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La Salud Es Importante: Libro De Actividades (80-Pages), Your Very Favorite, Children's Health, Lorraine Sheldon, May Bressler 2024 Children's Health

La Salud Es Importante: Libro De Actividades (80-Pages), Your Very Favorite, Children's Health, Lorraine Sheldon, May Bressler

Spanish

Health Matters! is a Spanish-language health literacy resource designed for pediatric patients and their families. Written at an approximately 6th-grade reading level, it supports patient education through engaging coloring and activity pages.

The content covers a wide range of health and wellness topics, including body systems, nutrition, mental wellness, patient safety, and social-emotional skills such as building friendships and navigating conversations when returning to school. Developed for use in both hospital settings and the broader community, the resource promotes learning through interactive, age-appropriate activities.

This printable PDF version contains the complete collection of activities and comprises 80 pages. The resource …


Negara Hukum Kesejahteraan Di Batas Pantai: Paradoks Perlindungan Negara Terhadap Masyarakat Pesisir Di Tengah Perubahan Iklim, Aji Baskoro 2024 Universitas Gadjah Mada, Indonesia

Negara Hukum Kesejahteraan Di Batas Pantai: Paradoks Perlindungan Negara Terhadap Masyarakat Pesisir Di Tengah Perubahan Iklim, Aji Baskoro

Jurnal Ilmu Kesejahteraan Sosial

Climate change poses significant challenges to vulnerable coastal communities in Indonesia. As a welfare state, the Indonesian government is expected to safeguard these vulnerable groups through policies that promote their welfare and sustainable livelihoods. However, current policies create a paradox. This article explores this paradox: on the one hand, Indonesia adheres to the welfare state principle, which demands that all government actions be grounded in law, ensuring public safety and welfare. On the other hand, the policies focus on exploiting natural resources, exacerbating the vulnerabilities of coastal communities, particularly in the face of climate change. The article employs a normative …


Residency Reflections, Naleen Patel MD 2024 University of Kansas Medical Center

Residency Reflections, Naleen Patel Md

Journal of Wellness

No abstract provided.


The Role Of Nutrition In Modulating Neurodevelopmental And Mental Health Outcomes In Pediatric Populations: A Review, Athul M. Vikas 2024 University of South Carolina

The Role Of Nutrition In Modulating Neurodevelopmental And Mental Health Outcomes In Pediatric Populations: A Review, Athul M. Vikas

Senior Theses

Introduction: Neurodevelopmental and mental health disorders, including Attention-Deficit/Hyperactivity Disorder (ADHD), anxiety, and depression, have risen sharply in prevalence among children and adolescents, creating substantial public health concerns. Traditional interventions, primarily pharmacological and behavioral, offer critical but limited support, underscoring the need for integrated approaches. Recent findings suggest that nutrition may play a significant role in supporting brain development and mitigating mental health risks, offering preventive benefits that complement conventional therapies. This review aims to evaluate the influence of specific nutrients—such as folate, iron, DHA, zinc, and vitamin B12—on neurodevelopmental outcomes, emphasizing the importance of these nutrients during critical growth …


Efficacy Of, And Barriers To, Treatment Options For Pans/Pandas, Kayla E. Pray 2024 University of South Carolina

Efficacy Of, And Barriers To, Treatment Options For Pans/Pandas, Kayla E. Pray

Senior Theses

Background: PANS/PANDAS are pediatric autoimmune disorders that cause an acute-onset of OCD-like symptoms and/or severe restricted eating, as well as anxiety, irritation, deterioration of fine motor skills, hyperactivity, and other psychiatric symptoms. An estimated 1-2% of the pediatric population is affected. Currently, there is little research published on the treatment options for PANS/PANDAS and there is no evidence-based consensus on the best treatment option.

Purpose: This study aimed to discover the efficacy of, and barriers to, available treatment options for PANS/PANDAS.

