Social and Behavioral Sciences Commons^™

Altered Emotional Interference Processing In The Amygdala And Insula In Women With Post-Traumatic Stress Disorder, Steven E. Bruce, Katherine R. Buchholz, Wilson J. Brown, Laura Yan

Steven Bruce

Background: Post-Traumatic Stress Disorder (PTSD) is characterized by distinct behavioral and physiological changes. Given the significant impairments related to PTSD, examination of the biological underpinnings is crucial to the development of theoretical models and improved treatments of PTSD. Methods: We used an attentional interference task using emotional distracters to test for top-down versus bottom-up dysfunction in the interaction of cognitive-control circuitry and emotion-processing circuitry. A total of 32 women with PTSD (based on an interpersonal trauma) and 21 matched controls were tested. Event-related functional magnetic resonance imaging was carried out as participants directly attended to, or attempted to ignore, fear-related …

Hiv Dna Reservoir Increases Risk For Cognitive Disorders In Cart-Nave Patients, Robert H. Paul, Victor G. Valcour, Jintanat Ananworanich, Melissa Agsalda

Robert Paul

Objectives Cognitive impairment remains frequent in HIV, despite combination antiretroviral therapy (cART). Leading theories implicate peripheral monocyte HIV DNA reservoirs as a mechanism for spread of the virus to the brain. These reservoirs remain present despite cART. The objective of this study was to determine if the level of HIV DNA in CD14+ enriched monocytes predicted cognitive impairment and brain injury. Methods We enrolled 61 cART-naïve HIV-infected Thais in a prospective study and measured HIV DNA in CD14+ enriched monocyte samples in a blinded fashion. We determined HAND diagnoses by consensus panel and all participants underwent magnetic resonance spectroscopy (MRS) …

Understanding Reported Cognitive Dysfunction In Older Adults With Cardiovascular Disease, Robert H. Paul, John Gunstad, Ronald A. Cohen, David F.

Robert Paul

High HIV-1 DNA (HIV DNA) levels in peripheral blood mononuclear cells (PBMC) correlate with HIV-1-associated dementia (HAD) in patients on highly active antiretroviral therapy (HAART). If this relationship also exists among HAART-naïve patients, then HIV DNA may be implicated in the pathogenesis of HAD. In this study, we evaluated the relationship between HIV DNA and cognition in subjects naïve to HAART in a neuro AIDS cohort in Bangkok, Thailand. Subjects with and without HAD were recruited and matched for age, gender, education, and CD4 cell count. PBMC and cellular subsets were analyzed for HIV DNA using real-time PCR. The median …

Application Of A Novel Quantitative Tractography Based Analysis Of Diffusion Tensor Imaging To Examine Fiber Bundle Length In Human Cerebral White Matter, Robert H. Paul, Laurie M. Baker, Ryan P. Cabeen, Sarah Cooley

Robert Paul

This paper reviews basic methods and recent applications of length-based fiber bundle analysis of cerebral white matter using diffusion magnetic resonance imaging (dMRI). Diffusion weighted imaging (DWI) is a dMRI technique that uses the random motion of water to probe tissue microstructure in the brain. Diffusion tensor imaging (DTI) is an extension of DWI that measures the magnitude and direction of water diffusion in cerebral white matter, using either voxel-based scalar metrics or tractography-based analyses. More recently, quantitative tractography based on diffusion tensor imaging (qtDTI) technology has been developed to help quantify aggregate structural anatomical properties of white matter fiber …

The Relationship Between Early Life Stress And Microstructural Integrity Of The Corpus Callosum In A Non-Clinical Population, Robert H. Paul, Lorrie Henry, Stuart M. Grieve, Thomas J. Guilmette

Robert Paul

Background: Previous studies have examined the impact of early life stress (ELS) on the gross morphometry of brain regions, including the corpus callosum. However, studies have not examined the relationship between ELS and the microstructural integrity of the brain. Previous studies have examined the impact of early life stress (ELS) on the gross morphometry of brain regions, including the corpus callosum. However, studies have not examined the relationship between ELS and the microstructural integrity of the brain. Methods: In the present study we evaluated this relationship in healthy non-clinical participants using diffusion tensor imaging (DTI) and self-reported history of ELS. …

Star: A Computerized Tutorial In General Psychology, Barbara S. Chaparro, Charles G. Halcomb

Barbara S. Chaparro

This study investigated the use of a computerized tutorial--Self-Test and Review (STAR)--in a computer-managed general psychology course. STAR consists of four major modules which provide the student with a variety of learning exercises, including practice quizzes, practice final exams, performance reviews, and structured study questions. The purpose of the study was to determine whether students would choose STAR as a study tool, the effect of lecture versus self-paced settings on the use of STAR, whether students who used STAR would perform better than those who did not, and the effect of the timing of feedback in STAR on performance. Students …

Increased Attention And Memory For Beloved-Related Information During Infatuation: Behavioral And Electrophysiological Data, Sandra J. E. Langeslag, Jamie R. Oliver, Martine E. Köhlen, Ilse M. Nijs

Sandra Langeslag

Emotionally salient information is well attended and remembered. It has been shown that infatuated individuals have increased attention for their beloved. It is unknown whether this attention bias generalizes to information related to the beloved. Moreover, infatuated individuals report to remember trivial things about their beloved, but this has not yet been tested empirically. In two studies, we tested whether infatuated individuals have increased attention and memory for beloved-related information. In a passive viewing task (Study 1), the late positive potential, an event-related potential (ERP) component reflecting motivated attention, was enhanced for beloved-related vs friend-related words/phrases. In a recognition task …

"How The Birth Control Pill Influences Women's Attitudes And Expectations Of Themselves.", Molly Santora

Molly Santora

Twila Wingrove.Jpg, Twila Wingrove

Dr. Twila Wingrove

No abstract provided.