Social and Behavioral Sciences Commons^™

Markers Of Alcohol Use Disorder Outpatient Treatment Outcome: Prediction Modeling Of Day One Treatment, Geoffrey J. Schaubhut

Graduate College Dissertations and Theses

ABSTRACT

Background: Alcohol use disorders (AUD) affect health and wellbeing, and have broad societal costs (Bouchery, Harwood, Sacks, Simon, & Brewer, 2011; Rehm et al., 2009; Sudhinaraset, Wigglesworth, Takeuchi, & Tsuker, 2016). While treatments have existed for decades, they are limited in success and expensive to administer. As such, understanding which factors best predict who will benefit most from treatment remains a laudable goal. Prior attempts to predict factors associated with positive treatment outcome are limited by methodology including statistical methods that lead to poor predictive power in new samples. This study aims to use a data-driven approach to clarify …

A Randomized Trial To Compare Switching To Very Low Nicotine Content Cigarettes Versus Reducing Cigarettes Per Day, Elias Mushabac Klemperer

Graduate College Dissertations and Theses

Smoking cigarettes is the most preventable cause of death in the US. Smokers are often unsuccessful at quitting because they are dependent. Reducing nicotine could be one way to reduce dependence. Currently, reducing cigarettes per day (CPD) is the most common strategy to reduce nicotine intake. However, some have proposed switching to very low nicotine content (VLNC) cigarettes to reduce nicotine and dependence. Both reducing CPD and switching to VLNC cigarettes aim to reduce nicotine but do so in different ways. I conducted a randomized trial to compare the degree to which switching to VLNC cigarettes vs reducing CPD 1) …

Examining The Roles Of Sex, Methamphetamine, And Degree Of Training In Habit Formation In Rats, Hannah Schoenberg

Graduate College Dissertations and Theses

Addiction is characterized by a progressive loss of executive control over drug-seeking and consumption, and may be associated with a behavioral shift from instrumental goal-directed actions to stimulus-response habits. Sex differences in drug addiction have been linked to changing hormone levels across the estrous cycle, and females exhibit a particular vulnerability to psychostimulants such as cocaine and amphetamines. Psychostimulants and estrogen both influence dopaminergic activity in the dorsal striatum, a region of the brain in which dopamine activity is thought to mediate the shift from action to habit. In the present set of experiments, we examined the roles of sex, …

Intra-Cellular Mechanisms By Which Pac1 Receptor Activation Mediates Stress-Induced Reinstatement To Drug-Seeking, Olivia Miles

Graduate College Dissertations and Theses

The abuse of and addiction to drugs of abuse, such as tobacco, alcohol, opioids, and illicit drugs, are growing global problems that affect the welfare of individuals and societies worldwide. The National Institute of Drug Abuse estimates the annual cost of substance abuse to be over $740 billion in costs related to drug intoxication, withdrawal and relapse. A primary challenge in the treatment of substance abuse is the tendency of users to relapse following acute or extended periods of abstinence; on average over 60% of substance abusers will return to drug use within a year of receiving treatment, many relapsing …