Validation Of A Novel Heritable Rodent Model Of Drug Abuse Vulnerability In Psychosis And Investigation Of Therapeutic Targets, Loren D. Peeters

Electronic Theses and Dissertations

Schizophrenia is a severe neuropsychiatric disorder of largely unknown etiology that is often accompanied by high rates of cigarette smoking, reduced quit success, and high relapse rates. Dysregulated dopamine signaling and aberrant synaptic plasticity in the mesocorticolimbic pathway are implicated in the pathophysiology of schizophrenia and conferred substance abuse disorder and relapse vulnerability. Genetic factors are presumed to play a significant role in the development of schizophrenia, with a 40-50% concordance rate for monozygotic twins, although genetic markers are inconsistent. As such, epigenetic factors have instead been implicated. Specifically, there is strong evidence to suggest DNA methylation at several candidate …

Molecular Mechanisms Of Opioid Use Disorder In Human Brain Models, Emily Mendez

Dissertations and Theses (Open Access)

Opioid use disorder (OUD) is a national and global public health crisis with no end in sight. While studies from animal models hint at widespread epigenetic and transcriptomic alterations of opioid drugs, the molecular consequences of long-term exposure to opioid drugs in human brain is still unclear, and human-centered translational models are necessary to discern the human cell type-specific effects of OUD.

Using postmortem brain Brodmann area 9 (BA9) from the UTHealth Brain Collection for Research on Psychiatric Disorders, I identified angiogenic gene networks perturbed in the RNA and protein of OUD subjects, as well as downregulation of many neuron-correlated …

Comparing Ait And Eft In Reduction Of Negative Emotions Associated With A Past Memory: A Randomized Control Study, Gregory Brown, Kavita Batra, Emily Dorin, Raveena Bakhru, Andrew Han, Arianna Palermini, Robert Sottile, Sherine Khanbijian

Psychiatry & Behavioral Health Faculty Research

PURPOSE: To assess whether Quick AIT was statistically equivalent to Basic Recipe Clinical EFT for the reduction of negative emotion associated with a past event.

Examining The Relationship Between Deafness And Mental Health Status: An Analysis Of The Behavioral Risk Factor Surveillance System (Brfss) 2022, Brianna Stroud-Williams

Capstone Experience: Master of Public Health

Objective: The objective of the research is to examine the association between mental health status as measured by number of mentally healthy days in the past month and deafness and binge drinking.

Methods: The Behavioral Risk Factor Surveillance System (BRFSS) study was conducted via telephone survey in 50 states, including the District of Columbia and US territories. The sample size is 402,156 participants. Univariate, bivariate, and multivariate regressions, odds ratio, and 95% confidence interval were used to measure the data.

Results: Deaf respondents have 1.56 times the odds of having poor mental health than those who are not deaf. (95% …

Examining The Effects Of A Week-Long Social Media Abstinence Intervention, Iweek, On General Well-Being, Mental Health, And Body Image Concerns In Latina College Students, Roberto Sagaribay

Open Access Theses & Dissertations

Latina college students, on average, spend approximately 30 hours per week on social media, highlighting the pervasive influence of social media on their lives. While social media can facilitate interpersonal relationships, its impact on mental and physical health is evident in the literature. Problematic social media use has been associated with increased rates of depression, anxiety, and decreased life satisfaction. Additionally, exposure to idealized images on social media platforms often leads to lower body satisfaction, particularly among women. Social media may also influence eating behaviors through the abundance of food advertisements and contribute to sedentary behavior, as individuals spend significant …

Implementation And Effectiveness Of Stress Management Strategies Among Stem Students At The University Of Nebraska-Lincoln, Dylan Hiser

Honors Program: Senior Projects (Public)

High-stakes exams often induce significant stress among STEM (Science, Technology, Engineering, and Math) students, impacting their academic performance and overall well-being. As the opportunity for careers in STEM grows rapidly, understanding the stressors that students face remains critical in mitigating the effects of this stress and ensuring the success of these students. The objective of this study is to determine how well STEM students respond to recommended interventions that mitigate exam stress and to identify trends in these students’ exam scores. To accomplish this, a set of surveys was sent to undergraduate STEM students at the University of Nebraska-Lincoln. The …

"My Longest Relationship Is With Food": Exploring Eating Related Behaviors Throughout The Gender Identity Journey Of Transgender Males, Angeles Polett Coss

Dissertations

This study sought to explore how transgender adult males have navigated the development of their eating behaviors throughout their gender identity trajectory. While recent research has focused on gender identity development and protective factors of the transgender community, this study explored and examined elements regarding the eating related behaviors of transgender males. Interviews were conducted with six participants within the United States during semi structured virtual sessions; the age range of participants was 19 to 35. Results of this research revealed identity management, Sociopolitical discourse, identity management and inter-relational identity affirmations as inter-multicultural segments that connected with eating related behaviors …

