Social and Behavioral Sciences Commons^™

Association Of Caregiver Attitudes With Adolescent Hpv Vaccination In 13 Southern Us States, Lavanya Vasudevan, Jan Ostermann, Yunfei Wang, Sayward Harrison, Valerie Yelverton, Laura J. Fish, Charnetta Williams, Emmanuel B. Walter

Faculty Publications

Background and objectives: HPV vaccination coverage is lower than that of other adolescent vaccines in the southern US. This study sought to characterize caregiver attitudes associated with adolescent HPV vaccination in the southern US and to inform interventions to promote HPV vaccination. Methods: From December 2019 – January 2020, caregivers of adolescents (ages 9–17 years) living in thir- teen southern US states were recruited from a nationally-representative online survey panel. Caregivers (N = 1,105) completed a cross-sectional survey that assessed general adolescent vaccine attitudes as well as those associated with the HPV vaccine and HPV vaccination decision-making. The primary study …

Future Orientation Among Children Affected By Parental Hiv In China: An Exploratory Analysis Of Complex Interactions, Heather L. Mcdaniel, Sayward Harrison, Amanda Fairchild, Xiaoming Li

Faculty Publications

We utilized an exploratory analytic approach to examine predictors of children's future beliefs, an internal asset associated with resilience among children affected by HIV, with emphasis on complex interactions among multisystem factors. Children (N = 1221) affected by parental HIV in China reported on psychosocial functioning, as well as internal, familial, and community resilience assets. Exploratory data analysis was conducted using a binary segmentation program. Six binary splits on predictors accounted for 22.78% of the variance in future expectation, suggesting interactions between children's perceived control of their future, loneliness, caregiver trust, and social support. Four binary splits accounted for …

Intraneuronal Β-Amyloid Accumulation: Aging Hiv-1 Human And Hiv-1 Transgenic Rat Brain, Hailong Li, Kristen A. Mclaurin, Charles F. Mactutus, Benjamin Linkins, Wenfei Huang, Sulie L. Chang, Rosemarie M. Booze

Faculty Publications

The prevalence of HIV-1 associated neurocognitive disorders (HAND) is significantly greater in older, relative to younger, HIV-1 seropositive individuals; the neural pathogenesis of HAND in older HIV-1 seropositive individuals, however, remains elusive. To address this knowledge gap, abnormal protein aggregates (i.e., β-amyloid) were investigated in the brains of aging (>12 months of age) HIV-1 transgenic (Tg) rats. In aging HIV-1 Tg rats, double immunohistochemistry staining revealed abnormal intraneuronal β-amyloid accumulation in the prefrontal cortex (PFC) and hippocampus, relative to F344/N control rats. Notably, in HIV-1 Tg animals, increased β-amyloid accumulation occurred in the absence of any genotypic changes in …

Key Stakeholder Perspectives On Challenges And Opportunities For Rural Hpv Vaccination In North And South Carolina, Laura J. Fish, Sayward Harrison, Jodi-Ann Mcdonald, Valerie Yelverton, Charnetta Williams, Emmanuel B. Walter, Lavanya Vasudevan

Faculty Publications

The objective of this study was to identify factors at the individual, provider, and systems levels that serve as challenges or opportunities for increasing adolescent vaccination—including Human Papillomavirus (HPV) vaccination—in rural communities in the southern United States (US). As part of a broader study to increase HPV vaccine uptake in the southern US, we conducted in-depth interviews with vaccination stakeholders representing public health and education agencies in North Carolina (NC) and South Carolina (SC). Fourteen key stakeholders were recruited using purposive sampling to obtain insights into challenges and solutions to rural-urban disparities in HPV vaccination coverage. Stakeholders were also queried …

A Resilience-Based Intervention To Mitigate The Effect Of Hiv-Related Stigma: Protocol For A Stepped Wedge Cluster Randomized Trial, Xiaoming Li, Shan Qiao, Xueying Yang, Sayward Harrison, Cheuk Chi Tam, Zhiyong Shen, Yuejiao Zhou

