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Characterizing Resting Cerebral Blood Flow In Obsessive-Compulsive Disorder With Arterial Spin Labeling, Hannah R. Wild
Characterizing Resting Cerebral Blood Flow In Obsessive-Compulsive Disorder With Arterial Spin Labeling, Hannah R. Wild
Theses and Dissertations--Psychology
Obsessive-compulsive disorder (OCD) is a condition characterized by intrusive thoughts (obsessions) and ritualistic behaviors (compulsions) profoundly impacting daily functioning and quality of life. Neuroimaging studies using various techniques have revealed inconsistent resting cerebral blood flow (rCBF) patterns in OCD patients, particularly within the cortico-striatal-thalamo-cortical (CSTC) circuit and sensorimotor network. Arterial Spin Labeling (ASL) MRI offers a promising, noninvasive method for directly measuring rCBF. This study, using data from the Yale HCP Trio study, analyzed unmedicated OCD patients and healthy controls, who underwent two consecutive resting pulsed-ASL scans. OCD patients with lower obsessional severity exhibited higher perfusion in the pre- and …