Single Case Experimental Design Examining Cognitive Behavioural Therapy For Post-Stroke Depression, Liam Alexander Mackenzie Myles, Emma Jones

Journal of Mind and Medical Sciences

Background. Post-stroke depression (PSD) is common in older-age adults and is typically treated with cognitive-behavioural therapy (CBT). However, research has ascertained mixed findings regarding the efficacy of CBT for PSD in older-age adults, with limited evidence in people from global majority backgrounds. Materials and Methods. This case study used single case experimental design methodology to examine the effectiveness of CBT for PSD in a black, older-age man. The effects of health conditions, cohort beliefs, transitions in role investments, socio-cultural context and early experiences on the client’s thoughts, emotions, physical sensations and behaviours were formulated, before behavioural activation was used to …

Selective Serotonin Reuptake Inhibitors And Pharmacological Resetting Of The Mind, Ion G. Motofei, David L. Rowland

Journal of Mind and Medical Sciences

Mental activity is capable of processing analytical data (mathematics, physics, socio-political science, philosophy, etc.) similar to computer software. At the same time, mental activity largely depends on the brain, which works like a hard component of a computer. While the computer stores data on a physical medium, mental activity and data are supported by physiological mechanisms that are constantly operating (both in wakefulness and sleep). For this reason, the lack of brain oxygenation even for short periods of time (5-10 minutes) causes the loss of all data, including the disappearance of the individual's existence as a mental entity. This means …

Medication Assisted Therapy And First Episode Psychosis: Evaluating Treatment And Readmission Rates, Kayla Sherea Williams Bsn, Rn, Hannah Lee Brenner Bsn, Rn, Madison Makenzie Yount Bsn, Rn, Jacqueline Sharp Dnp, Aprn, Pmhp-Bc

Doctor of Nursing Practice Projects

Background The Centers for Disease Control and Prevention (CDC) found that each day more than 140 U.S. residents die from drug overdoses, specifically due to opioids. Due to this, alternatives were created to reduce overdoses and ensure safety. Medication assistance therapy (MAT) is an effective form of treatment for people with substance use disorders and is defined as the use of medication in conjunction with counseling or therapy for the treatment of substance use disorders. The efficacy of MAT is used adjunctively with psychotropic medications compared to using no MAT and using psychotropic medications alone with individuals who are experiencing …

Nurse Suicide: Examining Depression And Anxiety In Critical Care Settings, Arianna Bernardine Barata

Nursing | Student Research Posters

Nurses play a critical role in healthcare, yet the demanding work environment often exposes them to stressors, leading to the development of depression and anxiety. According to the National Library of Medicine (NLM) (2021), 50.8% of nurses have stress, 74% have anxiety, 70.8% have depression, and 79.1% have at least one of them. Burnout, understaffing, COVID fatigue, alarm fatigue, patient ratios, and disrupted sleep patterns are some of the stressors nurses contend with in every shift. While some nurses may cope and overcome these challenges, many face more severe issues, such as suicide. Nurse suicide is an issue that has …

Incorporation Of Mindfulness Application Use In Doctoral Nurse Anesthesia Curricula For Mitigation Of Stress And Anxiety In Student Registered Nurse Anesthetists, Kerrie Rodgers

Doctor of Nursing Practice Scholarly Projects

The nurse anesthesia specialty is highly stressful, with educational training being no exception. High didactic demands and intensive clinical experiences are placed on student registered nurse anesthetists (SRNAs), increasing stress and anxiety in their personal and professional lives. High levels of psychological distress can lead to inadvertent consequences in students’ mental, emotional, and physical health and can contribute to illness, burnout, substance use, and compromise in patient safety. Some degree of stress is necessary for motivation to succeed and perform at high levels, and encountering stress while enrolled in a doctoral nurse anesthesia program is expected and unavoidable. A search …

Asylum Architecture: The Brick-By-Brick Development Of Patient Treatment, Kris D. Sass

The Purdue Historian

The following research and analysis will investigate the intersection of architecture and treatment in asylums with a specific interest on the time period of the late 19^th century to mid-20^th century in the United States. Not only were specific environmental demands key to some treatment methodologies, such as rural environments to moral therapy, but the architecture of mental hospitals were integral parts of patient’s experiences. Here three specific hospital designs will be analyzed: the Kirkbride Plan, the Cottage Plan, and Kiyoshi Izumi’s Socio-Petal. The following analysis will be built on a series of blueprints, building notes, secondary histories, …

