Social and Behavioral Sciences Commons^™

Muscle Sympathetic Nerve Activity Is Associated With Liver Insulin Sensitivity In Obese Non-Diabetic Men, Daniel L.T Chen, Rachael Brown, Carsten Liess, Anne Poljak, Aimin Xu, Jialiang Zhang, Michael Trenell, Arthur Jenkins, Donald B. Chisholm, Dorit Samocha-Bonet, Vaughan G. Macefield, Jerry R. Greenfield

Faculty of Science, Medicine and Health - Papers: part A

Introduction: Muscle sympathetic nerve activity (MSNA) may play a role in insulin resistance in obesity. However, the direction and nature of the relationship between MSNA and insulin resistance in obesity remain unclear. We hypothesized that resting MSNA would correlate inversely with both muscle and liver insulin sensitivity and that it would be higher in insulin-resistant vs. insulin-sensitive subjects.

Materials and methods: Forty-five non-diabetic obese subjects were studied. As no significant relationships were found in women, the data presented in on 22 men aged 48 ± 12 years. Two-step (15 and 80 mU/m2/min) hyperinsulinaemic-euglycaemic clamps were performed using deuterated …

Lean Body Mass Associated With Upper Body Strength In Healthy Older Adults While Higher Body Fat Limits Lower Extremity Performance And Endurance, Karen E. Charlton, Marijka Batterham, Kelly Langford, Jenna Lateo, Erin Brock, Karen L. Walton, Philippa M. Lyons-Wall, Katie Eisenhauer, Nick Green, Cameron Mclean

Faculty of Science, Medicine and Health - Papers: part A

Impaired strength adversely influences an older person's ability to perform activities of daily living. A cross-sectional study of 117 independently living men and women (age = 73.4 9.4 year; body mass index (BMI) = 27.6 4.8 kg/m2) aimed to assess the association between body composition and: (1) upper body strength (handgrip strength, HGS); (2) lower extremity performance (timed up and go (TUG) and sit to stand test (STS)); and (3) endurance (6-minute walk (SMWT). Body composition (% fat; lean body mass (LBM)) was assessed using bioelectrical impedance. Habitual physical activity was measured using the Minnesota Leisure Time Physical Activity Questionnaire …

Maternal Obesity Is Associated With The Formation Of Small Dense Ldl And Hypoadiponectinemia In The Third Trimester, Barbara J. Meyer, Frances M. Stewart, Elizabeth A. Brown, Josephine Cooney, Solveig Nilsson, Gunilla Olivecrona, Jane E. Ramsay, Bruce A. Griffin, Muriel J. Caslake, Dilys J. Freeman

Faculty of Science, Medicine and Health - Papers: part A

CONTEXT: Maternal obesity is associated with high plasma triglyceride, poor vascular function, and an increased risk for pregnancy complications. In normal-weight pregnant women, higher triglyceride is associated with increased small, dense low-density lipoprotein (LDL). HYPOTHESIS: In obese pregnancy, increased plasma triglyceride concentrations result in triglyceride enrichment of very low-density lipoprotein-1 particles and formation of small dense LDL via lipoprotein lipase. DESIGN: Women (n = 55) of body mass index of 18-46 kg/m(2) were sampled longitudinally at 12, 26, and 35 weeks' gestation and 4 months postnatally. SETTING: Women were recruited at hospital antenatal appointments, and study visits were in a …

Sediment Disturbance Associated With Trampling By Humans Alters Species Assemblages On A Rocky Intertidal Seashore, Todd E. Minchinton, Katie J. Fels

Faculty of Science, Medicine and Health - Papers: part A

Our observations reveal that species living on rocky intertidal reefs can be positively and negatively associated with increasing sediment load. We therefore tested the hypothesis that sediment disturbance, including increased sediment loads associated with trampling by humans, alters the abundance of macroinvertebrates on a sheltered rocky intertidal platform in southern Australia. First we trampled the reef in shallow water at several disturbance intensities, simulating different numbers of people walking on the platform on a rising tide, and determined that sediment load was directly related to trampling intensity. Trampling displaced sediment, and up to an order of magnitude more sediment accumulated …

