Social and Behavioral Sciences Commons^™

A Genome-Wide Association Study Discovers 46 Loci Of The Human Metabolome In The Hispanic Community Health Study/Study Of Latinos, Elena V Feofanova, Han Chen, Yulin Dai, Peilin Jia, Megan L Grove, Alanna C Morrison, Qibin Qi, Martha Daviglus, Jianwen Cai, Kari E North, Cathy C Laurie, Robert C Kaplan, Eric Boerwinkle, Bing Yu

Student and Faculty Publications

Variation in levels of the human metabolome reflect changes in homeostasis, providing a window into health and disease. The genetic impact on circulating metabolites in Hispanics, a population with high cardiometabolic disease burden, is largely unknown. We conducted genome-wide association analyses on 640 circulating metabolites in 3,926 Hispanic Community Health Study/Study of Latinos participants. The estimated heritability for 640 metabolites ranged between 0%-54% with a median at 2.5%. We discovered 46 variant-metabolite pairs (p value < 1.2 × 10

Direct Visualization And Characterization Of The Human Zona Incerta And Surrounding Structures, Jonathan C. Lau, Yiming Xiao, Roy A.M. Haast, Greydon Gilmore, Kâmil Uludağ, Keith W. Macdougall, Ravi S. Menon, Andrew G. Parrent, Terry M. Peters, Ali R. Khan

Brain and Mind Institute Researchers' Publications

The zona incerta (ZI) is a small gray matter region of the deep brain first identified in the 19th century, yet direct in vivo visualization and characterization has remained elusive. Noninvasive detection of the ZI and surrounding region could be critical to further our understanding of this widely connected but poorly understood deep brain region and could contribute to the development and optimization of neuromodulatory therapies. We demonstrate that high resolution (submillimetric) longitudinal (T1) relaxometry measurements at high magnetic field strength (7 T) can be used to delineate the ZI from surrounding white matter structures, specifically the fasciculus cerebellothalamicus, fields …

A Translational Investigation Of Reinforced Behavioral Variability: Implications For Promoting Behavioral Variability In Individuals With Autism Spectrum Disorder, Ann Galizio

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Behavioral variability is sometimes adaptive and can be maintained by the delivery of reinforcement. Individuals with autism spectrum disorder (ASD) often show restricted and repetitive behaviors. Therefore, interventions to promote behavioral variability in individuals with ASD are needed. The present line of research was designed to inform such interventions by investigating reinforced behavioral variability from basic, applied, and translational perspectives. Each of these laboratory studies involved participants making sequences of well-defined responses, which were compared to previous responses. Responses that meet a variability contingency (i.e., were sufficiently different from previous responses) produced rewards. Studies 1 and 2 were basic experiments, …

Chaprates, Brinly Xavier, Micole Amanda Marietta, Nidhi Vedantam

Student Scholar Symposium Abstracts and Posters

On the Chapman campus, through taking and choosing various classes, there is a significant need for communication and feedback between students and peers, professors, tutors, and study groups. With this, we wanted to create an application that enables users from various majors to not only easily and effectively communicate with various people in their field, but one that also enables them to give and receive feedback on various classes through a rating system. We believe that the application will aid students in a myriad of specific ways, including being involved in study groups and getting tutoring help, determining which classes …

Pushing Boundaries: Experimental Expressions - Unnatural (Part Two), Abigail Emens, Olivia Kelly, Sydney Kruise, Jillian Neumann, Kimberley Quinn, Meghan Reiman, Jacob Westbrook, Zoe Zaroff

Student Scholars Day Oral Presentations

Part Two - Unnatural

As a continuation of part one, we attempt to accentuate the growing disconnect from nature. In their obsession for perfection, humans have sought to replicate everything natural in a flawless and everlasting way. Not only have we produced fake plants and artificial flavoring, but we have also started manipulating ourselves to form a distorted version of the original. To show this, we are combining human elements with our synthetic products and framing our work in a way that you can clearly see the distortion. Nature is essential to human survival, yet we continue to become unnatural. …

Human Resources' Capacity To Drive Organizational Change In Ghana, Harriet Bani

Walden Dissertations and Doctoral Studies

Human Resource Management Departments (HRMDs) drive organizational change by implementing effective and efficient policies. This study explored staff perceptions in Ghana's Nursing and Midwifery Council (N&MC), a public-service institution, regarding the extent to which their HRMD could stimulate change by implementing the Human Resource Management Policy Framework and Manual (HRMPF&M). May and Finch's theory of normalization propelled this qualitative case study, which consisted of interviewing 23 purposively selected participants and examining secondary data from the N&MC, the Public Services Commission, HRMPF&M, other relevant legal documents, as well as relevant literature on the subject. The data analysis generated themes which were …

Spatiotemporal Partitioning Of Mammalian Mesopredators In Response To Drought And Urbanization In California's Central Valley, Chad W. Moura

Cal Poly Humboldt theses and projects

Mammalian mesopredators commonly associated with human dominated landscapes often exhibit generalist diets, behavioral plasticity, and relatively high reproductive rates. Because of this wide range of adaptive traits, ecologists have been speculative of what conditions may drive species to change their activity and behavior to avoid or mitigate against resource competition, intraguild predation, and human disturbance. I investigated a community of common mesopredators within the Sacramento Metropolitan Area of California’s Central Valley to address whether species are spatially and/or temporally partitioning due to a defacto apex predator, coyotes (Canis latrans), and humans alongside large landscape altering disturbances: urbanization and drought. I …

Coproid Predicts The Source Of Coprolites And Paleofeces Using Microbiome Composition And Host Dna Content, Maxime Borry, Bryan Cordova, Angela Perri, Marsha Wibowo, Tanvi Prasad Honap, Jada Ko, Kate Britton, Linus Girdland-Flink, Robert C. Power, Ingelise Stuijts, Domingo C. Salazar-García, Courtney Hofman, Richard Hagan, Thérèse Samdapawindé Kagoné, Nicolas Meda, Helene Carabin, David Jacobson, Karl Reinhard, Cecil Lewis, Aleksandar Kostic, Choongwon Jeong, Alexander Herbig, Alexander Hübner, Christina Warinner

Karl Reinhard Publications

Shotgun metagenomics applied to archaeological feces (paleofeces) can bring new insights into the composition and functions of human and animal gut microbiota from the past. However, paleofeces often undergo physical distortions in archaeological sediments, making their source species difficult to identify on the basis of fecal morphology or microscopic features alone. Here we present a reproducible and scalable pipeline using both host and microbial DNA to infer the host source of fecal material. We apply this pipeline to newly sequenced archaeological specimens and show that we are able to distinguish morphologically similar human and canine paleofeces, as well as non-fecal …