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Disruption Of The Discriminative Stimulus Effects Of (+)-3, 4-Methylenedioxymethamphetamine (Mdma) By (± )-Mdma Neurotoxicity: Protection By Fluoxetine, Thomas B. Virden Iii

Dissertations

It is well established that repeated, high doses of 3, 4-methylenedioxymethamphetamine (MDMA) result in the long-term depletion of serotonin levels and destruction of serotonergic terminals in various locations in the brains of a variety of species. Further, it is also well known that concomitant injections of the serotonin reuptake inhibitor, fluoxetine, prevents this deterioration. It has recently been noted that such MDMA neurotoxicity disrupts stimulus control in rats trained to discriminate MDMA from saline in a drug discrimination procedure (Schechter, 1991a).

In order to extend Schechter's findings to the optical isomers of MDMA and to explore the potential of fluoxetine …

Direct Service Staff's Perceptions Of Psychotropic Medication In Noninstitutional Settings For Individuals With Developmental Disabilities, Leeann Christian

Dissertations

Approximately 35-55% of individuals with mental retardation who live in the community are prescribed psychotropic and/or antiepileptic medication (Aman, Saphare, & Burrows, 1995; Singh, Guernsey, & Ellis, 1992). As more individuals with severe behavior challenges are transitioned from institutions into the community, these rates are likely to increase. Given these prevalence rates, it is important to determine whether staff who serve people with mental retardation are adequately educated about psychotropic medications. Previous studies (Aman, Singh, & White, 1987; Gadow, 1983; Singh, Epstein, Stout, Luebke, & Ellis, 1994; Singh et al., 1996) surveyed a variety of service providers in school and …