Social and Behavioral Sciences Commons^™

A Comparison Of Methods To Harmonize Cortical Thickness Measurements Across Scanners And Sites, Delin Sun, Gopalkumar Rakesh, Courtney C. Haswell, Mark Logue, C. Lexi Baird, Erin N. O'Learly, Andrew S. Cotton, Hong Xie, Marijo Tamburrino, Tian Chen, Emily L. Dennis, Neda Jahanshad, Lauren Salminen, Sophia I. Thomopoulos, Faisal Rashid, Christopher R.K. Ching, Saskia B.J. Koch, Jessie L. Frijling, Laura Nawijn, Mirjam Van Zuiden, Xi Zhu, Benjamin Suarez-Jimenez, Anika Sierk, Henrik Walter, Antje Manthey, Jennifer S. Stevens, Negar Fani, Sanne J.H. Van Rooij, Murray Stein, Jessica A. Bomyea, Inga K. Koerte, Kyle Choi, Steven J.A. Van Der Werff, Robert R.J.M. Vermeiren, Julia Herzog, Lauren A. M. Lebois, Justin T. Baker, Elizabeth A. Olson, Thomas Straube, Mayuresh S. Korgaonkar, Elpiniki Andrew, Ye Zhu, Gen Li, Jonathan Ipser, Anna R. Hudson, Matthew Peverill, Kelly Sambrook, Evan Gordon, Lee A. Baugh, Gina L. Forster, Raluca M. Simons, Jeffrey S. Simons, Vincent A. Magnotta, Adi Maron-Katz, Stefan Du Plessis, Seth Disner, Nicholas Davenport, Daniel W. Grupe, Jack B. Nitschke, Terri A. Deroon-Cassini, Jacklynn M. Fitzgerald, John H. Krystal, Ifat Levy, Miranda Olff, Dick J. Veltman, Li Wang, Yuval Neria, Michael D. De Bellis, Tanja Jovanovic, Judith K. Daniels, Martha E. Shenton, Nic J.A. Van De Wee, Christian Schmahl, Milissa L. Kaufman, Isabelle M. Rosso, Scott R. Sponheim, David Hofmann, Richard A. Bryant, Kelene A. Fercho, Dan J. Stein, Sven C. Mueller, Bobak Hosseini, K. Luan Phan, Katie A. Mclaughlin, Richard J. Davidson, Christine L. Larson, Geoffrey May, Steven M. Nelson, Chadi G. Abdallah, Hassaan Gomaa, Amit Etkin, Soraya Seedat, Ilan Harpaz-Rotem, Israel Liberzon, Theo G.M. Van Erp, Yann Quidé, Xin Wang, Paul M. Thompson, Rajendra A. Morey

Psychology Faculty Research and Publications

Results of neuroimaging datasets aggregated from multiple sites may be biased by site-specific profiles in participants’ demographic and clinical characteristics, as well as MRI acquisition protocols and scanning platforms. We compared the impact of four different harmonization methods on results obtained from analyses of cortical thickness data: (1) linear mixed-effects model (LME) that models site-specific random intercepts (LMEINT), (2) LME that models both site-specific random intercepts and age-related random slopes (LMEINT+SLP), (3) ComBat, and (4) ComBat with a generalized additive model (ComBat-GAM). Our test case for comparing harmonization methods was cortical thickness data aggregated from 29 sites, which included 1,340 …

A Cluster Analytic Approach To Examining The Role Of Cortisol In The Development Of Post-Traumatic Stress And Dysphoria In Adult Traumatic Injury Survivors, Devi Jayan, Terri A Deroon-Cassini, Garrett Sauber, Cecilia J. Hillard, Jacklynn M. Fitzgerald

Psychology Faculty Research and Publications

Identification of specific risk factors for posttraumatic stress disorder (PTSD) versus depression after trauma has been challenging, in part due to the high comorbidity of these disorders. As exposure to trauma triggers activation of the hypothalamic-pituitary-adrenal (HPA)-axis, examining atypical stress responses via HPA-axis hormones, namely cortisol, may help in the delineation of these disorders. Indeed, extant research demonstrates that, following stress, individuals with chronic PTSD exhibit hypocortisolism (e.g., lower cortisol response than controls), while those with chronic depression exhibit hypercortisolism (e.g., higher response than controls). Less is known about the role of cortisol and these seemingly disparate profiles immediately following …