Faculty Publications

Background: Despite decades of global efforts to tackle HIV-related stigma, previous interventions designed to reduce stigma have had limited effects that were typically in the small- to-moderate range. The knowledge gaps and challenges for combating HIV-related stigma are rooted both in the complexity of the stigma and in the limitations of current conceptualizations of stigma reduction efforts. Recent research has shown the promise of resilience-based approaches that focus on the development of strengths, competencies, resources, and capacities of people living with HIV (PLWH) and their key supporting systems (e.g., family members and healthcare providers) to prevent, reduce, and mitigate the …

Family History Of Fxtas Is Associated With Age-Related Cognitive-Linguistic Decline Among Mothers With The Fmr1 Premutation, Jessica Klusek, Amanda Fairchild, Carly Moser, Marsha R. Mailick, Angela John Thurman, Leonard Abbeduto

Faculty Publications

BACKGROUND: Women who carry a premutation allele of the FMR1 gene are at increased vulnerability to an array of age-related symptoms and disorders, including age-related decline in select cognitive skills. However, the risk factors for age-related decline are poorly understood, including the potential role of family history and genetic factors. In other forms of pathological aging, early decline in syntactic complexity is observed and predicts the later onset of neurodegenerative disease. To shed light on the earliest signs of degeneration, the present study characterized longitudinal changes in the syntactic complexity of women with the FMR1 premutation across midlife, and associations …

Neurodevelopmental Processes In The Prefrontal Cortex Derailed By Chronic Hiv-1 Viral Protein Exposure, Kristen A. Mclaurin, Hailong Li, Rosemarie M. Booze, Charles F. Mactutus

Faculty Publications

Due to the widespread access to, and implementation of, combination antiretroviral therapy, individuals perinatally infected with human immunodeficiency virus type 1 (HIV-1) are living into adolescence and adulthood. Perinatally infected adolescents living with HIV-1 (pALHIV) are plagued by progressive, chronic neurocognitive impairments; the pathophysiological mechanisms underlying these deficits, however, remain understudied. A longitudinal experimental design from postnatal day (PD) 30 to PD 180 was utilized to establish the development of pyramidal neurons, and associated dendritic spines, from layers II-III of the medial prefrontal cortex (mPFC) in HIV-1 transgenic (Tg) and control animals. Three putative neuroinflammatory markers (i.e., IL-1β, IL-6, and …

A Scoping Review Investigating Relationships Between Depression, Anxiety, And The Prep Care Continuum In The United States, Sarah J. Miller, Sayward Harrison, Kamla Devi Sanasi-Bhola

Faculty Publications

Men who have sex with men and transgender women in the United States are at increased risk for HIV and may benefit from pre-exposure prophylaxis (PrEP), a once-a-day pill to prevent HIV. Due to stigma and discrimination, sexual and gender minority (SGM) populations are also at risk for depression and anxiety. This scoping review sought to identify literature addressing relationships between the PrEP care continuum, depression, and anxiety among SGM individuals and others at high risk for HIV. We conducted a systematic review of four databases (i.e., PubMed, PsycInfo, Web of Science, Google Scholar) and identified 692 unique articles that …

Trajectories Of Heart Activity Across Infancy To Early Childhood Differentially Predict Autism And Anxiety Symptoms In Fragile X Syndrome, Abigail Hogan, Erin Hunt, Kayla Smith, Conner Black, Katherine Bangert, Jessica Klusek, Jane Roberts

Faculty Publications

Fragile X syndrome (FXS) is a monogenic disorder characterized by high rates of autism spectrum disorder (ASD) and anxiety. A longstanding "hyperarousal hypothesis" in FXS has argued that ANS dysfunction underpins many symptoms of FXS. However, the developmental onset and trajectory of ANS dysfunction, as well as the consequences of ANS dysfunction on later psychiatric symptoms, remain poorly understood in FXS. Insight into the emergence, trajectory, and consequences of ANS dysfunction across early development in FXS has critical implications for prevention, intervention, and optimal outcomes in both typical and atypical development. This longitudinal study investigated whether and when males with …

Pre-Exposure Prophylaxis (Prep) Uptake Among Black Men Who Have Sex With Men (Bmsm) In The Southern U.S., Oluwafemi Atanda Adeagbo, Sayward Harrison, Shan Qiao, Xiaoming Li