Methods: A convenience sample of individuals diagnosed with PANS/PANDAS or their parent/caregiver was recruited anonymously through Facebook support groups. …


Clonal Hematopoiesis Of Indeterminate Potential Is Associated With Reduced Risk Of Cognitive Impairment In Patients With Chronic Kidney Disease, Cissy Xiao, Manjula Kurella Tamura, Yang Pan, Varun Rao, Celestin Missikpode, Caitlyn Vlasschaert, Tetsushi Nakao, Xiao Sun, Changwei Li, Zhijie Huang, Amanda Anderson, Md Mesbah Uddin, Do-Kyun Kim, Jonathan Taliercio, Rajat Deo, Zeenat Bhat, Dawei Xie, Panduranga Rao, Jing Chen, James P Lash, Jiang He, Pradeep Natarajan, James E Hixson, Kristine Yaffe, Tanika N Kelly, CRIC Study Investigators 2024 The Texas Medical Center Library

Clonal Hematopoiesis Of Indeterminate Potential Is Associated With Reduced Risk Of Cognitive Impairment In Patients With Chronic Kidney Disease, Cissy Xiao, Manjula Kurella Tamura, Yang Pan, Varun Rao, Celestin Missikpode, Caitlyn Vlasschaert, Tetsushi Nakao, Xiao Sun, Changwei Li, Zhijie Huang, Amanda Anderson, Md Mesbah Uddin, Do-Kyun Kim, Jonathan Taliercio, Rajat Deo, Zeenat Bhat, Dawei Xie, Panduranga Rao, Jing Chen, James P Lash, Jiang He, Pradeep Natarajan, James E Hixson, Kristine Yaffe, Tanika N Kelly, Cric Study Investigators

Faculty, Staff and Student Publications

Introduction: Clonal hematopoiesis of indeterminate potential (CHIP) and dementia disproportionately burden patients with chronic kidney disease (CKD). The association between CHIP and cognitive impairment in CKD patients is unknown.

Methods: We conducted time-to-event analyses in up to 1452 older adults with CKD from the Chronic Renal Insufficiency Cohort who underwent CHIP gene sequencing. Cognition was assessed using four validated tests in up to 6 years mean follow-up time. Incident cognitive impairment was defined as a test score one standard deviation below the baseline mean.

Results: Compared to non-carriers, CHIP carriers were markedly less likely to experience impairment in attention (adjusted …


Hippocampal Gray Matter Volume In Young Adulthood Varies With Adolescent Alcohol Use, Juliann B Purcell, Nathaniel G Harnett, Sylvie Mrug, Marc N Elliott, Susan Tortolero Emery, Mark A Schuster, David C Knight 2024 The Texas Medical Center Library

Hippocampal Gray Matter Volume In Young Adulthood Varies With Adolescent Alcohol Use, Juliann B Purcell, Nathaniel G Harnett, Sylvie Mrug, Marc N Elliott, Susan Tortolero Emery, Mark A Schuster, David C Knight

Faculty, Staff and Student Publications

Adolescent substance use is linked with negative future outcomes (e.g., depression, anxiety, substance use disorder). Given that the brain undergoes significant maturation during adolescence, this developmental period may represent a time of particular vulnerability to substance use. Neuroimaging research has largely focused on heavy or binge patterns of substance use; thus, relatively less is known about the neural impact of a broader range of adolescent substance use. Characterizing the neural impact of a broader range of adolescent substance use may inform prevention and treatment efforts. The present study investigated relationships between adolescent substance use trajectories (i.e., alcohol, tobacco, and cannabis) …


Measuring Anxiety Among Latino Immigrant Populations: Within-Country And Between-Country Comparisons, Sumeyra Sahbaz, Ronald B Cox, Pablo Montero-Zamora, Christopher P Salas-Wright, Mildred M Maldonado-Molina, Melissa M Bates, Augusto Pérez-Gómez, Juliana Mejía-Trujillo, Saskia R Vos, Carolina Scaramutti, Patrizia A Perazzo, Maria Duque, Maria Fernanda Garcia, Eric C Brown, Seth J Schwartz 2024 The Texas Medical Center Library

Measuring Anxiety Among Latino Immigrant Populations: Within-Country And Between-Country Comparisons, Sumeyra Sahbaz, Ronald B Cox, Pablo Montero-Zamora, Christopher P Salas-Wright, Mildred M Maldonado-Molina, Melissa M Bates, Augusto Pérez-Gómez, Juliana Mejía-Trujillo, Saskia R Vos, Carolina Scaramutti, Patrizia A Perazzo, Maria Duque, Maria Fernanda Garcia, Eric C Brown, Seth J Schwartz

Faculty, Staff and Student Publications

Anxiety is the most prevalent mental health disorder among adults worldwide. Given its increased prevalence among migrants due to their marginalized position in the societies where they reside, psychometric evaluations of anxiety measures such as the Generalized Anxiety Disorder-7 (GAD-7) are needed for use with migrants. The present study is the first attempt to compare the structure of GAD-7 scores for (a) different Latino groups in the same country and (b) the same Latino group in two different countries. Using three samples of Mexican and Venezuelan migrants (total N = 933), we provide reliability and validity evidence of the GAD-7 …


