Social and Behavioral Sciences Commons^™

Predicting Change In Autism Symptomatology In Young Children At Risk For Autism Spectrum Disorder: Fragile X Syndrome, Down Syndrome And Non-Syndromic Asd, Kelly Elizabeth Caravella

Theses and Dissertations

This dissertation is comprised of two manuscripts which examine the longitudinal development of autism symptomatology in young children at risk for developing autism spectrum disorder (ASD); individuals with Fragile x syndrome (FXS) and Down syndrome (DS). The first study is a within group analysis of the longitudinal development of ASD symptomatology in young children with FXS, and how diagnostic stability, language and non-verbal cognitive functioning may predict these trajectories. This paper provides insight into ASD diagnostic stability patterns within FXS, and how symptoms change over time across these groups. The second paper will extend this work by presenting a pilot …

The Effects Of Autism Symptom Severity And Social Anxiety On Pragmatic Language In Young Adult Males With Fragile X Syndrome, Sara Mcgrath Matherly

Theses and Dissertations

Pragmatic, or social, language skills play a pivotal role in abilities that facilitate interpersonal relationships and independence, particularly in adulthood. Pragmatic language deficits are considered a core trait of males with fragile X syndrome (FXS); however, mechanisms that influence these abilities are not well known. This research is also limited by a lack of valid assessments that adequately capture pragmatic language skills. The present dissertation is the first to examine pragmatic language skills and mechanisms that influence these abilities using a novel, dynamic language assessment, the Yale in vivo Pragmatic Protocol (YiPP) in young adult males with FXS. Results revealed …

Infant Social Avoidance Predicts Autism But Not Anxiety In Fragile X Syndrome, Jane E. Roberts, Hayley Crawford, Elizabeth A. Will, Abigail L. Hogan, Samuel Dale Mcquillin, Bridgette L. Tonnsen, Shannon O'Connor, Douglas A. Roberts, Alexis M. Brewe

Faculty Publications

Objective: Autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and anxiety are three of the most common childhood psychiatric disorders. Early trajectories of social avoidance have been linked with these psychiatric disorders in previous studies, but it remains unclear how social avoidance differentially predicts comorbid disorders in a high-risk genetic subgroup. Here, we delineate the association between trajectories of social avoidance from infancy and subsequent ASD, ADHD, and anxiety outcomes at preschool in children with fragile X syndrome (FXS), a well-characterized single-gene disorder highly associated with social avoidance as well as elevated rates of ASD, ADHD, and anxiety.

Method: Males with …