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Dnp Final Report: Conquering Rn Turnover: Implementing Flexible Scheduling To Improve Job Satisfaction, Camille Y. Parsee 2023 University of Texas at Tyler

Dnp Final Report: Conquering Rn Turnover: Implementing Flexible Scheduling To Improve Job Satisfaction, Camille Y. Parsee

DNP Final Reports

Nurse turnover is a complex problem for the nursing profession, especially in the behavioral health setting, where turnover rates are higher than the overall RN national average. The consequences of high nurse turnover include increased health costs, low-quality patient care, and staffing constraints. The association between nurse turnover and job satisfaction is profound because of their reciprocal relationship; therefore, implementing an intervention to help mitigate nurse dissatisfaction is essential to overcoming nurse turnover. Flexible scheduling is an intervention that gives nurses independence with their schedule which improves work-life balance and promotes nurse retention (Wright, 2017). The following PICOT question was …


Evaluating The Efficacy Of Medication-Assisted Treatment For First Episode Psychosis: A Scoping Review, Chanel Thomas MSN, APRN, FNP-BC, RN-BC, Alexandra Wittenberg BSN, RN-BC, Anttrenika Anderson BSN, RN, Tracy McClinton DNP, APRN, AGACNP-BC, EBP-C 2023 University of Tennessee Health Science Center

Evaluating The Efficacy Of Medication-Assisted Treatment For First Episode Psychosis: A Scoping Review, Chanel Thomas Msn, Aprn, Fnp-Bc, Rn-Bc, Alexandra Wittenberg Bsn, Rn-Bc, Anttrenika Anderson Bsn, Rn, Tracy Mcclinton Dnp, Aprn, Agacnp-Bc, Ebp-C

Doctor of Nursing Practice Projects

Purpose/Background

The Substance Abuse and Mental Health Services Administration (SAMHSA) recommends that individuals with substance use disorder (SUD) receive medicated-assisted treatment (MAT), as a complete approach to substance use treatment (SAMHSA, 2019). However, treatment measures using combination treatment for SUD in individuals experiencing first episode psychosis (FEP) are seldom used. This scoping review assesses the efficacy of MAT in conjunction with antipsychotics compared to the use of antipsychotic monotherapy for FEP individuals on hospital readmission rates.

Methods

The authors conducted a literature review utilizing PubMed, EBSCO, Elsevier, Google Scholar, PsychINFO, and Medline from August 2020 to November 2022. Key phrases …


Moral Injury To Inform Analysis Of Post-Traumatic Stress Disorder, Amanda Julia Manea 2023 University of South Carolina - Columbia

Moral Injury To Inform Analysis Of Post-Traumatic Stress Disorder, Amanda Julia Manea

Senior Theses

Post-traumatic stress disorder (PTSD) is a mental health condition that almost one out of ten veterans struggle with. Although the National Center for PTSD has made extensive progress in characterizing and developing new treatments for PTSD, most veterans still experience symptoms of PTSD following treatment. Novel avenues of investigation, such as developing algorithms to review electronic health record (EHR) data and better understanding moral injury, are being pursued to address the gap that still exists when it comes to treating veterans. Moral injury is the individual evaluation of exposure to a potentially morally injurious event (PMIE) and can lead to …


Single-Case Pilot Study For Longitudinal Analysis Of Referential Failures And Sentiment In Schizophrenic Speech From Client-Centered Psychotherapy Recordings, Travis A. Musich 2023 National Louis University

Single-Case Pilot Study For Longitudinal Analysis Of Referential Failures And Sentiment In Schizophrenic Speech From Client-Centered Psychotherapy Recordings, Travis A. Musich

Dissertations

Though computational linguistic analyses have revealed the presence of distinctly characteristic language features in schizophrenic disordered speech, the relative stability of these language features in longitudinal samples is still unknown. This longitudinal pilot study analyzed schizophrenic disordered speech data from the archival therapy audio recordings of one patient spanning 23 years. End-to-end Neural Coreference Resolution software was used to analyze transcribed speech data from three therapy sessions to identify ambiguous pronouns, referred to as referential failures, which were reviewed and confirmed by multiple raters. Speech samples were analyzed using Google Cloud Natural Language API software for sentiment variables (i.e., score, …