Physical Activity And Sedentary Time Among Us Adolescents Before And During Covid-19: Findings From A Large Cohort Study, Ethan T Hunt, Keith Brazendale, Augusto C F De Moraes, Raja Malkani, Natalia I Heredia, Christopher D Pfledderer, Denver M Brown, Deanna M Hoelscher, Michael W Beets, Robert G Weaver 2024 The Texas Medical Center Library

Physical Activity And Sedentary Time Among Us Adolescents Before And During Covid-19: Findings From A Large Cohort Study, Ethan T Hunt, Keith Brazendale, Augusto C F De Moraes, Raja Malkani, Natalia I Heredia, Christopher D Pfledderer, Denver M Brown, Deanna M Hoelscher, Michael W Beets, Robert G Weaver

Faculty, Staff and Student Publications

INTRODUCTION: Evidence suggests that adolescents engage in less physical activity during the summer break. Less is known regarding physical activity during the summer months of the COVID-19 pandemic.

METHODS: Utilizing data from the Adolescent Brain Cognitive Development study, the authors examined daily activity measured by Fitbit Charge 2 devices before and after the onset of the COVID-19 pandemic during school and summer months. Linear models estimated activity during pre-COVID-19 school, pre-COVID-19 summer, COVID-19 school, and COVID-19 summer.

RESULTS: Participants (N=7,179, aged 11.96 years, 51% female, 51% White) accumulated 8,671.0 (95% CI=8,544.7; 8,797.3) steps, 32.5 (95% CI=30.8, 32.3) minutes of moderate-to-vigorous …


The Role Of The Basolateral Nuclear Complex & Central Nucleus Of The Amygdala In Fear-Conditioned Responses To External Stimuli And Anxiety Responses, Oluwaseyi A. Adelakun 2024 University of South Carolina

The Role Of The Basolateral Nuclear Complex & Central Nucleus Of The Amygdala In Fear-Conditioned Responses To External Stimuli And Anxiety Responses, Oluwaseyi A. Adelakun

Senior Theses

This thesis reviews the role of the amygdala, particularly the basolateral nuclear complex (BLA) and central nucleus (CeA), in fear-conditioned responses and generalized anxiety disorder (GAD). By investigating the neurological and physiological mechanisms that influence the amygdala’s fear and anxiety responses, further connections can be made between this region and other notable brain regions, like the prefrontal cortex (PFC). We review both human and rodent models to explore the overlap between the two and explore various therapeutic interventions that regulate amygdalar activity and therefore mitigate anxiety symptoms. Key research into the patient SM, who lacks fear responses due to bilateral …


Law Library Blog (October 2024): Legal Beagle's Blog Archive, Roger Williams University School of Law 2024 Roger Williams University

Law Library Blog (October 2024): Legal Beagle's Blog Archive, Roger Williams University School Of Law

Law Library Newsletters/Blog

No abstract provided.


Does Job Satisfaction Take A Hit? The Relationships Between Employee Cannabis Use, Job Satisfaction, And Absenteeism, Caroline Jordan Moughan 2024 Old Dominion University

Does Job Satisfaction Take A Hit? The Relationships Between Employee Cannabis Use, Job Satisfaction, And Absenteeism, Caroline Jordan Moughan

Psychology Theses & Dissertations

Despite the frequency of cannabis use, limited research has examined how employees’ cannabis use relates to job attitudes and behaviors. This study responds to calls to examine the effects of employee cannabis use on work-relevant outcomes by exploring how employee cannabis use relates to job satisfaction and voluntary absenteeism by analyzing a sample of 526 employed young adults from the most recent three waves of the National Longitudinal Survey of Youth (NLSY) Child and Young Adult Cohort. Through estimating cross-lagged panel models, this study clarifies the direction of relationships between employee cannabis use and job satisfaction, and how these relate …


Self-Identifying Minoritized Doctoral Students’ Experiences Of Epistemic Injustice In Counselor Education And Supervision, Francisca Rivas 2024 Old Dominion University

Self-Identifying Minoritized Doctoral Students’ Experiences Of Epistemic Injustice In Counselor Education And Supervision, Francisca Rivas

