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Effects Of Medial Prefrontal Cortex Nmda Nr-1 Subunit Deletion In Adult Mice On Spatial Reference And Working Memory, Melissa Gorham, Dane Dewees

Scholars Week

Dysfunction of glutamate NMDA receptors may contribute to cognitive deficits in schizophrenia. In the present study, we examined the effects of chronic NMDA receptor dysfunction in the ventral medial prefrontal cortex (mPFC) on the acquisition of a spatial reference memory (SRM) and spatial working memory (SWM) radial maze task as employed by Niewoehner et al (2007). Localized NR1 gene deletions were induced in the ventral mPFC of floxed NR1 mice (DEL, n=10) using an AAV-Cre vector; control mice (CON, n=10) received sham deletions. In the SRM task, food was placed in 3 of 6 arms of an automated radial maze …