomes. The current study examined the association between contact with individuals who misuse opioids and stigma perceptions among healthcare professionals. A one-time survey was administered to healthcare professionals who practice in Utah using convenience …

In Silico Identification Of Small Molecule Agonist Binding Sites On Kcc2, Kenyon Mitchell, Alfred Amendolara, Ruth Hunter, Jaden Miner, Andrew Payne

Annual Research Symposium

Purpose: Potassium-Chloride Cotransporter 2 (KCC2) is a neuronal membrane protein specific to the central nervous system. It is responsible for removing Cl- ions from the intracellular space, maintaining a normal Cl- gradient essential for proper function at inhibitory synapses. Dysregulation causes an upward shift in the Cl- reversal potential resulting in a hyperexcitable state of the postsynaptic neuron. Existing literature indicates that KCC2 may be involved in the addiction pathway of a variety of drugs of abuse, including opioids and alcohol. This makes KCC2 an attractive potential drug target when treating substance use disorders. A novel direct KCC2 agonist, VU0500469, …

Health Leadership Perspectives On Challenges To Providing & Expanding Withdrawal Management Capacity In Maine, Sarah Mclaughlin Mph

Substance Use Research & Evaluation

Currently, the Maine Department of Health and Human Services (Maine DHHS) and the Cutler Institute’s Substance Use Research and Evaluation Team (SURE) are working together through the SUPPORT for ME Cooperative Agreement to monitor and assess Maine’s behavioral health system. As a part of this Cooperative Agreement, Maine DHHS and the SURE team have identified withdrawal management (WM) as an area of interest and have determined that more information is needed to understand the landscape of WM in Maine, especially as it pertains to non-opioid substances. Therefore, this project will involve collecting data through interviews with health care leadership from …

Qualitative Brief: Baseline Needs Assessment Treatment Experiences In Rural Vermont, Katie Rosingana Ba, Evelyn Ali Mph, Tyler Egeland Ba, Karen Pearson Mlis, Mary Lindsey Smith Phd, C. Peasley-Miklus, J. Shaw

Substance Use Research & Evaluation

This qualitative data brief provides findings from the Vermont baseline needs assessment, conducted in collaboration with research staff at the University of Southern Maine's Catherine Cutler Institute, with the goal to identify current and future opioid use disorder (OUD) treatment needs and barriers in rural Vermont. This data brief aims to identify current and future addiction treatment needs and barriers in Vermont with direct input from practitioners, community partners, and people impacted personally by opioid use. Preceptions included in this data brief are informed by semi-structured qualitative interviews conducted with people with lived experience (PWLE) with OUD, as well as …

Western Maine Addiction And Recovery Initiative's Substance Misuse Prevention And Wellness Day: Year 2 Feedback Survey For Ohchs, Tyler Egeland Ba, Evelyn Ali Bs, Mary Lindsey Smith Phd

Substance Use Research & Evaluation

As part of the evaluation of the Western Maine Addiction Recovery Initiative’s (WMARI) HRSA Rural Communities Opioid Response Program grant, staff from the Substance Use Research & Evaluation Unit, USM developed a survey to gather feedback from individuals who participated in the 2nd annual OHCHS Substance Use Prevention and Wellness Day. For more information, please contact Lindsey Smith at [email protected]

Evaluating A Program To Lower Prescription Opioid Doses For Patients With Chronic Pain, Reach Dissemination Committee, Maine, Usa

REACH: Research Evidence-to-Action for Community Health

Patients who use opioids for a long time are at increased risk for addiction, care crashes, overdose, & injuries.

Willingness To Utilize A Mobile Treatment Unit In Five Counties At The Epicenter Of The Us Rural Opioid Epidemic., Snigdha R. Peddireddy, Melvin D. Livingston Iii, April M. Young, Patricia R. Freeman, Umedjon Ibragimov, Kelli A. Komro, Michelle R. Lofwall, Carrie B. Oser, Michele Staton, Hannah L. F. Cooper

Epidemiology and Environmental Health Faculty Publications

INTRODUCTION: US federal policies are evolving to expand the provision of mobile treatment units (MTUs) offering medications for opioid use disorder (MOUD). Mobile MOUD services are critical for rural areas with poor geographic access to fixed-site treatment providers. This study explored willingness to utilize an MTU among a sample of people who use opioids in rural Eastern Kentucky counties at the epicenter of the US opioid epidemic.