Musculoskeletal Pain Latent Classes And Biopsychosocial Characteristics Among Emerging Adults, Kaitlin M. Gallagher, Erin K. Howie, Makayla Carney 2023 University of Arkansas, Fayetteville

Musculoskeletal Pain Latent Classes And Biopsychosocial Characteristics Among Emerging Adults, Kaitlin M. Gallagher, Erin K. Howie, Makayla Carney

Health, Human Performance and Recreation Faculty Publications and Presentations

Background

Emerging adults (aged 18–29) report high levels of musculoskeletal pain; however, it is unknown if body location and intensity patterns are related to different biopsychosocial characteristics. This study identified patterns of self-reported musculoskeletal pain among emerging adults and assessed if there were differences in their lifestyle and psychological characteristics.

Methods

Data from survey responses from a large public university and a large medical university in the United States were used (n = 1,318). Self-reported pain location and intensity at five body regions were assessed, and latent class analysis identified classes separately for men and women. Mental health, physical activity, …


The Effects Of Stigma Against Hiv And Tuberculosis On Patient Mental Health And Healthcare-Seeking Behavior In Dharamshala, Isabel Powell 2023 SIT Study Abroad

The Effects Of Stigma Against Hiv And Tuberculosis On Patient Mental Health And Healthcare-Seeking Behavior In Dharamshala, Isabel Powell

Independent Study Project (ISP) Collection

HIV and tuberculosis are highly impactful diseases in India, causing severe morbidity, mortality, and suffering for millions. The stigmatization of these diseases unnecessarily exacerbates suffering for those afflicted and their families, compounding to the existing physical and emotional burden of diagnosis. Individual interviews with healthcare workers were conducted at Delek Hospital and the Tibetan Children’s Village in order to identify the existence and effects of stigma in the Tibetan refugee population in Dharamshala. Respondents reported an extremely high burden of tuberculosis in the community, complicated by the refugee status and unique infrastructural challenges of the population. The burden of HIV …


An Exploration Of The Social And Economic Factors That Influence The Mental Health Of Lgbtq College Students, Alexandria MH Fossum 2023 University of South Carolina - Columbia

An Exploration Of The Social And Economic Factors That Influence The Mental Health Of Lgbtq College Students, Alexandria Mh Fossum

Senior Theses

LGBTQ individuals face a much higher prevalence of psychiatric disorders and mental health issues than their heterosexual, cisgender counterparts. The added academic pressures of college introduce a unique set of challenges that LGBTQ students face. This thesis includes a review of academic literature and data examining the intersections between social isolation, institutional discrimination, and financial insecurity and the effects they have on the mental health outcomes of LGBTQ college students. The paper is accompanied by a documentary consisting of a set of interviews of LGBTQ college students, giving a more personal insight into the multitude of factors that affect their …


Efficacy Of A Relaxation Scenario In Virtual Reality For The Comorbid Symptoms Of Anxiety And Asthenia In A General Hospital Setting: A Pilot Comparative Randomized Open-Label Study, Taisiya А Lepilkina, Allan G Beniashvili, Roman A Cheremin, Natalya G Malyukova, Margarita A Morozova, Mikhail A Bogdanov, Denis S Burminsky, Sergei S Potanin, Svetlana V Rodkina, George E Rupchev, Margarita N Eip 2023 The Texas Medical Center Library

Efficacy Of A Relaxation Scenario In Virtual Reality For The Comorbid Symptoms Of Anxiety And Asthenia In A General Hospital Setting: A Pilot Comparative Randomized Open-Label Study, Taisiya А Lepilkina, Allan G Beniashvili, Roman A Cheremin, Natalya G Malyukova, Margarita A Morozova, Mikhail A Bogdanov, Denis S Burminsky, Sergei S Potanin, Svetlana V Rodkina, George E Rupchev, Margarita N Eip

Faculty, Staff and Student Publications

BACKGROUND: Patients in general hospitals often display concomitant signs of mental maladjustment: low mood, anxiety, apathy, asthenia, all of which can have a negative impact on the course of the underlying disease and the recovery process. One of the non-pharmacological approaches that has gained wider acceptance in medical practice in recent years is the use of procedures based on virtual reality.

