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Full-Text Articles in Social and Behavioral Sciences
Food Dependence In Rats Selectively Bred For Low Versus High Saccharin Intake. Implications For "Food Addiction"., Clinton Chapman, Nancy Dess, Veronica Yakovenko, Elizabeth Speidel
Food Dependence In Rats Selectively Bred For Low Versus High Saccharin Intake. Implications For "Food Addiction"., Clinton Chapman, Nancy Dess, Veronica Yakovenko, Elizabeth Speidel
Clinton D Chapman
The "food addiction" concept implies that proneness to drug dependence and to food dependence should covary. The latter was studied in low- (LoS) and high- (HiS) saccharin-consuming rats, who differ in drug self-administration (HiS > LoS) and withdrawal (LoS > HiS). Sugary food intake in the first 1–2 h was higher in HiS than LoS rats. Sugar intake predicted startle during abstinence only among LoS rats. These results may suggest bingeing-proneness in HiS rats and withdrawal-proneness among LoS rats. However, intake escalation and somatic withdrawal did not differ between lines. Further study with selectively bred rats, with attention to definitions and measures, …
Modulation Of Methylphenidate Effects On Wheel Running And Acoustic Startle By Acute Food Deprivation In Commercially And Selectively Bred Rats., Clinton Chapman, Nancy Dess, Ian Mclaughlin
Modulation Of Methylphenidate Effects On Wheel Running And Acoustic Startle By Acute Food Deprivation In Commercially And Selectively Bred Rats., Clinton Chapman, Nancy Dess, Ian Mclaughlin
Clinton D Chapman
Behavioral effects of the same dose of the same drug can vary in degree and direction between and within individuals. The present study examines behavioral base rates, feeding status, and dispositional differences as sources of inter- and intra-individual heterogeneity in drug response. Modulation of the effects of methylphenidate (MPD) on wheel running and acoustic startle by food deprivation was examined in three experiments. Freely fed or food deprived Harlan Sprague–Dawley rats (running study) or rats selectively bred for low (LoS) and high (HiS) saccharin intake (running and startle studies) were given MPD (10 mg/kg) or saline before testing. Overall drug …