Social and Behavioral Sciences Commons^™

Early Integration Of The Individual Student In Academic Activities: A Novel Classroom Concept For Graduate Education In Molecular Biophysics And Structural Biology, Sanford H. Leuba, Sean M. Carney, Elizabeth M. Dahlburg, Rebecca J. Eells, Harshad Ghodke, Naveena Yanamala, Grant Schauer, Judith Klein-Seetharaman

Faculty of Science, Medicine and Health - Papers: part A

Background: A key challenge in interdisciplinary research is choosing the best approach from a large number of techniques derived from different disciplines and their interfaces.

Results: To address this challenge in the area of Biophysics and Structural Biology, we have designed a graduate level course to teach students insightful use of experimental biophysical approaches in relationship to addressing biological questions related to biomolecular interactions and dynamics. A weekly seminar and data and literature club are used to compliment the training in class. The course contains wet-laboratory experimental demonstration and real-data analysis as well as lectures, grant proposal preparation and assessment, …

Resolving Sub-Molecular Binding And Electrical Switching Mechanisms Of Single Proteins At Electroactive Conducting Polymers, A Gelmi, M J. Higgins, Gordon G. Wallace

Faculty of Science, Medicine and Health - Papers: part A

Polymer-based electrodes for interfacing biological tissues are becoming increasingly sophisticated. Their many functions place them at the cross-roads of electromaterials, biomaterials, and drug-delivery systems. For conducting polymers, the mechanism of conductivity requires doping with anionic molecules such as extracellular matrix molecules, a process that distinguishes them as biomaterials and provides a means to control interactions at the cellular-electrode interface. However, due to their complex structure, directly observing the selective binding of target molecules or proteins has so far eluded researchers. This situation is compounded by the polymer's ability to adopt different electronic states that alter the polymer-dopant interactions. Here, the …

Short-Term Effects Of Fish And Fish Oil Consumption On Total And High Molecular Weight Adiponectin Levels In Overweight And Obese Adults, Elizabeth P. Neale, Beverly Muhlhausler, Yasmine C. Probst, Marijka J. Batterham, Francesca Fernandez, Linda C. Tapsell

Faculty of Science, Medicine and Health - Papers: part A

Objective: Fish or fish oil consumption may increase levels of total and high molecular weight (HMW) adiponectin, a hormone associated with anti-inflammatory and insulin-sensitising effects, however it is not known if the effects of the food and supplement are the same. The aim of this study was to compare the effect of consuming fish and fish oil supplements on plasma total and HMW adiponectin concentrations in overweight human participants.

Materials/Methods: 29 overweight and obese participants underwent a two week run-in period, followed by a four week isocaloric dietary intervention which provided 1.8g of long chain omega-3 polyunsaturated fatty acids (LC …

Molecular Evidence Of N-Methyl-D-Aspartate Receptor Hypofunction In Schizophrenia, C S. Weickert, S J. Fung, V S. Catts, P R. Schofield, K M. Allen, L T. Moore, Kelly A. Newell, D Pellen, Xu-Feng Huang, S V. Catts, T W Weickert

Faculty of Science, Medicine and Health - Papers: part A

Blockade of N-methyl-D-aspartate receptors (NMDARs) produces behavior in healthy people that is similar to the psychotic symptoms and cognitive deficits of schizophrenia and can exacerbate symptoms in people with schizophrenia. However, an endogenous brain disruption of NMDARs has not been clearly established in schizophrenia. We measured mRNA transcripts for five NMDAR subunit mRNAs and protein for the NR1 subunit in the dorsolateral prefrontal cortex (DLPFC) of schizophrenia and control (n=74) brains. Five NMDAR single-nucleotide polymorphisms (SNPs) previously associated with schizophrenia were tested for association with NMDAR mRNAs in postmortem brain and for association with cognitive ability in an antemortem cohort …

Dietary N-3 And N-6 Fatty Acids Alter Avian Metabolism: Molecular-Species Compostiton Of Breast-Muscle Phospholipids, Ronald Newman, Wayne Bryden, Eva Fleck, John R. Ashes, Leonard Storlien, Jeffery A. Downing

Faculty of Science, Medicine and Health - Papers: part A

The effects of diets high in n-3 polyunsaturated fatty acids (PUFA; provided by fish oil), n-6 PUFA (sunflower oil) or in more-saturated fatty acids (tallow) on the distribution of subclasses of choline phospholipids (PC) and ethanolamine phospholipids (PE) from the breast muscle of broiler chickens were examined. Supplementation with the different fatty acids had no effect on the distribution of phospholipid subclasses. Feeding sunflower oil or tallow gave a molecular-species profile similar in both fatty acid subtype and proportion. In the diacyl PC phospholipids, 16: 0–18: 1n-9 and 16: 0–18: 2n-6 accounted for approximately …

Molecular Analysis Of Group B Protective Surface Protein, A New Cell Surface Protective Antigen Of Group B Steptococci, Sezgin Erdogan, Peter K. Fagan, Susanne R. Talay, Manfred Rohde, Patricia Ferrieri, Aurea E. Flores, Carlos A. Guzman, Mark J. Walker, Gursharan S. Chhatwal

Faculty of Science, Medicine and Health - Papers: part A

Group B streptococci (GBS) express various surface antigens designated c, R, and X antigens. A new R-like surface protein from Streptococcus agalactiae strain Compton R has been identified by using a polyclonal antiserum raised against the R protein fraction of this strain to screen a lambda Zap library. DNA sequence analysis of positive clones allowed the prediction of the primary structure of a 105-kDa protein designated BPS protein (group B protective surface protein) that exhibited typical features of streptococcal surface proteins such as a signal sequence and a membrane anchor region but did not show significant similarity with other known …