Faculty Publications

Black men who have sex with men (BMSM) living in the United States (U.S.) South are disproportionately affected by HIV and experience significant disparities in HIV incidence, access to HIV care, and prevention across ages and socio-economic statuses. The aim of this commentary is to critically review current literature on the state of PrEP use among BMSM in the U.S. South, including identifying barriers and facilitators to PrEP use in order to inform intervention development. Extant literature shows that despite the documented benefits of PrEP as an effective HIV-prevention method, its uptake among BMSM is limited across the U.S. South. …

Concurrent Associations Between Expressive Language Ability And Independence In Adolescents And Adults With Fragile X Syndrome, Leonard Abbeduto, Jessica Klusek, Julie Lounds Taylor, Nadia Abdelnur, Nicole Sparapani, Angela John Thurman

Faculty Publications

BACKGROUND: Few individuals with fragile X syndrome (FXS) successfully meet adult normative expectations in education, employment, peer relations, and habitation, although there is within-syndrome variability in this regard. The primary goal of this study was to determine whether expressive language skills contribute to the capacity for independent functioning in adulthood even after controlling for nonverbal cognitive ability. METHODS: Participants were 18- to 23-year-olds with FXS. Expressive language was assessed using the psychometrically validated Expressive Language Sampling (ELS) conversation and narration procedures. The language produced was transcribed and analyzed to yield measures of expressive vocabulary, syntax, and intelligibility. Parents concurrently completed …

Examining Associations Between Knowledge And Vaccine Uptake Using The Human Papillomavirus Knowledge Questionnaire (Hpv-Kq), Sayward Harrison, Valerie Yelverton, Yunfei Wang, Jan Ostermann, Laura J. Fish, Charnetta L. Williams, Lavanya Vasudevan, Emmanuel B. Walter

Faculty Publications

Objectives: Understanding the relationship between human papillomavirus (HPV) knowledge and vaccination behavior is important to inform public health interventions, yet few validated HPV knowledge scales exist. This study describes development of the Human Papillomavirus Knowledge Questionnaire (HPV-KQ) and its validation with parents residing in the southern United States (US). Methods: Drawing on previously published measures, we developed the 13-item HPV-KQ and administered the scale via Web-based survey to parents (N=1105) of adolescents ages 9 to 17 years. Dimensionality, internal consistency, model fit, and predictive validity were assessed. Results: The scale was bidimensional. One factor captured general HPV knowledge, and the …

A Systematic Literature Review Of Sexual Harassment Studies With Text Mining, Amir Karami, Melek Yildiz Spinel, Nicole White, Kayla Ford, Suzanne Swan

Faculty Publications

Sexual harassment has been the topic of thousands of research articles in the 20th and 21st centuries. Several review papers have been developed to synthesize the literature about sexual harassment. While traditional literature review studies provide valuable insights, these studies have some limitations including analyzing a limited number of papers, being time-consuming and labor-intensive, focusing on a few topics, and lacking temporal trend analysis. To address these limitations, this paper employs both computational and qualitative approaches to identify major research topics, explore temporal trends of sexual harassment topics over the past few decades, and point to future possible directions in …

Age-Related Changes In Diffuse Optical Tomography Sensitivity Profiles In Infancy, Xiaoxue Fu, John E. Richards

Faculty Publications

Diffuse optical tomography uses near-infrared light spectroscopy to measure changes in cerebral hemoglobin concentration. Anatomical interpretations of the location that generates the hemodynamic signal requires accurate descriptions of diffuse optical tomography sensitivity to the underlying cortical structures. Such information is limited for pediatric populations because they undergo rapid head and brain development. The present study used photon propagation simulation methods to examine diffuse optical tomography sensitivity profiles in realistic head models among infants ranging from 2 weeks to 24 months with narrow age bins, children (4 and 12 years) and adults (20 to 24 years). The sensitivity profiles changed systematically …

S-Equol Mitigates Motivational Deficits And Dysregulation Associated With Hiv-1, Kristen A. Mclaurin, Sarah J. Bertrand, Jessica M. Illenberger, Steven B. Harrod, Charles F. Mactutus, Rosemarie M. Booze