METHODS: The study analyzed Cross-sectional survey data from the Kentucky Communities and Researchers Engaging to Halt the Opioid Epidemic (CARE2HOPE) study covering five rural counties in the state. Logistic regression models investigated the …

Adolescent Marijuana Use And The Contribution To The Development Of Schizophrenia, Jocelyn Spandikow

Psychology Student Papers and Posters

Schizophrenia is an often debilitating mental condition that has become a popular topic of psychological research in recent years. Current research examines the correlation between drug use, genetics, and environment on the development of schizophrenia. Research looks at the structure of the brain in individuals with and without schizophrenia. However, research has failed to look at the specific correlation between marijuana use in adolescent youth and the developmental impact on the brain, including in the development of schizophrenia. The legalization of many recreational drugs, including marijuana, has come to fruition in recent years. This has raised concerns over adolescent access …

Effects Of The Communities That Heal (Cth) Intervention On Perceived Opioid-Related Community Stigma In The Healing Communities Study: Results Of A Multi-Site, Community-Level, Cluster-Randomized Trial, Alissa Davis, Hannah K. Knudsen, Daniel M. Walker, Deborah Chassler, Karsten Lunze, Philip M. Westgate, Emmanuel Oga, Sandra Rodriguez, Sylvia Tan, Janae Holloway, Sharon L. Walsh, Carrie B. Oser, R. Craig Lefebvre, Laura C. Fanucchi, Lashawn Glasgow, Ann Scheck Mcalearney, Hilary L. Surratt, Michael W. Konstan, Terry T-K Huang, Patricia Lebaron, Julie Nakayima, Michael D. Stein, Maria Rudorf, Monica Nouvong, Elizabeth N. Kinnard, Nabila El-Bassel, Jess Tilley, Aaron Macoubray, Caroline Savitzky, Amy Farmer, Donna Beers, Pamela Salsberry, Timothy R. Huerta

Behavioral Science Faculty Publications

BACKGROUND: Community stigma against people with opioid use disorder (OUD) and intervention stigma (e.g., toward naloxone) exacerbate the opioid overdose crisis. We examined the effects of the Communities that HEAL (CTH) intervention on perceived opioid-related community stigma by stakeholders in the HEALing Communities Study (HCS).

METHODS: We collected three surveys from community coalition members in 66 communities across four states participating in HCS. Communities were randomized into Intervention (Wave 1) or Wait-list Control (Wave 2) arms. We conducted multilevel linear mixed models to compare changes in primary outcomes of community stigma toward people treated for OUD, naloxone, and medication for …

Kajian Literatur Distribusi Kompensasi Dampak Tempat Pengelolahan Sampah Terpadu (Tpst) Bantargebang: Analisis Keadilan Distributif Dan Keadilan Sosial, Wahyu Pratama Tamba

Jurnal Ilmu Kesejahteraan Sosial

The waste problem in Jakarta is a complex issue related to the large volume of waste, dependence on Bantargebang TPST, and the various environmental impacts caused. Waste from Jakarta brought to Bantargebang TPST reaches 6,500-7,000 tons daily. This TPST hurts the environment and the health of the surrounding community, as well as the risk of ARI, air pollution, groundwater pollution, and environmental aesthetics. As compensation for these negative impacts, the DKI Jakarta Provincial Government allocates compensation funds for affected communities. This is regulated in Article 10 letter (e) of DKI Jakarta Regional Regulation number 4 of 2019 which states that …

Telaah Konsep Asset Bassed Comunity Development Bagi Pembangunan Pariwisata Berbasis Masyarakat, Silva Amanda, Rudi Saprudin Darwis

Jurnal Ilmu Kesejahteraan Sosial

The tourism sector is one of the sectors that contributes the largest foreign exchange in Indonesia. To develop this, the Ministry of Tourism and Creative Economy continues to encourage the community-based tourism industry, with one of them developing a tourist village program. One way to realize the tourist village program in Indonesia is to use the Asset Based Community Development approach by emphasizing the use of potential assets owned by an area. The purpose of this research is to identify the potential or assets that exist in a village/region that can be developed into a tourist village by emphasizing community …

Evaluation Of Dietary Probiotic Supplements On Methamphetamine-Induced Impulsive Action In Rats Maintained On A Differential Reinforcement Of Low Rate Schedule, Kaitlyn Steck

Masters Theses

Substance Use Disorder (SUD) is a chronic, debilitating condition often comorbid with anxiety and depression. Both SUD and affective disorders are characterized by cognitive dysfunction, including impaired decision-making and impulsivity. A mounting body of research implicates gut microbiome alterations as a contributing factor to the pathophysiology of affective disorders. No published studies have assessed behavioral effects of dietary interventions targeting psychostimulant-induced gut microbiome changes. The present study utilized a differential reinforcement of low rate responding schedule (DRL 18 s) as a behavioral index of drug-induced impulsive action to determine if a dietary probiotic supplement alters the behavioral effects of (+)-methamphetamine …

Older Adults Are At Greater Risk Of Opioid Use Disorder In Communities With High Social Vulnerability, Tse-Chuan Yang, Seulki Kim, Stephen A. Matthews, Carla Shoff

Population Health Research Brief Series

The prevalence of opioid use disorder (OUD) among older adults has increased and imposes a heavy burden on the health care system in the United States. This brief summarizes findings from a study that used data from the Centers for Medicare and Medicaid Services to examine how county characteristics contributed to the prevalence of OUD among Medicare beneficiaries age 65+ in U.S. counties in 2021. They found that the prevalence of OUD among these adults is higher in counties with more place-level social vulnerability (e.g., socioeconomic disadvantage, high housing cost burden).