AIM: Assess the efficacy of the new domestic, virtual reality application Flow as relates to symptoms of anxiety and asthenia in patients undergoing inpatient treatment.

METHODS: The study was open-label and had a comparison group; the patients were assigned …


Suicidality Among College Students From 2000 To 2022: Findings From The National College Health Assessment, Jackson Gieger, Khanh Bui Dr. 2023 Pepperdine University

Suicidality Among College Students From 2000 To 2022: Findings From The National College Health Assessment, Jackson Gieger, Khanh Bui Dr.

Seaver College Research And Scholarly Achievement Symposium

With suicide being the second leading cause of death for college students, research concerning suicidality is imperative. The National College Health Assessment (NCHA), conducted by the American College Health Association (ACHA) each spring and fall semester since 2000, asks questions regarding suicide ideation and suicide attempts. There have been three versions of NCHA: NCHA-I (spring 2000 - spring 2008), NCHA-II (fall 2008 - spring 2019), and NCHA-III (fall 2019 - present). The analysis of NCHA-I and NCHA-II was limited due to the wording of the questions being different in the fall and spring. This leads to difficulty in comparing data …


Physical Activity Among Adults With Psychiatric Illness In Karachi, Pakistan: A Survey Based Research, Aneeta JEVTANI, Erum PERVEEN, Mustafa UROOSA, Nazia ZEYA, Farkhanda EMAD, Fareeha KANWAL, Mahum AZHAAR, Faisal YAMIN 2023 Institute of Physical Medicine and Rehabilitation, Dow University of Health Sciences, Karachi, Pakistan

Physical Activity Among Adults With Psychiatric Illness In Karachi, Pakistan: A Survey Based Research, Aneeta Jevtani, Erum Perveen, Mustafa Uroosa, Nazia Zeya, Farkhanda Emad, Fareeha Kanwal, Mahum Azhaar, Faisal Yamin

Baltic Journal of Health and Physical Activity

Introduction: In Pakistan, psychological wellbeing is still considered a stigma and has limited resources to provide maximum care. Individuals with mental illness struggle with maintaining their sedentary behaviors and have poor wellbeing. The aim of the study is to investigate the physical activity among individuals with a psychiatric illness. Materials and Methods: A sample data of 144 outpatients, diagnosed with a psychiatric illness were collected from the Outpatient Department (OPD) of a public sector psychiatric set-up in Karachi, Pakistan. The participants were assessed with the International Physical Activity Questionnaire (IPAQ). Results: Females with a psychiatric illness were found to be …


Demographic And Psychosocial Factors Associated With Suicide Mortality Among Childbearing-Aged Individuals: A Case-Control Study, Katerina A. Furman, Amy Loree PhD, Lyuba Gavrilova BS, Leah Hecht PhD, Hsueh-Han Yeh, Frances Lynch, Brian Ahmedani, Rebecca Rossom, Anne Beck PhD, Yihe Daida PhD, Gregory Simon MD, Christine Lu PhD, Joslyn Westphal MPH, Ashii Owen-Smith PhD, Stephen Waring, Cathrine Frank MD 2023 Wayne State University

Demographic And Psychosocial Factors Associated With Suicide Mortality Among Childbearing-Aged Individuals: A Case-Control Study, Katerina A. Furman, Amy Loree Phd, Lyuba Gavrilova Bs, Leah Hecht Phd, Hsueh-Han Yeh, Frances Lynch, Brian Ahmedani, Rebecca Rossom, Anne Beck Phd, Yihe Daida Phd, Gregory Simon Md, Christine Lu Phd, Joslyn Westphal Mph, Ashii Owen-Smith Phd, Stephen Waring, Cathrine Frank Md

Medical Student Research Symposium

Objective: Examine pregnancy-related, demographic, psychosocial and healthcare utilization factors associated with suicide mortality among childbearing-aged women. Methods: Data from nine health care systems in the Mental Health Research Network were included. A case-control study design was used in which 290 childbearing-age women who died by suicide (cases) from 2000-2015 were matched with 2,900 childbearing-age women from the same healthcare system and enrolled during the same time period who did not die by suicide. Conditional logistic regression was used to analyze associations between patient characteristics and suicide. Results: Women who died by suicide were more likely to have mental health or …


