Social and Behavioral Sciences Commons^™

Tattoos Of Girls Under Pimp Control & Pimp Rules For The Control Of Victims, Donna M. Hughes Dr.

Donna M. Hughes

Application Layer End-To-End Arguments: From Ends To Means, And Beyond Network Neutrality, Matthias Bärwolff

Matthias Bärwolff

This paper observes that the ultimate objectives of the end-to-end arguments do not necessarily entail a preference for having functions with the end hosts rather than with the network. The horizontal connotations of the end-to-end metaphor collapse when it is elevated to an application layer argument featuring strong "second order" objectives such as those pursued by network neutrality adherents. An internet that serves those ends will have to allow for ISPs to tussle with end users over economic value and surplus considerations, and acknowledge the beneficial rôle of the resulting transactions between the internet’s stakeholders.

The Chaperone Action Of Clusterin And Its Putative Role In Quality Control Of Extracellular Protein Folding, Amy Wyatt, Justin Yerbury, Stephen Poon, Rebecca Dabbs, Mark Wilson

Mark R Wilson

The function(s) of clusterin may depend upon its topological location. A variety of intracellular "isoforms" of clusterin have been reported but further work is required to better define their identity. The secreted form of clusterin has a potent ability to inhibit both amorphous and amyloid protein aggregation. In the case of amorphous protein aggregation, clusterin forms stable, soluble high-molecular-weight complexes with misfolded client proteins. Clusterin expression is increased during many types of physiological and pathological stresses and is thought to function as an extracellular chaperone (EC). The pathology of a variety of serious human diseases is thought to arise as …