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Social and Behavioral Sciences Commons™
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Articles 1 - 3 of 3
Full-Text Articles in Social and Behavioral Sciences
Effects Of Repeated Nicotine Vapor Exposure And Withdrawal On Somatic Signs, Anxiety-Like Behavior, And Brain Reward Thresholds In Male Sprague Dawley Rats, Michelle Martinez
Effects Of Repeated Nicotine Vapor Exposure And Withdrawal On Somatic Signs, Anxiety-Like Behavior, And Brain Reward Thresholds In Male Sprague Dawley Rats, Michelle Martinez
Open Access Theses & Dissertations
No abstract provided.
Ketamine Pre-Exposure Does Not Influence Later-Life Responses To Reward-Related Stimuli In Female C57bl/6 Mice, Israel Garcia
Ketamine Pre-Exposure Does Not Influence Later-Life Responses To Reward-Related Stimuli In Female C57bl/6 Mice, Israel Garcia
Open Access Theses & Dissertations
Preclinical work indicates that exposure to traditional antidepressant medications, in adolescent and adult female subjects, alters reward-related behavior later in life. In recent years, the anesthetic ketamine (KET), now used as a fast-acting antidepressant, has shown promising therapeutic efficacy for the management of depression. However, the potential long-term behavioral consequences of KET exposure across development have not been thoroughly assessed. Thus, to address this issue, we examined if KET exposure, during adolescence or early adulthood, results in enduring alterations in responsivity to the rewarding properties of sucrose and cocaine later in life. Specifically, female C57BL/6 mice were randomly assigned to …
Fluoxetine Exposure Results In Decreased Sensitivity To Cocaine And Sucrose Later In Life: A Study In Female C57bl/6 Mice, Francisco Javier Flores Ramirez
Fluoxetine Exposure Results In Decreased Sensitivity To Cocaine And Sucrose Later In Life: A Study In Female C57bl/6 Mice, Francisco Javier Flores Ramirez
Open Access Theses & Dissertations
Preclinical evidence indicates that exposure to psychotropic medications, during early development, results in long-lasting altered responses to stress- and reward-related stimuli. However, these animal studies have been conducted, primarily, using male subjects. This is surprising, given that clinical data suggests that females have a higher likelihood, than their male counterparts, to be diagnosed with mood-related illnesses, and thus, be prescribed with psychotropic medications, mostly antidepressants. Therefore, to examine whether enduring reward-related alterations are exhibited as a result of antidepressant exposure, in female subjects specifically, we exposed C57BL/6 female mice to fluoxetine (FLX; 250 mg/l in their drinking water). Specifically, separate …