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Full-Text Articles in Social and Behavioral Sciences
The Effects Of Repeated Ketamine Administration During Adolescence On Anxiety And Depressive-Like Behaviors Induced By A Predator Odor, Shannon L. Haas
The Effects Of Repeated Ketamine Administration During Adolescence On Anxiety And Depressive-Like Behaviors Induced By A Predator Odor, Shannon L. Haas
Seton Hall University Dissertations and Theses (ETDs)
Disorders of anxiety and depression are major public health problems evident by their increasing prevalence and lack of effective treatments. These disorders are highly comorbid and share several debilitating symptoms. Previous research has implicated ketamine in the treatment of depression because of its rapid effects. Ketamine is a noncompetitive NMDA receptor antagonist that stimulates glutamate transmission. The efficacy of non-competitive NMDA receptor antagonists in anxiety treatment, however, lacks consistent findings. The goal of the present study was to examine the effects of repeated ketamine administration during rat adolescence on anxiety and depressive-like behaviors induced by a predator odor.
The use …