Social and Behavioral Sciences | Open Access Articles

Different Radiolabelling Methods Alter The Pharmacokinetic And Biodistribution Properties Of Plasminogen Activator Inhibitor Type 2 (Pai-2) Forms, Marie Ranson, Paula Berghofer, Kara L. Vine, Ivan Greguric, Rachael Shepherd, Andrew Katsifis

Faculty of Science - Papers (Archive)

Introduction: Tumour-associated urokinase plasminogen activator (uPA) is a critical marker of invasion and metastasis, and it is recognised as having strong prognostic relevance as well as being a therapeutic target. The specific uPA inhibitor plasminogen activator inhibitor type-2 (PAI-2, SerpinB2) specifically targets cell bound uPA and is internalised. Furthermore, preclinical studies have established the “proof-of-principle” of uPA-targeting by PAI-2-cytotoxin conjugates in human carcinoma models. However, these studies also suggest that PAI-2 is rapidly cleared via the renal system with low total dose reaching the tumour. In this study, a comparative single photon emission computed tomography (SPECT) and biodistribution (BD) analysis …

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Effects Of Atmospheric Light Scattering On Spectroscopic Observations Of Greenhouse Gases From Space: Validation Of Ppdf-Based Co 2 Retrievals From Gosat, Sergey Oshchepkov, Andrey Bril, Tatsuya Yokota, Isamu Morino, Yukio Yoshida, Tsuneo Matsunaga, Dmitry Belikov, Debra Wunch, Paul Wennberg, Geoffrey Toon, Christopher O'Dell, André Butz, Sandrine Guerlet, Austin Cogan, Hartmut Boesch, Nawo Eguchi, Nicholas Deutscher, David Griffith, Ronald Macatangay, Justus Notholt, Ralf Sussmann, Markus Rettinger, Vanessa Sherlock, John Robinson, Esko Kyro, Pauli Heikkinen, Dietrich G. Feist, Tomoo Nagahama, Nikolay Kadygrov, Shamil Maksyutov, Osamu Uchino, Hiroshi Watanabe

Faculty of Science - Papers (Archive)

This report describes a validation study of Greenhouse gases Observing Satellite (GOSAT) data processing using ground-based measurements of the Total Carbon Column Observing Network (TCCON) as reference data for column-averaged dry air mole fractions of atmospheric carbon dioxide (X CO2). We applied the photon path length probability density function method to validate X CO2 retrievals from GOSAT data obtained during 22months starting from June 2009. This method permitted direct evaluation of optical path modifications due to atmospheric light scattering that would have a negligible impact on ground-based TCCON measurements but could significantly affect gas retrievals when observing reflected sunlight from …

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Synthesis And Anti-Leukaemic Activity Of Pyrrolo[3,2,1-Hi]Indole-1,2- Diones, Pyrrolo[3,2,1-Ij]Quinoline-1,2-Diones And Other Polycyclic Isatin Derivatives, Lidia Matesic, Julie M. Locke, Kara Vine, Marie Ranson, John B. Bremner, Danielle Skropeta

Faculty of Science - Papers (Archive)

To further expand the structure–cytotoxic activity relationships of isatin derivatives and to reduce flexibility in substituent groups at nitrogen, 20 analogues incorporating a ring system between the N1 and C7 atoms of isatin were prepared using a variety of synthetic strategies. This yielded pyrroloindole-, pyrroloquinoline-, pyrroloacridine-, pyrrolophenanthridine- and benzopyrrolophenanthridine-based systems with embedded isatin moieties, the latter possessing a novel carbon skeleton. These compounds were subsequently assessed for their in vitro cytotoxicity against human U937 lymphoma cells, with the brominated pyrroloacridine dione 27 showing the most promising activity (IC50 3.01 μM) after 24 h.

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Comparisons Of Observed And Modeled Oh And Ho 2 Concentrations During The Ambient Measurement Period Of The Hoxcomp Field Campaign, Y Kanaya, A Hofzumahaus, H-P Dorn, T Brauers, H Fuchs, F Holland, F Rohrer, B Bohn, R Tillmann, Rebekah Wegener, A Wahner, Y Kajii, K Miyamoto, S Nishida, K Watanabe, A Yoshino, Dagmar C. Kubistin, M Martinez, M Rudolf, H Harder, H Berresheim, T Elste, C Plass-Dulmer, G Stange, J Kleffmann, Y Elshorbany, U Schurath

Faculty of Science - Papers (Archive)

A photochemical box model constrained by ancillary observations was used to simulate OH and HO 2 concentrations for three days of ambient observations during the HOxComp field campaign held in Jülich, Germany in July 2005. Daytime OH levels observed by four instruments were fairly well reproduced to within 33% by a base model run (Regional Atmospheric Chemistry Mechanism with updated isoprene chemistry adapted from Master Chemical Mechanism ver. 3.1) with high R 2 values (0.72-0.97) over a range of isoprene (0.3-2 ppb) and NO (0.1-10 ppb) mixing ratios. Daytime HO 2(*) levels, reconstructed from the base model results taking into …

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Different Radiolabelling Methods Alter The Pharmacokinetic And Biodistribution Properties Of Plasminogen Activator Inhibitor Type 2 (Pai-2) Forms, Marie Ranson, Paula Berghofer, Kara L. Vine, Ivan Greguric, Rachael Shepherd, Andrew Katsifis

Faculty of Science - Papers (Archive)

Faculty of Science - Papers (Archive)

Synthesis And Anti-Leukaemic Activity Of Pyrrolo[3,2,1-Hi]Indole-1,2- Diones, Pyrrolo[3,2,1-Ij]Quinoline-1,2-Diones And Other Polycyclic Isatin Derivatives, Lidia Matesic, Julie M. Locke, Kara Vine, Marie Ranson, John B. Bremner, Danielle Skropeta

Faculty of Science - Papers (Archive)

Faculty of Science - Papers (Archive)