Counseling & Human Services Theses & Dissertations

The purpose of this qualitative study was to examine and understand how epistemic injustice (EI) is experienced by minoritized doctoral students in Counselor Education and Supervision programs. The primary researcher performed a phenomenological study examining the experiences of EI for minoritized CES students (n = 8). There were three female participants with an average age of 31, two male participants with an average age of 31, and three nonbinary/trans participants with the average age of 33. Five participants were BIPOC, one being an international student, and six participants were LGBTQPA+. Five participants held Ph.Ds. at time of their interview, having …


The Relationship Between Adverse Childhood Experiences, Symptom Severity, Negative Thinking, Comorbidity, And Treatment Response In Youth With Obsessive-Compulsive Disorder, Mariana Vazquez, Amanda Palo, McKenzie Schuyler, Brent J Small, Joseph F McGuire, Sabine Wilhelm, Wayne K Goodman, Daniel Geller, Eric A Storch 2024 The Texas Medical Center Library

The Relationship Between Adverse Childhood Experiences, Symptom Severity, Negative Thinking, Comorbidity, And Treatment Response In Youth With Obsessive-Compulsive Disorder, Mariana Vazquez, Amanda Palo, Mckenzie Schuyler, Brent J Small, Joseph F Mcguire, Sabine Wilhelm, Wayne K Goodman, Daniel Geller, Eric A Storch

Faculty, Staff and Students Publications

Although youth and adults with obsessive-compulsive disorder (OCD) endorse elevated incidence of exposure to traumatic life events during childhood, the existing literature on adverse childhood experiences (ACEs) and OCD is mixed and studies focusing on pediatric OCD are limited. The present study examines the relationship between ACEs and OCD onset, symptom severity, negative cognitive patterns, comorbidity, and cognitive-behavioral therapy (CBT) response in 142 children and adolescents with OCD. ACEs were ascertained from parent reports. Most parents reported child exposure to ACEs. Out of the parents who reported ACEs, 50% reported ACE exposure prior to OCD diagnosis and 50% reported ACE …


Fostering Physical Activity Motivation At Substance Use Disorder Treatment Facilities: A Qualitative Study Grounded In Self-Determination Theory, Sascha Thal, Chloe Graham, Nikos Ntoumanis, Bronwyn Myers, Stephen Bright, Jocelyn Jones, Eleanor Quested 2024 Edith Cowan University

Fostering Physical Activity Motivation At Substance Use Disorder Treatment Facilities: A Qualitative Study Grounded In Self-Determination Theory, Sascha Thal, Chloe Graham, Nikos Ntoumanis, Bronwyn Myers, Stephen Bright, Jocelyn Jones, Eleanor Quested

Research outputs 2022 to 2026

Background and aims: Studies have found inconclusive results for the effects of physical activity (PA) interventions on substance use, mental health, and physiological health of people experiencing substance use disorders (SUDs). To improve PA interventions for individuals with SUDs, a deeper understanding of the underlying motivational processes is imperative. This study employs self-determination theory as a framework to explore factors impacting PA motivation in SUD treatment contexts. Methods: A qualitative research design utilising semi-structured interviews explored the experiences and perspectives of five people with lived or living experience of SUD treatment and five stakeholders within SUD treatment facilities across Western …


Cumulative Radiation Exposure And Lifetime Cancer Risk In Patients With Tetralogy Of Fallot Requiring Early Intervention, Jeannette R Wong-Siegel, Andrew C Glatz, Courtney McCracken, Choonsik Lee, Cari M Kitahara, Lene H S Veiga, Yun Zhang, Bryan H Goldstein, Christopher J Petit, Athar M Qureshi, George T Nicholson, Mark A Law, Jeffery Meadows, Shabana Shahanavaz, Michael L O'Byrne, Sarosh P Batlivala, Joelle Pettus, Asaad Beshish, Christopher E Mascio, Jennifer C Romano, Kathyrn O Stack, Ivor Asztalos, Tacy E Downing, Jeffrey D Zampi 2024 The Texas Medical Center Library

Cumulative Radiation Exposure And Lifetime Cancer Risk In Patients With Tetralogy Of Fallot Requiring Early Intervention, Jeannette R Wong-Siegel, Andrew C Glatz, Courtney Mccracken, Choonsik Lee, Cari M Kitahara, Lene H S Veiga, Yun Zhang, Bryan H Goldstein, Christopher J Petit, Athar M Qureshi, George T Nicholson, Mark A Law, Jeffery Meadows, Shabana Shahanavaz, Michael L O'Byrne, Sarosh P Batlivala, Joelle Pettus, Asaad Beshish, Christopher E Mascio, Jennifer C Romano, Kathyrn O Stack, Ivor Asztalos, Tacy E Downing, Jeffrey D Zampi

Faculty, Staff and Students Publications

Background: Neonates with tetralogy of Fallot and symptomatic cyanosis (sTOF) require early intervention, utilizing either a staged repair (SR) or primary repair (PR) approach. They are exposed to several sources of low-dose ionizing radiation, which may contribute to increased cancer risk.