Faculty Publications

Motivational deficits (e.g., apathy) and dysregulation (e.g., addiction) in HIV-1 seropositive individuals, despite treatment with combination antiretroviral therapy, necessitates the development of innovative adjunctive therapeutics. S-Equol (SE), a selective estrogen receptor beta agonist, has been implicated as a neuroprotective and/or neurorestorative therapeutic for HIV-1 associated neurocognitive disorders (HAND); its therapeutic utility for motivational alterations, however, has yet to be systematically evaluated. Thus, HIV-1 transgenic (Tg) and control animals were treated with either a daily oral dose of SE (0.2 mg) or vehicle and assessed in a series of tasks to evaluate goal-directed and drug-seeking behavior. First, at the genotypic level, …

Telepsychiatry Adoption Across Hospitals In The United States: A Cross-Sectional Study, Zhong Li, Sayward Harrison, Xiaoming Li, Peiyin Hung

Faculty Publications

Background: Access to psychiatric care is critical for patients discharged from hospital psychiatric units to ensure continuity of care. When face-to-face follow-up is unavailable or undesirable, telepsychiatry becomes a promising alternative. This study aimed to investigate hospital- and county-level characteristics associated with telepsychiatry adoption. Methods: Cross-sectional national data of 3475 acute care hospitals were derived from the 2017 American Hospital Association Annual Survey. Generalized linear regression models were used to identify characteristics associated with telepsychiatry adoption. Results: About one-sixth (548 [15.8%]) of hospitals reported having telepsychiatry with a wide variation across states. Rural noncore hospitals were less likely to adopt …

Structural Templates For Imaging Eeg Cortical Sources In Infants, Christian O'Reilly, Eric Larson, J. E. Richards, Mayada Elsabbagh

Faculty Publications

Electroencephalographic (EEG) source reconstruction is a powerful approach that allows anatomical localization of electrophysiological brain activity. Algorithms used to estimate cortical sources require an anatomical model of the head and the brain, generally reconstructed using magnetic resonance imaging (MRI). When such scans are unavailable, a population average can be used for adults, but no average surface template is available for cortical source imaging in infants. To address this issue, we introduce a new series of 13 anatomical models for subjects between zero and 24 months of age. These templates are built from MRI averages and boundary element method (BEM) segmentation …

Variable- And Person-Centered Approaches To Affect-Biased Attention In Infancy Reveal Unique Relations With Infant Negative Affect And Maternal Anxiety, Alicia Vallorani, Xiaoxue Fu, Santiago Morales, Vanessa Lobue, Kristin A. Buss, Koraly Perez-Edgar

Faculty Publications

Affect-biased attention is an automatic process that prioritizes emotionally or motivationally salient stimuli. Several models of affect-biased attention and its development suggest that it comprises an individual's ability to both engage with and disengage from emotional stimuli. Researchers typically rely on singular tasks to measure affect-biased attention, which may lead to inconsistent results across studies. Here we examined affect-biased attention across three tasks in a unique sample of 193 infants, using both variable-centered (factor analysis; FA) and person-centered (latent profile analysis; LPA) approaches. Using exploratory FA, we found evidence for two factors of affect-biased attention: an Engagement factor and a …

Impact Of Adverse Childhood Events On The Psychosocial Functioning Of Children Affected By Parental Hiv In Rural China, Jordan Ezell, Sayward Harrison, Yanping Jiang, Xiaoming Li

Faculty Publications

Introduction: Children affected by parental HIV are more likely than unaffected peers to experience trauma and are at-risk for negative psychological and social outcomes. This study aimed to examine the relationship between adverse childhood events and psychosocial functioning among children affected by parental HIV.

Methods: A total of 790 children ages 6–17 from Henan, China were enrolled in a longitudinal, randomized controlled trial of a resilience-based psychosocial intervention. At baseline, children reported on numerous psychosocial factors, including trauma exposure, symptoms of anxiety and depression, and peer social functioning. We used linear regression analysis to test the direct effect of trauma …

Early Negative Affect In Males And Females With Fragile X Syndrome: Implications For Anxiety And Autism, Carla A. Will, Abigail L. Hogan, Elizabeth A. Will, Samuel Mcquillin, Bridgette L. Kelleher, Jane E. Roberts

Faculty Publications

Background Fragile X syndrome (FXS) is a genetic disorder that is highly comorbid with anxiety and autism spectrum disorder (ASD). Elevated negative affect in young children has been associated with increased risk for both anxiety and ASD; however, these relations remain poorly understood in FXS.