Childhood-Onset Attention-Deficit/Hyperactivity Disorder Exacerbates Opioid Use Disorder Consequences: Mediation By Impulsive Phenotypes, Liam R. Browning, Ciara Cannoy, Tabitha E. H. Moses, Leslie H. Lundahl PhD, David M. Ledgerwood PhD, Mark K. Greenwald PhD 2023 Wayne State University

Childhood-Onset Attention-Deficit/Hyperactivity Disorder Exacerbates Opioid Use Disorder Consequences: Mediation By Impulsive Phenotypes, Liam R. Browning, Ciara Cannoy, Tabitha E. H. Moses, Leslie H. Lundahl Phd, David M. Ledgerwood Phd, Mark K. Greenwald Phd

Medical Student Research Symposium

Background: Attention deficit hyperactivity disorder (ADHD) is highly prevalent and associated with opioid use disorder (OUD). Yet, little is known about the mechanisms by which ADHD (which is a heterogeneous construct/diagnosis) might alter the trajectory of OUD outcomes.

Aim: This cross-sectional study examines relationships between childhood ADHD (inferred as predating substance use) and the extent to which the effects of ADHD on lifetime heroin-use consequences are mediated by foreshortened time perspective and drug-use impulsivity.

Methods: Individuals who report heroin use (N=214) were screened using the Assessment of Hyperactivity and Attention (AHA), Impulsive Relapse Questionnaire (IRQ), Stanford Time Perception Inventory (STPI), …


Anatomy Lab, Brian R. Smith 2023 Stanford University School of Medicine

Anatomy Lab, Brian R. Smith

Journal of Wellness

No abstract provided.


Secondary Traumatic Stress: Therapists' Past Trauma And Workplace Intervention [Poster], Morgan A. Wickman 2023 University of Northern Iowa

Secondary Traumatic Stress: Therapists' Past Trauma And Workplace Intervention [Poster], Morgan A. Wickman

Research in the Capitol

  • Secondary traumatic stress (STS): type of indirect trauma wherein listening to the traumatic experiences of another causes causes a stress reaction and can lead to PTSD-like symptoms (6, 18, 13).
  • Secondary traumatic stress affects mental health professionals at high rates because they have higher rates of exposure to traumatic content (1, 2, 6, 20).
  • The current study analyzes the impact of personal history of trauma on the therapist and how the workplace environment impacts STS to identify ways to reduce the severity and frequency of STS occurring in therapists.


Stress And Stress Coping Strategies Among Foreign Bachelor’S Medical Interns In Bangkok Metropolitan Administration (Bma) Hospitals, Prakasit Wannapaschaiyong, Kraiwuth Kallawicha 2023 Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

Stress And Stress Coping Strategies Among Foreign Bachelor’S Medical Interns In Bangkok Metropolitan Administration (Bma) Hospitals, Prakasit Wannapaschaiyong, Kraiwuth Kallawicha

Journal of Health Research

Background– Stress among medical personnel is crucial, as it can cause the adverse health outcome to individuals who suffer from the stress as well as their clinical practice performance, which may cause serious outcomes to patients. This study focuses on the interns who received their medical degree overseas because they may have more stress due to their required clinical work and license examination. We conducted our study to determine the stress level, coping strategies, and associated factors among foreign bachelor’s medical interns in Bangkok, Thailand.

