Social and Behavioral Sciences Commons^™

Hippocampal Theta And Gamma: Effects Of Aging, Environmental Change, Cholinergic Activation And Learning, Matthew D. Howe

Honors Scholar Theses

During aging, hippocampal functioning is impaired; specifically aged humans and rats show reduced performance on spatial memory tasks. An age-related reduction in the neurotransmitter acetylcholine has been postulated to underlie this impairment. Rhythmic oscillations (theta, gamma) may serve to synchronize activity within the hippocampus and across the brain during learning; these may also change with aging.

To determine what aspects of oscillation are important for memory processing, the effects of aging, encountering a novel situation, learning a new task and cholinergic system activation (with physostigmine) were examined. Both age groups showed increased theta, but not gamma activity when encoding a …

A Randomized Controlled Trial Of The Efficacy And Cost-Effectiveness Of A Brief Intensified Cognitive Behavioral Therapy And/Or Pharmacotherapy For Mood And Anxiety Disorders: Design And Methods, Denise Meuldijk, Ingrid V. Carlier, Irene M. Van Vliet, M E. Van Den Akker-Van Marle, Frans G. Zitman

Faculty of Social Sciences - Papers (Archive)

Background: Anxiety and mood disorders involve a high disease burden and are associated with high economic costs. A stepped-care approach intervention and abbreviated diagnostic method are assumed to increase effectiveness and efficiency of the mental healthcare and are expected to reduce economic costs. Methods: Presented are the rationale, design, and methods of a two-armed randomized controlled trial comparing 'treatment as usual' (TAU) with a brief intensified cognitive behavioral therapy (CBT) and/or pharmacotherapy. Eligible participants (N =500) of five Dutch outpatient Mental Healthcare Centers are randomly assigned to either TAU or to the experimental condition (brief CBT and/or pharmacotherapy). Data on …