Methods The present prospective longitudinal study examined the trajectory of negative affect from infancy through preschool in males and females with FXS and typical development and its relation to anxiety and ASD.

Results Results indicate a complex association reflecting group, developmental, and sex effects. Specifically, the group with FXS displayed a trajectory of increasing negative …

Infant Social Avoidance Predicts Autism But Not Anxiety In Fragile X Syndrome, Jane E. Roberts, Hayley Crawford, Elizabeth A. Will, Abigail L. Hogan, Samuel Dale Mcquillin, Bridgette L. Tonnsen, Shannon O'Connor, Douglas A. Roberts, Alexis M. Brewe

Faculty Publications

Objective: Autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and anxiety are three of the most common childhood psychiatric disorders. Early trajectories of social avoidance have been linked with these psychiatric disorders in previous studies, but it remains unclear how social avoidance differentially predicts comorbid disorders in a high-risk genetic subgroup. Here, we delineate the association between trajectories of social avoidance from infancy and subsequent ASD, ADHD, and anxiety outcomes at preschool in children with fragile X syndrome (FXS), a well-characterized single-gene disorder highly associated with social avoidance as well as elevated rates of ASD, ADHD, and anxiety.

Method: Males with …

Knowledge And Awareness Of Human Papillomavirus Among College Students In South Carolina, Salima Kasymova, Sayward Harrison, Caroline Pascal

Faculty Publications

Despite the existence of a safe and effective vaccine, human papillomavirus (HPV) remains prevalent in the United States, with late adolescence and early adulthood being periods of increased risk. Thus, targeting college-aged individuals for HPV prevention and vaccination promotion is critical—particularly in regions such as the Deep South where vaccination rates remain low. This study sought to examine awareness and knowledge of HPV as well as experiences and attitudes regarding HPV vaccination among college students in the Deep South. Specifically, we completed a cross-sectional survey of 256 undergraduate students from a large public university in South Carolina. Although a majority …

Curvilinear Association Between Language Disfluency And Fmr1 Cgg Repeat Size Across The Normal, Intermediate, And Premutation Range, Jessica Klusek, Ann Porter, Leonard Abbeduto, Tatyana Adayev, Flora Tassone, Marsha R. Mailick, Anne Glicksman, Bridgette L. Tonnsen, Jane E. Roberts

Faculty Publications

Historically, investigations of FMR1 have focused almost exclusively on the clinical effects of CGG expansion within the categories of the premutation (55–200 CGG repeats) and fragile X syndrome (>200 CGG repeats). However, emerging evidence suggests that CGG-dependent phenotypes may occur across allele sizes traditionally considered within the “normal” range. This study adopted an individual-differences approach to determine the association between language production ability and CGG repeat length across the full range of normal, intermediate, and premutation alleles. Participants included 61 adult women with CGG repeats within the premutation (n = 37), intermediate (i.e., 41–54 repeats; n = 2), …

Heart Rate-Defined Sustained Attention In Infants At Risk For Autism, Bridgette L. Tonnsen, J. E. Richards, Jane E. Roberts

Faculty Publications

Background: Although aberrant visual attention has been identified in infants at high familial risk for autism, the developmental emergence of atypical attention remains unclear. Integrating biological measures of attention into prospective high-risk infant studies may inform more nuanced developmental trajectories, clarifying the onset and course of atypical attention and potentially advancing early screening or treatment protocols. Heart rate-defined sustained attention (HRDSA) is a well-validated biological measure of attentional engagement that, in non-clinical infant populations, provides incremental information about attentional engagement beyond looking behaviors alone. The present study aimed to examine the characteristics and clinical correlates of HRDSA in high-risk infants, …

Altered Sensitivity To Social Gaze In The Fmr1 Premutation And Pragmatic Language Competence, Jessica Klusek, Joseph Schmidt, Amanda J. Fairchild, Ann Porter, Jane E. Roberts

