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Social and Behavioral Sciences Commons™
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Full-Text Articles in Social and Behavioral Sciences
Behavioral, Endocrine, And Neural Responses To Stress In Postpartum And Nulliparous Rats : Potential Mechanisms Of Postpartum Stress Resilience, Joanna Medina
Legacy Theses & Dissertations (2009 - 2024)
Major depressive disorder is one of the most pervasive psychiatric illnesses in the United States. Women are at greater risk for developing depression, particularly during their childbearing years. Approximately 17% of new mothers develop postpartum depression within 4 weeks after parturition. The risk for postpartum depression is even greater in women who do not breastfeed or stop breastfeeding early. Major depressive disorder and postpartum depression share the same symptomology and common etiological bases. Dysregulated stress responses, dopamine activity, and neuroinflammation are recognized mechanisms for depression. The transition to motherhood encompasses physiological and behavioral adaptations in the brain essential for ensuring …
Characterization Of A Novel, Stress-Responsive Sexually Dimorphic Corticotropin-Releasing Factor Receptor 1 (Crfr1) Nucleus In The Rostral Anteroventral Periventricular Nucleus Of The Mouse, Zachary Julius Rosinger
Characterization Of A Novel, Stress-Responsive Sexually Dimorphic Corticotropin-Releasing Factor Receptor 1 (Crfr1) Nucleus In The Rostral Anteroventral Periventricular Nucleus Of The Mouse, Zachary Julius Rosinger
Legacy Theses & Dissertations (2009 - 2024)
Within the United States, women are at double the risk of men to develop a stress-related mood disorder (e.g., anxiety or depression) during their reproductive years (Kornstein et al., 2000; Kessler et al., 2005). Many factors contribute to the potential sex difference in such disorders, including gonadal hormones (hypothalamic-pituitary-gonadal axis; HPG) and how they interact with the stress response system, or hypothalamic-pituitary-adrenal (HPA) axis. Corticotropin-releasing factor (CRF) signals through binding the GS-coupled receptor, CRF receptor 1 (CRFR1), and activity between CRF/CRFR1 regulates the hormonal and behavioral stress response (Chen et al., 1993; Bale and Vale, 2004; Heinrichs et al., 1995; …