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Full-Text Articles in Social Psychology
Decreases In The Frontal Cortical Areas Following A Developmental Disruption Model Of Schizophrenia, Anna Healy
Decreases In The Frontal Cortical Areas Following A Developmental Disruption Model Of Schizophrenia, Anna Healy
Honors Program Theses and Projects
Methylazoxmethanol Acetate (MAM) is a toxin that temporarily blocks mitosis in developing embryonic brains. Exposure in rats on embryonic day 17 (E17) selectively targets frontal and hippocampal regions of the brain and produces behavioral and anatomical effects strikingly similar to those seen in human patients with schizophrenia. While previous studies examining these induced neuroanatomical disruptions support E17 MAM exposure as an animal model of schizophrenia, the vast majority focused on male rats. However, there have been a dearth of studies specifically looking at female rats in this model. This is significant since there is evidence of sex differences in the …