Method – A cross-sectional study design was conducted among 49 interns from Bangkok Metropolitan …


Interventions To Modify Psychological Well-Being: Progress, Promises, And An Agenda For Future Research, Laura D. Kubzansky, Eric S. Kim, Julia K. Boehm, Richard J. Davidson, Jeffrey C. Huffman, Eric B. Loucks, Sonja Lyubomirsky, Rosalind W. Picard, Stephen M. Schueller, Claudia Trudel-Fitzgerald, Tyler J. VanderWeele, Katey Warran, David S. Yeager, Charlotte S. Yeh, Judith T. Moskowitz 2023 Harvard T. H. Chan School of Public Health

Interventions To Modify Psychological Well-Being: Progress, Promises, And An Agenda For Future Research, Laura D. Kubzansky, Eric S. Kim, Julia K. Boehm, Richard J. Davidson, Jeffrey C. Huffman, Eric B. Loucks, Sonja Lyubomirsky, Rosalind W. Picard, Stephen M. Schueller, Claudia Trudel-Fitzgerald, Tyler J. Vanderweele, Katey Warran, David S. Yeager, Charlotte S. Yeh, Judith T. Moskowitz

Psychology Faculty Articles and Research

Psychological well-being, characterized by feelings, cognitions, and strategies that are associated with positive functioning (including hedonic and eudaimonic well-being), has been linked with better physical health and greater longevity. Importantly, psychological well-being can be strengthened with interventions, providing a strategy for improving population health. But are the effects of well-being interventions meaningful, durable, and scalable enough to improve health at a population-level? To assess this possibility, a cross-disciplinary group of scholars convened to review current knowledge and develop a research agenda. Here we summarize and build on the key insights from this convening, which were: (1) existing interventions should continue …


Mental Health And Psychosocial Interventions Integrating Sexual And Reproductive Rights And Health, And Hiv Care And Prevention For Adolescents And Young People (10–24 Years) In Sub-Saharan Africa: A Systematic Scoping Review, Otsetswe Musindo, Sheharbano Jafry, Joseph Nyamiobo, Kimberly D. Becker, Resham Gellatly, Caitlin Maloy, Alvaro Lozano-Ruiz, Borja Romero-Gonzalez, Zul Merali, Manasi Kumar 2023 Vrije University, Netherlands

Mental Health And Psychosocial Interventions Integrating Sexual And Reproductive Rights And Health, And Hiv Care And Prevention For Adolescents And Young People (10–24 Years) In Sub-Saharan Africa: A Systematic Scoping Review, Otsetswe Musindo, Sheharbano Jafry, Joseph Nyamiobo, Kimberly D. Becker, Resham Gellatly, Caitlin Maloy, Alvaro Lozano-Ruiz, Borja Romero-Gonzalez, Zul Merali, Manasi Kumar

Brain and Mind Institute

Background: Interventions targeting combined sexual and reproductive health, Human Immunodeficiency Virus (HIV) management and mental health care in sub-Saharan Africa (SSA) are few. There is a need to address common determinants of poor mental, psychosocial and sexual and reproductive health and rights (SRHR) through multimodal and multipronged interventions for adolescents. The main objective of this study was to identify whether and how interventions targeting adolescent SRHR and HIV with a focus on pregnant and parenting adolescents in SSA include mental health components and how these components and their outcomes have been reported in the literature.

Methods: We carried …


Electrophysiological Normative Responses To Emotional, Neutral, And Cigarette-Related Images, Francesco Versace, Nicola Sambuco, Menton M Deweese, Paul M Cinciripini 2023 The Texas Medical Center Library

Electrophysiological Normative Responses To Emotional, Neutral, And Cigarette-Related Images, Francesco Versace, Nicola Sambuco, Menton M Deweese, Paul M Cinciripini

Faculty, Staff and Student Publications

To create reproducible emotional probes, affective scientists rely on sets of standardized pictures that are normed using subjective ratings of valence and emotional arousal. However, when emotional responses are investigated using neurophysiological measures, it might be more appropriate to select pictures integrating information from normative subjective reports and normative neurophysiological responses. Here, we provide electrophysiological normative responses for 323 emotional pictures (215 from the IAPS) covering a wide range of categories (erotica, romantic, appetizing foods, landscapes, people engaged in mundane activities, household objects, disgusting objects, accidents, sad people, violence, mutilations, and cigarette-related contents). Event-related potentials (ERPs) and subjective ratings of …