Objectives: The purpose of this study was to compare cumulative radiation exposure and associated lifetime attributable risk (LAR) of cancer between treatment strategies in sTOF.

Methods: Neonates with sTOF who underwent SR or PR from 2012 to 2017 were retrospectively reviewed from the Congenital Cardiac Research Collaborative. Radiation exposure from all radiologic studies prior to 18 months of age …


Dsm-5 Criterion-A-Based Trauma Types In Service Members And Veterans Seeking Treatment For Posttraumatic Stress Disorder, Natasha Benfer, Breanna Grunthal, Katherine A Dondanville, Stacey Young-McCaughan, Abby Blankenship, Chadi G Abdallah, Sudie E Back, Julianne Flanagan, Edna B Foa, Peter T Fox, John H Krystal, Brian P Marx, Donald D McGeary, Carmen P McLean, Kristi E Pruiksma, Patricia A Resick, John D Roache, Paulo Shiroma, Denise M Sloan, Daniel J Taylor, Jennifer Schuster Wachen, Argelio L López-Roca, Karin L Nicholson, Richard P Schobitz, Christian C Schrader, Allah-Fard M Sharrieff, Jeffrey S Yarvis, Jim Mintz, Terence M Keane, Alan L Peterson, Brett T Litz 2024 The Texas Medical Center Library

Dsm-5 Criterion-A-Based Trauma Types In Service Members And Veterans Seeking Treatment For Posttraumatic Stress Disorder, Natasha Benfer, Breanna Grunthal, Katherine A Dondanville, Stacey Young-Mccaughan, Abby Blankenship, Chadi G Abdallah, Sudie E Back, Julianne Flanagan, Edna B Foa, Peter T Fox, John H Krystal, Brian P Marx, Donald D Mcgeary, Carmen P Mclean, Kristi E Pruiksma, Patricia A Resick, John D Roache, Paulo Shiroma, Denise M Sloan, Daniel J Taylor, Jennifer Schuster Wachen, Argelio L López-Roca, Karin L Nicholson, Richard P Schobitz, Christian C Schrader, Allah-Fard M Sharrieff, Jeffrey S Yarvis, Jim Mintz, Terence M Keane, Alan L Peterson, Brett T Litz

Faculty, Staff and Students Publications

Objective: In posttraumatic stress disorder (PTSD), the assumption of the equipotentiality of traumas ignores potentially unique contexts and consequences of different traumas. Accordingly, Stein et al. (2012) developed a reliable typing scheme in which assessors categorized descriptions of traumatic events into six "types": life threat to self (LTS), life threat to other, aftermath of violence (AV), traumatic loss, moral injury by self (MIS), and moral injury by other (MIO). We extended this research by validating the typing scheme using participant endorsements of type, rather than assesor-based types. We examined the concordance of participant and assesor types, frequency, and validity …


Intimate Partner Violence-Related Brain Injury: Unmasking And Addressing The Gaps, Carrie Esopenko, Divya Jain, Shambhu Prasad Adhikari, Kristen Dams-O'Connor, Michael Ellis, Halina Lin Haag, Elizabeth S Hovenden, Finian Keleher, Inga K Koerte, Hannah M Lindsey, Amy D Marshall, Karen Mason, J Scott McNally, Deleene S Menefee, Tricia L Merkley, Emma N Read, Philine Rojcyk, Sandy R Shultz, Mujun Sun, Danielle Toccalino, Eve M Valera, Paul van Donkelaar, Cheryl Wellington, Elisabeth A Wilde 2024 The Texas Medical Center Library

Intimate Partner Violence-Related Brain Injury: Unmasking And Addressing The Gaps, Carrie Esopenko, Divya Jain, Shambhu Prasad Adhikari, Kristen Dams-O'Connor, Michael Ellis, Halina Lin Haag, Elizabeth S Hovenden, Finian Keleher, Inga K Koerte, Hannah M Lindsey, Amy D Marshall, Karen Mason, J Scott Mcnally, Deleene S Menefee, Tricia L Merkley, Emma N Read, Philine Rojcyk, Sandy R Shultz, Mujun Sun, Danielle Toccalino, Eve M Valera, Paul Van Donkelaar, Cheryl Wellington, Elisabeth A Wilde

