Social and Behavioral Sciences Commons^™

Early Negative Affect In Males And Females With Fragile X Syndrome: Implications For Anxiety And Autism, Carla A. Will, Abigail L. Hogan, Elizabeth A. Will, Samuel Mcquillin, Bridgette L. Kelleher, Jane E. Roberts

Faculty Publications

Background Fragile X syndrome (FXS) is a genetic disorder that is highly comorbid with anxiety and autism spectrum disorder (ASD). Elevated negative affect in young children has been associated with increased risk for both anxiety and ASD; however, these relations remain poorly understood in FXS.

Methods The present prospective longitudinal study examined the trajectory of negative affect from infancy through preschool in males and females with FXS and typical development and its relation to anxiety and ASD.

Results Results indicate a complex association reflecting group, developmental, and sex effects. Specifically, the group with FXS displayed a trajectory of increasing negative …

Infant Social Avoidance Predicts Autism But Not Anxiety In Fragile X Syndrome, Jane E. Roberts, Hayley Crawford, Elizabeth A. Will, Abigail L. Hogan, Samuel Dale Mcquillin, Bridgette L. Tonnsen, Shannon O'Connor, Douglas A. Roberts, Alexis M. Brewe

Faculty Publications

Objective: Autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and anxiety are three of the most common childhood psychiatric disorders. Early trajectories of social avoidance have been linked with these psychiatric disorders in previous studies, but it remains unclear how social avoidance differentially predicts comorbid disorders in a high-risk genetic subgroup. Here, we delineate the association between trajectories of social avoidance from infancy and subsequent ASD, ADHD, and anxiety outcomes at preschool in children with fragile X syndrome (FXS), a well-characterized single-gene disorder highly associated with social avoidance as well as elevated rates of ASD, ADHD, and anxiety.

Method: Males with …