Brain Ageing In Schizophrenia: Evidence From 26 International Cohorts Via The Enigma Schizophrenia Consortium, Constantinos Constantinides, Laura K M Han, Clara Alloza, Linda Antonella Antonucci, Celso Arango, Rosa Ayesa-Arriola, Nerisa Banaj, Alessandro Bertolino, Stefan Borgwardt, Jason Bruggemann, Juan Bustillo, Oleg Bykhovski, Vince Calhoun, Vaughan Carr, Stanley Catts, Young-Chul Chung, Benedicto Crespo-Facorro, Covadonga M Díaz-Caneja, Gary Donohoe, Stefan Du Plessis, Jesse Edmond, Stefan Ehrlich, Robin Emsley, Lisa T Eyler, Paola Fuentes-Claramonte, Foivos Georgiadis, Melissa Green, Amalia Guerrero-Pedraza, Minji Ha, Tim Hahn, Frans A Henskens, Laurena Holleran, Stephanie Homan, Philipp Homan, Neda Jahanshad, Joost Janssen, Ellen Ji, Stefan Kaiser, Vasily Kaleda, Minah Kim, Woo-Sung Kim, Matthias Kirschner, Peter Kochunov, Yoo Bin Kwak, Jun Soo Kwon, Irina Lebedeva, Jingyu Liu, Patricia Mitchie, Stijn Michielse, David Mothersill, Bryan Mowry, Víctor Ortiz-García de la Foz, Christos Pantelis, Giulio Pergola, Fabrizio Piras, Edith Pomarol-Clotet, Adrian Preda, Yann Quidé, Paul E Rasser, Kelly Rootes-Murdy, Raymond Salvador, Marina Sangiuliano, Salvador Sarró, Ulrich Schall, André Schmidt, Rodney J Scott, Pierluigi Selvaggi, Kang Sim, Antonin Skoch, Gianfranco Spalletta, Filip Spaniel, Sophia I Thomopoulos, David Tomecek, Alexander S Tomyshev, Diana Tordesillas-Gutiérrez, Therese van Amelsvoort, Javier Vázquez-Bourgon, Daniela Vecchio, Aristotle Voineskos, Cynthia S Weickert, Thomas Weickert, Paul M Thompson, Lianne Schmaal, Theo G M van Erp, Jessica Turner, James H Cole, ENIGMA Schizophrenia Consortium, Danai Dima, Esther Walton 2023 The Texas Medical Center Library

Brain Ageing In Schizophrenia: Evidence From 26 International Cohorts Via The Enigma Schizophrenia Consortium, Constantinos Constantinides, Laura K M Han, Clara Alloza, Linda Antonella Antonucci, Celso Arango, Rosa Ayesa-Arriola, Nerisa Banaj, Alessandro Bertolino, Stefan Borgwardt, Jason Bruggemann, Juan Bustillo, Oleg Bykhovski, Vince Calhoun, Vaughan Carr, Stanley Catts, Young-Chul Chung, Benedicto Crespo-Facorro, Covadonga M Díaz-Caneja, Gary Donohoe, Stefan Du Plessis, Jesse Edmond, Stefan Ehrlich, Robin Emsley, Lisa T Eyler, Paola Fuentes-Claramonte, Foivos Georgiadis, Melissa Green, Amalia Guerrero-Pedraza, Minji Ha, Tim Hahn, Frans A Henskens, Laurena Holleran, Stephanie Homan, Philipp Homan, Neda Jahanshad, Joost Janssen, Ellen Ji, Stefan Kaiser, Vasily Kaleda, Minah Kim, Woo-Sung Kim, Matthias Kirschner, Peter Kochunov, Yoo Bin Kwak, Jun Soo Kwon, Irina Lebedeva, Jingyu Liu, Patricia Mitchie, Stijn Michielse, David Mothersill, Bryan Mowry, Víctor Ortiz-García De La Foz, Christos Pantelis, Giulio Pergola, Fabrizio Piras, Edith Pomarol-Clotet, Adrian Preda, Yann Quidé, Paul E Rasser, Kelly Rootes-Murdy, Raymond Salvador, Marina Sangiuliano, Salvador Sarró, Ulrich Schall, André Schmidt, Rodney J Scott, Pierluigi Selvaggi, Kang Sim, Antonin Skoch, Gianfranco Spalletta, Filip Spaniel, Sophia I Thomopoulos, David Tomecek, Alexander S Tomyshev, Diana Tordesillas-Gutiérrez, Therese Van Amelsvoort, Javier Vázquez-Bourgon, Daniela Vecchio, Aristotle Voineskos, Cynthia S Weickert, Thomas Weickert, Paul M Thompson, Lianne Schmaal, Theo G M Van Erp, Jessica Turner, James H Cole, Enigma Schizophrenia Consortium, Danai Dima, Esther Walton