Food Groups And Fatty Acids Associated With Self-Reported Depression: An Analysis From The Australian National Nutrition And Health Surveys, Barbara J. Meyer, Nithin Kolanu, David A. Griffiths, Ben Grounds, Peter R. C Howe, Irene A. Kreis

Faculty of Science, Medicine and Health - Papers: part A

Objective The aim of this study was to explore the associations between incidence of depression and dietary intakes of foods and fatty acids in adult Australians. Methods Data from the 1995 Australian National Nutrition Survey (NNS), the 1995 Australian National Health Survey (NHS) and an updated fatty acid database were merged and the 24-h fatty acid intakes were calculated for the 10 986 adult participants ages 18 to 79 y in the 1995 NNS. The merged data set was used to run a logistic regression with depression as the response variable and the food groups and calculated fatty acid values, …

Demographic Patterns Of A Widespread Long-Lived Tree Are Associated With Rainfall And Disturbances Along Rainfall Gradients In Se Australia, Janet S. Cohn, Ian D. Lunt, Ross A. Bradstock, Quan Hua, Simon Mcdonald

Faculty of Science, Medicine and Health - Papers: part A

Predicting species distributions with changing climate has often relied on climatic variables, but increasingly there is recognition that disturbance regimes should also be included in distribution models. We examined how changes in rainfall and disturbances along climatic gradients determined demographic patterns in a widespread and long-lived tree species, Callitris glaucophylla in SE Australia. We examined recruitment since 1950 in relation to annual (200-600 mm) and seasonal (summer, uniform, winter) rainfall gradients, edaphic factors (topography), and disturbance regimes (vertebrate grazing [tenure and species], fire). A switch from recruitment success to failure occurred at 405 mm mean annual rainfall, coincident with a …

Higher Regular Fat Dairy Consumption Is Associated With Lower Incidence Of Metabolic Syndrome But Not Type 2 Diabetes, J C. Y Louie, V M. Flood, A M. Rangan, G Burlutsky, T P. Gill, B Gopinath, P Mitchell

Faculty of Science, Medicine and Health - Papers: part A

Background and aims Limited evidence suggests habitual dairy consumption to be protective against metabolic syndrome (MetSyn) and type 2 diabetes among older adults. We assessed the association of baseline consumption of dairy products with the incidence of MetSyn and type 2 diabetes among a cohort of Australian adults aged 49 years and over. Methods and results A validated 145-item semi-quantitative food frequency questionnaire was used to assess food and nutrient intake at baseline. Ten-year incidence of MetSyn and type 2 diabetes were obtained from 1807 and 1824 subjects respectively. Odds ratios (OR) were calculated by discrete time logistic regression modelling. …

Can Poor Health Literacy Contribute To Potential Side Effects Associated With Buying Over-The-Counter Non-Steroidal Anti-Inflammatory Drugs?, J R. Mullan, Judy Mullan, K M. Weston, A Bonney, C Magee

Faculty of Science, Medicine and Health - Papers: part A

No abstract provided.

Glutathionylation Potentiates Benign Superoxide Dismutase 1 Variants To The Toxic Forms Associated With Amyotrophic Lateral Sclerosis, Luke Mcalary, Justin J. Yerbury, J. Andrew Aquilina

Faculty of Science, Medicine and Health - Papers: part A

Dissociation of superoxide dismutase 1 dimers is enhanced by glutathionylation, although the dissociation constants reported to date are imprecise. We have quantified the discreet dissociation constants for wild-type superoxide dismutase 1 and six naturally occurring sequence variants, in their unmodified and glutathionylated forms, at the ratios expressed. Unmodified superoxide dismutase 1 variants that shared similar dissociation constants with SOD1WT had disproportionately increased dissociation constants when glutathionylated. This defines a key role for glutathionylation in superoxide dismutase 1 associated familial amyotrophic lateral sclerosis.