Brain-Specific Serine/Threonine-Protein Kinase 1 Is A Substrate Of Protein Kinase C Epsilon Involved In Sex-Specific Ethanol And Anxiety Phenotypes, Michael P. Dugan, Rajani Maiya, Caleb Fleischer, Michal Bajo, Angela E. Snyder, Ashwin Koduri, Sathvik Srinivasan, Marisa Roberto, Robert O. Messing

School of Graduate Studies Faculty Publications

Protein kinase C epsilon (PKCε) regulates behavioural responses to ethanol and plays a role in anxiety-like behaviour, but knowledge is limited on downstream substrates of PKCε that contribute to these behaviours. We recently identified brain-specific serine/threonine-protein kinase 1 (BRSK1) as a substrate of PKCε. Here, we test the hypothesis that BRSK1 mediates responses to ethanol and anxiety-like behaviours that are also PKCε dependent. We used in vitro kinase assays to further validate BRSK1 as a substrate of PKCε and used Brsk1−/− mice to assess the role of BRSK1 in ethanol- and anxiety-related behaviours and in physiological responses to ethanol. We …

Surgery Of The Palatomaxillary Structure, Jessica R Burgess, Kathleen C Heneghan, Tarra G Barot, Jonah J Stulberg

Faculty, Staff and Student Publications

BACKGROUND: Patients with opioid use disorder (OUD) are increasing, challenging surgeons to adjust post-operative pain management guidelines. A literature review identified limited information on how to best care for these patients. The purpose of this study was to determine surgical perioperative management of OUD, challenges, and support needed for optimal care.

METHODS: This study utilized an anonymous voluntary survey that was distributed to members of the American College of Surgeons through the association's electronic weekly newsletter. The survey was advertised weekly for three consecutive weeks. The survey included questions regarding surgeons' management of perioperative pain in patients with opioid use …

Western Maine Addiction And Recovery Initiative's Substance Misuse Prevention And Wellness Day: Year 2 Planning Survey Summary For Ohchs, Evelyn Ali Bs, Tyler Egeland Ba, Mary Lindsey Smith Phd

Substance Use Research & Evaluation

The RCORP local evaluation team at the Catherine Cutler Institute deployed a survey to Oxford Hills Comprehensive High School (OHCHS). The purpose of the survey was to understand needs unique to OHCHS to plan for types of activities and information presented at the school’s Substance Use Prevention and Wellness Day. For more information, please contact Lindsey Smith at [email protected]

Reducing Harm: The Legal Viability Of Supervised Consumption Sites In Georgia, Kathleen Kassa

Georgia State University Law Review

Every five minutes in the United States, someone dies from a drug overdose. This public health crisis, referred to as the opioid epidemic, caused the federal government and many states and localities to issue public health emergency declarations. Despite billions of dollars in funding and response at every level of government, overdoses continue to increase.

The complexity of addiction prevention and treatment, socioeconomic inequalities, and the stigmatization of drug use make the opioid crisis difficult to solve. The severity of the epidemic led many jurisdictions to adopt once-controversial harm reduction approaches aimed at reducing the stigma and negative impacts of …

Alcohol Withdrawal Severity Measures For Identifying Patients Requiring High-Intensity Care, Daniel C. To, Tessa L. Steel, Kyle A. Carey, Cara Joyce, Elizabeth M. Salisbury-Afshar, Dana P. Edelson, Anoop Mayampurath, Matthew M. Churpek, Majid Afshar

Biostatistics Collaborative Core: Faculty Publications and Other Works

OBJECTIVES: Alcohol withdrawal syndrome (AWS) may progress to require high-intensity care. Approaches to identify hospitalized patients with AWS who received higher level of care have not been previously examined. This study aimed to examine the utility of Clinical Institute Withdrawal Assessment Alcohol Revised (CIWA-Ar) for alcohol scale scores and medication doses for alcohol withdrawal management in identifying patients who received high-intensity care.

DESIGN: A multicenter observational cohort study of hospitalized adults with alcohol withdrawal.

SETTING: University of Chicago Medical Center and University of Wisconsin Hospital.

PATIENTS: Inpatient encounters between November 2008 and February 2022 with a CIWA-Ar score greater than …