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The Efficacy Of Hippocampal Stimulation In Preventing Depressive Symptoms, Timothy B. Patrick

ETD Archive

The hippocampus provides negative feedback for the Hypothalamic-Pituitary- Adrenal (HPA) axis. The HPA axis is responsible for producing a response to stressful stimuli. The hippocampus is sensitive to high levels of glucocorticoids (GCs), because of its large number of GC receptors. In times of severe stress, hippocampal function is inhibited and its control over the HPA axis is diminished, leading to hyperactivity of the adrenal glands as well as hypercortisolism, typical of depression. Long-term stress and depression can eventually lead to chronic impairments in cognitive ability, as well as structural damage in the hippocampus. Exercise and environmental enrichment stimulate significant …