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Social and Behavioral Sciences Commons

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Full-Text Articles in Social and Behavioral Sciences

The Effects Of Early Postnatal Pcp Administration On Performance In Locomotor Activity, Reference Memory, And Working Memory Tasks In C57bl/6 Mice, Alan L. Pehrson Jan 2007

The Effects Of Early Postnatal Pcp Administration On Performance In Locomotor Activity, Reference Memory, And Working Memory Tasks In C57bl/6 Mice, Alan L. Pehrson

Theses and Dissertations

There is a growing consensus, based on several converging lines of evidence, which suggests schizophrenia is the product of a developmental insult occurring in the late 2 nd or early 3 rd trimester. Additionally, it has been observed that adults who abuse the noncompetitive NMDA antagonist PCP present with symptoms that mimic schizophrenia, such as hallucinations, formal thought disorder, delusions, unstable or flattened affect, social withdrawal, and impaired cognition. Thus, several labs have attempted to use early postnatal PCP administration in rodents as a drug model of schizophrenia. The current study investigated the cognitive effects of early postnatal PCP administration …


Assessing Phonology, Syntax & Working Memory Using Erp: Towards An Understanding Of The Underlying Cause Of Developmental Dyslexia, Courtney Patterson Jan 2007

Assessing Phonology, Syntax & Working Memory Using Erp: Towards An Understanding Of The Underlying Cause Of Developmental Dyslexia, Courtney Patterson

Theses and Dissertations (Comprehensive)

Event-related brain potentials (ERPs) were recorded from 20 children with dyslexia and controls matched on age, sex, nonverbal reasoning, and handedness (ages 8-12 years) as they listened to and read sentences that varied in syntactic complexity and the working memory load they induced [subject-subject (SS) and subject-object (SO) relative clause sentences]. In each modality, control children demonstrated amplitude differences between the brainwave potentials elicited to each sentence type. When listening, controls, and children with dyslexia did not differ in the N400 effect elicited in response to the relative verb of SO sentences, thus indicating auditory sentential processing occurred in a …