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Full-Text Articles in Social and Behavioral Sciences
The Contribution Of Genes And Hormones To The Sexual Differention Of The Zebra Finch Song System, Jessica Bayley Thompson
The Contribution Of Genes And Hormones To The Sexual Differention Of The Zebra Finch Song System, Jessica Bayley Thompson
Wayne State University Theses
Recent studies in the zebra finch suggest the sexual differentiation of the song system and singing behavior may not be solely driven by steroid hormones organizing the brain, and may be genetically driven. In fact, genes and hormones might act together to produce sexual differentiation of the brain. To test this hypothesis, animals were implanted with a 1mm pellet containing 50ug of 17b-estradiol or a blank pellet on the third day post-hatching. At post-hatch day 25, the brains were collected and a double label fluorescence in situ hybridization protocol using biotin and digoxigenin-tagged mRNA probes was used to simultaneously label …
Comparison Of Affective Analgesia And Conditioned Place Preference Following Cholinergic Activation Of, Elena Schifirnet
Comparison Of Affective Analgesia And Conditioned Place Preference Following Cholinergic Activation Of, Elena Schifirnet
Wayne State University Dissertations
Activation of the dopaminergic mesolimbic reward circuitry that originates in the ventral tegmental area (VTA) is postulated to preferentially suppress affective reactions to noxious stimuli (affective analgesia, AA). VTA dopamine neurons are activated via cholinergic inputs, and we have observed that microinjections of the acetylcholine agonist carbachol suppressed vocalizations of rats that occur following administration of brief (1 sec) tail-shocks (vocalization afterdischarges = VAD). VADs are a validated rodent model of pain affect. In addition, the capacity of carbachol to support reinforcement appears to be regionally dependent within VTA. Ikemoto and Wise (2002) reported that carbachol was self-administered in the …