Faculty, Staff and Students Publications

Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and premature mortality. We investigated evidence for advanced brain ageing in adult SZ patients, and whether this was associated with clinical characteristics in a prospective meta-analytic study conducted by the ENIGMA Schizophrenia Working Group. The study included data from 26 cohorts worldwide, with a total of 2803 SZ patients (mean age 34.2 years; range 18–72 years; 67% male) and 2598 healthy controls (mean age 33.8 years, range 18–73 years, 55% male). Brain-predicted age was individually estimated using a model trained on independent data based on …


In Vivo White Matter Microstructure In Adolescents With Early-Onset Psychosis: A Multi-Site Mega-Analysis, Claudia Barth, Sinead Kelly, Stener Nerland, Neda Jahanshad, Clara Alloza, Sonia Ambrogi, Ole A Andreassen, Dimitrios Andreou, Celso Arango, Inmaculada Baeza, Nerisa Banaj, Carrie E Bearden, Michael Berk, Hannes Bohman, Josefina Castro-Fornieles, Yann Chye, Benedicto Crespo-Facorro, Elena de la Serna, Covadonga M Díaz-Caneja, Tiril P Gurholt, Catherine E Hegarty, Anthony James, Joost Janssen, Cecilie Johannessen, Erik G Jönsson, Katherine H Karlsgodt, Peter Kochunov, Noemi G Lois, Mathias Lundberg, Anne M Myhre, Saül Pascual-Diaz, Fabrizio Piras, Runar E Smelror, Gianfranco Spalletta, Therese S Stokkan, Gisela Sugranyes, Chao Suo, Sophia I Thomopoulos, Diana Tordesillas-Gutiérrez, Daniela Vecchio, Kirsten Wedervang-Resell, Laura A Wortinger, Paul M Thompson, Ingrid Agartz 2023 The Texas Medical Center Library

In Vivo White Matter Microstructure In Adolescents With Early-Onset Psychosis: A Multi-Site Mega-Analysis, Claudia Barth, Sinead Kelly, Stener Nerland, Neda Jahanshad, Clara Alloza, Sonia Ambrogi, Ole A Andreassen, Dimitrios Andreou, Celso Arango, Inmaculada Baeza, Nerisa Banaj, Carrie E Bearden, Michael Berk, Hannes Bohman, Josefina Castro-Fornieles, Yann Chye, Benedicto Crespo-Facorro, Elena De La Serna, Covadonga M Díaz-Caneja, Tiril P Gurholt, Catherine E Hegarty, Anthony James, Joost Janssen, Cecilie Johannessen, Erik G Jönsson, Katherine H Karlsgodt, Peter Kochunov, Noemi G Lois, Mathias Lundberg, Anne M Myhre, Saül Pascual-Diaz, Fabrizio Piras, Runar E Smelror, Gianfranco Spalletta, Therese S Stokkan, Gisela Sugranyes, Chao Suo, Sophia I Thomopoulos, Diana Tordesillas-Gutiérrez, Daniela Vecchio, Kirsten Wedervang-Resell, Laura A Wortinger, Paul M Thompson, Ingrid Agartz

Faculty, Staff and Students Publications

Emerging evidence suggests brain white matter alterations in adolescents with early-onset psychosis (EOP; age of onset <18 >years). However, as neuroimaging methods vary and sample sizes are modest, results remain inconclusive. Using harmonized data processing protocols and a mega-analytic approach, we compared white matter microstructure in EOP and healthy controls using diffusion tensor imaging (DTI). Our sample included 321 adolescents with EOP (median age = 16.6 years, interquartile range (IQR) = 2.14, 46.4% females) and 265 adolescent healthy controls (median age = 16.2 years, IQR = 2.43, 57.7% females) pooled from nine sites. All sites extracted mean fractional anisotropy (FA), mean …


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