Role Of Cortisol In The Development Of Post-Traumatic Stress And Dysphoria, Devi Jayan

Dissertations (1934 -)

Exposure to a traumatic event is a significant predictor for the development of posttraumatic stress disorder (PTSD) and depression. Identification of specific risk factors for PTSD and depression after trauma exposure has been challenging due to comorbid and heterogeneous presentations of these conditions. Pre-existing research demonstrates reduced cortisol response (hypocortisolism) in chronic PTSD and an exaggerated cortisol response (hypercortisolism) in depression. The current longitudinal study examined cortisol response following a traumatic injury as a potential biomarker for deciphering specific risk for PTSD, depression, and PTSD depression comorbidity. Saliva samples for cortisol assay (post-injury cortisol) were collected from 172 trauma survivors …

Acute White Matter Integrity Post-Trauma And Prospective Posttraumatic Stress Disorder Symptoms, Carissa N. Weis, Ashley A. Huggins, Tara A. Miskovich, Jacklynn M. Fitzgerald, Kenneth P. Bennett, Jessica L. Krukowski, E. Kate Webb, Terri A Deroon-Cassini, Christine L. Larson

Psychology Faculty Research and Publications

Background: Little is known about what distinguishes those who are resilient after trauma from those at risk for developing posttraumatic stress disorder (PTSD). Previous work indicates white matter integrity may be a useful biomarker in predicting PTSD. Research has shown changes in the integrity of three white matter tracts—the cingulum bundle, corpus callosum (CC), and uncinate fasciculus (UNC)—in the aftermath of trauma relate to PTSD symptoms. However, few have examined the predictive utility of white matter integrity in the acute aftermath of trauma to predict prospective PTSD symptom severity in a mixed traumatic injury sample.

Method: Thus, the current study …

Stability Of Hippocampal Subfield Volumes After Trauma And Relationship To Development Of Ptsd Symptoms, C. N. Weis, E. Kate Webb, Ashley A. Huggins, Maddy Kallenbach, Tara A. Miskovich, Jacklynn M. Fitzgerald, Kenneth P. Bennett, Jessica L. Krukowski, Terri A Deroon-Cassini, Christine L. Larson

Psychology Faculty Research and Publications

Background

The hippocampus plays a central role in post-traumatic stress disorder (PTSD) pathogenesis, and the majority of neuroimaging research on PTSD has studied the hippocampus in its entirety. Although extensive literature demonstrates changes in hippocampal volume are associated with PTSD, fewer studies have probed the relationship between symptoms and the hippocampus’ functionally and structurally distinct subfields. We utilized data from a longitudinal study examining post-trauma outcomes to determine whether hippocampal subfield volumes change post-trauma and whether specific subfields are significantly associated with, or prospectively related to, PTSD symptom severity. As a secondary aim, we leveraged our unique study design sample …

Towards Predicting Risky Behavior Among Veterans With Ptsd By Analyzing Gesture Patterns, Tanvir Roushan

Master's Theses (2009 -)

Risky behavior including violence and aggression, self-injury, anger outburst, domestic violence along with self-injury, sexual abuse, rule breaking, use of drugs and alcohol, suicide etc. are alarming issues among US military veterans who return from combat zone deployment in Iraq and Afghanistan. Veterans are exposed to trauma in war zones which affect most of them with posttraumatic stress disorder (PTSD) or other metal health problems to some degree. Studies have shown that veterans have much higher rates of PTSD than civilians and are more likely to engage in risky behavior. One of the form of displaying and engaging in risky …

Relations Of Discriminatory Experiences And Marianismo Beleifs With Ptsd Symptoms In Latinx Women, Claire Maria Bird

Master's Theses (2009 -)

