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Assessment Of Neurotensin Receptor Agonist Effects On Fear-Potentiated Startle, Mark Aaron Vanden Avond

All NMU Master's Theses

Systemic administration of the NTS₁ receptor agonist PD149163 has exhibited anxiolytic effects in male rats. The present study sought to further evaluate the potential anxiolytic effects of PD149163 by assessing this compound in both male and female C57BL/J6 mice using the fear-potentiated startle (FPS) paradigm. Startle chambers were equipped with a shock-grid floor, fluorescent light, and an acoustic startle speaker. Conditioning took place between the light and floor shock, and test sessions measured startle to a 90 dB noise burst while the light was on (FPS) or off. Startle magnitude did not differ between the male and female mice. …