Improvement Of Major Depression Is Associated With Increased Erythrocyte Dha, Barbara J. Meyer, Brin F. S Grenyer, Trevor Crowe, Alice J. Owen, Elizabeth M. Grigonis-Deane, Peter R.C Howe

Faculty of Science, Medicine and Health - Papers: part A

The aim of this study was to determine if changes in omega-3 polyunsaturated fatty acid status following tuna oil supplementation correlated with changes in scores of depression. A total of 95 volunteers receiving treatment for major depression were randomised to consume 8 × 1 g capsules per day of HiDHA (2 g DHA, 0.6 g EPA and 10 mg Vitamin E) or olive oil (placebo) for 16 weeks, whilst undergoing weekly counseling sessions by trained clinical psychologists using a standard empirically validated psychotherapy. Depression status was assessed using the 17 item Hamilton rating scale for depression and the Beck Depression …

Ling, A New Integron-Associated Gene Cassette Encoding A Lincosamide Nucleotidyltransferase, Renee S. Levings, Ruth M. Hall, Diane Lightfoot, Steven P. Djordjevic

Faculty of Science, Medicine and Health - Papers: part A

Lincosamide antibiotics include lincomycin, a compound produced by several actinomycetes, and its semisynthetic chlorinated derivative clindamycin. These antibiotics block the peptidyltransferase activity of the 50S subunit of the bacterial ribosome, inhibiting protein synthesis, and are active against most gram-positive cocci and anaerobes. However, they are not generally effective against gram-negative bacilli due to intrinsic resistance.

Estimated Intake Of Milk Fat Is Negatively Associated With Cardiovascular Risk Factors And Does Not Increase The Risk Of A First Acute Myocardial Infarction. A Prospective Case-Control Study, Eva Warensjo, Jan-Hakan Jansson, Lars Berglund, Kurt Boman, Bo Ahren, Lars Weinehall, Bernt Lindahl, Goran Hallmans, Bengt Vessby

Faculty of Science, Medicine and Health - Papers: part A

Milk fat is high in saturated fatty acids (SFA) and high intakes of SFA are associated with cardiovascular diseases. The aim of the present study was to prospectively evaluate the potential risk of a first-ever acute myocardial infarction (AMI) in relation to the estimated milk-fat intake, reflected as the proportions of pentadecanoic acid (15:0) and heptadecanoic acid (17:0) in serum lipid esters. This was evaluated in a study population selected within the Västerbotten Intervention Program and the northern Sweden ‘Monitoring of Trends and Determinants in Cardiovascular disease’ survey populations. A prospective case–control design was used. The proportions of the biomarkers …

Ascorbic Acid Losses In Vegetables Associated With Cook-Chill Food Preparation, Karen E. Charlton, Paula Patrick, L Dowling, E Jensen

Faculty of Science, Medicine and Health - Papers: part A

Objective. To assess ascorbic acid (AA) losses in four vegetables (broccoli, peas, cauliflower and cabbage) at each production stage in a cook-chill food service system. Setting. A long-stay psychiatric hospital in Cape Town. Design. Cross-sectional analytical study. On two repeat occasions, three samples of each vegetable were taken at the following stages: (i) delivery (day 1); (ii) after preparation (day 2); (iii) after cooking (day 5); (iv) after blastchilling (day 5); and (v) in the holdroom and after regeneration over a 4-day period (days 6 - 9). AA content of each sample was assessed in duplicate using the 2,6 dichloroindophenol …

The Prevalence Of Diabetes Mellitus And Associated Risk Factors In Elderly Coloured South Africans, Karen E. Charlton, Naomi S. Levitt, Carl J. Lombard

Faculty of Science, Medicine and Health - Papers: part A

Objective. To determine the prevalence of diabetes and its associated risk factors in elderly coloured South Africans. Research design. Cross-sectional analytical study. Methods. A random sample of 200 non-institutionalised coloured (mixed ancestry) subjects aged 65 years of age, resident in urban Cape Town, was drawn by means of a two-stage cluster design. The survey procedure included an oral glucose tolerance test, anthropometric measurements, and physical activity and alcohol intake assessments. Results. The prevalence of diabetes was 28.7% (95% Cl 21.7 - 35.7%), 25.7% in men and 30.3% in women. The prevalence of impaired glucose tolerance was 15% (95% Cl 9.2 …