Faculty, Staff and Students Publications

Intimate partner violence (IPV) is a significant, global public health concern. Women, individuals with historically underrepresented identities, and disabilities are at high risk for IPV and tend to experience severe injuries. There has been growing concern about the risk of exposure to IPV-related head trauma, resulting in IPV-related brain injury (IPV-BI), and its health consequences. Past work suggests that a significant proportion of women exposed to IPV experience IPV-BI, likely representing a distinct phenotype compared with BI of other etiologies. An IPV-BI often co-occurs with psychological trauma and mental health complaints, leading to unique issues related to identifying, prognosticating, and …


Disruption Of Neural Periodicity Predicts Clinical Response After Deep Brain Stimulation For Obsessive-Compulsive Disorder, Nicole R Provenza, Sandesh Reddy, Anthony K Allam, Sameer V Rajesh, Nabeel Diab, Gabriel Reyes, Rose M Caston, Kalman A Katlowitz, Ajay D Gandhi, Raphael A Bechtold, Huy Q Dang, Ricardo A Najera, Nisha Giridharan, Katherine E Kabotyanski, Faiza Momin, Mohammed Hasen, Garrett P Banks, Brian J Mickey, Brent M Kious, Ben Shofty, Benjamin Y Hayden, Jeffrey A Herron, Eric A Storch, Ankit B Patel, Wayne K Goodman, Sameer A Sheth 2024 The Texas Medical Center Library

Disruption Of Neural Periodicity Predicts Clinical Response After Deep Brain Stimulation For Obsessive-Compulsive Disorder, Nicole R Provenza, Sandesh Reddy, Anthony K Allam, Sameer V Rajesh, Nabeel Diab, Gabriel Reyes, Rose M Caston, Kalman A Katlowitz, Ajay D Gandhi, Raphael A Bechtold, Huy Q Dang, Ricardo A Najera, Nisha Giridharan, Katherine E Kabotyanski, Faiza Momin, Mohammed Hasen, Garrett P Banks, Brian J Mickey, Brent M Kious, Ben Shofty, Benjamin Y Hayden, Jeffrey A Herron, Eric A Storch, Ankit B Patel, Wayne K Goodman, Sameer A Sheth

Faculty, Staff and Students Publications

Recent advances in surgical neuromodulation have enabled chronic and continuous intracranial monitoring during everyday life. We used this opportunity to identify neural predictors of clinical state in 12 individuals with treatment-resistant obsessive-compulsive disorder (OCD) receiving deep brain stimulation (DBS) therapy ( NCT05915741 ). We developed our neurobehavioral models based on continuous neural recordings in the region of the ventral striatum in an initial cohort of five patients and tested and validated them in a held-out cohort of seven additional patients. Before DBS activation, in the most symptomatic state, theta/alpha (9 Hz) power evidenced a prominent circadian pattern and a high …


Targeting Snai1-Mediated Colorectal Cancer Chemoresistance And Stemness By Sphingosine Kinase 2 Inhibition, Harinarayanan Janakiraman, Zachary Gao, Yun Zhu, Jiangling Dong, Scott A Becker, Alhaji Janneh, Besim Ogretmen, E Ramsay Camp 2024 The Texas Medical Center Library

Targeting Snai1-Mediated Colorectal Cancer Chemoresistance And Stemness By Sphingosine Kinase 2 Inhibition, Harinarayanan Janakiraman, Zachary Gao, Yun Zhu, Jiangling Dong, Scott A Becker, Alhaji Janneh, Besim Ogretmen, E Ramsay Camp

Faculty, Staff and Students Publications

BACKGROUND: Epithelial-to-mesenchymal transition (EMT), cancer stem cells (CSCs), and colorectal cancer (CRC) therapy resistance are closely associated. Prior reports have demonstrated that sphingosine-1-phosphate (S1P) supports stem cells and maintains the CSC phenotype. We hypothesized that the EMT inducer SNAI1 drives S1P signaling to amplify CSC self-renewal capacity and chemoresistance.

METHODS: CRC cell lines with or without ectopic expression of SNAI1 were used to study the role of S1P signaling as mediators of cancer stemness and 5-fluorouracil (5FU) chemoresistance. The therapeutic ability of sphingosine kinase 2 (SPHK2) was assessed using siRNA and ABC294640, a SPHK2 inhibitor. CSCs were isolated from patient-derived …


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