The Media’S Influence On Disordered Eating And Body Dysmorphia In Males And Females, Alexis Kotanidis, Jamie Vitrano

Molloy Multidisciplinary Undergraduate Research Conference

The media typically refers to various means of communication that reach or influence people widely. This includes television, radio, newspapers, magazines, social media platforms, websites, podcasts, and more. Essentially, it has many ways through which information is transmitted to a large audience. The media plays a significant role in shaping public opinion, especially with regard to disordered eating and body dysmorphia in both men and women. Disordered eating refers to a wide range of irregular eating behaviors that may or may not meet the criteria for a specific eating disorder diagnosis such as anorexia nervosa, bulimia nervosa, or binge-eating disorder. …

Maltreatment And Resilience: Examining The Unique Roles Of Threat And Deprivation, Priscilla Herrera

Undergraduate Research Symposium Posters

Background and objectives: This study aimed to investigate the involvement that maltreatment type, specifically threat and deprivation, play in a child’s life. We examine how threat uniquely contributes to resilience and how deprivation impacts resilience. Literature has highlighted differences in the effects of deprivation and threat in recent research that shows the impact on various neurological systems.

Methods and approach: Participants included youth aged 11-17 years in the Department of Family Services (DFS) custody following removal from their home after substantiated child maltreatment and were assessed. 90 of the youth in the sample reported that they have experienced threat-based maltreatment, …

Burnout In Optometry.....How Do We Compare?, Jeffrey L. Weaver Od, Mba

Optometric Clinical Practice

Letter to the Editor

Nursing Care Of Individuals Engaging In Non-Suicidal Self-Injury: Impact Of Dialectical Behavior Therapy Skills Reinforcement, Lucas Bridgens

MSN Capstone Projects

As explained by Linehan et al. (2006b), the seriousness of borderline personality disorder can be highlighted by the manifestations of emotional dysregulation, such as impulsive and suicidal and non-suicidal self-injurious (NSSI) behaviors. As the mental health field grows, so too does the knowledge base from which practitioners derive therapeutic interventions with hopes of effectively and safely treating patients while maintaining a culture of dignity and respect. One such treatment modality that has proven to reduce NSSI and improve interpersonal functioning, specifically in patients with borderline personality disorder, is Dialectical Behavior Therapy (DBT) which is a form of cognitive-behavioral therapy developed …

Predicting Hospitalization Risk Of Schizophrenia Patients In Missouri, Arun Kumar

Theses

Understanding the factors that contribute to the risk of hospitalization among individuals with schizophrenia is crucial for optimizing treatment strategies and improving patient outcomes. In this study, we used recent Medicaid adminis trative claims data in Missouri (from 2016 to 2019) and predicted the risk of hospitalization of patients diagnosed with Schizophrenia (N=143446). We ana lyzed the association between previous hospitalizations and the likelihood of future hospitalizations. We developed machine learning techniques, including logistic re gression and decision tree classifiers, to predict the risk of hospitalization based on demographic factors, clinical variables, and historical hospitalization records. Our findings reveal that …

Implementing Universal Adult Depression Screening In A Rural Maine Free Medical Clinic, Karen Hussion

Doctor of Nursing Practice Scholarly Projects

Abstract

BACKGROUND: Depression in adults is a leading cause of disability, morbidity and mortality worldwide with an estimated prevalence of 20% in the US population. Despite estimates that one out of every five Americans suffers from depression, less than 50% of adult primary care patients with depression are identified, and less than 5% of all adult primary care patients are screened. To increase early detection and management of depression, the United States Protective Service Task Force (USPSTF) recommends routine depression screening for adults older than 18 years in primary care settings.

LOCAL PROBLEM: This project site was a rural, free, …

Nurse Anesthetists’ Perceptions And Experiences Of Managing Emergence Delirium: A Qualitative Study, Yi Xin, Fu-Cai Lin, Chen Huang, Bin He, Ya-Ling Yan, Shuo Wang, Guang-Ming Zhang, Rui Li

Faculty, Staff and Student Publications

BACKGROUND: This study employs a descriptive phenomenological approach to investigate the challenges anesthesia nurses face in managing emergence delirium (ED), a common and complex postoperative complication in the post-anesthesia care unit. The role of nurses in managing ED is critical, yet research on their understanding and management strategies for ED is lacking.

AIM: To investigate anesthetic nurses' cognition and management experiences of ED in hopes of developing a standardized management protocol.

METHODS: This study employed a descriptive phenomenological approach from qualitative research methodologies. Purposeful sampling was utilized to select 12 anesthetic nurses from a tertiary hospital in Shanghai as research …