Faculty Publications

Background: The FMR1 premutation affects 1:291 women and is associated with a range of cognitive, affective, and physical health complications, including deficits in pragmatic language (i.e., social language). This study investigated attention to eye gaze as a fundamental social-cognitive skill that may be impaired in the FMR1 premutation and could underlie pragmatic deficits. Given the high prevalence of the FMR1 premutation, efforts to define its phenotype and mechanistic underpinnings have significant public health implications. Methods: Thirty-five women with the FMR1 premutation and 20 control women completed an eye-tracking paradigm that recorded time spent dwelling within the eye region in response …

Reduced Vagal Tone In Women With The Premutation Is Associated With Mrna But Not Depression Or Anxiety, Jessica Klusek, Giuseppe Lafauci, Tatyana Adayev, W Ted Brown, Flora Tassone, Jane E. Roberts

Faculty Publications

BACKGROUND: Autonomic dysfunction is implicated in a range of psychological conditions, including depression and anxiety. The () premutation is a common genetic mutation that affects ~1:150 women and is associated with psychological vulnerability. This study examined cardiac indicators of autonomic function among women with the premutation and control women as potential biomarkers for psychological risk that may be linked to . METHODS: Baseline inter-beat interval and respiratory sinus arrhythmia (a measure of parasympathetic vagal tone) were measured in 35 women with the premutation and 28 controls. The women completed anxiety and depression questionnaires. genetic indices (i.e., CGG repeat, quantitative FMRP, …

The Lateral Occipital Cortex Is Selective For Object Shape, Not Texture/Color, At Six Months, Lauren L. Emberson, Stephen L. Crosswhite, J. E. Richards, Richard N. Aslin

Faculty Publications

Understanding howthe human visual system develops is crucialto understandingthe nature and organization of our complex and varied visual representations. However, previous investigations of the development of the visual system using fMRI are primarily confined to a subset of the visual system (high-level vision: faces, scenes) and relatively late in visual development (starting at 4 –5 years of age). The current study extends our understanding of human visual development by presenting the first systematic investigation of a mid-level visual region [the lateral occipital cortex (LOC)] in a population much younger than has been investigated in the past: 6 month olds. We …

Neural Correlates Of Face Processing In Etiologically-Distinct 12-Month-Old Infants At High-Risk Of Autism Spectrum Disorder, Maggie W. Guy, J. E. Richards, Bridgette L. Tonnsen, Jane E. Roberts

Faculty Publications

Neural correlates of face processing were examined in 12-month-olds at high-risk for autism spectrum disorder (ASD), including 21 siblings of children with ASD (ASIBs) and 15 infants with fragile X syndrome (FXS), as well as 21 low-risk (LR) controls. Event-related potentials were recorded to familiar and novel face and toy stimuli. All infants demonstrated greater N290 amplitude to faces than toys. At the Nc component, LR infants showed greater amplitude to novel stimuli than to their mother’s face and own toy, whereas infants with FXS showed the opposite pattern of responses and ASIBs did not differentiate based on familiarity. These …

Developmental Markers Of Genetic Liability To Autism In Parents: A Longitudinal, Multigenerational Study, Molly Losh, Gary E. Martin, Michelle Lee, Jessica Klusek, John Sideris, Sheila Barron, Thomas Wassink

Faculty Publications

Genetic liability to autism spectrum disorder (ASD) can be expressed in unaffected relatives through subclinical, genetically meaningful traits, or endophenotypes. This study aimed to identify developmental endophenotypes in parents of individuals with ASD by examining parents' childhood academic development over the school-age period. A cohort of 139 parents of individuals with ASD were studied, along with their children with ASD and 28 controls. Parents' childhood records in the domains of language, reading, and math were studied from grades K-12. Results indicated that relatively lower performance and slower development of skills (particularly language related skills), and an uneven rate of development …

Pragmatic Language Features Of Mothers With The Fmr1 Premutation Are Associated With The Language Outcomes Of Adolescents And Young Adults With Fragile X Syndrome, Jessica Klusek, S E. Mcgrath, L Abbeduto, J E. Roberts

Faculty Publications

No abstract provided.