Research examining the discriminatory experiences of Latinx women in minimal. The present study examined if various forms of discrimination predicted mental health symptoms in a sample of Latinx women, with the conceptualization of chronic discrimination as a possible form of trauma. There is evidence showing that Latinx individuals are at risk to develop posttraumatic stress disorder at higher rates than their non-Hispanic White counterparts, with many studies pointing to the experiences of racial/ethnic discrimination as a significant contributor (Kaczkurkin, Asnaani, Hall-Clark, Peterson, Yarvis, & Foa, 2016). Given the multiple forms of discrimination that women of color experience, ethnic discrimination, sexism, …

Battling On The Home Front: Posttraumatic Stress Disorder And Conflict Behavior Among Military Couples, Lynne M. Knobloch-Fedders, Catherine Caska-Walace, Timothy W. Smith, Keith Renshaw

Psychology Faculty Research and Publications

This study evaluated interpersonal behavior differences among male military service members with and without PTSD and their female partners. Couples (N = 64) completed a 17-minute videotaped conflict discussion, and their interaction behavior was coded using the circumplex-based Structural Analysis of Social Behavior model (SASB; Benjamin, 1979, 1987, 2000). Within couples, the behavior of partners was very similar. Compared to military couples without PTSD, couples with PTSD displayed more interpersonal hostility and control. Couples with PTSD also exhibited more sulking, blaming, and controlling behavior, and less affirming and connecting behavior, than couples without PTSD. Results advance our understanding of …

Mechanisms Of Regulation: Profiling The Impact Of Emotion Regulation On Posttraumatic Stress Symptoms, Samantha Ann Chesney

Master's Theses (2009 -)

Trauma survivors are at a high risk for developing symptoms of posttraumatic stress (PTS) and often experience difficulties with emotion regulation. However, there is no clear understanding of how multiple strategies may be used to effectively regulate PTS. The current study evaluates participants' use of six different strategies and investigates whether a specific profile of emotion regulation (i.e., the individual's default pattern of regulation, determined by the frequency with which s/he uses different strategies from a regulation inventory) is related to PTS. Results of a hierarchical cluster analysis indicated that four profiles of emotion regulation were present in the current …

Treatment Of Dual Diagnosis Post Traumatic Stress Disorder And Substance Use Disorders: A Meta-Analysis, Joshua Dolan

Dissertations (1934 -)

The dual diagnosis of post-traumatic stress disorder and substance use disorders affects a large number of people. Various treatments have been used for addressing these co-occurring disorders and have now been empirically tested. These treatments can be divided into two categories: sequential and integrated. The goal of this study was to meta-analytically examine the effectiveness of these treatments and compare these two categories of treatment. Secondary objectives included the exploration of potential moderator variables and the symptom interplay between the two disorders after treatment. The results of the study suggested that treatment for the dual diagnosis of posttraumatic stress disorder …

Long Term Effects Of Chronic Variable Stress Administered During Different Developmental Stages In Mice, Henry Boeh

Dissertations (1934 -)

A number of studies have suggested that the occurrence of past trauma can increase an individual's chance of developing PTSD from a new traumatic experience later in life. Trauma that occurs during childhood appears to have a particularly strong effect on this risk increase. Furthermore, conditioned fear responses have been shown to incubate over extended periods of time in animal models. To further investigate the role these phenomena play in the development of PTSD, this study exposed juvenile and adult mice to 7 days of chronic variable stress (CVS). One month later, a Pavlovian delay fear conditioning procedure was used …

Muscle Fatigue And Motor Output Variability With Acute Stress In Healthy Young Adults And Veterans With Posttraumatic Stress Disorder, Manda Linea Keller

Dissertations (1934 -)

Acute stress can alter motor performance differently for men and women. The first aim of this dissertation addresses possible causes for the sex difference in the motor response of a low-intensity fatiguing contraction of the elbow flexor muscles to an acute stressor (difficult mental math) in young, healthy adults. Muscle fatigue increased for men and women when exposed to the stressor, but impairment was more prominent for the women. This work showed that fatigue in the central nervous system, specifically in cortical motor and premotor areas, as well as relaxation rates of the muscle (quantified with cortical stimulation) were not …